Old wine in new wineskins: the underappreciated roles of E3 ubiquitin ligases in immunity and development

Four decades after their discovery, the TNF family of receptors, particularly the TNF-receptor 1 (TNFR1), are still under the spotlight, largely due to the pleiotropic functions of TNFR1 as proinflammatory or cell death-inducing receptor. Though various molecules are involved, E3 ubiquitin ligases remain a critical checkpoint for signal transduction downstream TNFR1. 

The cellular inhibitor of apoptosis proteins (cIAPs) and the linear-ubiquitin chain assembly complex (LUBAC) are key E3 ligases that propagate context-dependent signals downstream the TNFR1 and other immune receptors. Systemic ablation of cIAPs or LUBAC results in TNFR1-driven embryonic lethality, whereas manipulation of LUBAC or cIAPs induces diverse phenotypes in immune cells, particularly in T cell-populations and ILCs. I will discuss our investigation of the role of cIAPs and LUBAC in immune regulation using mouse models. 

---

From 14 May 2024 14:00
Until 14 May 2024 15:00
Location FSVMII building, seminar room, L5

Speaker John Rizk
Affiliation LEO Foundation Skin Immunology Research Center, University of Copenhagen, Denmark.
Host Esther Hoste

Stream View stream
Stream ID NA
Stream Password NA

---

About the speaker

John Rizk did his PhD in the lab of Vasileios Bekiaris working on the role of different signalling pathways including STAT5 and cIAPs in innate and adaptive immune cells, particularly T cells and ILCs. He is currently a postdoc in the lab of Mads Gyrd- Hansen at the University of Copenhagen, LEO foundation Skin immunology research center, where he works on understanding the roles of LUBAC in regulating immunity and development.