Publications from this research unit

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Ackermann, M, Anders, HJ, Bilyy, R, Bowlin, GL, Daniel, C, De Lorenzo, R, Egeblad, M, Henneck, T, Hidalgo, A, Hoffmann, M, Hohberger, B, Kanthi, Y, Kaplan, MJ, Knight, JS, Knopf, J, Kolaczkowska, E, Kubes, P, Leppkes, M, Mahajan, A, et al..
Patients with COVID-19: in the dark-NETs of neutrophils
Cell Death Differ , in press, 2021. (Epub 2021 May 24)

Coornaert, I, Puylaert, P, Marcasolli, G, Grootaert, MOJ, Vandenabeele, P, De Meyer, GRY, Martinet, W.
Impact of myeloid RIPK1 gene deletion on atherogenesis in ApoE-deficient mice
Atherosclerosis 322, 51-60, 2021. (Epub 2021 Feb 24)

De Schutter, E, Roelandt, R, Riquet, FB, Van Camp, G, Wullaert, A, Vandenabeele, P.
Punching Holes in Cellular Membranes: Biology and Evolution of Gasdermins
Trends Cell Biol 31, 500-513, 2021. (Epub 2021 Mar 23)

Le Naour, J, Liu, P, Zhao, L, Adjemian, S, Sztupinszki, Z, Taieb, J, Mulot, C, Silvin, A, Dutertre, CA, Ginhoux, F, et al., Vandenabeele, P, et al., Kroemer, G.
A TLR3 ligand reestablishes chemotherapeutic responses in the context of FPR1 deficiency
Cancer Discov 11, 408-423, 2021. (Epub 2020 Oct 12)

Lu, Z, Van Eeckhoutte, HP, Liu, G, Nair, PM, Jones, B, Gillis, CM, Nalkurthi, BC, Verhamme, F, Buyle-Huybrecht, T, Vandenabeele, P, Vanden Berghe, T, Brusselle, GG, Murphy, JM, Wark, PA, Bracke, KR, Fricker, M, Hansbro, PM.
Necroptosis Signalling Promotes Inflammation, Airway Remodelling and Emphysema in COPD
Am J Respir Crit Care Med , in press, 2021. (Epub 2021 Jun 16)

Martens, S, Bridelance, J, Roelandt, R, Vandenabeele, P, Takahashi, N.
MLKL in cancer: more than a necroptosis regulator
Cell Death Differ 28, 1757-1772, 2021. (Epub 2021 May 5)

Meyts, I, Bucciol, G, Quinti, I, Neven, B, Fischer, A, Seoane, E, Lopez-Granados, E, Gianelli, C, Robles-Marhuenda, A, Jeandel, PY, Paillard, C, Sankaran, VG, Demirdag, YY, et al, Bosteels, C, Lambrecht, BN, et al..
Coronavirus Disease 2019 in patients with inborn errors of immunity: an international study
J Allergy Clin Immunol 147, 520-531, 2021. (Epub 2020 Sep 24)

Oltean, T, Van San, E, Divert, T, Vanden Berghe, T, Saelens, X, Maelfait, J, Takahashi, N, Vandenabeele, P.
Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL
Cell Death Dis 12, 471, 2021. (Epub 2021 May 11)

Ponsioen, B, Post, JB, Buissant des Amorie, JR, Laskaris, D, van Ineveld, RL, Kersten, S, Bertotti, A, Sassi, F, Sipieter, F, Cappe, B, Mertens, S, Verlaan-Klink, I, Boj, SF, Vries, RGJ, Rehmann, H, Vandenabeele, P, Riquet, FB, Trusolino, L, Bos, JL, et al..
Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling
Nat Cell Biol 23, 377-390, 2021. (Epub 2021 Apr 1)

Aaes, TL, Vandenabeele, P.
The intrinsic immunogenic properties of cancer cell lines, immunogenic cell death, and how these influence host antitumor immune responses
Cell Death Differ 28, 843-860, 2020. (Epub 2020 Nov 19)

Aaes, TL, Verschuere, H, Kaczmarek, A, Heyndrickx, L, Wiernicki, B, Delrue, I, De Craene, B, Taminau, J, Delvaeye, T, Bertrand, MJM, Declercq, W, Berx, G, Krysko, DV, Adjemian, S, Vandenabeele, P.
Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection
J Immunol 204, 775-787, 2020. (Epub 2020 Jan 3)

Adjemian, S, Oltean, T, Martens, S, Wiernicki, B, Goossens, V, Vanden Berghe, T, Cappe, B, Ladik, M, Riquet, FB, Heyndrickx, L, Bridelance, J, Vuylsteke, M, Vandecasteele, K, Vandenabeele, P.
Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death
Cell Death Dis 11, 1003, 2020. (Epub 2020 Nov 23)

