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Publications from this research unit

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Souffriau, J, Timmermans, S, Vanderhaeghen, T, Wallaeys, C, Van Looveren, K, Aelbrecht, L, Dewaele, S, Vandewalle, J, et al., Eggermont, M, De Rycke, R, De Bruyne, M, Ballegeer, M, Vandevyver, S, Hochepied, T, Beyaert, R, Libert, C.
Zinc inhibits lethal inflammatory shock by preventing microbe-induced interferon signature in intestinal epithelium
EMBO Mol Med , e11917, 2020. (Epub 2020 Sep 11)

Vanderhaeghen, T, Vandewalle, J, Libert, C.
Hypoxia-inducible factors in metabolic reprogramming during sepsis
FEBS J , in press, 2020. (Epub 2020 Jan 23)

Vandewalle, J, Libert, C.
GILZ in sepsis: "Poor is the pupil who does not surpass his master"
Eur J Immunol 50, 490-493, 2020. (Epub 2020 Feb 27)

Vandewalle, J, Libert, C.
Glucocorticoids in Sepsis: To Be or Not to Be
Front Immunol 11, 1318, 2020. (Epub 2020 Jul 21)

Vandewalle, J, Vanderhaeghen, T, Beyaert, R, Libert, C.
Taking the STING Out of Sepsis?
Cell Host Microbe 27, 491-493, 2020. (Epub 2020 Apr 8)

Van Looveren, K, Timmermans, S, Vanderhaeghen, T, Wallaeys, C, Ballegeer, M, Souffriau, J, Eggermont, M, Vandewalle, J, Van Wyngene, L, De Bosscher, K, Libert, C.
Glucocorticoids limit lipopolysaccharide-induced lethal inflammation by a double control system
EMBO Rep 21, e49762, 2020. (Epub 2020 May 8)

Van Looveren, K, Van Wyngene, L, Libert, C.
An extracellular microRNA can rescue lives in sepsis
EMBO Rep , e49193, 2020. (Epub 2019 Nov 14)

Van Looveren, K, Wallaeys, C, Libert, C.
Potential of glucocorticoids to treat intestinal inflammation during sepsis
Curr Opin Pharmacol 53, 1-7, 2020. (Epub 2020 Jan 25)

Van Wyngene, L, Vanderhaeghen, T, Timmermans, S, Vandewalle, J, Van Looveren, K, Souffriau, J, Wallaeys, C, Eggermont, M, Ernst, S, Van Hamme, E, Goncalves, A, Eelen, G, Remmerie, A, Scott, CL, Rombouts, C, Vanhaecke, L, De Bus, L, Decruyenaere, J, Carmeliet, P, et al..
Hepatic PPARalpha function and lipid metabolic pathways are dysregulated in polymicrobial sepsis
EMBO Mol Med , e11319, 2020. (Epub 2020 Jan 9)

Woo Kim, S, Goossens, A, Libert, C, Van Immerseel, F, Staal, J, Beyaert, R.
Phytohormones: Multifunctional nutraceuticals against metabolic syndrome and comorbid diseases
Biochem Pharmacol 175, 113866, 2020. (Epub 2020 Feb 20)

Ballegeer, M, Vandewalle, J, Eggermont, M, Van Isterdael, G, Dejager, L, De Bus, L, Decruyenaere, J, Vandenbroucke, RE, Libert, C.
Overexpression of Gilz Protects Mice Against Lethal Septic Peritonitis
Shock 52, 208-214, 2019. (Epub 2018 Aug 17)

Bougarne, N, Mylka, V, Ratman, D, Beck, IM, Thommis, J, De Cauwer, L, Tavernier, J, Staels, B, Libert, C, De Bosscher, K.
Mechanisms Underlying the Functional Cooperation Between PPARalpha and GRalpha to Attenuate Inflammatory Responses
Front Immunol 10, 1769, 2019. (Epub 2019 Aug 9)

De Francesco, D, Wit, FW, Burkle, A, Oehlke, S, Kootstra, NA, Winston, A, Franceschi, C, Garagnani, P, Pirazzini, C, Libert, C, Grune, T, Weber, D, Jansen, E, Sabin, CA, Reiss, P, The Co-morBidity in Relation to, AC.
Do people living with HIV experience greater age advancement than their HIV-negative counterparts?
AIDS 33, 259268, 2019. (Epub 2018 Oct 15)

