» Home » Research 
Print this pageEmail this page URLConvert this page to PDF

Publications from this research unit

This page shows only publications with IRC as the affiliation of at least one author.
Publications by IRC members mentioning other affiliations are not in our database. Sorry.
See "Extra muros" papers of the units.

For copyright reasons, PDF-versions of our publications are available on the intranet only (login required  ). If you would like to receive a reprint of an IRC paper, please copy/paste the reference in the
reprint request form 


Bibli, SI, Papapetropoulos, A, Iliodromitis, EK, Daiber, A, Randriamboavonjy, V, Steven, S, Brouckaert, P, Chatzianastasiou, A, Kypreos, KE, Hausenloy, DJ, Fleming, I, Andreadou, I.
Nitroglycerin limits infarct size through S-nitrosation of Cyclophilin D: A novel mechanism for an old drug
Cardiovasc Res , in press, 2018. (Epub 2018 Aug 27)

Bibli, SI, Zhou, Z, Zukunft, S, Fisslthaler, B, Andreadou, I, Szabo, C, Brouckaert, P, Fleming, I, Papapetropoulos, A.
Tyrosine phosphorylation of eNOS regulates myocardial survival after an ischaemic insult: role of PYK2
Cardiovasc Res 113, 926-937, 2017. (Epub 2017 Apr 20)

Crassous, PA, Shu, P, Huang, C, Gordan, R, Brouckaert, P, Lampe, PD, Xie, LH, Beuve, A.
Newly Identified NO-Sensor Guanylyl Cyclase/Connexin 43 Association Is Involved in Cardiac Electrical Function
J Am Heart Assoc 6, e006397, 2017. (Epub 2017 Dec 21)

Decaluwe, K, Pauwels, B, Boydens, C, Thoonen, R, Buys, ES, Brouckaert, P, Van de Voorde, J.
Erectile Dysfunction in Heme-Deficient Nitric Oxide-Unresponsive Soluble Guanylate Cyclase Knock-In Mice
J Sex Med 14, 196-204, 2017. (Epub 2017 Feb)

Moon, Y, Balke, JE, Madorma, D, Siegel, MP, Knowels, GM, Brouckaert, P, Buys, E, Marcinek, DJ, Percival, J.
Nitric oxide regulates skeletal muscle fatigue, fiber type, microtubule organization and mitochondrial ATP synthesis efficiency through cGMP-dependent mechanisms
Antioxid Redox Signal 26, 966-985, 2017. (Epub 2016 Jul 8)

Muenster, S, Lieb, WS, Fabry, G, Allen, KN, Kamat, SS, Guy, AH, Dordea, AC, Teixeira, L, Tainsh, RE, Yu, B, Zhu, W, Ashpole, NE, Malhotra, R, Brouckaert, P, Bloch, DB, Scherrer-Crosbie, M, Stamer, WD, Kuehn, MH, Pasquale, LR, et al..
The Ability of Nitric Oxide to Lower Intraocular Pressure Is Dependent on Guanylyl Cyclase
Invest Ophthalmol Vis Sci 58, 4826-4835, 2017. (Epub 2017 Sep 1)

Nagasaka, Y, Wepler, M, Thoonen, R, Sips, PY, Allen, K, Graw, JA, Yao, V, Burns, SM, Muenster, S, Brouckaert, P, Miller, K, Solt, K, Buys, ES, Ichinose, F, Zapol, WM.
Sensitivity to Sevoflurane anesthesia is decreased in mice with a congenital deletion of Guanylyl Cyclase-1 alpha
BMC Anesthesiol 17, 76, 2017. (Epub 2017 Jun 14)

Vandenwijngaert, S, Swinnen, M, Walravens, AS, Beerens, M, Gillijns, H, Caluwe, E, Tainsh, RE, Nathan, DI, Allen, K, Brouckaert, P, Bartunek, J, Scherrer-Crosbie, M, Bloch, KD, Bloch, DB, Janssens, SP, Buys, ES.
Decreased Soluble Guanylate Cyclase Contributes To Cardiac Dysfunction Induced By Chronic Doxorubicin Treatment In Mice
Antioxid Redox Signal 26, 153-164, 2017. (Epub 2016 Aug 9)