Delanghe, T, Dondelinger, Y, Bertrand, MJM.
RIPK1 Kinase-Dependent Death: A Symphony of Phosphorylation Events
Trends Cell Biol 30, 189-200, 2020. (Epub 2020 Jan 17)

De Samber, B, Vanden Berghe, T, Meul, E, Bauters, S, Seyrich, M, Smet, J, De Paepe, B, da Silva, JC, Bohic, S, Cloetens, P, Van Coster, R, Vandenabeele, P, Vincze, L.
Nanoscopic X-ray imaging and quantification of the iron cellular architecture within single fibroblasts of Friedreich's ataxia patients
J Synchrotron Radiat 27, 185-198, 2020. (Epub 2020 Jan 1)

de Vasconcelos, NM, Van Opdenbosch, N, Van Gorp, H, Martin-Perez, R, Zecchin, A, Vandenabeele, P, Lamkanfi, M.
An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages
Cell Rep 32, 107959, 2020. (Epub 2020 Jul 28)

Devos, M, Tanghe, G, Gilbert, B, Dierick, E, Verheirstraeten, M, Nemegeer, J, de Reuver, R, Lefebvre, S, De Munck, J, Rehwinkel, J, Vandenabeele, P, Declercq, W, Maelfait, J.
Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation
J Exp Med 217, e20191913, 2020. (Epub 2020 Apr 21)

Ferrada, L, Barahona, MJ, Salazar, K, Vandenabeele, P, Nualart, F.
Vitamin C controls neuronal necroptosis under oxidative stress
Redox Biol 29, 101408, 2020. (Epub 2019 Dec 16)

Galluzzi, L, Vitale, I, Warren, S, Adjemian, S, Agostinis, P, Martinez, AB, Chan, TA, Coukos, G, Demaria, S, Deutsch, E, Draganov, D, Edelson, RL, Formenti, SC, Fucikova, J, Gabriele, L, Gaipl, US, Gameiro, SR, Garg, AD, Golden, E, et al..
Consensus guidelines for the definition, detection and interpretation of immunogenic cell death
J Immunother Cancer 8, e000337, 2020. (Epub 2020 Mar 9)

Hassannia, B, Logie, E, Vandenabeele, P, Vanden Berghe, T, Vanden Berghe, W.
Withaferin A: from Ayurvedic folk medicine to preclinical anti-cancer drug
Biochem Pharmacol 173, 113602, 2020. (Epub 2019 Aug 9)

Laurien, L, Nagata, M, Schunke, H, Delanghe, T, Wiederstein, JL, Kumari, S, Schwarzer, R, Corona, T, Kruger, M, Bertrand, MJM, Kondylis, V, Pasparakis, M.
Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation
Nat Commun 11, 1747, 2020. (Epub 2020 Apr 8)

Maelfait, J, Liverpool, L, Rehwinkel, J.
Nucleic Acid Sensors and Programmed Cell Death
J Mol Biol 432, 552-568, 2020. (Epub 2019 Nov 28)

Martens, A, Priem, D, Hoste, E, Vetters, J, Rennen, S, Catrysse, L, Voet, S, Deelen, L, Sze, M, Vikkula, H, Slowicka, K, Hochepied, T, Iliaki, K, Wullaert, A, Janssens, S, Lamkanfi, M, Beyaert, R, Armaka, M, Bertrand, MJM, et al..
Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities
Nat Immunol 21, 381-387, 2020. (Epub 2020 Mar 16)

Martens, S, Hofmans, S, Declercq, W, Augustyns, K, Vandenabeele, P.
Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs
Trends Pharmacol Sci 41, 209-224, 2020. (Epub 2020 Feb 5)

Priem, D, van Loo, G, Bertrand, MJM.
A20 and Cell Death-driven Inflammation
Trends Immunol 41, 421-435, 2020. (Epub 2020 Mar 30)

Roberti, MP, Yonekura, S, Duong, CPM, Picard, M, Ferrere, G, Tidjani Alou, M, , et al., Kourula, S, et al., Vanden Berghe, T, Ghiringhelli, F, Vandenabeele, P, Kroemer, G, Zitvogel, L.
Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer
Nat Med 26, 919-931, 2020. (Epub 2020 May 25)

Seo, J, Seong, D, Nam, YW, Hwang, CH, Lee, SR, Lee, CS, Jin, Y, Lee, HW, Oh, DB, Vandenabeele, P, Song, J.
Beclin 1 functions as a negative modulator of MLKL oligomerisation by integrating into the necrosome complex
Cell Death Differ 27, 3065-3081, 2020. (Epub 2020 May 26)

