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Publications from this research unit

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Borras-Tuduri, R, Alcaide, A, Aspeslag, S, Usero, L, Serra, C, Roura-Mir, C, Elewaut, D, Llebaria, A.
New paradigm in NKT cell antigens: MCS-0208 (2-(Hydroxymethyl)phenylthio-phytoceramide) an aryl-phytoceramide compound with a single hydroxyl group stimulates NKT cells
ChemMedChem , in press, 2021. (Epub 2021 Apr 6)

de Vlam, K, Steinfeld, S, Toukap, AN, van den Bosch, F, Joos, R, Geussens, P, Leroi, H, Lories, R, Investigators, BS.
The burden of psoriatic arthritis in the biological era: data from the Belgian Epidemiological Psoriatic Arthritis Study (BEPAS)
Rheumatology (Oxford) , in press, 2021. (Epub 2021 Mar 12)

Fleischmann, RM, Blanco, R, Hall, S, Thomson, GTD, Van den Bosch, FE, Zerbini, C, Bessette, L, Enejosa, J, Li, Y, Song, Y, DeMasi, R, Song, IH.
Switching between Janus kinase inhibitor upadacitinib and adalimumab following insufficient response: efficacy and safety in patients with rheumatoid arthritis
Ann Rheum Dis 80, 432-439, 2021. (Epub 2020 Nov 4)

Guggino, G, Mauro, D, Rizzo, A, Alessandro, R, Raimondo, S, Bergot, AS, Rahman, MA, Ellis, JJ, Milling, S, Lories, R, Elewaut, D, Brown, MA, Thomas, R, Ciccia, F.
Inflammasome activation in Ankylosing Spondylitis is associated to gut dysbiosis
Arthritis Rheumatol , in press, 2021. (Epub 2021 Jan 16)

Jans, LBO, Chen, M, Elewaut, D, Van den Bosch, F, Carron, P, Jacques, P, Wittoek, R, Jaremko, JL, Herregods, N.
MRI-based Synthetic CT in the Detection of Structural Lesions in Patients with Suspected Sacroiliitis: Comparison with MRI
Radiology 298, 343-349, 2021. (Epub 2020 Dec 22)

Landewe, RB, Gensler, LS, Poddubnyy, D, Rahman, P, Hojnik, M, Li, X, Liu Leage, S, Adams, D, Carlier, H, Van den Bosch, F, group, C-Ys.
Continuing versus withdrawing ixekizumab treatment in patients with axial spondyloarthritis who achieved remission: efficacy and safety results from a placebo-controlled, randomised withdrawal study (COAST-Y)
Ann Rheum Dis , in press, 2021. (Epub 2021 May 6)

Lukasik, Z, Gracey, E, Venken, K, Ritchlin, C, Elewaut, D.
Crossing the boundaries: IL-23 and its role in linking inflammation of the skin, gut and joints
Rheumatology (Oxford) , in press, 2021. (Epub 2021 May 7)

Mease, PJ, Lertratanakul, A, Anderson, JK, Papp, K, Van den Bosch, F, Tsuji, S, Dokoupilova, E, Keiserman, M, Wang, X, Zhong, S, McCaskill, RM, Zueger, P, Pangan, AL, Tillett, W.
Upadacitinib for psoriatic arthritis refractory to biologics: SELECT-PsA 2
Ann Rheum Dis 80, 312-320, 2021. (Epub 2020 Dec 3)

Mease, PJ, Lertratanakul, A, Papp, KA, van den Bosch, FE, Tsuji, S, Dokoupilova, E, Keiserman, MW, Bu, X, Chen, L, McCaskill, RM, Zueger, P, McDearmon-Blondell, EL, Pangan, AL, Tillett, W.
Upadacitinib in Patients with Psoriatic Arthritis and Inadequate Response to Biologics: 56-Week Data from the Randomized Controlled Phase 3 SELECT-PsA 2 Study
Rheumatol Ther , in press, 2021. (Epub 2021 Apr 28)