Dendoncker, K, Timmermans, S, Vandewalle, J, Eggermont, M, Lempiainen, J, Van Hamme, E, Dewaele, S, Vandevyver, S, Ballegeer, M, Souffriau, J, Van Wyngene, L, Van Looveren, K, Vanderhaeghen, T, Beyaert, R, De Bosscher, K, Palvimo, JJ, Van Montagu, M, Libert, C.
TNF-alpha inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile
Proc Natl Acad Sci U S A 116, 12942-12951, 2019. (Epub 2019 Jun 10)

Libert, C, Ayala, A, Bauer, M, Cavaillon, JM, Deutschman, C, Frostell, C, Knapp, S, Kozlov, AV, Wang, P, Osuchowski, MF, Remick, DG.
Part II: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS) for Types of Infections and Organ Dysfunction Endpoints
Shock 51, 23-32, 2019. (Epub 2018 Aug 14)

Osuchowski, MF, Hellman, J, Huber-Lang, M, Libert, C, Remick, DG, Thiemermann, C, Zingarelli, B.
The Response to the Letter to the Editor Titled: "Is Triple Self-plagiarism "OK" If Only Made Transparent?" by Volker R Jacobs, MD, MBA
Shock 51, 140-141, 2019. (Epub 2018 Nov 20)

Timmermans, S, Souffriau, J, Libert, C.
A General Introduction to Glucocorticoid Biology
Front Immunol 10, 1545, 2019. (Epub 2019 Jul 25)

Underwood, J, De Francesco, D, Cole, JH, Caan, MWA, van Zoest, RA, Schmand, BA, Sharp, DJ, Sabin, CA, Reiss, P, Winston, A, COmorBidity in Relation to AIDS Collaboration and the, PacOiPof, Y. Study Group.
Validation of a Novel Multivariate Method of Defining HIV-Associated Cognitive Impairment
Open Forum Infect Dis 6, ofz198, 2019. (Epub 2019 May 3)

Vandewalle, J, Steeland, S, Van Ryckeghem, S, Eggermont, M, Van Wonterghem, E, Vandenbroucke, RE, Libert, C.
A Study of Cecal Ligation and Puncture-Induced Sepsis in Tissue-Specific Tumor Necrosis Factor Receptor 1-Deficient Mice
Front Immunol 10, 2574, 2019. (Epub 2019 Nov 8)

Van Looveren, K, Van Boxelaere, M, Callaerts-Vegh, Z, Libert, C.
Cognitive dysfunction in mice lacking proper glucocorticoid receptor dimerization
PLoS One 14, e0226753, 2019. (Epub 2019 Dec 23)

Ballegeer, M, Van Looveren, K, Timmermans, S, Eggermont, M, Vandevyver, S, Thery, F, Dendoncker, K, Souffriau, J, Vandewalle, J, Van Wyngene, L, De Rycke, R, Takahashi, N, Vandenabeele, P, Tuckermann, J, Reichardt, HM, Impens, F, Beyaert, R, De Bosscher, K, Vandenbroucke, RE, et al..
Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice
J Clin Invest 128, 3265-3279, 2018. (Epub 2018 May 10)

Beyaert, R, Libert, C.
How Good Roommates Can Protect against Microbial Sepsis
Cell Host Microbe 23, 283-285, 2018. (Epub 2018 Mar 14)

Boeck, C, Pfister, S, Burkle, A, Vanhooren, V, Libert, C, Salinas-Manrique, J, Dietrich, DE, Kolassa, IT, Karabatsiakis, A.
Alterations of the serum N-glycan profile in female patients with Major Depressive Disorder
J Affect Disord 234, 139-147, 2018. (Epub 2018 Feb 27)

Borghi, A, Haegman, M, Fischer, R, Carpentier, I, Bertrand, MJM, Libert, C, Afonina, IS, Beyaert, R.
The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2-induced canonical NF-kappaB signaling
Biochem Pharmacol 153, 292-298, 2018. (Epub 2018 Jan 26)

Bouhy, D, Juneja, M, Katona, I, Holmgren, A, Asselbergh, B, De Winter, V, Hochepied, T, Goossens, S, Haigh, JJ, Libert, C, Ceuterick-de Groote, C, Irobi, J, Weis, J, Timmerman, V.
A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8
Acta Neuropathol 135, 131-148, 2018. (Epub 2017 Aug 5)

De Francesco, D, Wit, FW, Cole, JH, Kootstra, NA, Winston, A, Sabin, CA, Underwood, J, van Zoest, RA, Schouten, J, Kooij, KW, Prins, M, Guaraldi, G, Caan, MWA, Burger, D, Franceschi, C, Libert, C, Burkle, A, Reiss, P, collaboration, COiRtA.
The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics
PLoS One 13, e0191791, 2018. (Epub 2018 Mar 29)

