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Publications from this research unit

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Gracey, E, Dumas, E, Yerushalmi, M, Qaiyum, Z, Inman, RD, Elewaut, D.
The ties that bind: skin, gut and spondyloarthritis
Curr Opin Rheumatol 31, 62-69, 2019. (Epub 2018 Nov 6)

Janssens, J, Bitra, A, Wang, J, Decruy, T, Venken, K, van der Eycken, J, Elewaut, D, Zajonc, DM, van Calenbergh, S.
4"-O-Alkylated alpha-Galactosylceramide Analogues as iNKT-Cell Antigens: Synthetic, Biological, and Structural Studies
ChemMedChem 14, 147-168, 2019. (Epub 2018 Dec 17)

Venken, K, Jacques, P, Mortier, C, Labadia, ME, Decruy, T, Coudenys, J, et al., Van Gassen, S, Martens, L, Smith, D, Harcken, C, Wahle, J, Wang, CT, Verheugen, E, Schryvers, N, Varkas, G, Cypers, H, et al.,Van den Bosch, F, Saeys, Y, Nabozny, G, Elewaut D.
RORgammat inhibition selectively targets IL-17 producing iNKT and gammadelta-T cells enriched in Spondyloarthritis patients
Nat Commun 10, 9, 2019. (Epub 2019 Jan 2)

Bogie, JF, Boelen, E, Louagie, E, Delputte, P, Elewaut, D, van Horssen, J, Hendriks, JJ, Hellings, N.
CD169 is a marker for highly pathogenic phagocytes in multiple sclerosis
Multiple Sclerosis Journal 24, 290-300, 2018. (Epub 2017 Mar 1)

Cambre, I, Gaublomme, D, Burssens, A, Jacques, P, Schryvers, N, De Muynck, A, Meuris, L, Lambrecht, S, Carter, S, de Bleser, P, Saeys, Y, Van Hoorebeke, L, Kollias, G, Mack, M, Simoens, P, Lories, R, Callewaert, N, Schett, G, Elewaut, D.
Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis
Nat Commun 9, 4613, 2018. (Epub 2018 Nov 5)

Carron, P, Varkas, G, Renson, T, Colman, R, Elewaut, D, Van den Bosch, F.
High rate of drug-free remission after induction therapy with golimumab in early peripheral spondyloarthritis
Arthritis Rheumatol 70, 1769-1777, 2018. (Epub 2018 May 27)

Chuang, YT, Leung, K, Chang, YJ, DeKruyff, RH, Savag, PB, Cruse, R, Benoit, C, Elewaut, D, Baumgarth, N, Umetsu, DT.
A Natural Killer T cell subset that protects against airway hyperreactivity
J Allergy Clin Immunol , in press, 2018. (Epub 2018 May 28)

De Bruyne, M, Bogaert, DJ, Venken, K, Van den Bossche, L, Bonroy, C, Roels, L, Tavernier, SJ, van de Vijver, E, Driessen, A, van Gijn, M, Gamez-Diaz, L, Elewaut, D, Grimbacher, B, Haerynck, F, Moes, N, Dullaers, M.
A novel LRBA mutation presents with normal CTLA-4 and overactive Th17 immunity
J Allergy Clin Immunol , in press, 2018. (Epub 2018 Sep 4)

Gilis, E, Mortier, C, Venken, K, Debusschere, K, Vereecke, L, Elewaut, D.
The Role of the Microbiome in Gut and Joint Inflammation in Psoriatic Arthritis and Spondyloarthritis
J Rheumatol Suppl 94, 36-39, 2018. (Epub 2018 Jun)

Govindarajan, S, Gaublomme, D, Van der Cruyssen, R, Verheugen, E, Van Gassen, S, Saeys, Y, Tavernier, S, Iwawaki, T, Bloch, Y, Savvides, SN, Lambrecht, BN, Janssens, S, Elewaut, D, Drennan, MB.
Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha
Nat Commun 9, 5340, 2018. (Epub 2018 Dec 17)