Van Rymenant, E, Van Camp, J, Pauwels, B, Boydens, C, Vanden Daele, L, Beerens, K, Brouckaert, P, Smagghe, G, Kerimi, A, Williamson, G, Grootaert, C, Van de Voorde, J.
Ferulic acid-4-O-sulfate rather than ferulic acid relaxes arteries and lowers blood pressure in mice
J Nutr Biochem 44, 44-51, 2017. (Epub 2017 Mar 23)

De Pauw, A, Massion, P, Sekkali, B, Andre, E, Dubroca, C, Kmecova, J, Bouzin, C, Friart, A, Sibille, C, Gilon, P, De Mulder, D, Esfahani, H, Strapart, A, Martherus, R, Payen, V, Sonveaux, P, Brouckaert, P, Janssens, S, Balligand, JL.
Paracrine nitric oxide induces expression of cardiac sarcomeric proteins in adult progenitor cells through soluble guanylyl cyclase/cyclic-guanosine monophosphate and Wnt/beta-catenin inhibition
Cardiovasc Res 112, 478-490, 2016. (Epub 2016 Aug 12)

Dordea, AC, Vandenwijngaert, S, Garcia, V, Tainsh, RE, Nathan, DI, Allen, K, Raher, MJ, Tainsh, LT, Zhang, FF, Lieb, WS, Mikelman, S, Kirby, A, Stevens, C, Thoonen, R, Hindle, AG, Sips, PY, Falck, JR, Daly, MJ, Brouckaert, P, et al..
Androgen-Sensitive Hypertension Associated with Soluble Guanylate Cyclase Alpha1 Deficiency Is Mediated by 20-Hete
Am J Physiol Heart Circ Physiol 310, H1790-H1800, 2016. (Epub 2016 May 3)

Hobai, IA, Aziz, K, Buys, ES, Brouckaert, P, Siwik, DA, Colucci, WS.
Distinct Myocardial Mechanisms Underlie Cardiac Dysfunction in Endotoxemic Male and Female Mice
Shock 46, 713-722, 2016. (Epub 2016 Jul 11)

Sips, M, Krykbaeva, M, Diefenbach, TJ, Ghebremichael, M, Bowman, BA, Dugast, AS, Boesch, AW, Streeck, H, Kwon, DS, Ackerman, ME, Suscovich, TJ, Brouckaert, P, Schacker, TW, Alter, G.
Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategies
Mucosal Immunol 9, 1584-1595, 2016. (Epub 2016 Feb 17)

Sips, M, Liu, Q, Draghi, M, Ghebremichael, M, Berger, CT, Suscovich, TJ, Sun, Y, Walker, BD, Carrington, M, Altfeld, M, Brouckaert, P, De Jager, PL, Alter, G.
HLA-C levels impact natural killer cell subset distribution and function
Hum Immunol 77, 1147-1153, 2016. (Epub 2016 Aug 10)

Bibli, SI, Andreadou, I, Chatzianastasiou, A, Tzimas, C, Sanoudou, D, Kranias, E, Brouckaert, P, Coletta, C, Szabo, C, Kremastinos, DT, Iliodromitis, EK, Papapetropoulos, A.
Cardioprotection by H2S engages a cGMP-dependent protein kinase G/phospholamban pathway
Cardiovasc Res 106, 432-442, 2015. (Epub 2015 Apr 13)

Hultberg, A, Morello, V, Huyghe, L, De Jonge, N, Blanchetot, C, Hanssens, V, de Boeck, G, Silence, K, Festjens, E, Heukers, R, Roux, B, Lamballe, F, Ginestier, C, Charafe-Jauffret, E, Maina, F, Brouckaert, P, Saunders, M, Thibault, A, Dreier, T, et al..
Depleting MET-expressing tumor cells by ADCC provides a therapeutic advantage over inhibiting HGF/MET signaling
Cancer Res 75, 3373-3383, 2015. (Epub 2015 Jul 3)

Pauwels, B, Boydens, C, Brouckaert, P, Van de Voorde, J.
Oximes Induce Erection and Are Resistant to Oxidative Stress
J Sex Med 12, 906-915, 2015. (Epub 2015 Feb 16)

Schepers, E, Houthuys, E, Dhondt, A, De Meyer, G, Neirynck, N, Bernaert, P, Van den Bergh, R, Brouckaert, P, Vanholder, R, Glorieux, G.
Transcriptome Analysis in Patients with Chronic Kidney Disease on Hemodialysis Disclosing a Key Role for CD16+CX3CR1+ Monocytes
PLoS One 40, e0121750, 2015. (Epub 2015 Apr 1)