Gorle, N, Blaecher, C, Bauwens, E, Vandendriessche, C, Balusu, S, Vandewalle, J, Van Cauwenberghe, C, Van Wonterghem, E, Van Imschoot, G, Liu, C, Ducatelle, R, Libert, C, Haesebrouck, F, Smet, A, Vandenbroucke, RE.
The choroid plexus epithelium as a novel player in the stomach-brain axis during Helicobacter infection
Brain Behav Immun 69, 35-47, 2018. (Epub 2017 Dec 16)

Imbrechts, M, De Samblancx, K, Fierens, K, Brisse, E, Vandenhaute, J, Mitera, T, Libert, C, Smets, I, Goris, A, Wouters, C, Matthys, P.
IFN-gamma stimulates CpG-induced IL-10 production in B cells via p38 and JNK signalling pathways
Eur J Immunol 48, 1506-1521, 2018. (Epub 2018 Jul 13)

Kip, E, Staal, J, Tima, HG, Verstrepen, L, Romano, M, Lemeire, K, Suin, V, Hamouda, A, Baens, M, Libert, C, Kalai, M, Van Gucht, S, Beyaert, R.
Inhibition of MALT1 decreases neuroinflammation and pathogenicity of virulent rabies virus in mice
J Virol 92, e00720-18, 2018. (Epub 2018 Aug 29)

Lazzarano, S, Kucka, M, Castro, JPL, Naumann, R, Medina, P, Fletcher, MNC, Wombacher, R, Gribnau, J, Hochepied, T, Van Montagu, M, Libert, C, Chan, YF.
Genetic mapping of species differences via in vitro crosses in mouse embryonic stem cells
Proc Natl Acad Sci U S A 115, 3680-3685, 2018. (Epub 2018 Mar 21)

Mylka, V, Deckers, J, Ratman, D, De Cauwer, L, Thommis, J, De Rycke, R, Impens, F, Libert, C, Tavernier, J, Vanden Berghe, W, Gevaert, K, De Bosscher, K.
The autophagy receptor SQSTM1/p62 mediates anti-inflammatory actions of the selective NR3C1/glucocorticoid receptor modulator compound A (CpdA) in macrophages
Autophagy 14, 2049-2064, 2018. (Epub 2018 Sep 14)

Osuchowski, MF, Ayala, A, Bahrami, S, Bauer, M, Boros, M, Cavaillon, JM, Chaudry, IH, Coopersmith, CM, Deutschman, C, Drechsler, S, Efron, P, Frostell, C, Fritsch, G, Gozdzik, W, Hellman, J, Huber-Lang, M, Inoue, S, Knapp, S, et al., Libert, C.
Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis
Intensive Care Med Exp 6, 26, 2018. (Epub 2018 Aug 14)

Osuchowski, MF, Ayala, A, Bahrami, S, Bauer, M, Boros, M, Cavaillon, JM, Chaudry, IH, Coopersmith, CM, Deutschman, C, Drechsler, S, Efron, P, Frostell, C, Fritsch, G, Gozdzik, W, Hellman, J, Huber-Lang, M, Inoue, S, Knapp, S, et al., Libert, C.
Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis
Shock 50, 377-380, 2018. (Epub 2018 Aug 14)

Osuchowski, MF, Ayala, A, Bahrami, S, Bauer, M, Boros, M, Cavaillon, JM, Chaudry, IH, Coopersmith, CM, Deutschman, C, Drechsler, S, Efron, P, Frostell, C, Fritsch, G, Gozdzik, W, Hellman, J, Huber-Lang, M, Inoue, S, Knapp, S, Libert, C, et al..
Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis
Infection 46, 687-691, 2018. (Epub 2018 Aug 14)

Souffriau, J, Eggermont, M, Van Ryckeghem, S, Van Looveren, K, Van Wyngene, L, Van Hamme, E, Vuylsteke, M, Beyaert, R, De Bosscher, K, Libert, C.
A screening assay for Selective Dimerizing Glucocorticoid Receptor Agonists and Modulators (SEDIGRAM) that are effective against acute inflammation
Sci Rep 8, 12894, 2018. (Epub 2018 Aug 27)

Souffriau, J, Libert, C.
Mechanistic insights into the protective impact of zinc on sepsis
Cytokine Growth Factor Rev 39, 92-101, 2018. (Epub 2017 Dec 22)

Steeland, S, Gorle, N, Vandendriessche, C, Balusu, S, Brkic, M, Van Cauwenberghe, C, Van Imschoot, G, Van Wonterghem, E, De Rycke, R, Kremer, A, Lippens, S, Stopa, E, Johanson, CE, Libert, C, Vandenbroucke, RE.
Counteracting the effects of TNF receptor-1 has therapeutic potential in Alzheimer's disease
EMBO Mol Med 10, UNSP e8300, 2018. (Epub 2018 Feb 22)

