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Publications from this research unit

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De Bock, M, De Smet, MA, Verwaerde, S, Tahiri, H, Schumacher, S, Van Haver, V, Witschas, K, Steinhauser, C, Rouach, N, Vandenbroucke, RE, Leybaert, L.
Targeting gliovascular connexins prevents inflammatory blood-brain barrier leakage and astrogliosis
JCI Insight 7, e135263, 2022. (Epub 2022 Jul 26)

De Galan, C, Gonzales, GB, Van Welden, S, Tavernier, SJ, Lobaton, T, Van Moerkercke, W, Strubbe, B, Peeters, H, Macken, E, De Vos, M, Laukens, D, Hindryckx, P.
Role of integrin expression in the prediction of response to vedolizumab: A prospective real-life multicentre cohort study
Clin Transl Med 12, e769, 2022. (Epub 2022 Apr 5)

De Galan, C, Truyens, M, Peeters, H, Mesonero Gismero, F, Elorza, A, Torres, P, Vandermeulen, L, Jauregui Amezaga, A, Ferreiro-Iglesias, R, Holvoet, T, Zabana, Y, Peries Reverter, L, Gonzales, GB, Geldof, J, Varkas, G, De Vos, M, Lobaton, T.
The impact of vedolizumab and ustekinumab on articular extra-intestinal manifestations in inflammatory bowel disease patients: a real-life multicentric cohort study
J Crohns Colitis , in press, 2022. (Epub 2022 Apr 20)

De Vlieger, L, Vandenbroucke, RE, Van Hoecke, L.
Recent insights into viral infections as a trigger and accelerator in alzheimer's disease
Drug Discov Today 27, 103340, 2022. (Epub 2022 Aug 18)

Dujardin, P, Vandenbroucke, RE, Van Hoecke, L.
Fighting fire with fire: The immune system might be key in our fight against Alzheimer's disease
Drug Discov Today 27, 1261-1283, 2022. (Epub 2022 Jan 12)

Hobin, K, Costas-Rodriguez, M, Van Wonterghem, E, Vandenbroucke, RE, Vanhaecke, F.
High-Precision Isotopic Analysis of Cu and Fe via Multi-Collector Inductively Coupled Plasma-Mass Spectrometry Reveals Lipopolysaccharide-Induced Inflammatory Effects in Blood Plasma and Brain Tissues
Front Chem 10, 896279, 2022. (Epub 2022 Jun 15)

Truyens, M, Lobaton, T, Ferrante, M, Bossuyt, P, Vermeire, S, Pouillon, L, Dewint, P, Cremer, A, Peeters, H, Lambrecht, G, Louis, E, Rahier, JF, Dewit, O, Muls, V, Holvoet, T, Vandermeulen, L, Peeters, A, Gonzales, GB, Bos, S, et al..
Effect of 5-hydroxytryptophan on fatigue in quiescent inflammatory bowel disease: a randomized controlled trial
Gastroenterology , in press, 2022. (Epub 2022 Aug 5)

Vandendriessche, C, Kapogiannis, D, Vandenbroucke, RE.
Biomarker and therapeutic potential of peripheral extracellular vesicles in Alzheimer's disease
Adv Drug Deliv Rev , 114486, 2022. (Epub 2022 Aug 8)

Xie, J, Li, Q, Haesebrouck, F, Van Hoecke, L, Vandenbroucke, RE.
The tremendous biomedical potential of bacterial extracellular vesicles
Trends Biotechnol 40, 1173-1194, 2022. (Epub 2022 May 14)

Xie, J, Van Hoecke, L, Vandenbroucke, RE.
The Impact of Systemic Inflammation on Alzheimer's Disease Pathology
Front Immunol 12, 796867, 2022. (Epub 2022 Jan 6)

Yshii, L, Pasciuto, E, Bielefeld, P, Mascali, L, Lemaitre, P, Marino, M, Dooley, J, Kouser, L, Verschoren, S, Lagou, V, Kemps, H, Gervois, P, de Boer, A, Burton, OT, Wahis, J, Verhaert, J, Tareen, SHK, Roca, CP, Singh, K, et al..
Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation
Nat Immunol 23, 878-891, 2022. (Epub 2022 May 26)

