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Publications from this research unit

This page shows only publications with IRC as the affiliation of at least one author.
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De Francesco, D, Wit, FW, Burkle, A, Oehlke, S, Kootstra, NA, Winston, A, Franceschi, C, Garagnani, P, Pirazzini, C, Libert, C, Grune, T, Weber, D, Jansen, E, Sabin, CA, Reiss, P, The Co-morBidity in Relation to, AC.
Do people living with HIV experience greater age advancement than their HIV-negative counterparts?
AIDS 33, 259268, 2019. (Epub 2018 Oct 15)

Dendoncker, K, Timmermans, S, Vandewalle, J, Eggermont, M, Lempiainen, J, Van Hamme, E, Dewaele, S, Vandevyver, S, Ballegeer, M, Souffriau, J, Van Wyngene, L, Van Looveren, K, Vanderhaeghen, T, Beyaert, R, De Bosscher, K, Palvimo, JJ, Van Montagu, M, Libert, C.
TNF-alpha inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile
Proc Natl Acad Sci U S A , in press, 2019. (Epub 2019 Jun 10)

Libert, C, Ayala, A, Bauer, M, Cavaillon, JM, Deutschman, C, Frostell, C, Knapp, S, Kozlov, AV, Wang, P, Osuchowski, MF, Remick, DG.
Part II: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS) for Types of Infections and Organ Dysfunction Endpoints
Shock 51, 23-32, 2019. (Epub 2018 Aug 14)

Osuchowski, MF, Hellman, J, Huber-Lang, M, Libert, C, Remick, DG, Thiemermann, C, Zingarelli, B.
The Response to the Letter to the Editor Titled: "Is Triple Self-plagiarism "OK" If Only Made Transparent?" by Volker R Jacobs, MD, MBA
Shock 51, 140-141, 2019. (Epub 2018 Nov 20)

Ballegeer, M, Vandewalle, J, Eggermont, M, Van Isterdael, G, Dejager, L, De Bus, L, Decruyenaere, J, Vandenbroucke, RE, Libert, C.
Overexpression of Gilz Protects Mice Against Lethal Septic Peritonitis
Shock , in press, 2018. (Epub 2018 Aug 17)

Ballegeer, M, Van Looveren, K, Timmermans, S, Eggermont, M, Vandevyver, S, Thery, F, Dendoncker, K, Souffriau, J, Vandewalle, J, Van Wyngene, L, De Rycke, R, Takahashi, N, Vandenabeele, P, Tuckermann, J, Reichardt, HM, Impens, F, Beyaert, R, De Bosscher, K, Vandenbroucke, RE, et al..
Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice
J Clin Invest 128, 3265-3279, 2018. (Epub 2018 May 10)

Beyaert, R, Libert, C.
How Good Roommates Can Protect against Microbial Sepsis
Cell Host Microbe 23, 283-285, 2018. (Epub 2018 Mar 14)

Boeck, C, Pfister, S, Burkle, A, Vanhooren, V, Libert, C, Salinas-Manrique, J, Dietrich, DE, Kolassa, IT, Karabatsiakis, A.
Alterations of the serum N-glycan profile in female patients with Major Depressive Disorder
J Affect Disord 234, 139-147, 2018. (Epub 2018 Feb 27)

Borghi, A, Haegman, M, Fischer, R, Carpentier, I, Bertrand, MJM, Libert, C, Afonina, IS, Beyaert, R.
The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2-induced canonical NF-kappaB signaling
Biochem Pharmacol 153, 292-298, 2018. (Epub 2018 Jan 26)

Bouhy, D, Juneja, M, Katona, I, Holmgren, A, Asselbergh, B, De Winter, V, Hochepied, T, Goossens, S, Haigh, JJ, Libert, C, Ceuterick-de Groote, C, Irobi, J, Weis, J, Timmerman, V.
A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8
Acta Neuropathol 135, 131-148, 2018. (Epub 2017 Aug 5)

De Francesco, D, Wit, FW, Cole, JH, Kootstra, NA, Winston, A, Sabin, CA, Underwood, J, van Zoest, RA, Schouten, J, Kooij, KW, Prins, M, Guaraldi, G, Caan, MWA, Burger, D, Franceschi, C, Libert, C, Burkle, A, Reiss, P, collaboration, COiRtA.
The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics
PLoS One 13, e0191791, 2018. (Epub 2018 Mar 29)

Gorle, N, Blaecher, C, Bauwens, E, Vandendriessche, C, Balusu, S, Vandewalle, J, Van Cauwenberghe, C, Van Wonterghem, E, Van Imschoot, G, Liu, C, Ducatelle, R, Libert, C, Haesebrouck, F, Smet, A, Vandenbroucke, RE.
The choroid plexus epithelium as a novel player in the stomach-brain axis during Helicobacter infection
Brain Behav Immun 69, 35-47, 2018. (Epub 2017 Dec 16)