Steeland, S, Libert, C, Vandenbroucke, RE.
A New Venue of TNF Targeting
Int J Mol Sci 19, e1442, 2018. (Epub 2018 May 11)

Steeland, S, Van Ryckeghem, S, Vandewalle, J, Ballegeer, M, Van Wonterghem, E, Eggermont, M, Decruyenaere, J, De Bus, L, Libert, C, Vandenbroucke, RE.
Simultaneous Inhibition of Tumor Necrosis Factor Receptor 1 and Matrix Metalloproteinase 8 Completely Protects Against Acute Inflammation and Sepsis
Crit Care Med 46, e67e75, 2018. (Epub 2017 Oct 31)

Timmermans, S, Libert, C.
Easy Access to and Applications of the Sequences of All Protein-Coding Genes of All Sequenced Mouse Strains
Trends Genet 34, 899-902, 2018. (Epub 2018 Sep 19)

Timmermans, S, Libert, C.
Learning lessons in sepsis from the children
Mol Syst Biol 14, e8335, 2018. (Epub 2018 May 17)

Timmermans, S, Libert, C.
Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J
JCI Insight 3, e121758, 2018. (Epub 2018 Jul 12)

Timmermans, S, Souffriau, J, Vandewalle, J, Van Wyngene, L, Van Looveren, K, Vanderhaeghen, T, Libert, C.
Using the inbred mouse strain SPRET/EiJ to provide novel insights in inflammation and infection research
Mamm Genome 29, 585-592, 2018. (Epub 2018 Aug)

Vandewalle, J, Luypaert, A, De Bosscher, K, Libert, C.
Therapeutic Mechanisms of Glucocorticoids
Trends Endocrinol Metab 29, 42-54, 2018. (Epub 2017 Nov 18)

Van Looveren, K, Libert, C.
Should we target TNF receptors in the intestinal epithelium with glucocorticoids during systemic inflammation?
Expert Opin Ther Targets 22, 1029-1037, 2018. (Epub 2018 Oct 20)

Van Wyngene, L, Vandewalle, J, Libert, C.
Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?
EMBO Mol Med 10, e8712, 2018. (Epub 2018 Jul 5)

van Zoest, RA, Underwood, J, De Francesco, D, Sabin, CA, Cole, JH, Wit, FW, Caan, MWA, Kootstra, NA, Fuchs, D, Zetterberg, H, Majoie, C, Portegies, P, Winston, A, Sharp, DJ, Gisslen, M, Reiss, P, Comorbidity in Relation to, AC.
Structural Brain Abnormalities in Successfully Treated HIV Infection: Associations With Disease and Cerebrospinal Fluid Biomarkers
J Infect Dis 217, 69-81, 2018. (Epub 2017 Dec 27)

Voet, S, Mc Guire, C, Hagemeyer, N, Martens, A, Schroeder, A, Wieghofer, P, Daems, C, Staszewski, O, Vande Walle, L, Jordao, MJC, Sze, M, Vikkula, HK, Demeestere, D, Van Imschoot, G, Scott, CL, Hoste, E, Goncalves, A, Guilliams, M, Lippens, S, Libert, C, Vandenbroucke, RE, et al., Lamkanfi, M, Prinz, M, van Loo, G.
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation
Nat Commun 9, 2036, 2018. (Epub 2018 May 23)

Zagato, E, Vermeulen, L, Dewitte, H, Van Imschoot, G, Vandenbroucke, RE, Demeester, J, De Schmedt, SC, Neyts, K, Remaut, K, Braeckmans, K.
Quantifying the average number of nucleic acid therapeutics per nanocarrier by Single Particle Tracking microscopy
Mol Pharm 15, 1142-1149, 2018. (Epub 2018 Feb 12)

Booiman, T, Wit, FW, Maurer, I, De Francesco, D, Sabin, CA, Harskamp, AM, Prins, M, Garagnani, P, Pirazzini, C, Franceschi, C, Fuchs, D, Gisslen, M, Winston, A, Reiss, P, Kootstra, NA, Comorbidity in Relation to, AC.
High Cellular Monocyte Activation in People Living With Human Immunodeficiency Virus on Combination Antiretroviral Therapy and Lifestyle-Matched Controls Is Associated With Greater Inflammation in Cerebrospinal Fluid
Open Forum Infect Dis 4, ofx108, 2017. (Epub 2017 May 25)

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