Molto, A, Lopez-Medina, C, Van den Bosch, FE, Boonen, A, Webers, C, Dernis, E, van Gaalen, FA, Soubrier, M, Claudepierre, P, Baillet, A, Starmans-Kool, M, Spoorenberg, A, Jacques, P, Carron, P, Joos, R, Lenaerts, J, Gossec, L, Pouplin, S, Ruyssen-Witrand, A, et al..
Efficacy of a tight-control and treat-to-target strategy in axial spondyloarthritis: results of the open-label, pragmatic, cluster-randomised TICOSPA trial
Ann Rheum Dis , in press, 2021. (Epub 2021 May 6)

Nash, P, Kerschbaumer, A, Dorner, T, Dougados, M, Fleischmann, RM, Geissler, K, McInnes, I, Pope, JE, van der Heijde, D, Stoffer-Marx, M, Takeuchi, T, Trauner, M, Winthrop, KL, de Wit, M, Aletaha, D, Baraliakos, X, Boehncke, WH, Emery, P, Isaacs, JD, et al..
Points to consider for the treatment of immune-mediated inflammatory diseases with Janus kinase inhibitors: a consensus statement
Ann Rheum Dis 80, 71-87, 2021. (Epub 2020 Nov 6)

Rathinam, E, Govindarajan, S, Rajasekharan, S, Declercq, H, Elewaut, D, De Coster, P, Martens, L.
Transcriptomic profiling of human dental pulp cells treated with tricalcium silicate-based cements by RNA sequencing
Clin Oral Investig 25, 3181-3195, 2021. (Epub 2020 Oct 27)

Rathinam, E, Govindarajan, S, Rajasekharan, S, Declercq, H, Elewaut, D, De Coster, P, Martens, L, Leybaert, L.
The calcium dynamics of human dental pulp stem cells stimulated with tricalcium silicate-based cements determine their differentiation and mineralization outcome
Sci Rep 11, 645, 2021. (Epub 2021 Jan 12)

Renson, T, Carron, P, De Craemer, AS, Deroo, L, de Hooge, M, Krabbe, S, Jans, L, Chen, M, Ostergaard, M, Van den Bosch, FE, Elewaut, D.
Axial involvement in patients with early peripheral spondyloarthritis: a prospective MRI study of sacroiliac joints and spine
Ann Rheum Dis 80, 103-108, 2021. (Epub 2020 Oct 28)

Renson, T, Carron, P, De Craemer, AS, Deroo, L, de Hooge, M, Krabbe, S, Jans, L, Ostergaard, M, Elewaut, D, Van den Bosch, F.
The value of magnetic resonance imaging for assessing disease extent and prediction of relapse in early peripheral spondyloarthritis
Arthritis Rheumatol , in press, 2021. (Epub 2021 May 13)

Schett, G, Baraliakos, X, Van den Bosch, F, Deodhar, A, Ostergaard, M, Das Gupta, A, Mpofu, S, Fox, T, Winseck, A, Porter, B, Shete, A, Gensler, LS.
Secukinumab Efficacy on Enthesitis in Patients with Ankylosing Spondylitis: Pooled Analysis of Four Pivotal Phase 3 Studies
J Rheumatol in press, , 2021. (Epub 2021 Mar 15)

Vanden Bulcke, M, Vanhaecke, A, Deschepper, E, Cutolo, M, Jacques, P, Smith, V.
Laser speckle contrast analysis in rheumatoid arthritis: a pilot study
Clin Exp Rheumatol , in press, 2021. (Epub 2021 Mar 9)

Aouad, K, De Craemer, AS, Carron, P.
Can Imaging Be a Proxy for Remission in Axial Spondyloarthritis?
Rheum Dis Clin North Am 46, 311-325, 2020. (Epub May 2020)

Baraliakos, X, Van den Bosch, F, Machado, PM, Gensler, LS, Marzo-Ortega, H, Sherif, B, Quebe-Fehling, E, Porter, B, Gaillez, C, Deodhar, A.
Achievement of Remission Endpoints with Secukinumab Over 3 Years in Active Ankylosing Spondylitis: Pooled Analysis of Two Phase 3 Studies
Rheumatol Ther , in press, 2020. (Epub 2020 Dec 22)