Imbrechts, M, De Samblancx, K, Fierens, K, Brisse, E, Vandenhaute, J, Mitera, T, Libert, C, Smets, I, Goris, A, Wouters, C, Matthys, P.
IFN-gamma stimulates CpG-induced IL-10 production in B cells via p38 and JNK signalling pathways
Eur J Immunol 48, 1506-1521, 2018. (Epub 2018 Jul 13)

Kip, E, Staal, J, Tima, HG, Verstrepen, L, Romano, M, Lemeire, K, Suin, V, Hamouda, A, Baens, M, Libert, C, Kalai, M, Van Gucht, S, Beyaert, R.
Inhibition of MALT1 decreases neuroinflammation and pathogenicity of virulent rabies virus in mice
J Virol 92, e00720-18, 2018. (Epub 2018 Aug 29)

Lazzarano, S, Kucka, M, Castro, JPL, Naumann, R, Medina, P, Fletcher, MNC, Wombacher, R, Gribnau, J, Hochepied, T, Van Montagu, M, Libert, C, Chan, YF.
Genetic mapping of species differences via in vitro crosses in mouse embryonic stem cells
Proc Natl Acad Sci U S A 115, 3680-3685, 2018. (Epub 2018 Mar 21)

Mylka, V, Deckers, J, Ratman, D, De Cauwer, L, Thommis, J, De Rycke, R, Impens, F, Libert, C, Tavernier, J, Vanden Berghe, W, Gevaert, K, De Bosscher, K.
The autophagy receptor SQSTM1/p62 mediates anti-inflammatory actions of the selective NR3C1/glucocorticoid receptor modulator compound A (CpdA) in macrophages
Autophagy 14, 2049-2064, 2018. (Epub 2018 Sep 14)

Osuchowski, MF, Ayala, A, Bahrami, S, Bauer, M, Boros, M, Cavaillon, JM, Chaudry, IH, Coopersmith, CM, Deutschman, C, Drechsler, S, Efron, P, Frostell, C, Fritsch, G, Gozdzik, W, Hellman, J, Huber-Lang, M, Inoue, S, Knapp, S, et al., Libert, C.
Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis
Intensive Care Med Exp 6, 26, 2018. (Epub 2018 Aug 14)

Osuchowski, MF, Ayala, A, Bahrami, S, Bauer, M, Boros, M, Cavaillon, JM, Chaudry, IH, Coopersmith, CM, Deutschman, C, Drechsler, S, Efron, P, Frostell, C, Fritsch, G, Gozdzik, W, Hellman, J, Huber-Lang, M, Inoue, S, Knapp, S, et al., Libert, C.
Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis
Shock 50, 377-380, 2018. (Epub 2018 Aug 14)

Osuchowski, MF, Ayala, A, Bahrami, S, Bauer, M, Boros, M, Cavaillon, JM, Chaudry, IH, Coopersmith, CM, Deutschman, C, Drechsler, S, Efron, P, Frostell, C, Fritsch, G, Gozdzik, W, Hellman, J, Huber-Lang, M, Inoue, S, Knapp, S, Libert, C, et al..
Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis
Infection 46, 687-691, 2018. (Epub 2018 Aug 14)

Souffriau, J, Eggermont, M, Van Ryckeghem, S, Van Looveren, K, Van Wyngene, L, Van Hamme, E, Vuylsteke, M, Beyaert, R, De Bosscher, K, Libert, C.
A screening assay for Selective Dimerizing Glucocorticoid Receptor Agonists and Modulators (SEDIGRAM) that are effective against acute inflammation
Sci Rep 8, 12894, 2018. (Epub 2018 Aug 27)

Souffriau, J, Libert, C.
Mechanistic insights into the protective impact of zinc on sepsis
Cytokine Growth Factor Rev 39, 92-101, 2018. (Epub 2017 Dec 22)

Steeland, S, Gorle, N, Vandendriessche, C, Balusu, S, Brkic, M, Van Cauwenberghe, C, Van Imschoot, G, Van Wonterghem, E, De Rycke, R, Kremer, A, Lippens, S, Stopa, E, Johanson, CE, Libert, C, Vandenbroucke, RE.
Counteracting the effects of TNF receptor-1 has therapeutic potential in Alzheimer's disease
EMBO Mol Med 10, UNSP e8300, 2018. (Epub 2018 Feb 22)

Steeland, S, Libert, C, Vandenbroucke, RE.
A New Venue of TNF Targeting
Int J Mol Sci 19, e1442, 2018. (Epub 2018 May 11)

