Interplay between retinal regeneration and inflammatory response to injury

Perron's laboratory is interested in a complex and intriguing issue in neurobiology, namely the tremendous variability of neural tissue regeneration efficiency among vertebrates. Regarding the retina, mammalian Müller glial cells possess remnants of stemness but are unable to sustain retinal regeneration, contrasting with their teleost or amphibian counterparts. They are studying the molecular mechanisms that underlie such divergent regenerative properties, taking advantage of both Xenopus and mouse models. Muriel will focus my talk on the coupling between inflammatory signaling and regeneration.

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From 11 Dec 2024 11:30
Until 11 Dec 2024 12:30
Location FSVM I building, seminar room

Speaker Muriel Perron
Affiliation CNRS - Université Paris-Saclay
Host Kris Vleminckx

Stream View stream
Stream ID 850 7165 6806
Stream Password 551573

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About the speaker

Muriel Perron was a post-doctoral fellow in Bill Harris’ lab at UCSD San Diego (1996-97) and then in Cambridge UK (1997-99), where she worked on Xenopus retinal stem cells in the ciliary marginal zone. In 2014-15 she was a visiting Scientist at the Jules Stein Eye Institute, Los Angeles, in Xian-Jie Yang’s lab. She obtained a permanent position at the CNRS in France in 2000. She is now a Director of Research at the Paris-Saclay Institute of Neuroscience, of which she is the deputy director. Her lab focuses on retinal regeneration, using both Xenopus and mouse models, with a recent interest in the links between neuroinflammation and regeneration potential.