Berlamont, H, Bruggeman, A, Bauwens, E, Vandendriessche, C, Clarebout, E, Xie, J, De Bruyckere, S, Van Imschoot, G, Van Wonterghem, E, Ducatelle, R, Santens, P, Smet, A, Haesebrouck, F, Vandenbroucke, RE.
Gastric Helicobacter suis Infection Partially Protects against Neurotoxicity in A 6-OHDA Parkinson's Disease Mouse Model
Int J Mol Sci 22, 11328, 2021. (Epub 2021 Oct 20)

Burgelman, M, Vandendriessche, C, Vandenbroucke, RE.
Extracellular Vesicles: A Double-Edged Sword in Sepsis
Pharmaceuticals (Basel) 14, 829, 2021. (Epub 2021 Aug 23)

Claeys, W, Van Hoecke, L, Lefere, S, Geerts, A, Verhelst, X, Van Vlierberghe, H, Degroote, H, Devisscher, L, Vandenbroucke, RE, Van Steenkiste, C.
The neurogliovascular unit in hepatic encephalopathy
JHEP Rep 3, 100352, 2021. (Epub 2021 Aug 11 )

De Galan, C, De Vos, M, Hindryckx, P, Laukens, D, Van Welden, S.
Long-Term Environmental Hypoxia Exposure and Haematopoietic Prolyl Hydroxylase-1 Deletion Do Not Impact Experimental Crohn's Like Ileitis
Biology (Basel) 10, 887, 2021. (Epub 2021 Sep 8)

Gorle, N, Bauwens, E, Haesebrouck, F, Smet, A, Vandenbroucke, RE.
Helicobacter and the Potential Role in Neurological Disorders: There Is More Than Helicobacter pylori
Front Immunol 11, 584165, 2021. (Epub 2021 Jan 28)

Grigoryan, R, Costas-Rodriguez, M, Van Wonterghem, E, Vandenbroucke, RE, Vanhaecke, F.
Effect of Endotoxemia Induced by Intraperitoneal Injection of Lipopolysaccharide on the Mg isotopic Composition of Biofluids and Tissues in Mice
Front Med (Lausanne) 8, 664666, 2021. (Epub 2021 Jul 23)

Gupta, D, Wiklander, OPB, Gorgens, A, Conceicao, M, Corso, G, Liang, X, Seow, Y, Balusu, S, Feldin, U, Bostancioglu, B, Jawad, R, Mamand, DR, Lee, YXF, Hean, J, Mager, I, Roberts, TC, Gustafsson, M, Mohammad, DK, Sork, H, et al..
Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles
Nat Biomed Eng 5, 1084-1098, 2021. (Epub 2021 Oct 6)

Pauwels, MJ, Vandendriessche, C, Vandenbroucke, RE.
Special delEVery: Extracellular Vesicles as Promising Delivery Platform to the Brain
Biomedicines 9, 1734, 2021. (Epub 2021 Nov 20)

Pombo Antunes, AR, Scheyltjens, I, Lodi, F, Messiaen, J, Antoranz, A, Duerinck, J, Kancheva, D, Martens, L, De Vlaminck, K, Van Hove, H, Kjolner Hansen, SS, Bosisio, FM, Van der Borght, K, De Vleeschouwer, S, Sciot, R, Bouwens, L, Verfaillie, M, Vandamme, N, Vandenbroucke, RE, et al..
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization
Nat Neurosci 24, 595-610, 2021. (Epub 2021 Mar 29)

Sork, H, Conceicao, M, Corso, G, Nordin, J, Lee, YXF, Krjutskov, K, Orzechowski Westholm, J, Vader, P, Pauwels, M, Vandenbroucke, RE, Wood, MJ, El Andaloussi, S, Mager, I.
Profiling of Extracellular Small RNAs Highlights a Strong Bias towards Non-Vesicular Secretion
Cells 10, 1543, 2021. (Epub 2021 Jun 18)