Thoonen, R, Cauwels, A, Decaluwe, K, Geschka, S, Tainsh, RE, Delanghe, J, Hochepied, T, De Cauwer, L, Rogge, E, Voet, S, Sips, P, Karas, RH, Bloch, KD, Vuylsteke, M, Stasch, JP, Van de Voorde, J, Buys, ES, Brouckaert, P.
Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice
Nat Commun 6, 8482, 2015. (Epub 2015 Oct 7)

Wijnands, KA, Meesters, DM, van Barneveld, KW, Visschers, RG, Briede, JJ, Vandendriessche, B, van Eijk, HM, Bessems, BA, Hoven, NV, von Wintersdorff, CJ, Brouckaert, P, Bouvy, ND, Lamers, WH, Cauwels, A, Poeze, M.
Citrulline Supplementation Improves Organ Perfusion and Arginine Availability under Conditions with Enhanced Arginase Activity
Nutrients 7, 5217-5238, 2015. (Epub 2015 Jun 29)

Boydens, C, Pauwels, B, Decaluwe, K, Brouckaert, P, Van de Voorde, J.
Relaxant and antioxidant capacity of the red wine polyphenols, resveratrol and quercetin, on isolated mice corpora cavernosa
J Sex Med 12, 303-312, 2014. (Epub 2014 Dec 2)

Cauwels, A, Bultinck, J, De Zwaef, R, Vandendriessche, B, Magez, S, Brouckaert, P.
Nitric oxide production by endotoxin preparations in TLR4-deficient mice
Nitric Oxide-Biol Chem 36, 36, 2014. (Epub 2013 Nov 20)

Cauwels, A, Rogge, E, Vandendriessche, B, Shiva, S, Brouckaert, P.
Extracellular ATP drives systemic inflammation, tissue damage and mortality
Cell Death Dis 5, e1102, 2014. (Epub 2014 Mar 6)

Cosyns, SM, Huyghe, L, Thoonen, R, Stasch, JP, Brouckaert, P, Lefebvre, RA.
Influence of cinaciguat on gastrointestinal motility in apo-sGC mice
Neurogastroenterol Motil 26, 1573-1585, 2014. (Epub 2014 Sep 8)

Dupont, LL, Glynos, C, Bracke, KR, Brouckaert, P, Brusselle, GG.
Role of the nitric oxide - soluble guanylyl cyclase pathway in obstructive airway diseases
Pulm Pharmacol Ther 29, 1-6, 2014. (Epub 2014 Jul 17)

Glynos, C, Toumpanakis, D, Loverdos, K, Karavana, V, Zhou, Z, Magkou, C, Dettoraki, M, Perlikos, F, Pavlidou, A, Kotsikoris, V, Topouzis, S, Theocharis, SE, Brouckaert, P, Giannis, A, Papapetropoulos, A, Vassilakopoulos, T.
Guanylyl cyclase activation reverses resistive breathing-induced lung injury and inflammation
Am J Resp Cell Mol Biol 52, 762-771, 2014. (Epub 2014 Oct 29)

Hervé, D, Philippi, A, Belbouab, R, Zerah, M, Chabrier, S, Collardeau-Frachon, S, Bergametti, F, Essongue, A, Berrou, E, Krivosic, V, Sainte-Rose, C, Houdart, E, Adam, F, Billiemaz, K, Lebret, M, Roman, S, Passemard, S, Boulday, G, Delaforge, A, Guey, S, Dray, X, Chabriat, H, Brouckaert, P, Bryckaer, M, Tournier-Lasserve, E.
Loss of alfa-1 beta-1 soluble guanylate cyclase, the major nitric oxide receptor, leads to moyamoya and achalasia.
Am J Hum Genet 94, 385-394, 2014. (Epub 2014 Feb 25)

Silence, K, Dreier, T, Moshir, M, Ulrichts, P, Gabriels, SME, Saunders, M, Wajant, H, Brouckaert, P, Huyghe, L, Van Hauwermeiren, T, Thibault, A, De Haard, HJ.
ARGX-110, a highly potent antibody targeting CD70, eliminates tumors via both enhanced ADCC and immune checkpoint blockade
mAbs 6, 523-532, 2014. (Epub 2013 Dec 6)

