Host-Microbe Interactions in inflammatory disease and cancer
The Host-Microbiota-Interaction (HMI) lab studies the complex interplay between the intestinal microbiota and the host, during the development of inflammatory disease and cancer. We investigate the fundamental mechanisms underlying various inflammatory pathologies and colorectal cancer, using transgenic mouse models. The HMI lab established first Belgian Germfree and Gnotobiotic mouse facility, in which we rederive transgenic mouse models of human disease in germ-free and gnotobiotic conditions. This allows us to study diseases which are strongly influenced by the intestinal microbiota, both during disease development and during therapeutic interventions. We study how specific bacteria and fungi can promote colorectal cancer, and how specific bacteria can promote response to immunotherapy. We are collaborating with clinicians at the Ghent and Leuven University Hospitals to collect microbiota samples for functional characterization in the HMI lab. In addition, we have a special interest in goblet cell biology, and developed various transgenic models for goblet-cell gene editing and mucus depletion, which allow us to study the role of goblet cells in health and disease. Together, we aim to acquire a better understanding of how the microbiota influences gut biology and human health, which can lead to better microbiota-based therapies in various diseases.
Areas of Expertise
- Colorectal cancer
- Intestinal inflammation
- Germ-Free Mouse Technology
- Goblet cell Biology
Technology Transfer Potential
- Microbiome-based diagnostics
- Microbiome-based therapeutics
- Intestinal epithelial barrier interventions
Selected publications
- Thiran A. et al. Sterile triggers drive joint inflammation in TNF and IL-1β dependent mouse arthritis models. EMBO Molecular Medicine, in press (2023).
- Slowicka, K. et al. Zeb2 drives invasive and microbiota-dependent colon carcinoma. Nature Cancer 1, 620-634 (2020). Visit ➚
- Gracey, E. et al. Revisiting the gut-joint axis: links between gut inflammation and spondyloarthritis. Nat Rev Rheumatol 16, 415-433 (2020). Visit ➚
- Takahashi, N. et al. RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis. Nature 513, 95-99 (2014). Visit ➚
- Vereecke, L. et al. A20 controls intestinal homeostasis through cell-specific activities. Nat. Comm. 5, 5103 (2014). Visit ➚
Bibliography
- Full bibliography Visit ➚
