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Publications from this research unit

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de Vasconcelos, NM, Vliegen, G, Goncalves, A, De Hert, E, Martin-Perez, R, Van Opdenbosch, N, Jallapally, A, Geiss-Friedlander, R, Lambeir, AM, Augustyns, K, Van Der Veken, P, De Meester, I, Lamkanfi, M.
DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages
Life Sci Alliance 2, e201900313, 2019. (Epub 2019 Feb 4)

Persyn, A, Rogiers, O, Brock, M, Vande Velde, G, Lamkanfi, M, Jacobsen, ID, Himmelreich, U, Lagrou, K, Van Dijck, P, Kucharikova, S.
Monitoring of Fluconazole and Caspofungin Activity against In Vivo Candida glabrata Biofilms by Bioluminescence Imaging
Antimicrob Agents Chemother 63, e01555-18, 2019. (Epub 2018 Nov 12)

Van Gorp, H, Van Opdenbosch, N, Lamkanfi, M.
Inflammasome-Dependent Cytokines at the Crossroads of Health and Autoinflammatory Disease
Cold Spring Harb Perspect Biol 11, a028563, 2019. (Epub 2017 Oct 16)

de Vasconcelos, NM, Van Opdenbosch, N, Van Gorp, H, Parthoens, E, Lamkanfi, M.
Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture
Cell Death Differ 26, 146-161, 2018. (Epub 2018 Apr 17)

Kanneganti, A, Malireddi, RKS, Saavedra, PHV, Vande Walle, L, Van Gorp, H, Kambara, H, Tillman, H, Vogel, P, Luo, HR, Xavier, RJ, Chi, H, Lamkanfi, M.
GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever
J Exp Med 215, 1519-1529, 2018. (Epub 2018 Jun 4)

Mamantopoulos, M, Ronchi, F, McCoy, KD, Wullaert, A.
Inflammasomes make the case for littermate-controlled experimental design in studying host-microbiota interactions
Gut Microbes 9, 374-381, 2018. (Epub 2018 Apr 19)

Rogiers, O, Holtappels, M, Siala, W, Lamkanfi, M, Van Bambeke, F, Lagrou, K, Van Dijck, P, Kucharikova, S.
Anidulafungin increases the antibacterial activity of tigecycline in polymicrobial Candida albicans/Staphylococcus aureus biofilms on intraperitoneally implanted foreign bodies
J Antimicrob Chemother 73, 2806-2814, 2018. (Epub 2018 Jul 13)

Saavedra, PHV, Huang, L, Ghazavi, F, Kourula, S, Vanden Berghe, T, Takahashi, N, Vandenabeele, P, Lamkanfi, M.
Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis
Nat Commun 9, 4846, 2018. (Epub 2018 Nov 19)

Voet, S, Mc Guire, C, Hagemeyer, N, Martens, A, Schroeder, A, Wieghofer, P, Daems, C, Staszewski, O, Vande Walle, L, Jordao, MJC, Sze, M, Vikkula, HK, Demeestere, D, Van Imschoot, G, Scott, CL, Hoste, E, Goncalves, A, Guilliams, M, Lippens, S, Libert, C, Vandenbroucke, RE, et al., Lamkanfi, M, Prinz, M, van Loo, G.
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation
Nat Commun 9, 2036, 2018. (Epub 2018 May 23)

Wullaert, A, Lamkanfi, M, McCoy, KD.
Defining the Impact of Host Genotypes on Microbiota Composition Requires Meticulous Control of Experimental Variables
Immunity 48, 605-607, 2018. (Epub 2018 Apr 17)

Adriaenssens, Y, Jimenez Fernandez, D, Vande Walle, L, Elvas, F, Joossens, J, Lambeir, A, Augustyns, K, Lamkanfi, M, Van der Veken, P.
Carboxylate isosteres for caspase inhibitors: the acylsulfonamide case revisited
Org Biomol Chem 15, 7456-7473, 2017. (Epub 2017 Aug 24)

Hassane, M, Demon, D, Soulard, D, Fontaine, J, Keller, LE, Patin, EC, Porte, R, Prinz, I, Ryffel, B, Kadioglu, A, Veening, JW, Sirard, JC, Faveeuw, C, Lamkanfi, M, Trottein, F, Paget, C.
Neutrophilic NLRP3 inflammasome-dependent IL-1beta secretion regulates the gammadeltaT17 cell response in respiratory bacterial infections
Mucosal Immunol 10, 1056-1068, 2017. (Epub 2017 Jan 4)