Vanden Berghe, T, Demon, D, Bogaert, P, Vandendriessche, B, Goethals, A, Depuydt, B, Vuylsteke, M, Roelandt, R, Van Wonterghem, E, Vandenbroecke, J, Choi, SM, Meyer, E, Krautwald, S, Declercq, W, Takahashi, N, Cauwels, A, Vandenabeele, P.
Simultaneous targeting of Interleukin-1 and -18 is required for protection against inflammatory and septic shock
Am J Respir Crit Care Med 189, 282-291, 2014. (Epub 2014 Jan 23)

Vandendriessche, B, Goethals, A, Simats, A, Van Hamme, E, Brouckaert, P, Cauwels, A.
MAPK-activated protein kinase 2-deficiency causes hyperacute tumor necrosis factor-induced inflammatory shock
BMC Physiol 14, 5, 2014. (Epub 2014 Sep 4)

Vandendriessche, B, Peperstraete, H, Rogge, E, Cauwels, P, Hoste, E, Stiedl, O, Brouckaert, P, Cauwels, A.
A multiscale entropy-based tool for scoring severity of systemic inflammation
Crit Care Med 42, e560-569, 2014. (Epub 2014 Apr 8)

Buys, ES, Ko, YC, Alt, C, Hayton, SR, Jones, A, Tainsh, LT, Ren, R, Giani, A, Clerte, M, Abernathy, E, Tainsh, RE, Oh, DJ, Malhotra, R, Arora, P, de Waard, N, Yu, B, Turcotte, R, Nathan, D, Scherrer-Crosbie, M, Loomis, SJ, Kang, JH, Lin, CP, Gong, H, Rhee, DJ, Brouckaert, P, Wiggs, JL, Gregory, MS, Pasquale, LR, Bloch, KD, Ksander, BR.
Soluble guanylate cyclase alpha1-deficient mice: a novel murine model for primary open angle glaucoma.
PLoS One 8, e60156, 2013. (Epub 2013 Mar 20)

Cauwels, A, Vandendriessche, B, Brouckaert, P.
Of mice, men, and inflammation.
Proc Natl Acad Sci USA 110, E3150, 2013. (Epub 2013 Jul 12)

Cauwels, A, Vandendriessche, B, Bultinck, J, Descamps, B, Rogge, E, Van Nieuwenhuysen, T, Sips, M, Vanhove, C, Brouckaert, P.
TLR2 activation causes no morbidity or cardiovascular failure, despite excessive systemic nitric oxide production
Cardiovasc Res 100, 28-35, 2013. (Epub 2013 Jun 19)

Clerte, M, Baron, DM, Brouckaert, P, Ernande, L, Raher, MJ, Flynn, AW, Picard, MH, Bloch, KD, Buys, ES, Scherrer-Crosbie, M.
Brown adipose tissue blood flow and mass in obesity: A contrast ultrasound study in mice
J Am Soc Echocardiog 26, 1465-1473, 2013. (Epub 2013 Aug 28)

Cosyns, SMR, Dhaese, I, Thoonen, R, Buys, ES, Vral, A, Brouckaert, P, Lefebvre, RA.
Heme deficiency of soluble guanylate cyclase induces gastroparesis
Neurogastroent Motil 25, e339-352, 2013. (Epub 2013 Mar 28)

Glynos, C, Dupont, LL, Vassilakopoulos, T, Papapetropoulos, A, Brouckaert, P, Giannis, A, Joos, GF, Bracke, KR, Brusselle, GG.
The role of soluble guanylyl cyclase in chronic obstructive pulmonary disease
Am J Respir Crit Care Med 188, 789-799, 2013. (Epub 2013 Jul 10)

Hobai, IA, Buys, ES, Morse, JC, Edgecomb, J, Weiss, E, Armoundas, AA, Hou, X, Khandelwal, AR, Siwik, DA, Brouckaert, P, Cohen, RA, Colucci, WS.
SERCA cysteine-674 sulphonylation and inhibition of L-type calcium influx contribute to cardiac dysfunction in endotoxemic mice, independently of cGMP synthesis
Am J Physiol Heart Circ Physiol 305, H1189-H1200, 2013. (Epub 2013 Aug 9)

Vanden Berghe, T, Goethals, A, Demon, D, Bogaert, P, Mak, TW, Cauwels, A, Vandenabeele, P.
An inactivating caspase-11 passenger mutation muddles sepsis research
Am J Respir Crit Care Med 188, 120-121, 2013. (Epub 2013 Jul 1)

