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Vandenbroucke, K, de Haard, H, Beirnaert, E, Dreier, T, Lauwereys, M, Huyck, L, Van Huysse, J, Demetter, P, Steidler, L, Remaut, E, Cuvelier, C, Rottiers, P.
Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis
Mucosal Immunol 3, 49-56, 2010. (Epub 2009 Sep 30)

Breyer, D, Herman, P, Brandenburger, A, Gheysen, G, Remaut, E, Soumillion, P, Van Doorsselaere, J, Custers, R, Pauwels, K, Sneyers, M, Reheul, D.
Genetic modification through oligonucleotide-mediated mutagenesis. A GMO regulatory challenge?
Environ Biosafety Res 8, 57-64, 2009. (Epub 2009 Oct 16)

Huibregtse, IL, Marietta, EV, Rashtak, S, Koning, F, Rottiers, P, David, CS, van Deventer, SJ, Murray, JA.
Induction of antigen-specific tolerance by oral administration of lactococcus lactis delivered immunodominant DQ8-restricted gliadin peptide in sensitized nonobese diabetic abdegrees Dq8 transgenic mice
J Immunol 183, 2390-6239, 2009. (Epub 2009 Jul 27)

Loos, M, Remaut, E, Rottiers, P, De Creus, A.
Genetically engineered Lactococcus lactis secreting murine IL-10 modulates the functions of bone marrow-derived dendritic cells in the presence of LPS
Scand J Immunol 69, 130-139 , 2009. (Epub 2008 Dec 22)

Van Huynegem, K, Loos, M, Steidler, L.
Immunomodulation by genetically engineered lactic acid bacteria
Front Biosci 14, 4825-4835, 2009. (Epub ---)

Waeytens, A, Ferdinande, L, Neirynck, S, Rottiers, P, De Vos, M, Steidler, L, Cuvelier, CA.
Paracellular entry of interleukin-10 producing Lactococcus lactis in inflamed intestinal mucosa in mice
Inflamm Bowel Dis 14, 471-479, 2008. (Epub 2007 Dec 18)

Coppieters, K, Van Beneden, K, Jacques, P, Dewint, P, Vervloet, A, Vander Cruyssen, B, Van Calenbergh, S, Chen, G, Franck, RW, Verbruggen, G, Deforce, D, Matthys, P, Tsuji, M, Rottiers, P, Elewaut, D.
A single early activation of invariant NK T cells confers long-term protection against collagen-induced arthritis in a ligand-specific manner
J Immunol 179, 2300-2309, 2007. (Epub ---)

Huibregtse, IL, Snoeck, V, De Creus, A, Braat, H, de Jong, EC, van Deventer, SJ, Rottiers, P.
Induction of OVA-specific tolerance by oral administration of Lactococcus lactis secreting OVA
Gastroenterology 133, 517–528, 2007. (Epub 2007 May 4)

Loos, M, De Creus, A, Thim, L, Remaut, E, Rottiers, P.
Murine trefoil factor 3 does not directly modulate LPS-mediated dendritic cell function
Scand J Immunol 66, 35-42, 2007. (Epub 2007 Apr 27)

Peeters, H, Bogaert, S, Laukens, D, Rottiers, P, De Keyser, F, Darfeuille-Michaud, A, Glasser, A-L, Elewaut, D, De Vos, M.
CARD15 variants determine a disturbed early response of monocytes to adherent-invasive Escherichia coli strain LF82 in Crohn's disease
Int J Immunogenet 34, 181–191, 2007. (Epub ---)

Braat, H, Rottiers, P, Hommes, DW, Huyghebaert, N, Remaut, E, Remon, JP, van Deventer, SJ, Neirynck, S, Peppelenbosch, MP, Steidler, L.
A phase I trial with transgenic bacteria expressing Interleukin-10 in Crohn's disease
Clin Gastroenterol Hepatol 4, 754-759, 2006. (Epub 2006 May 19)

