Stromal cells and macrophages constantly communicate to maintain tissue homeostasis and regulate local immune responses. This cellular crosstalk is crucial for various biological functions, yet its exact mechanisms in vivo remain difficult to dissect. In this talk, I will focus on the dialogue between stromal cells and macrophages within the testis, a highly specialized microenvironment where local regulation is essential for organ function. I will present our recent evidence detailing how these two cell types interact and influence each other. Furthermore, I will introduce a novel in vivo model developed by our group. This innovative tool will allows us to precisely address these cellular interactions in a physiological context, opening new avenues to understand macrophage-stromal cell communication in health and disease.
Dr. Marc Bajenoff performed his doctoral training under the supervision of Dr S. Guerder at the Centre d'Immunologie de Marseille Luminy (CIML). He then joined the laboratory of Prof Glaichenhaus (Valbonne, France) and Prof R. Germain at the Lymphocyte Biology Section, National Institutes of Health for his post-doctoral studies. Here, he developed the first applications of the 2-photon methods for intravital imaging to an extensive analysis of the function of stromal elements within lymphoid tissues. In 2010, he established the "Immunobiology of stromal cells" group at CIML and in 2015, he was awarded an ERC consolidator grant to study the dynamics of lymphoid stromal cells. His general research interests are in understanding the immunobiology of stromal cells and how these versatile cells control the immune system at multiple levels. More recently, his laboratory has developed a strong interest in studying the crosstalk between stromal cells and macrophages across tissues.