Truyens, M, De Ruyck, E, Gonzales, GB, Bos, S, Laukens, D, De Vos, M.
Prevalence of Fatigue and Unrecognized Depression in Patients with Inflammatory Bowel Disease in Remission under Immunosuppressants and Biologicals
J Clin Med 10, 4107, 2021. (Epub 2021 Sep 11)

Vandendriessche, C, Balusu, S, Van Cauwenberghe, C, Brkic, M, Pauwels, M, Plehiers, N, Bruggeman, A, Dujardin, P, Van Imschoot, G, Van Wonterghem, E, Hendrix, A, Baeke, F, De Rycke, R, Gevaert, K, Vandenbroucke, RE.
Importance of extracellular vesicle secretion at the blood-cerebrospinal fluid interface in the pathogenesis of Alzheimer's disease
Acta Neuropathol Commun 9, 143, 2021. (Epub 2021 Aug 23)

Van den Hoecke, S, Ballegeer, M, Vrancken, B, Deng, L, Job, ER, Roose, K, Schepens, B, Van Hoecke, L, Lemey, P, Saelens, X.
In Vivo Therapy with M2e-Specific IgG Selects for an Influenza A Virus Mutant with Delayed Matrix Protein 2 Expression
mBio 12, e0074521, 2021. (Epub 2021 Aug 31)

Van Hoecke, L, Van Cauwenberghe, C, Borger, V, Bruggeman, A, Castelein, J, Van Imschoot, G, Van Wonterghem, E, Dittrich, R, Claeys, W, Xie, J, Giebel, B, Vandenbroucke, RE.
Anti-Inflammatory Mesenchymal Stromal Cell-Derived Extracellular Vesicles Improve Pathology in Niemann-Pick Type C Disease
Biomedicines 9, 1864, 2021. (Epub 2021 Dec 8)

Van Hoecke, L, Van Cauwenberghe, C, Dominko, K, Van Imschoot, G, Van Wonterghem, E, Castelein, J, Xie, J, Claeys, W, Vandendriessche, C, Kremer, A, Borghgraef, P, De Rycke, R, Hecimovic, S, Vandenbroucke, RE.
Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C
Front Cell Neurosci 15, 757482, 2021. (Epub 2021 Oct 15)

Van Hoecke, L, Verbeke, R, Dewitte, H, Lentacker, I, Vermaelen, K, Breckpot, K, Van Lint, S.
mRNA in cancer immunotherapy: beyond a source of antigen
Mol Cancer 20, 48, 2021. (Epub 2021 Mar 3)

Verweij, FJ, Balaj, L, Boulanger, CM, Carter, DRF, Compeer, EB, D'Angelo, G, El Andaloussi, S, Goetz, JG, Gross, JC, Hyenne, V, Kramer-Albers, EM, Lai, CP, Loyer, X, Marki, A, Momma, S, Nolte-'t Hoen, ENM, Pegtel, DM, Peinado, H, Raposo, G, et al..
The power of imaging to understand extracellular vesicle biology in vivo
Nat Methods 18, 1013-1026, 2021. (Epub 2021 Aug 26)

Xie, J, Gorle, N, Vandendriessche, C, Van Imschoot, G, Van Wonterghem, E, Van Cauwenberghe, C, Parthoens, E, Van Hamme, E, Lippens, S, Van Hoecke, L, Vandenbroucke, RE.
Low-grade peripheral inflammation affects brain pathology in the App(NL-G-F)mouse model of Alzheimer's disease
Acta Neuropathol Commun 9, 163, 2021. (Epub 2021 Oct 7)

Bos, S, Laukens, D.
Metabolic modulation during intestinal fibrosis
J Dig Dis 21, 319-325, 2020. (Epub 2020 May 14)