Lamkanfi, M, Dixit, VM.
A new lead to NLRP3 inhibition
J Exp Med 11, 3147-3149, 2017. (Epub 2017 Oct 23)

Lamkanfi, M, Dixit, VM.
In Retrospect: The inflammasome turns 15
Nature 548, 534-535, 2017. (Epub 2017 Aug 30)

Mamantopoulos, M, Ronchi, F, Van Hauwermeiren, F, Vieira-Silva, S, Yilmaz, B, Martens, L, Saeys, Y, Drexler, SK, Yazdi, AS, Raes, J, Lamkanfi, M, McCoy, KD, Wullaert, A.
Nlrp6- and ASC-Dependent Inflammasomes Do Not Shape the Commensal Gut Microbiota Composition
Immunity 47, 339-348, 2017. (Epub 2017 Aug 15)

Porte, R, Van Maele, L, Munoz-Wolf, N, Foligne, B, Dumoutier, L, Tabareau, J, Cayet, D, Gosset, P, Jonckheere, N, Van Seuningen, I, Chabalgoity, AJ, Simonet, M, Lamkanfi, M, Renauld, JC, Sirard, JC, Carnoy, C.
Flagellin-mediated protection against intestinal Yersinia pseudotuberculosis infection does not require interleukin-22
Infect Immun 85, e00806-16, 2017. (Epub 2016 Nov 21)

Saavedra, PHV, Lamkanfi, M.
Immunology: Gut sensor halts viral attack
Nature 546, 606-608, 2017. (Epub 2017 Jun 29)

Van Opdenbosch, N, Van Gorp, H, Verdonckt, M, Saavedra, PHV, de Vasconcelos, NM, Goncalves, A, Vande Walle, L, Demon, D, Matusiak, M, Van Hauwermeiren, F, D'Hont, J, Hochepied, T, Krautwald, S, Kanneganti, TD, Lamkanfi, M.
Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4
Cell Rep 21, 3427-3444, 2017. (Epub 2017 Dec 19)

Wuytens, PC, Demol, H, Turk, N, Gevaert, K, Skirtach, AG, Lamkanfi, M, Baets, R.
Gold nanodome SERS platform for label-free detection of protease activity
Faraday Discuss 205, 345-361, 2017. (Epub 2017 Sep 18)

Akiyama, T, Oishi, K, Wullaert, A.
Bifidobacteria Prevent Tunicamycin-Induced Endoplasmic Reticulum Stress and Subsequent Barrier Disruption in Human Intestinal Epithelial Caco-2 Monolayers
PLoS One 11, e0162448, 2016. (Epub 2016 Sep 9)

de Vasconcelos, NM, Van Opdenbosch, N, Lamkanfi, M.
Inflammasomes as polyvalent cell death platforms
Cell Mol Life Sci 73, 2335-2347, 2016. (Epub 2016 Apr 5)

Dubois, H, Wullaert, A, Lamkanfi, M.
General Strategies in Inflammasome Biology
Curr Top Microbiol Immunol 397, 1-22, 2016. (Epub 2016 Jul 27)

Hobai, IA, Aziz, K, Buys, ES, Brouckaert, P, Siwik, DA, Colucci, WS.
Distinct Myocardial Mechanisms Underlie Cardiac Dysfunction in Endotoxemic Male and Female Mice
Shock 46, 713-722, 2016. (Epub 2016 Jul 11)

Kuchmiy, AA, D'Hont, J, Hochepied, T, Lamkanfi, M.
NLRP2 controls age-associated maternal fertility
J Exp Med 213, 2851-2860, 2016. (Epub 2016 Nov 23)

Qi, X, Man, SM, Malireddi, RK, Karki, R, Lupfer, C, Gurung, P, Neale, G, Guy, CS, Lamkanfi, M, Kanneganti, TD.
Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection
J Exp Med 213, 2081-2097, 2016. (Epub 2016 Aug 22)

