Neutrophil heterogeneity in autoimmune diseases

Neutrophils are essential for host defense and key contributors to inflammatory pathology. However, their heterogeneity is poorly understood in contrast to other leukocytes. Here we explore the emerging concept of neutrophil heterogeneity through the lens of different autoimmune and inflammatory conditions. We will discuss driving factors and organizing principles of neutrophil heterogeneity and assess its conservation across humans and mice.

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From 11 Apr 2025 11:30
Until 11 Apr 2025 12:30
Location FSVMI building, seminar room

Speaker Ricardo Grieshaber -Bouyer
Affiliation Department of Internal Medicine 3 – Rheumatology and Immunology FAU Erlangen-Nürnberg and University Hospital Erlangen
Host Dirk Elewaut

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About the speaker

Professor Grieshaber-Bouyer studied medicine and business administration. He received his clinical training in medicine, rheumatology, and immunology at the Universities of Heidelberg and Zurich, at Duke University School of Medicine, and at Harvard Medical School. His immunological research focuses on neutrophils, inflammatory arthritis, and bioinformatics. After postdoctoral training with the Boston-based ImmGen Consortium, he then established a DFG-funded research group at Heidelberg University as clinician scientist, focusing on neutrophil heterogeneity in rheumatic disease.

He was then appointed Professor of Clinical Systems Immunology at FAU Erlangen-Nürnberg. In his clinical role he heads the clinical trial unit and focuses on the interdisciplinary care of patients with rheumatic and immune-mediated diseases, particularly in the context of emerging immunotherapies such as T cell engagers and CAR T cell therapies. His research group investigates the mechanisms driving immune cell heterogeneity in tissues and inflammatory conditions and develops new bioinformatics analysis tools for high dimensional data