Jans, L, De Kock, I, Herregods, N, Verstraete, KL, Van den Bosch, FE, Carron, P, Oei, EH, Elewaut, D, Jacques, P.
Response to: 'The use of dual-energy CT to detect and depict bone marrow oedema in rheumatoid arthritis: is it ready to substitute MRI?' by Wu et al
Ann Rheum Dis , annrheumdis-2018-213960, 2018. (Epub 2018 Jul 12)

Jans, L, De Kock, I, Herregods, N, Verstraete, K, Van den Bosch, F, Carron, P, Oei, EH, Elewaut, D, Jacques, P.
Dual-energy CT: a new imaging modality for bone marrow oedema in rheumatoid arthritis
Ann Rheum Dis , in press, 2018. (Epub 2018 Mar 1)

Kloppenburg, M, Ramonda, R, Bobacz, K, Kwok, WY, Elewaut, D, Huizinga, TWJ, Kroon, FPB, Punzi, L, Smolen, JS, Vander Cruyssen, B, Wolterbeek, R, Verbruggen, G, Wittoek, R.
Etanercept in patients with inflammatory hand osteoarthritis (EHOA): a multicentre, randomised, double-blind, placebo-controlled trial
Ann Rheum Dis 77, 1757-1764, 2018. (Epub 2018 Oct 3)

Laloo, F, Herregods, N, Jaremko, JL, Carron, P, Elewaut, D, Van den Bosch, F, Verstraete, K, Jans, L.
New bone formation in the intervertebral joint space in spondyloarthritis: An MRI study
Eur J Radiol 109, 210-217, 2018. (Epub 2018 Dec)

Mortier, C, Govindarajan, S, Venken, K, Elewaut, D.
It Takes "Guts" to Cause Joint Inflammation: Role of Innate-Like T Cells
Front Immunol 9, in press, 2018. (Epub 2018 Jun 29)

Nikiphorou, E, van der Heijde, D, Norton, S, Landewe, RB, Molto, A, Dougados, M, Van den Bosch, FE, Ramiro, S, Collaborators.
Inequity in biological DMARD prescription for spondyloarthritis across the globe: results from the ASAS-COMOSPA study
Ann Rheum Dis 77, 3, 2018. (Epub 2017 Dec 8)

Varkas, G, de Hooge, M, Renson, T, De Mits, S, Carron, P, Jacques, P, Moris, M, Souverijns, G, Jans, L, Elewaut, D, Van den Bosch, F.
Effect of mechanical stress on magnetic resonance imaging of the sacroiliac joints: assessment of military recruits by magnetic resonance imaging study
Rheumatology (Oxford) 57, 508-513, 2018. (Epub 2017 Dec 14)

Varkas, G, Elewaut, D.
Response to: 'Simultaneous inhibition of alpha4/beta7 integrin and tumor necrosis factor-alpha in concomitant spondyloarthritis and inflammatory bowel disease' by Richard et al
Ann Rheum Dis , in press, 2018. (Epub 2018 Jan 26)

Varkas, G, Vastesaeger, N, Cypers, H, Colman, R, Renson, T, Van Praet, L, Carron, P, Raeman, F, Devinck, M, Gyselbrecht, L, Corluy, L, Piette, Y, Lenaerts, J, Thevissen, K, Vanneuville, B, Van den Bosch, F, Elewaut, D.
Association of Inflammatory Bowel Disease and Acute Anterior Uveitis, but Not Psoriasis, With Disease Duration in Patients With Axial Spondyloarthritis: Results From Two Belgian Nationwide Axial Spondyloarthritis Cohorts
Arthritis Rheumatol 70, 1588-1596, 2018. (Epub 2018 May 9)