Grigoryan, R, Costas-Rodriguez, M, Vandenbroucke, RE, Vanhaecke, F.
High-precision isotopic analysis of Mg and Ca in biological samples using multi-collector ICP-mass spectrometry after their sequential chromatographic isolation - Application to the characterization of the body distribution of Mg and Ca isotopes in mice
Anal Chim Acta 1130, 137-145, 2020. (Epub 2020 Jul 28)

Lefevere, E, Salinas-Navarro, M, Andries, L, Noterdaeme, L, Etienne, I, Van Wonterghem, E, Vinckier, S, Davis, BM, Van Bergen, T, Van Hove, I, Movahedi, K, Vandenbroucke, RE, Moons, L, De Groef, L.
Tightening the retinal glia limitans attenuates neuroinflammation after optic nerve injury
Glia 68, 2643-2660, 2020. (Epub 2020 Jul 9)

Vandendriessche, C, Bruggeman, A, Van Cauwenberghe, C, Vandenbroucke, RE.
Extracellular Vesicles in Alzheimer's and Parkinson's Disease: Small Entities with Large Consequences
Cells 9, 2485, 2020. (Epub 2020 Nov 15)

van Olst, L, Verhaege, D, Franssen, M, Kamermans, A, Roucourt, B, Carmans, S, Ytebrouck, E, van der Pol, SMA, Wever, D, Popovic, M, Vandenbroucke, RE, Sobrino, T, Schouten, M, de Vries, HE.
Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model
Neurobiol Aging 89, 89-98, 2020. (Epub 2020 Jan 10)

Ballegeer, M, Vandewalle, J, Eggermont, M, Van Isterdael, G, Dejager, L, De Bus, L, Decruyenaere, J, Vandenbroucke, RE, Libert, C.
Overexpression of Gilz Protects Mice Against Lethal Septic Peritonitis
Shock 52, 208-214, 2019. (Epub 2018 Aug 17)

Coenen-Stass, AML, Pauwels, MJ, Hanson, B, Martin Perez, C, Conceicao, M, Wood, MJA, Mager, I, Roberts, TC.
Extracellular microRNAs exhibit sequence-dependent stability and cellular release kinetics
RNA Biol 16, 696-706, 2019. (Epub 2019 Mar 5)

Delvaeye, T, De Smet, MAJ, Verwaerde, S, Decrock, E, Czekaj, A, Vandenbroucke, RE, Lemeire, K, Goncalves, A, Declercq, W, Vandenabeele, P, Krysko, DV, Leybaert, L.
Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock
Sci Rep 9, 16623, 2019. (Epub 2019 Nov 12)

Gorle, N, Vandenbroucke, RE.
Interferons: A molecular switch between damage and repair in ageing and Alzheimer's disease
Mech Ageing Dev 183, 111148, 2019. (Epub 2019 Sep 18)

Lepko, T, Pusch, M, Muller, T, Schulte, D, Ehses, J, Kiebler, M, Hasler, J, Huttner, HB, Vandenbroucke, RE, Vandendriessche, C, Modic, M, Martin-Villalba, A, Zhao, S, E, LL-B, Schneider, A, Fischer, A, Breunig, CT, Stricker, SH, Gotz, M, et al..
Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain
EMBO J , e100481, 2019. (Epub 2019 Jul 15)

Naessens, S, De Zaeytijd, J, Syx, D, Vandenbroucke, RE, Smeets, F, Van Cauwenbergh, C, Leroy, BP, Peelman, F, Coppieters, F.
The N-terminal p.(Ser38Cys) TIMP3 mutation underlying Sorsby fundus dystrophy is a founder mutation disrupting an intramolecular disulfide bond
Hum Mutat 40, 539-551, 2019. (Epub 2019 Feb 6)

Russell, AE, Sneider, A, Witwer, KW, Bergese, P, Bhattacharyya, SN, Cocks, A, Cocucci, E, Erdbrugger, U, Falcon-Perez, JM, Freeman, DW, Gallagher, TM, Hu, S, Huang, Y, Jay, SM, Kano, SI, Lavieu, G, Leszczynska, A, Llorente, AM, Lu, Q, et al..
Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop
J Extracell Vesicles 8, 1684862, 2019. (Epub 2019 Nov 8)