Seong, D, Jeong, M, Seo, J, Lee, JY, Hwang, CH, Shin, HC, Shin, JY, Nam, YW, Jo, JY, Lee, H, Kim, HJ, Kim, HR, Oh, JH, Ha, SJ, Kim, SJ, Roe, JS, Kim, W, et al., Vandenabeele, P , et al..
Identification of MYC as an antinecroptotic protein that stifles RIPK1-RIPK3 complex formation
Proc Natl Acad Sci U S A 117, 19982-19993, 2020. (Epub 2020 Aug 04)

Simpson, J, Loh, Z, Ullah, MA, Lynch, JP, Werder, RB, Collinson, N, Zhang, V, Dondelinger, Y, Bertrand, MJM, Everard, ML, Blyth, CC, Hartel, G, Van Oosterhout, AJ, Gough, PJ, Bertin, J, Upham, JW, Spann, KM, Phipps, S.
RSV Infection Promotes Necroptosis and HMGB1 Release by Airway Epithelial Cells
Am J Respir Crit Care Med 201, 1358-1371, 2020. (Epub 2020 Feb 27)

Sprooten, J, De Wijngaert, P, Vanmeerbeerk, I, Martin, S, Vangheluwe, P, Schlenner, S, Krysko, DV, Parys, JB, Bultynck, G, Vandenabeele, P, Garg, AD.
Necroptosis in Immuno-Oncology and Cancer Immunotherapy
Cells 9, 1823, 2020. (Epub 2020 Aug 01)

Teufelberger, AR, Van Nevel, S, Hulpiau, P, Nordengrun, M, Savvides, SN, De Graeve, S, Akula, S, Holtappels, G, De Ruyck, N, Declercq, W, Vandenabeele, P, Hellman, L, Broker, BM, Krysko, DV, Bachert, C, Krysko, O.
Mouse Strain-Dependent Difference Toward the Staphylococcus aureus Allergen Serine Protease-Like Protein D Reveals a Novel Regulator of IL-33
Front Immunol 11, 582044, 2020. (Epub 2020 Sep 25)

Thyssen, JP, Jakasa, I, Riethmuller, C, Schon, MP, Braun, A, Haftek, M, Fallon, PG, Wroblewski, J, Jakubowski, H, Eckhart, L, Declercq, W, Koppes, S, Engebretsen, KA, Bonefeld, C, Irvine, AD, Keita-Alassane, S, Simon, M, Kawasaki, H, Kubo, A, et al..
Filaggrin Expression and Processing Deficiencies Impair Corneocyte Surface Texture and Stiffness in Mice
J Invest Dermatol 140, 615-623, 2020. (Epub 2019 Aug 31)

Tougaard, P, Martinsen, LO, Lutzhoft, DO, Jensen, HE, Flethoj, M, Vandenabeele, P, Pedersen, AE, Skov, S, Hansen, AK, Hansen, CHF.
TL1A regulates adipose-resident innate lymphoid immune responses and enables diet-induced obesity in mice
Int J Obes (Lond) 44, 1062-1074, 2020. (Epub 2020 Jan 30)

Van Coillie, S, Wiernicki, B, Xu, J.
Molecular and Cellular Functions of CTLA-4
Adv Exp Med Biol 1248, 7-32, 2020. (Epub 2020 Mar 18)

Verboom, L, Martens, A, Priem, D, Hoste, E, Sze, M, Vikkula, HK, Van Hove, L, Voet, S, Roels, J, Maelfait, J, Bongiovanni, L, de Bruin, A, Scott, CL, Saeys, Y, Pasparakis, M, Bertrand, MJM, van Loo, G.
OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis
Cell Rep 30, 2237-2247, 2020. (Epub 2020 Feb 18)

Wiernicki, B, Dubois, H, Tyurina, YY, Hassannia, B, Bayir, H, Kagan, VE, Vandenabeele, P, Wullaert, A, Vanden Berghe, T.
Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis
Cell Death Dis 11, 922, 2020. (Epub 2020 Oct 27)

Beltran, S, Nassif, M, Vicencio, E, Arcos, J, Labrador, L, Cortes, BI, Cortez, C, Bergmann, CA, Espinoza, S, Hernandez, MF, Matamala, JM, Bargsted, L, Matus, S, Rojas-Rivera, D, Bertrand, MJM, Medinas, DB, Hetz, C, Manque, PA, Woehlbier, U.
Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis
Mol Neurodegener 14, 14, 2019. (Epub 2019 Mar 27)

Boeltz, S, Amini, P, Anders, HJ, Andrade, F, Bilyy, R, Chatfield, S, Cichon, I, Clancy, DM, Desai, J, et al., Maueroder, C, et al. , Vanden Berghe, T, Vandenabeele, P, Hahn, J, Hidalgo, A, Hoffmann, MH, Kaplan, MJ, Knight, JS, Kolaczkowska, E, Kubes, P, et al..
To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps
Cell Death Differ 26, 395-408, 2019. (Epub 2019 Jan 8)