Coppieters, K, Dreier , T, Silence, K, de Haard, H, Lauwereys, M, Casteels, P, Beirnaert, E, Jonckheere, H, Van de Wiele, C, Staelens, L, Hostens, J, Revets, H, Remaut, E, Elewaut, D, Rottiers, P.
Formatted anti-Tumor Necrosis Factor alpha VHH proteins derived from camelids show superior potency and targeting to inflamed joints in a murine model of collagen-induced arthritis
Arthritis Rheum 54, 1856-1866, 2006. (Epub ---)

Laukens, D, Peeters, H, Vander Cruyssen, B, Boonefaes, T, Elewaut, D, De Keyser, F, Mielants, H, Cuvelier, C, Veys, E, Knecht, K, Van Hummelen, P, Remaut, E, Steidler, L, De Vos, M, Rottiers, P.
Altered gut transcriptome in spondyloarthropathy
Ann Rheum Dis 65, 1293-1300, 2006. (Epub 2006 Feb 13)

Remaut, E, Braat, H, Vandenbroucke, K, Rottiers, P, Steidler, L.
Clinical potential of Lactococcus lactis mediated delivery of human Interleukin-10 and Trefoil Factors
Bioscience Microflora 25, 81-97, 2006. (Epub ---)

Robbens, J, De Coen, W, Fiers, W, Remaut, E.
Improved periplasmic production of biologically active murine interleukin-2 in Escherichia coli through a single amino acid change at the cleavage site
Process Biochem 41, 1343-1346, 2006. (Epub ---)

Steidler, L, Vandenbroucke, K.
Genetically modified Lactococcus lactis: novel tools for drug delivery
Intl J Dairy Technol 59, 140-146, 2006. (Epub ---)

Termont, S, Vandenbroucke, K, Iserentant, D, Neirynck, S, Steidler, L, Remaut, E, Rottiers, P.
Intracellular accumulation of trehalose protects Lactococcus lactis from freeze-drying damage and bile toxicity and increases gastric acid resistance
Appl Environ Microbiol 72, 7694–7700, 2006. (Epub 2006 Oct 6)

Huyghebaert, N, Vermeire, A, Neirynck, S, Steidler, L, Remaut, E, Remon, JP.
Development of an enteric-coated formulation containing freeze-dried, viable recombinant Lactococcus lactis for the ileal mucosal delivery of human interleukin-10
Eur J Pharm Biopharm 60, 349-359, 2005. (Epub ---)

Huyghebaert, N, Vermeire, A, Neirynck, S, Steidler, L, Remaut, E, Remon, JP.
Evaluation of extrusion/spheronisation, layering and compaction for the preparation of an oral, multi-particulate formulation of viable, hIL-10 producing Lactococcus lactis
Eur J Pharm Biopharm 59, 9-15, 2005. (Epub ---)

Huyghebaert, N, Vermeire, A, Rottiers, P, Remaut, E, Remon, JP.
Development of an enteric-coated, layered multi-particulate formulation for ileal delivery of viable recombinant Lactococcus lactis
Eur J Pharm Biopharm 61, 134-141, 2005. (Epub 2005 Jun 17)

Laukens, D, Peeters, H, Marichal, D, Vander Cruyssen, B, Mielants, H, Elewaut, D, Demetter, P, Cuvelier, C, Van Den Berghe, M, Rottiers, P, Veys, EM, Remaut, E, Steidler, L, De Keyser, F, De Vos, M.
CARD15 gene polymorphisms in patients with spondyloarthropathies identify a specific phenotype previously related to Crohn's disease
Ann Rheum Dis , 930-935, 2005. (Epub 2004 Nov 11)

Vander Cruyssen, B, Peeters, H, Hoffman, IE, Laukens, D, Coucke, P, Marichal, D, Cuvelier, C, Remaut, E, Veys, EM, Mielants, H, De Vos, M, De Keyser, F.
CARD15 polymorphisms are associated with anti-Saccharomyces cerevisiae antibodies in caucasian Crohn's disease patients
Clin Exp Immunol 140, 354-359, 2005. (Epub ---)