Steeland, S, Van Ryckeghem, S, Vandewalle, J, Ballegeer, M, Van Wonterghem, E, Eggermont, M, Decruyenaere, J, De Bus, L, Libert, C, Vandenbroucke, RE.
Simultaneous Inhibition of Tumor Necrosis Factor Receptor 1 and Matrix Metalloproteinase 8 Completely Protects Against Acute Inflammation and Sepsis
Crit Care Med 46, e67e75, 2018. (Epub 2017 Oct 31)

Timmermans, S, Libert, C.
Easy Access to and Applications of the Sequences of All Protein-Coding Genes of All Sequenced Mouse Strains
Trends Genet 34, 899-902, 2018. (Epub 2018 Sep 19)

Timmermans, S, Libert, C.
Learning lessons in sepsis from the children
Mol Syst Biol 14, e8335, 2018. (Epub 2018 May 17)

Timmermans, S, Libert, C.
Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J
JCI Insight 3, e121758, 2018. (Epub 2018 Jul 12)

Timmermans, S, Souffriau, J, Vandewalle, J, Van Wyngene, L, Van Looveren, K, Vanderhaeghen, T, Libert, C.
Using the inbred mouse strain SPRET/EiJ to provide novel insights in inflammation and infection research
Mamm Genome 29, 585-592, 2018. (Epub 2018 Aug)

Vandewalle, J, Luypaert, A, De Bosscher, K, Libert, C.
Therapeutic Mechanisms of Glucocorticoids
Trends Endocrinol Metab 29, 42-54, 2018. (Epub 2017 Nov 18)

Van Looveren, K, Libert, C.
Should we target TNF receptors in the intestinal epithelium with glucocorticoids during systemic inflammation?
Expert Opin Ther Targets 22, 1029-1037, 2018. (Epub 2018 Oct 20)

Van Wyngene, L, Vandewalle, J, Libert, C.
Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?
EMBO Mol Med 10, e8712, 2018. (Epub 2018 Jul 5)

van Zoest, RA, Underwood, J, De Francesco, D, Sabin, CA, Cole, JH, Wit, FW, Caan, MWA, Kootstra, NA, Fuchs, D, Zetterberg, H, Majoie, C, Portegies, P, Winston, A, Sharp, DJ, Gisslen, M, Reiss, P, Comorbidity in Relation to, AC.
Structural Brain Abnormalities in Successfully Treated HIV Infection: Associations With Disease and Cerebrospinal Fluid Biomarkers
J Infect Dis 217, 69-81, 2018. (Epub 2017 Dec 27)

Voet, S, Mc Guire, C, Hagemeyer, N, Martens, A, Schroeder, A, Wieghofer, P, Daems, C, Staszewski, O, Vande Walle, L, Jordao, MJC, Sze, M, Vikkula, HK, Demeestere, D, Van Imschoot, G, Scott, CL, Hoste, E, Goncalves, A, Guilliams, M, Lippens, S, Libert, C, Vandenbroucke, RE, et al., Lamkanfi, M, Prinz, M, van Loo, G.
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation
Nat Commun 9, 2036, 2018. (Epub 2018 May 23)

Zagato, E, Vermeulen, L, Dewitte, H, Van Imschoot, G, Vandenbroucke, RE, Demeester, J, De Schmedt, SC, Neyts, K, Remaut, K, Braeckmans, K.
Quantifying the average number of nucleic acid therapeutics per nanocarrier by Single Particle Tracking microscopy
Mol Pharm 15, 1142-1149, 2018. (Epub 2018 Feb 12)

Booiman, T, Wit, FW, Maurer, I, De Francesco, D, Sabin, CA, Harskamp, AM, Prins, M, Garagnani, P, Pirazzini, C, Franceschi, C, Fuchs, D, Gisslen, M, Winston, A, Reiss, P, Kootstra, NA, Comorbidity in Relation to, AC.
High Cellular Monocyte Activation in People Living With Human Immunodeficiency Virus on Combination Antiretroviral Therapy and Lifestyle-Matched Controls Is Associated With Greater Inflammation in Cerebrospinal Fluid
Open Forum Infect Dis 4, ofx108, 2017. (Epub 2017 May 25)

Cole, JH, Underwood, J, Caan, MW, De Francesco, D, van Zoest, RA, Leech, R, Wit, FW, Portegies, P, Geurtsen, GJ, Schmand, BA, Schim van der Loeff, MF, Franceschi, C, Sabin, CA, Majoie, CB, Winston, A, Reiss, P, Sharp, DJ, collaboration, C.
Increased brain-predicted aging in treated HIV disease
Neurology 88, 1349-1357, 2017. (Epub 2017 Mar 3)

Dendoncker, K, Libert, C.
Glucocorticoid resistance as a major drive in sepsis pathology
Cytokine Growth Factor Rev 35, 85-96, 2017. (Epub 2017 Apr 23)