Veale, DJ, McGonagle, D, McInnes, IB, Krueger, JG, Ritchlin, CT, Elewaut, D, Kanik, KS, Hendrikx, T, Berstein, G, Hodge, J, Telliez, JB.
The rationale for Janus kinase inhibitors for the treatment of spondyloarthritis
Rheumatology (Oxford) , in press, 2018. (Epub 2018 Apr 3)

Venken, K, Favreau, M, Gaublomme, D, Menu, E, Vanderkerken, K, Elewaut, D.
Checkpoint inhibition in the treatment of multiple myeloma: A way to boost innate-like T cell anti-tumor function?
Mol Immunol 101, 521-526, 2018. (Epub 2018 Aug 15)

Vereecke, L, Elewaut, D.
Tumour necrosis factor: out of my heart!
Ann Rheum Dis 77, 793-794, 2018. (Epub 2018 Apr 3)

Wang, X, Shaalan, A, Liefers, S, Coudenys, J, Elewaut, D, Proctor, GB, Bootsma, H, Kroese, FGM, Pringle, S.
Dysregulation of NF-kB in glandular epithelial cells results in Sjogren's-like features
PLoS One 13, e0200212, 2018. (Epub 2018 Aug 1)

Wittoek, R, Carron, P, Lambert, B, Meersseman, P, Verbruggen, G, Van den Bosch, F, Elewaut, D.
Immunoscintigraphic detection of tumour necrosis factor by radiolabelled certolizumab pegol in patients with erosive hand osteoarthritis: a proof-of-concept study
Ann Rheum Dis 77, 310-311, 2018. (Epub 2016 Dec 8)

Zhao, M, Svensson, MND, Venken, K, Chawla, A, Liang, S, Engel, I, Mydel, P, Day, J, Elewaut, D, Bottini, N, Kronenberg, M.
Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70
Nat Commun 9, 2627, 2018. (Epub 2018 Jul 6)

Bakker, P, Molto, A, Etcheto, A, Van den Bosch, F, Landewe, R, van Gaalen, F, Dougados, M, van der Heijde, D.
The performance of different classification criteria sets for spondyloarthritis in the worldwide ASAS-COMOSPA study
Arthritis Res Ther 19, 96, 2017. (Epub 2017 May 16)

Bloch, Y, Bouchareychas, L, Merceron, R, Skladanowska, K, Van den Bossche, L, Detry, S, Govindarajan, S, Elewaut, D, Haerynck, F, Dullaers, M, Adamopoulos, IE, Savvides, SN.
Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12Rbeta1
Immunity 48, 45-58, 2017. (Epub 2017 Dec 21)

Carron, P, Varkas, G, Cypers, H, Van Praet, L, Elewaut, D, Van den Bosch, F, group, Ci.
Anti-TNF-induced remission in very early peripheral spondyloarthritis: the CRESPA study
Ann Rheum Dis 76, 1389-1395, 2017. (Epub 2017 Feb 17)

Ciccia, F, Guggino, G, Rizzo, A, Alessandro, R, Luchetti, MM, Milling, S, Saieva, L, Cypers, H, Stampone, T, Di Benedetto, P, Gabrielli, A, Fasano, A, Elewaut, D, Triolo, G.
Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis
Ann Rheum Dis 76, 1123-1132, 2017. (Epub 2017 Jan 9)

De Beule, N, Menu, E, Bertrand, MJ, Favreau, M, De Bruyne, E, Maes, K, De Veirman, K, Radwanska, M, Samali, A, Magez, S, Vanderkerken, K, De Trez, C.
Experimental African trypanosome infection suppresses the development of multiple myeloma in mice by inducing intrinsic apoptosis of malignant plasma cells
Oncotarget 8, 52016-52025, 2017. (Epub 2017 May 24)

Debusschere, K, Cambre, I, Gracey, E, Elewaut, D.
Born to run: The paradox of biomechanical force in spondyloarthritis from an evolutionary perspective
Best Pract Res Clin Rheumatol 31, 887-894, 2017. (Epub 2017 Dec)