Steeland, S, Vandenbroucke, RE.
Choroid plexus tumor necrosis factor receptor 1: A new neuroinflammatory piece of the complex Alzheimer's disease puzzle
Neural Regen Res 14, 1144-1147, 2019. (Epub 2019 Feb 26)

Vandewalle, J, Steeland, S, Van Ryckeghem, S, Eggermont, M, Van Wonterghem, E, Vandenbroucke, RE, Libert, C.
A Study of Cecal Ligation and Puncture-Induced Sepsis in Tissue-Specific Tumor Necrosis Factor Receptor 1-Deficient Mice
Front Immunol 10, 2574, 2019. (Epub 2019 Nov 8)

Van Hove, H, Martens, L, Scheyltjens, I, De Vlaminck, K, Pombo Antunes, AR, De Prijck, S, Vandamme, N, De Schepper, S, Van Isterdael, G, Scott, CL, Aerts, J, Berx, G, Boeckxstaens, GE, Vandenbroucke, RE, Vereecke, L, Moechars, D, Guilliams, M, Van Ginderachter, JA, Saeys, Y, Movahedi, K.
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment
Nat Neurosci 22, 10211035, 2019. (Epub 2019 May 6)

Zhong, Z, Portela Catani, JP, Mc Cafferty, S, Couck, L, Van Den Broeck, W, Gorle, N, Vandenbroucke, RE, Devriendt, B, Ulbert, S, Cnops, L, Michels, J, Arien, KK, Sanders, NN.
Immunogenicity and Protection Efficacy of a Naked Self-Replicating mRNA-Based Zika Virus Vaccine
Vaccines (Basel) 7, 96, 2019. (Epub 2019 Aug 23)

Ballegeer, M, Van Looveren, K, Timmermans, S, Eggermont, M, Vandevyver, S, Thery, F, Dendoncker, K, Souffriau, J, Vandewalle, J, Van Wyngene, L, De Rycke, R, Takahashi, N, Vandenabeele, P, Tuckermann, J, Reichardt, HM, Impens, F, Beyaert, R, De Bosscher, K, Vandenbroucke, RE, et al..
Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice
J Clin Invest 128, 3265-3279, 2018. (Epub 2018 May 10)

Gorle, N, Blaecher, C, Bauwens, E, Vandendriessche, C, Balusu, S, Vandewalle, J, Van Cauwenberghe, C, Van Wonterghem, E, Van Imschoot, G, Liu, C, Ducatelle, R, Libert, C, Haesebrouck, F, Smet, A, Vandenbroucke, RE.
The choroid plexus epithelium as a novel player in the stomach-brain axis during Helicobacter infection
Brain Behav Immun 69, 35-47, 2018. (Epub 2017 Dec 16)

Steeland, S, Gorle, N, Vandendriessche, C, Balusu, S, Brkic, M, Van Cauwenberghe, C, Van Imschoot, G, Van Wonterghem, E, De Rycke, R, Kremer, A, Lippens, S, Stopa, E, Johanson, CE, Libert, C, Vandenbroucke, RE.
Counteracting the effects of TNF receptor-1 has therapeutic potential in Alzheimer's disease
EMBO Mol Med 10, UNSP e8300, 2018. (Epub 2018 Feb 22)

Steeland, S, Libert, C, Vandenbroucke, RE.
A New Venue of TNF Targeting
Int J Mol Sci 19, e1442, 2018. (Epub 2018 May 11)

Steeland, S, Van Ryckeghem, S, Vandewalle, J, Ballegeer, M, Van Wonterghem, E, Eggermont, M, Decruyenaere, J, De Bus, L, Libert, C, Vandenbroucke, RE.
Simultaneous Inhibition of Tumor Necrosis Factor Receptor 1 and Matrix Metalloproteinase 8 Completely Protects Against Acute Inflammation and Sepsis
Crit Care Med 46, e67e75, 2018. (Epub 2017 Oct 31)

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