Peeters, H, Vander Cruyssen, B, Laukens, D, Coucke, P, Marichal, D, Van Den Berghe, M, Cuvelier, C, Remaut, E, Mielants, H, De Keyser, F, De Vos, M.
Radiological sacroiliitis, a hallmark of spondylitis, is linked with Card15 gene polymorphisms in patients with Crohn’s disease
Ann Rheum Dis 63, 1131-1134, 2004. (Epub ---)

Vandenbroucke, K, Hans, W, Van Huysse, J, Neirynck, S, Demetter, P, Remaut, E, Rottiers, P, Steidler, L.
Active delivery of trefoil factors by genetically modified Lactococcus lactis prevents and heals acute colitis in mice
Gastroenterology 127, 502-513, 2004. (Epub ---)

O'Neil, D, Steidler, L.
Cytokines, chemokines and growth factors in the pathogenesis and treatment of inflammatory bowel disease
Adv Exp Med Biol 520, 252-285, 2003. (Epub ---)

Steidler, L, Neirynck, S, Huyghebaert, N, Snoeck, V, Vermeire, A, Goddeeris, B, Cox, E, Remon, JP, Remaut, E.
Biological containment of genetically modified Lactococcus lactis for intestinal delivery of human interleukin 10
Nat Biotechnol 21, 785-789, 2003. (Epub 2003 Jun 15)

Hochepied, T, Wullaert, A, Berger, FG, Baumann, H, Brouckaert, P, Steidler, L, Libert, C.
Overexpression of a1-acid glycoprotein in transgenic mice leads to sensitisation to acute colitis
Gut 51, 398-404, 2002. (Epub ---)

Steidler, L.
In situ delivery of cytokines by genetically engineered Lactococcus lactis
Antonie van Leeuwenhoek 82, 323-331, 2002. (Epub ---)

Steidler, L.
In situ delivery of cytokines at mucosal surfaces by genetically engineered Lactococcus lactis
In Novel Processes and Control Technologies in the Food Industry. (Bozoglu, F, Deak, T, Ray, B, eds.), NATO Science Series, Vol. I 338, Amsterdam, IOS Press, pp. 179-196, 2001. (Epub ---)

Steidler, L.
Lactococcus lactis, a tool for the delivery of therapeutic proteins. Treatment of IBD
TheScientificWorld 1, 216-217, 2001. (Epub ---)

Steidler, L.
Microbiological and immunological strategies for treatment of inflammatory bowel disease
Microbes Infect 3, 1157-1166, 2001. (Epub ---)

Tutino, ML, Duilio, A, Parrilli, R, Remaut, E, Sannia, G, Marino, G.
A novel replication element from an Antarctic plasmid as a tool for the expression of proteins at low temperature
Extremophiles 5, 257-264, 2001. (Epub ---)

O'Neil, D.
Web alert. Gene therapy in cancer treatment
Curr Opin Mol Ther 2, 359, 2000. (Epub ---)

O'Neil, D.
Web alert. Viruses as vectors for gene transfer
Curr Opin Mol Ther 2, 484-485, 2000. (Epub ---)

O'Neil, D, Jones, D.
Web alert. Genomics and proteomics
Curr Opin Mol Ther 2, 621-622, 2000. (Epub ---)

Schotte, L, Steidler, L, Vandekerckhove, J, Remaut, E.
Secretion of biologically active murine interleukin-10 by Lactococcus lactis
Enzyme Microb Technol 27, 761-765, 2000. (Epub ---)

Steidler, L, Hans, W, Schotte, L, Neirynck, S, Obermeier, F, Falk, W, Fiers, W, Remaut, E.
Treatment of murine colitis by Lactococcus lactis secreting interleukin-10
Science 289, 1352-1355, 2000. (Epub ---)