De Schryver, M, Cappoen, D, Elewaut, D, Nauwynck, HJ, Maes, L, Caljon, G, Cos, P, Delputte, PL.
Monoclonal antibody binding to the macrophage-specific receptor sialoadhesin alters the phagocytic properties of human and mouse macrophages
Cell Immunol 312, 51-60, 2017. (Epub 2016 Dec 9)

De Wilde, K, Martens, A, Lambrecht, S, Jacques, P, Drennan, MB, Debusschere, K, Govindarajan, S, Coudenys, J, Verheugen, E, Windels, F, Catrysse, L, Lories, R, McGonagle, D, Beyaert, R, van Loo, G, Elewaut, D.
A20 inhibition of STAT1 expression in myeloid cells: a novel endogenous regulatory mechanism preventing development of enthesitis
Ann Rheum Dis 76, 585-592, 2017. (Epub 2016 Aug 22)

Dougados, M, van der Heijde, D, Sieper, J, Braun, J, Citera, G, Lenaerts, J, van den Bosch, F, Wei, JC, Pedersen, R, Bonin, R, Jones, H, Marshall, L, Logeart, I, Vlahos, B, Bukowski, JF, Maksymowych, WP.
Effects of Long-Term Etanercept Treatment on Clinical Outcomes and Objective Signs of Inflammation in Early Nonradiographic Axial Spondyloarthritis: 104-Week Results From a Randomized, Placebo-Controlled Study
Arthritis Care Res (Hoboken) 69, 1590-1598, 2017. (Epub 2017 Aug 31)

Favreau, M, Menu, E, Gaublomme, D, Vanderkerken, K, Faict, S, Maes, K, De Bruyne, E, Govindarajan, S, Drennan, M, Van Calenbergh, S, Leleu, X, Zabeau, L, Tavernier, J, Venken, K, Elewaut, D.
Leptin receptor antagonism of iNKT cell function: a novel strategy to combat multiple myeloma
Leukemia 31, 2678-2685, 2017. (Epub 2017 May 11)

Favreau, M, Venken, K, Faict, S, Maes, K, De Veirman, K, De Bruyne, E, Leleu, X, Boon, L, Elewaut, D, Vanderkerken, K, Menu, E.
Both mucosal- associated invariant and natural killer T cell deficiency in multiple myeloma can be countered by PD-1 inhibition
Haematologica 102, E266-E270, 2017. (Epub 2017 Apr 6)

Guillaume, J, Seki, T, Decruy, T, Venken, K, Elewaut, D, Tsuji, M, Van Calenbergh, S.
Synthesis of C6''-modified alpha-C-GalCer analogues as mouse and human iNKT cell agonists
Org Biomol Chem 15, 2217-2225, 2017. (Epub 2017 Feb 21)

Guillaume, J, Wang, J, Janssens, J, Remesh, SG, Risseeuw, MDP, Decruy, T, Froeyen, M, Elewaut, D, Zajonc, DM, Calenbergh, SV.
Galactosylsphingamides: new alpha-GalCer analogues to probe the F'-pocket of CD1d
Sci Rep 7, 4276, 2017. (Epub 2017 Jun 27)

Herregods, N, Dehoorne, J, Van den Bosch, F, Jaremko, JL, Van Vlaenderen, J, Joos, R, Baraliakos, X, Varkas, G, Verstraete, K, Elewaut, D, Jans, L.
ASAS definition for sacroiliitis on MRI in SpA: applicable to children?
Pediatr Rheumatol 15, 24, 2017. (Epub 2017 Apr 11)

Janssens, J, Decruy, T, Venken, K, Seki, T, Krols, S, Van der Eycken, J, Tsuji, M, Elewaut, D, Van Calenbergh, S.
Efficient Divergent Synthesis of New Immunostimulant 4''-Modified alpha-Galactosylceramide Analogues
ACS Med Chem Lett 8, 642-647, 2017. (Epub 2017 Jun 8)