Carron, P, De Craemer, AS, Van den Bosch, F.
Peripheral spondyloarthritis: a neglected entity-state of the art
RMD Open 6, e001136, 2020. (Epub 2020 May)

Carron, P, Renson, T, de Hooge, M, Lambert, B, De Man, K, Jans, L, Elewaut, D, Van den Bosch, FE.
Immunoscintigraphy in axial spondyloarthritis: a new imaging modality for sacroiliac inflammation
Ann Rheum Dis 79, 844-846, 2020. (Epub 2020 Feb 26)

Chen, M, Herregods, N, Jaremko, JL, Carron, P, Elewaut, D, Van den Bosch, F, Jans, L.
Bone marrow edema in sacroiliitis: detection with dual-energy CT
Eur Radiol 30, 3393-3400, 2020. (Epub 2020 Feb 13)

Chen, M, Herregods, N, Jaremko, JL, Carron, P, Elewaut, D, Van den Bosch, F, Jans, L.
Diagnostic performance for erosion detection in sacroiliac joints on MR T1-weighted images: Comparison between different slice thicknesses
Eur J Radiol 133, 109352, 2020. (Epub 2020 Oct 16)

de Hooge, M.
The Future of Imaging in Axial Spondyloarthritis
Rheum Dis Clin North Am 46, 297-309, 2020. (Epub 2020 May)

Demeyer, A, Driege, Y, Skordos, I, Coudenys, J, Lemeire, K, Elewaut, D, Staal, J, Beyaert, R.
Long-Term MALT1 Inhibition in Adult Mice Without Severe Systemic Autoimmunity
iScience 23, 101557, 2020. (Epub 2020 Sep 12)

De Smet, EG, Van Eeckhoutte, HP, Avila Cobos, F, Blomme, E, Verhamme, FM, Provoost, S, Verleden, SE, Venken, K, Maes, T, Joos, GF, Mestdagh, P, Brusselle, GG, Bracke, KR.
The role of miR-155 in cigarette smoke-induced pulmonary inflammation and COPD
Mucosal Immunol 13, 423-436, 2020. (Epub 2019 Dec 9)

De Spiegeleer, A, Elewaut, D, Van Den Noortgate, N, Janssens, Y, Debunne, N, Van Langenhove, S, Govindarajan, S, De Spiegeleer, B, Wynendaele, E.
Quorum sensing molecules as a novel microbial factor impacting muscle cells
Biochim Biophys Acta Mol Basis Dis 1866, 165646, 2020. (Epub 2019 Dec 20)

De Volder, J, Vereecke, L, Joos, G, Maes, T.
Targeting neutrophils in asthma: a therapeutic opportunity?
Biochem Pharmacol 182, 114292, 2020. (Epub 2020 Oct 17)

Dougados, M, Wei, JC, Landewe, R, Sieper, J, Baraliakos, X, Van den Bosch, F, Maksymowych, WP, Ermann, J, Walsh, JA, Tomita, T, Deodhar, A, van der Heijde, D, Li, X, Zhao, F, Bertram, CC, Gallo, G, Carlier, H, Gensler, LS, Coast, V, et al..
Efficacy and safety of ixekizumab through 52 weeks in two phase 3, randomised, controlled clinical trials in patients with active radiographic axial spondyloarthritis (COAST-V and COAST-W)
Ann Rheum Dis 79, 176-185, 2020. (Epub 2019 Nov 4)

Dumas, E, Venken, K, Rosenbaum, JT, Elewaut, D.
Intestinal Microbiota, HLA-B27, and Spondyloarthritis: Dangerous Liaisons
Rheum Dis Clin North Am 46, 213-224, 2020. (Epub 2020 May)

Elewaut, D, Braun, J, Anderson, JK, Arikan, D, Chen, S, Hojnik, M, De Craemer, AS, Curtis, JR.
Low Incidence of Inflammatory Bowel Disease Adverse Events in Adalimumab Clinical Trials Across Nine Different Diseases
Arthritis Care Res (Hoboken) 73, 289–295, 2020. (Epub 2020 Feb 26)

