The Gut-Immune-Brain Axis in Parkinson’s disease

There is growing evidence that Parkinson’s disease may begin in the gut, with alpha-synuclein pathology spreading along the gut-brain axis. In this talk, I will present our recent findings on how gut-resident immune cells, specifically macrophages, play a critical role in modulating alpha-synuclein pathology and driving immune responses that migrate from gut to brain. Our work highlights a key link between gut immune activity and neurodegeneration, offering new insights into early Parkinson’s disease mechanisms and potential avenues for therapeutic intervention

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From 28 Feb 2025 11:30
Until 28 Feb 2025 12:30
Location FSVMI building, seminar room

Speaker Sebastiaan De Schepper
Affiliation University of Antwerp, VIB, Center for molecular neurology
Host Bart Lambrecht

Stream View stream
Stream ID 810 2042 7164
Stream Password 064837

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About the speaker

Dr. Seppe De Schepper is an incoming group leader at the VIB-Center for Molecular Neurology/ University of Antwerp. He received training in leading laboratories under the mentorship of Prof. Guy Boeckxstaens, Prof. Dario Alessi, and Dr. Soyon Hong, acquiring extensive expertise in neuroimmunology and neurodegeneration before establishing his own research line on the gut-immune-brain axis. The Laboratory for Gut-Immune-Brain Axis Research will investigate how the peripheral immune system influences brain immune states in health and disease, with a particular focus on the role of intestinal macrophages and immune cell trafficking in neurodegenerative disorders.