Laloo, F, Herregods, N, Varkas, G, Jaremko, JL, Baraliakos, X, Elewaut, D, Van den Bosch, F, Verstraete, K, Jans, L.
MR signal in the sacroiliac joint space in spondyloarthritis: a new sign
Eur Radiol 27, 2024-2030, 2017. (Epub 2016 Sep 20)

Mease, PJ, Van den Bosch, F, Sieper, J, Xia, Y, Pangan, AL, Song, IH.
Performance of 3 Enthesitis Indices in Patients with Peripheral Spondyloarthritis During Treatment with Adalimumab
J Rheumatol 44, 599-608, 2017. (Epub 2017 Mar 15)

Nikiphorou, E, Ramiro, S, van der Heijde, D, Norton, S, Molto, A, Dougados, M, van den Bosch, F, Landewe, R, Force, A-CT.
Comorbidities in Spondyloarthritis associate with poor function, work disability and quality of life: Results from the ASAS-COMOSPA study
Arthritis Care Res (Hoboken) , in press, 2017. (Epub 2017 Nov 10)

Schett, G, Lories, RJ, D'Agostino, MA, Elewaut, D, Kirkham, B, Soriano, ER, McGonagle, D.
Enthesitis: from pathophysiology to treatment
Nat Rev Rheumatol 13, 731-741, 2017. (Epub 2017 Nov 21)

Tito, RY, Cypers, H, Joossens, M, Varkas, G, Van Praet, L, Glorieus, E, Van den Bosch, F, De Vos, M, Raes, J, Elewaut, D.
Dialister as microbial marker of disease activity in spondyloarthritis
Arthritis Rheumatol 69, 114-121, 2017. (Epub 2016 Dec 1)

Van den Bosch, F, Ostor, AJK, Wassenberg, S, Chen, N, Wang, C, Garg, V, Kalabic, J.
Impact of Participation in the Adalimumab (Humira) Patient Support Program on Rheumatoid Arthritis Treatment Course: Results from the PASSION Study
Rheumatol Ther 4, 85-96, 2017. (Epub 2017 Mar 30)

van der Heijde, D, Dougados, M, Landewe, R, Sieper, J, Maksymowych, WP, Rudwaleit, M, Van den Bosch, F, Braun, J, Mease, PJ, Kivitz, AJ, Walsh, J, Davies, O, Bauer, L, Hoepken, B, Peterson, L, Deodhar, A.
Sustained efficacy, safety and patient-reported outcomes of certolizumab pegol in axial spondyloarthritis: 4-year outcomes from RAPID-axSpA
Rheumatology (Oxford) 56, 1498-1509, 2017. (Epub 2017 Sep 1)

Van Welden, S, De Vos, M, Wielockx, B, Tavernier, SJ, Dullaers, M, Neyt, S, Descamps, B, Devisscher, L, Devriese, S, Van den Bossche, L, Holvoet, T, Baeyens, A, Correale, C, D'Alessio, S, Vanhove, C, De Vos, F, Verhasselt, B, Breier, G, Lambrecht, BN, et al..
Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis
J Pathol 241, 547558 , 2017. (Epub 2016 Dec 16)

Varkas, G, Thevissen, K, De Brabanter, G, Van Praet, L, Czul-Gurdian, F, Cypers, H, De Kock, J, Carron, P, De Vos, M, Hindryckx, P, Arts, J, Vanneuville, I, Schoenaers, P, Claerhout, B, Abreu, M, Van den Bosch, F, Elewaut, D.
An induction or flare of arthritis and/or sacroiliitis by vedolizumab in inflammatory bowel disease: a case series
Ann Rheum Dis 76, 5, 2017. (Epub 2016 Nov 29)

Varkas, G, Van den Bosch, F, Elewaut, D.
Response to: 'Clinical benefit of vedolizumab on articular manifestations in patients with active spondyloarthritis associated with inflammatory bowel disease' by Orlando et al
Ann Rheum Dis 76, 9, 2017. (Epub 2017 Feb 9)

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