Rankin, LC, Girard-Madoux, MJ, Seillet, C, Mielke, LA, Kerdiles, Y, Fenis, A, Wieduwild, E, Putoczki, T, Mondot, S, Lantz, O, Demon, D, Papenfuss, AT, Smyth, GK, Lamkanfi, M, Carotta, S, Renauld, JC, Shi, W, Carpentier, S, Soos, T, et al..
Complementarity and redundancy of IL-22-producing innate lymphoid cells
Nat Immunol 17, 179-186, 2016. (Epub 2015 Nov 30)

Vande Walle, L, Jimenez Fernandez, D, Demon, D, Van Laethem, N, Van Hauwermeiren, F, Van Gorp, H, Van Opdenbosch, N, Kayagaki, N, Lamkanfi, M.
Does caspase-12 suppress inflammasome activation?
Nature 534, E1-4, 2016. (Epub 2016 Jun 2)

Vande Walle, L, Lamkanfi, M.
Curr Biol 26, R568-R572, 2016. (Epub 2016 Jul 11)

Van Gorp, H, Saavedra, PH, de Vasconcelos, NM, Van Opdenbosch, N, Vande Walle, L, Matusiak, M, Prencipe, G, Insalaco, A, Van Hauwermeiren, F, Demon, D, Bogaert, DJ, Dullaers, M, De Baere, E, Hochepied, T, Dehoorne, J, Vermaelen, KY, Haerynck, F, De Benedetti, F, Lamkanfi, M.
Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation
Proc Natl Acad Sci U S A 113, 14384-14389, 2016. (Epub 2016 Nov 22)

Van Hauwermeiren, F, Lamkanfi, M.
The NEK-sus of the NLRP3 inflammasome
Nat Immunol 17, 223-224, 2016. (Epub 2016 Feb 16)

Vlantis, K, Wullaert, A, Polykratis, A, Kondylis, V, Dannappel, M, Schwarzer, R, Welz, P, Corona, T, Walczak, H, Weih, F, Klein, U, Kelliher, M, Pasparakis, M.
NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-kappaB-Dependent and -Independent Functions
Immunity 44, 553-567, 2016. (Epub 2016 Mar 15)

Ydens, E, Demon, D, Lornet, G, De Winter, V, Timmerman, V, Lamkanfi, M, Janssens, S.
Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes
J Neuroinflammation 12, 143, 2015. (Epub 2015 Aug 8)

Puimege, L, Libert, C, Van Hauwermeiren, F.
Regulation and dysregulation of tumor necrosis factor receptor-1
Cytokine Growth Factor Rev 25, 285-300, 2014. (Epub 2014 Mar 24)

Steeland, S, Puimege, L, Vandenbroucke, RE, Van Hauwermeiren, F, Haustraete, J, Devoogdt, N, Hulpiau, P, Leroux-Roels, G, Laukens, D, Meuleman, P, De Vos, M, Libert, C.
Generation and characterization of small single domain antibodies inhibiting human TNF receptor 1
J Biol Chem 290, 4022-4037, 2014. (Epub 2014 Dec 23)

Vandenbroucke, RE, Vanlaere, I, Van Hauwermeiren, F, Van Wonterghem, E, Wilson, C, Libert, C.
Pro-inflammatory effects of matrix metalloproteinase 7 in acute inflammation
Mucosal Immunol 7, 579-588, 2014. (Epub 2013 Oct 16)

Vande Walle, L, Van Opdenbosch, N, Jacques, P, Fossoul, A, Verheugen, E, Vogel, P, Beyaert, R, Elewaut, D, Kanneganti, TV, van Loo, G, Lamkanfi, M.
Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis
Nature 512, 69-73, 2014. (Epub 2014 Jun 29)

Van Hauwermeiren, F, Vandenbroucke, RE, Grine, L, Lodens, S, Van Wonterghem, E, De Rycke, R, De Geest, N, Hassan, B, Libert, C.
TNFR1-induced lethal inflammation is mediated by goblet and Paneth cell dysfunction
Mucosal Immunol 8, 828-840, 2014. (Epub 2014 Nov 26)

Van Hauwermeiren, F, Vandenbroucke, RE, Grine, L, Puimege, L, Van Wonterghem, E, Zhang, H, Libert, C.
Antisense oligonucleotides against TNFR1 prevent toxicity of TNF/IFNgamma treatment in mouse tumor models
Int J Cancer 135, 742-750, 2014. (Epub 2013 Dec 31)

