Update on the gut-joint axis: If it's not the gut, is it the nerve?

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Chronic inflammatory diseases, like rheumatoid arthritis (RA) have been described to cause central nervous system (CNS) activation. Less is known about environmental factors that enable the CNS to suppress peripheral inflammation in RA. Here, we identified gut microbiota-derived histamine as such factor. We show that low levels of histamine activate the enteric nervous system, increase inhibitory neurotransmitter concentrations in the spinal cord and restore homeostatic microglia, thereby reducing inflammation in the joints. Moreover, therapeutic supplementation of the SCFA propionate identified one way to expand local intestinal histamine concentrations in mice and humans. Thus, we define a gut-CNS-joint axis pathway where microbiota-derived histamine initiates the resolution of arthritis via the CNS.



From 14 Mar 2025 11:30
Until 14 Mar 2025 12:30
Location FSVMI building, seminar room

Speaker Mario Zaiss
Affiliation Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany
Host Dirk Elewaut

Stream View stream
Stream ID 898 5895 8189
Stream Password 892433

About the speaker

Mario Zaiss graduated in zoology/ecology (Heidelberg) with a special focus on marine biology. Since then, his scientific curiosity has led him through various exciting areas (osteimmunology, parasitology, nutrition) and places (Greece, US, Switzerland) before he started his own lab in Erlangen in 2016. Since then he has enjoyed working with his fantastic team on various projects with a shared focus on tolerance induction, autoimmunity and the gut-joint axis.


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Seminar