The regenerative biology of the synovial joint

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Using genetic lineage tracing studies, we have identified skeletal progenitors in adult synovial joints as descending from the embryonic joint interzones, which are important players in joint homeostasis, cartilage repair, and arthritis pathophysiology in adulthood.

Single-cell transcriptomic analysis of mesenchymal cells, including fibroblasts, purified from healthy and cartilage-injured adult knees from transgenic mice have defined the developmental origin of the fibroblasts in the synovium and clarified the relationship between fibroblasts and professional progenitors. Two progenitor populations were identified in synovium, one located near blood vessels in the sublining, and the other in the lining layer.

Understanding the native progenitor cells and related signals in joint homeostasis, repair and arthritis will inform targeted therapeutic strategies to promote intrinsic repair mechanisms to maintain healthy joints and prevent progression of damage in arthritis.



From 27 Sep 2024 11:30
Until 27 Sep 2024 12:30
Location FSVMI building, seminar room

Speaker Cosimo De Bari
Affiliation Centre for Arthritis and Musculoskeletal Health University of Aberdeen, UK
Host Dirk Elewaut

Stream View stream
Stream ID 892 9388 0636
Stream Password 563280

About the speaker

Professor Cosimo De Bari is a clinically active rheumatologist and a translational scientist with expertise in musculoskeletal regenerative medicine and arthritis pathophysiology. He has a long-standing interest and track record in the study of joint health and disease, with a focus on cell-based therapies for cartilage repair and osteoarthritis.

Cosimo graduated in Medicine (summa cum laude) from the University of Bari (Italy), where he underwent specialist training in Rheumatology. He obtained his PhD from the University of Leuven (Belgium). In 2003 Cosimo moved to King's College London, where in 2005 he was awarded an MRC Clinician Scientist Fellowship. Since 2007 Cosimo holds a clinical chair in Experimental Medicine and Rheumatology (formerly Translational Medicine) at the University of Aberdeen.

Cosimo is the founder and director of the Aberdeen Centre for Arthritis and Musculoskeletal Health (awarded “Centre of Excellence in Rheumatology” status by the EULAR), leads the Arthritis and Regenerative Medicine Laboratory, and is deputy director of the Versus Arthritis Tissue Engineering & Regenerative Therapies Centre.


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Seminar