Delvaeye, T, De Smet, MAJ, Verwaerde, S, Decrock, E, Czekaj, A, Vandenbroucke, RE, Lemeire, K, Goncalves, A, Declercq, W, Vandenabeele, P, Krysko, DV, Leybaert, L.
Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock
Sci Rep 9, 16623, 2019. (Epub 2019 Nov 12)

Devos, M, Mogilenko, DA, Fleury, S, Gilbert, B, Becquart, C, Quemener, S, Dehondt, H, Tougaard, P, Staels, B, Bachert, C, Vandenabeele, P, Van Loo, G, Staumont-Salle, D, Declercq, W, Dombrowicz, D.
Keratinocyte expression of A20/TNFAIP3 controls skin inflammation associated with atopic dermatitis and psoriasis
J Invest Dermatol 139, 135-145, 2019. (Epub 2018 Aug 14)

Dondelinger, Y, Delanghe, T, Priem, D, Wynosky-Dolfi, MA, Sorobetea, D, Rojas-Rivera, D, Giansanti, P, Roelandt, R, Gropengiesser, J, Ruckdeschel, K, Savvides, SN, Heck, AJR, Vandenabeele, P, Brodsky, IE, Bertrand, MJM.
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
Nat Commun 10, 1729, 2019. (Epub 2019 Apr 15)

Elvas, F, Vanden Berghe, T, Adriaenssens, Y, Vandenabeele, P, Augustyns, K, Staelens, S, Stroobants, S, Van der Veken, P, Wyffels, L.
Caspase-3 probes for PET imaging of apoptotic tumor response to anticancer therapy
Org Biomol Chem 17, 4801-4824, 2019. (Epub 2019 Apr 29)

Hassannia, B, Vandenabeele, P, Vanden Berghe, T.
Targeting Ferroptosis to Iron Out Cancer
Cancer Cell 35, 830-849, 2019. (Epub 2019 May 16)

Hoste, E, Maueroder, C, van Hove, L, Catrysse, L, Vikkula, HK, Sze, M, Maes, B, Karjosukarso, D, Martens, L, Goncalves, A, Parthoens, E, Roelandt, R, Declercq, W, Fuentes, I, Palisson, F, Gonzalez, S, Salas-Alanis, JC, Boon, L, Huebener, P, et al..
Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils for NET Formation
Cell Rep 29, 2689-2701, 2019. (Epub 2019 Nov 26)

Kavcic, N, Pegan, K, Vandenabeele, P, Turk, B.
Comparative study of the differential cell death protecting effect of various ROS scavengers
Biol Chem 400, 149-160, 2019. (Epub 2018 Sep 19)

Konieczny, P, Lichawska-Cieslar, A, Kwiecinska, P, Cichy, J, Pietrzycka, R, Szukala, W, Declercq, W, Devos, M, Paziewska, A, Rumienczyk, I, Kulecka, M, Mikula, M, Fu, M, Borowczyk, J, Santamaria-Babi, LF, Jura, J.
Keratinocyte-specific ablation of Mcpip1 impairs skin integrity and promotes local and systemic inflammation
J Mol Med (Berl) 97, 1669-1684, 2019. (Epub 2019 Nov 30)

Napoletano, F, Baron, O, Vandenabeele, P, Mollereau, B, Fanto, M.
Intersections between Regulated Cell Death and Autophagy
Trends Cell Biol 29, 323-338, 2019. (Epub 2019 Jan 18)

Priem, D, Devos, M, Druwe, S, Martens, A, Slowicka, K, Ting, AT, Pasparakis, M, Declercq, W, Vandenabeele, P, van Loo, G, Bertrand, MJM.
A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms
Cell Death Dis 10, 692, 2019. (Epub 2019 Sep 18)

Sabel, R, Fronza, AS, Carrenho, LZB, Maes, A, Barros, ML, Pollo, LAE, Biavatti, MW, D'Herde, K, Vandenabeele, P, Kreuger.
Anti-inflammatory activity of the sesquiterpene lactone diacethylpiptocarphol in dextransulfate sodium-induced colitis in mice
J Ethnopharmacol 245, 112186, 2019. (Epub 2019 Aug 28)

Tanc, M, Cleenewerck, M, Kurdi, A, Roelandt, R, Declercq, W, De Meyer, G, Augustyns, K, Martinet, W, Van der Veken, P.
Synthesis and evaluation of novel benzotropolones as Atg4B inhibiting autophagy blockers
Bioorg Chem 87, 163-168, 2019. (Epub 2019 Mar 13)

Tang, D, Kang, R, Vanden Berghe, T, Vandenabeele, P, Kroemer, G.
The molecular machinery of regulated cell death
Cell Res 29, 347-364, 2019. (Epub 2019 Apr 6)