Mertens, N, Fiers, W, Remaut, E.
An advanced vector system for high-level recombinant gene expression in Escherichia coli
In Biotechnology International II. (Connor, TH, Weier, H-U, Fox, CF, eds.), San Francisco, Universal Medical Press, pp. 165-171, 1999. (Epub ---)

Remaut, E, Bliki, C, Iturizza, M, Keymeulen, K.
Development of regulatable expression systems for cloned genes in cold-adapted prokaryotes
In Biotechnological Applications of Cold-Adapted Organisms. (Margesin, R, Schinner, F, eds.), Berlin-Heidelberg-New York, Springer, pp. 1-16 , 1999. (Epub ---)

Steidler, L, Robinson, K, Chamberlain, L, Schofield, KM, Remaut, E, Le Page, RWF, Wells, JM.
Mucosal delivery of murine interleukin-2 (IL-2) and IL-6 by recombinant strains of Lactococcus lactis coexpressing antigen and cytokine
Infect Immun 66, 3183-3189, 1998. (Epub ---)

Steidler, L, Viaene, J, Fiers, W, Remaut, E.
Functional display of a heterologous protein on the surface of Lactococcus lactis by means of the cell wall anchor of Staphylococcus aureus protein A
Appl Environ Microbiol 64, 342-345, 1998. (Epub ---)

Mertens, N, Remaut, E, Fiers, W.
Increased stability of phage T7g10 mRNA is mediated by either a 5'- or a 3'-terminal stem-loop structure
Biol Chem 377, 811-817, 1996. (Epub ---)

Steidler, L, Fiers, W, Remaut, E.
Expression of human and murine interleukins in Lactococcus lactis
In Lactic Acid Bacteria: Current Advances in Metabolism, Genetics and Applications. (Bozoglu, TF, Ray, B, eds.), NATO ASI Series, Vol. H 98, Berlin-Heidelberg, Springer, pp. 63-79, 1996. (Epub ---)

Steidler, L, Yu, W, Fiers, W, Remaut, E.
The expression of the Photinus pyralis luciferase gene in Staphylococcus aureus Cowan I allows the development of a live amplifiable tool for immunodetection
Appl Environ Microbiol 62, 2356-2359, 1996. (Epub ---)

Flamez, D, Remaut, E, Fiers, W.
Production in Escherichia coli of a functional murine and murine::human chimeric F(ab')2 fragment and mature antibody directed against human placental alkaline phosphatase
J Biotechnol 42, 133-143, 1995. (Epub ---)

Mertens, N, Remaut, E, Fiers, W.
Tight transcriptional control mechanism ensures stable high-level expression from T7 promoter-based expression plasmids
Bio/Technology 13, 175-179, 1995. (Epub ---)

Mertens, N, Remaut, E, Fiers, W.
Versatile, multi-featured plasmids for high-level expression of heterologous genes in Escherichia coli: Overproduction of human and murine cytokines
Gene 164, 9-15, 1995. (Epub ---)

Robbens, J, Raeymaekers, A, Steidler, L, Fiers, W, Remaut, E.
Production of soluble and active recombinant murine interleukin-2 in Escherichia coli: High level expression, kil-induced release, and purification
Protein Expr Purif 6, 481-486, 1995. (Epub ---)

Steidler, L, Fiers, W, Remaut, E.
Simultaneous light emission from cloned Vibrio fischeri lux genes and expression of LamB or LamB-protein A fusion proteins in Escherichia coli depends on using a single chimeric operon
Biotechnol Bioengin 48, 667-672, 1995. (Epub ---)

Steidler, L, Wells, JM, Raeymaekers, A, Vandekerckhove, J, Fiers, W, Remaut, E.
Secretion of biologically active murine interleukin-2 by Lactococcus lactis subsp. lactis
Appl Environ Microbiol 61, 1627-1629, 1995. (Epub ---)

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