Pinheiro, I, Dejager, L, Petta, I, Vandevyver, S, Puimege, L, Mahieu, T, Ballegeer, M, Van Hauwermeiren, F, Riccardi, C, Vuylsteke, M, Libert, C.
LPS resistance of SPRET/Ei mice is mediated by Gilz, encoded by the Tsc22d3 gene on the X chromosome
EMBO Mol Med 5, 456-470, 2013. (Epub 2013 Mar 4)

Vandenbroucke, RE, Dejonckheere, E, Van Hauwermeiren, F, Lodens, S, De Rycke, R, Van Wonterghem, E, Staes, A, Gevaert, K, Lopez-Otin, C, Libert, C.
Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF
EMBO Mol Med 5, 1000-1016, 2013. (Epub 2013 May 30)

Van Hauwermeiren, F, Armaka, M, Karagianni, N, Kranidioti, K, Vandenbroucke, RE, Loges, S, Van Roy, M, Staelens, J, Puimege, L, Palagani, A, Vanden Berghe, W, Victoratos, P, Carmeliet, P, Libert, C, Kollias, G.
Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium
J Clin Invest 123, 2590-2603, 2013. (Epub 2013 May 15)

Takahashi, N, Duprez, L, Grootjans, S, Cauwels, A, Nerinckx, W, Duhadaway, JB, Goossens, V, Roelandt, R, Van Hauwermeiren, F, Libert, C, Declercq, W, Callewaert, N, Prendergast, GC, Degterev, A, Yuan, J, Vandenabeele, P.
Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models
Cell Death Dis 3, e437, 2012. (Epub 2012 Nov 29)

Vandenbroucke, RE, Dejonckheere, E, Van Lint, P, Demeestere, D, Van Wonterghem, E, Vanlaere, I, Puimege, L, Van Hauwermeiren, F, De Rycke, R, Mc Guire, C, Campestre, C, Lopez-Otin, C, Matthys, P, Leclercq, G, Libert, C.
Matrix Metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases
J Neurosci 32, 9805-9816, 2012. (Epub 2012 Jul 18)

Duprez, L, Takahashi, N, Van Hauwermeiren, F, Vandendriessche, B, Goossens, V, Vanden Berghe, T, Declercq, W, Libert, C, Cauwels, A, Vandenabeele, P.
RIP Kinase-dependent necroptosis drives lethal systemic inflammatory response syndrome
Immunity 35, 908-918, 2011. (Epub 2011 Dec 23)

Kersse, K, Bertrand, MJ, Lamkanfi, M, Vandenabeele, P.
NOD-like receptors and the innate immune system: Coping with danger, damage and death
Cytokine Growth Factor Rev 22, 257-276, 2011. (Epub 2011 Oct 11)

Kersse, K, Lamkanfi, M, Bertrand, MJ, Vanden Berghe, T, Vandenabeele, P.
Interaction patches of procaspase-1 CARD are differently involved in procaspase-1 activation and RIP2-dependent NF-KB signaling
J Biol Chem 286, 35874-35882, 2011. (Epub 2011 Aug 23)

Van Bogaert, T, Vandevyver, S, Dejager, L, Van Hauwermeiren, F, Pinheiro, I, Petta, I, Engblom, D, Kleyman, A, Schütz, G, Tuckermann, J, Libert, C.
TNF inhibits glucocorticoid receptor function in mice: A strong signal towards lethal shock
J Biol Chem 286, 26555-26567, 2011. (Epub 2011 Jun 6)

Van Hauwermeiren, F, Puimege, L, Vandevyver, S, Van Bogaert, T, Vanlaere, I, Huys, L, Dejager, L, Libert, C.
Strategies to inhibit the toxicity of systemic TNF treatment
Adv Exp Med Biol 691, 481-484, 2011. (Epub ---)

Van Hauwermeiren, F, Vandenbroucke, RE, Libert, C.
Treatment of TNF mediated diseases by selective inhibition of soluble TNF or TNFR1
Cytokine Growth Factor Rev 22, 311-319, 2011. (Epub 2011 Sep 29)

Welz, P-S, Wullaert, A, Vlantis, K, Kondylis, V, Fernandez-Majada, V, Ermolaeva, M, Kirsch, P, Sterner-Kock, A, van Loo, G, Pasparakis, M.
FADD prevents RIP3-mediated epithelial cell necroptosis and chronic intestinal inflammation
Nature 477, 330-334, 2011. (Epub 2011 Jul 31)

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