Dendoncker, K, Timmermans, S, Van Looveren, K, De Cauwer, L, De Bosscher, K, Libert, C.
The nature of the GRE influences the screening for GR-activity enhancing modulators
PLoS One 12, 7, 2017. (Epub 2017 Jul 7)

Greenwood, J, Hammarlund-Udenaes, M, Jones, HC, Stitt, AW, Vandenbroucke, RE, Romero, IA, Campbell, M, Fricker, G, Brodin, B, Manninga, H, Gaillard, PJ, Schwaninger, M, Webster, C, Wicher, KB, Khrestchatisky, M.
Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017
Fluids Barriers CNS 14, 31, 2017. (Epub 2017 Nov 7)

Holvoet, T, Devriese, S, Castermans, K, Boland, S, Leysen, D, Vandewynckel, YP, Devisscher, L, Van den Bossche, L, Van Welden, S, Dullaers, M, Vandenbroucke, RE, De Rycke, R, Geboes, K, Bourin, A, Defert, O, Hindryckx, P, De Vos, M, Laukens, D.
Treatment of intestinal fibrosis in experimental inflammatory bowel disease by the pleiotropic actions of a local Rho kinase inhibitor
Gastroenterology 153, 1054-1067, 2017. (Epub 2017 Jun 19)

Klassen, C, Karabinskaya, A, Dejager, L, Vettorazzi, S, Van Moorleghem, J, Luhder, F, Meijsing, SH, Tuckermann, JP, Bohnenberger, H, Libert, C, Reichardt, HM.
Airway Epithelial Cells Are Crucial Targets of Glucocorticoids in a Mouse Model of Allergic Asthma
J Immunol 199, 48-61, 2017. (Epub 2017 May 17)

Petta, I, Bougarne, N, Vandewalle, J, Dejager, L, Vandevyver, S, Ballegeer, M, Desmet, S, Thommis, J, De Cauwer, L, Lievens, S, Libert, C, Tavernier, J, De Bosscher, K.
Glucocorticoid Receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor
Sci Rep 7, 8941, 2017. (Epub 2017 Aug 21)

Steeland, S, Van Ryckeghem, S, Van Imschoot, G, De Rycke, R, Toussaint, W, Vanhoutte, L, Vanhove, C, De Vos, F, Vandenbroucke, RE, Libert, C.
TNFR1 inhibition with a Nanobody protects against EAE development in mice
Sci Rep 7, 13646, 2017. (Epub 2017 Oct 20)

Timmermans, S, Van Montagu, M, Libert, C.
Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains
Proc Natl Acad Sci U S A 114, 9158-9163, 2017. (Epub 2017 Aug 7)

Vandereyken, MM, Singh, P, Wathieu, CP, Jacques, S, Zurashvilli, T, Dejager, L, Amand, M, Musumeci, L, Singh, M, Moutschen, MP, Libert, C, Rahmouni, S.
Dual-Specificity Phosphatase 3 Deletion Protects Female, but Not Male, Mice from Endotoxemia-Induced and Polymicrobial-Induced Septic Shock
J Immunol 199, 2515-2527, 2017. (Epub 2017 Aug 28)

Balusu, S, Brkic, M, Libert, C, Vandenbroucke, RE.
The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease: more than just a barrier
Neural Regen Res 11, 534-537, 2016. (Epub 2016 Apr)

Balusu, S, Van Wonterghem, E, De Rycke, R, Raemdonck, K, Stremersch, S, Gevaert, K, Brkic, M, Demeestere, D, Vanhooren, V, Hendrix, A, Libert, C, Vandenbroucke, RE.
Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles
EMBO Mol Med 8, 1162-1183, 2016. (Epub 2016 Oct 4)

Carceller, E, Ballegeer, M, Deckers, J, Riccardi, C, Bruscoli, S, Hochepied, T, Libert, C, Perez, P.
Overexpression of Glucocorticoid-induced Leucine Zipper (GILZ) increases susceptibility to Imiquimod-induced psoriasis and involves cutaneous activation of TGF-beta1
Sci Rep 6, 38825, 2016. (Epub 2016 Dec 9)

De Bock, M, Van Haver, V, Vandenbroucke, RE, Decrock, E, Wang, N, Leybaert, L.
Into rather unexplored terrain-transcellular transport across the blood-brain barrier
Glia 64, 1097-1123, 2016. (Epub 2016 Feb 8)

De Bosscher, K, Beck, IM, Ratman, D, Berghe, WV, Libert, C.
Activation of the Glucocorticoid Receptor in Acute Inflammation: the SEDIGRAM Concept
Trends Pharmacol Sci 37, 4-16, 2016. (Epub 2015 Oct 22)

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