El-Sherbiny, YM, Md Yusof, MY, Psarras, A, Hensor, EMA, Kabba, KZ, Dutton, K, Mohamed, AAA, Elewaut, D, McGonagle, D, Tooze, R, Doody, G, Wittmann, M, Emery, P, Vital, EM.
B cell tetherin: a flow-cytometric cell-specific assay for response to Type-I interferon predicts clinical features and flares in SLE
Arthritis Rheumatol 72, 769-779, 2020. (Epub 2019 Dec 5)

Gossec, L, Baraliakos, X, Kerschbaumer, A, de Wit, M, McInnes, I, Dougados, M, Primdahl, J, McGonagle, DG, Aletaha, D, Balanescu, A, Balint, PV, Bertheussen, H, Boehncke, WH, Burmester, GR, Canete, JD, Damjanov, NS, Kragstrup, TW, Kvien, TK, Landewe, RBM, et al..
EULAR recommendations for the management of psoriatic arthritis with pharmacological therapies: 2019 update
Ann Rheum Dis 79, 700-712, 2020. (Epub 2020 Jun)

Govindarajan, S, Verheugen, E, Venken, K, Gaublomme, D, Maelegheer, M, Cloots, E, Gysens, F, De Geest, BG, Cheng, TY, Moody, DB, Janssens, S, Drennan, M, Elewaut, D.
ER stress in antigen-presenting cells promotes NKT cell activation through endogenous neutral lipids
EMBO Rep , e48927, 2020. (Epub 2020 May 3)

Gracey, E, Burssens, A, Cambre, I, Schett, G, Lories, R, McInnes, IB, Asahara, H, Elewaut, D.
Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis
Nat Rev Rheumatol 16, 193–207, 2020. (Epub 2020 Feb 20)

Gracey, E, Vereecke, L, McGovern, D, Frohling, M, Schett, G, Danese, S, De Vos, M, Van den Bosch, F, Elewaut, D.
Revisiting the gut-joint axis: links between gut inflammation and spondyloarthritis
Nat Rev Rheumatol 16, 415-433, 2020. (Epub 2020 Jul 13)

Hebeisen, M, Micheroli, R, Scherer, A, Baraliakos, X, de Hooge, M, van der Heijde, D, Landewe, R, Burki, K, Nissen, MJ, Moller, B, Zufferey, P, Exer, P, Ciurea, A.
Spinal radiographic progression in axial spondyloarthritis and the impact of classification as nonradiographic versus radiographic disease: Data from the Swiss Clinical Quality Management cohort
PLoS One 15, e0230268, 2020. (Epub 2020 Mar 20)

Hulstaert, E, Morlion, A, Avila Cobos, F, Verniers, K, Nuytens, J, Vanden Eynde, E, Yigit, N, Anckaert, J, Geerts, A, Hindryckx, P, Jacques, P, Brusselle, G, Bracke, KR, Maes, T, Malfait, T, Derveaux, T, Ninclaus, V, Van Cauwenbergh, C, Roelens, K, et al..
Charting Extracellular Transcriptomes in The Human Biofluid RNA Atlas
Cell Rep 33, 108552, 2020. (Epub 2020 Dec 29)

Kiltz, U, Landewe, RBM, van der Heijde, D, Rudwaleit, M, Weisman, MH, Akkoc, N, Boonen, A, Brandt, J, Carron, P, Dougados, M, Gossec, L, Jongkees, M, Machado, PM, Marzo-Ortega, H, Molto, A, Navarro-Compan, V, Niederman, K, Sampaio-Barros, PD, Slobodin, G, et al..
Development of ASAS quality standards to improve the quality of health and care services for patients with axial spondyloarthritis
Ann Rheum Dis 79, 193-201, 2020. (Epub 2019 Oct 11)

Kiltz, U, Wei, JC, van der Heijde, D, van den Bosch, F, Walsh, JA, Boonen, A, Gensler, LS, Hunter, T, Carlier, H, Dong, Y, Li, X, Bolce, R, Strand, V, Braun, J.
Ixekizumab Improves Functioning and Health in the Treatment of Radiographic Axial Spondyloarthritis: Week 52 Results from 2 pivotal studies
J Rheumatol 48, 188-197, 2020. (Epub 2020 Jul 15)