Vandendriessche, B, Rogge, E, Goossens, V, Vandenabeele, P, Stasch, J-P, Brouckaert, P, Cauwels, A.
The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems
PLoS One 8, e72155, 2013. (Epub 2013 Aug 28)

Baron, DM, Clerte, M, Brouckaert, P, Raher, MJ, Flynn, AW, Zhang, H, Carter, EA, Picard, MH, Bloch, KD, Buys, ES, Scherrer-Crosbie, M.
In vivo noninvasive characterization of brown adipose tissue blood flow by contrast ultrasound in mice
Circ Cardiovasc Imaging 5, 652-659, 2012. (Epub 2012 Jul 11)

Buys, ES, Raher, MJ, Kirby, A, Shahid, M, Baron, DM, Hayton, SR, Tainsh, LT, Sips, PY, Rauwerdink, KM, Yan, Q, Tainsh, RE, Shakartzi, HR, Stevens, C, Decaluwe, K, Rodrigues-Machado, MD, Malhotra, R, Van de Voorde, J, Wang, T, Brouckaert, P, Daly, MJ, Bloch, KD.
Genetic modifiers of hypertension in soluble guanylate cyclase alpha1-deficient mice
J Clin Invest 122, 2316-2325, 2012. (Epub 2012 May 8)

Emeagi, PU, Van Lint, S, Goyvaerts, C, Maenhout, S, Cauwels, A, McNeish, IA, Bos, T, Heirman, C, Thielemans, K, Aerts, JL, Breckpot, K.
Proinflammatory characteristics of SMAC/DIABLO-induced cell death in antitumor therapy
Cancer Res 72, 1342-1352, 2012. (Epub 2012 Feb 29)

Maddens, B, Vandendriessche, B, Demon, D, Vanholder, R, Chiers, K, Cauwels, A, Meyer, E.
Severity of sepsis-induced acute kidney injury in a novel mouse model is age dependent
Crit Care Med 40, 2638-2646, 2012. (Epub 2012 Jun 28)

Takahashi, N, Duprez, L, Grootjans, S, Cauwels, A, Nerinckx, W, Duhadaway, JB, Goossens, V, Roelandt, R, Van Hauwermeiren, F, Libert, C, Declercq, W, Callewaert, N, Prendergast, GC, Degterev, A, Yuan, J, Vandenabeele, P.
Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models
Cell Death Dis 3, e437, 2012. (Epub 2012 Nov 29)

Ydens, E, Cauwels, A, Asselbergh, B, Goethals, S, Peeraer, L, Lornet, G, Almeida-Souza, L, Van Ginderachter, JA, Timmerman, V, Janssens, S.
Acute injury in the peripheral nervous system triggers an alternative macrophage response
J Neuroinflammation 9, 176, 2012. (Epub 2012 Jul 20)

Boonefaes, T, Houthuys, E, Van den Bergh, R, Vander Beken, S, Raes, G, Brouckaert, P, De Baetselier, P, Grooten, J.
Do-it-yourself: construction of a custom cDNA macroarray platform with high sensitivity and linear range
BMC Biotechnol 11, 97, 2011. (Epub 2011 Oct 25)

Cauwels, A, Brouckaert, P.
Nitrite regulation of shock
Cardiovasc Res 89, 553-559, 2011. (Epub 2010 Oct 1)

Cawley, SM, Kolodziej, S, Ichinose, F, Brouckaert, P, Buys, ES, Bloch, KD.
sGCalpha1 mediates the negative inotropic effects of NO in cardiac myocytes independent of changes in calcium handling
Am J Physiol Heart Circ Physiol 301, H157-H163, 2011. (Epub 2011 May 2)

Duprez, L, Takahashi, N, Van Hauwermeiren, F, Vandendriessche, B, Goossens, V, Vanden Berghe, T, Declercq, W, Libert, C, Cauwels, A, Vandenabeele, P.
RIP Kinase-dependent necroptosis drives lethal systemic inflammatory response syndrome
Immunity 35, 908-918, 2011. (Epub 2011 Dec 23)

Back to previous page

Export in CSV

Page 1 of 4
<< 1 - 2 - 3 - 4 >>

To top

What do these icons mean?

pdf file (800 kb)