Landewe, RB, van der Heijde, D, Dougados, M, Baraliakos, X, Van den Bosch, FE, Gaffney, K, Bauer, L, Hoepken, B, Davies, OR, de Peyrecave, N, Thomas, K, Gensler, L.
Maintenance of clinical remission in early axial spondyloarthritis following certolizumab pegol dose reduction
Ann Rheum Dis 79, 920-928, 2020. (Epub 2020 May 7)

Landewe, R, van der Heijde, D, Dougados, M, Baraliakos, X, Van den Bosch, F, Gaffney, K, Bauer, L, Hoepken, B, de Peyrecave, N, Thomas, K, Gensler, LS.
Induction of Sustained Clinical Remission in Early Axial Spondyloarthritis Following Certolizumab Pegol Treatment: 48-Week Outcomes from C-OPTIMISE
Rheumatol Ther 7, 581-599, 2020. (Epub 2020 Jun 11)

Lovell, DJ, Brunner, HI, Reiff, AO, Jung, L, Jarosova, K, Nemcova, D, Mouy, R, Sandborg, C, Bohnsack, JF, Elewaut, D, Gabriel, C, Higgins, G, Kone-Paut, I, Jones, OY, Vargova, V, Chalom, E, Wouters, C, Lagunes, I, Song, Y, et al..
Long-term outcomes in patients with polyarticular juvenile idiopathic arthritis receiving adalimumab with or without methotrexate
RMD Open 6, e001208, 2020. (Epub 2020 Jul 13)

Lukasik, Z, Elewaut, D, Venken, K.
MAIT Cells Come to the Rescue in Cancer Immunotherapy?
Cancers (Basel) 12, 413, 2020. (Epub 2020 Feb 11)

Maksymowych, WP, Pedersen, SJ, Weber, U, Baraliakos, X, Machado, PM, Eshed, I, de Hooge, M, Sieper, J, Wichuk, S, Rudwaleit, M, van der Heijde, D, Landewe, RBM, Poddubnyy, D, Ostergaard, M, Lambert, RGW.
Central reader evaluation of MRI scans of the sacroiliac joints from the ASAS classification cohort: discrepancies with local readers and impact on the performance of the ASAS criteria
Ann Rheum Dis 79, 935-942, 2020. (Epub 2020 May 5)

Melsens, K, Leone, MC, Paolino, S, Elewaut, D, Gerli, R, Vanhaecke, A, Peene, I, Cutolo, M, Smith, V.
Nailfold capillaroscopy in Sjogren's syndrome: a systematic literature review and standardised interpretation
Clin Exp Rheumatol 38 Suppl 126, 150-157, 2020. (Epub 2020 Sep 21)

Renson, T, Depicker, A, De Craemer, AS, Deroo, L, Varkas, G, de Hooge, M, Carron, P, Jans, L, Herregods, N, Dehaene, I, Vandenberghe, G, Roelens, K, Van den Bosch, FE, Elewaut, D.
High prevalence of spondyloarthritis-like MRI lesions in postpartum women: a prospective analysis in relation to maternal, child and birth characteristics
Ann Rheum Dis 79, 929-934, 2020. (Epub 2020 Apr 16)

Renson, T, Van den Bosch, FE, Elewaut, D.
Response to: 'Finding the right one' by Zanwar
Ann Rheum Dis , in press, 2020. (Epub 2020 May 28)

Savvides, SN, Elewaut, D.
Small-molecule inhibitors get pro-inflammatory TNF into shape
Nat Rev Rheumatol 16, 189-190, 2020. (Epub 2020 Feb 14)

Slowicka, K, Petta, I, Blancke, G, Hoste, E, Dumas, E, Sze, M, Vikkula, H, Radaelli, E, Haigh, J, Jonckheere, S, Taminau, J, Vandamme, N, Wullaert, A, Tulchinsky, E, Nittner, D, Van Vlierberghe, P, De Hertogh, G, Baldin, P, Etlioglu, E, et al. Berx, G, Vereecke, L, van Loo,G.
Zeb2 drives invasive and microbiota-dependent colon carcinoma
Nature Cancer 1, 620-634, 2020. (Epub 2020 Jun 15)

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