Publications from this research unit

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Boeltz, S, Amini, P, Anders, HJ, Andrade, F, Bilyy, R, Chatfield, S, Cichon, I, Clancy, DM, Desai, J, et al., Maueroder, C, et al. , Vanden Berghe, T, Vandenabeele, P, Hahn, J, Hidalgo, A, Hoffmann, MH, Kaplan, MJ, Knight, JS, Kolaczkowska, E, Kubes, P, et al..
To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps
Cell Death Differ , in press, 2019. (Epub 2019 Jan 8)

Devos, M, Mogilenko, DA, Fleury, S, Gilbert, B, Becquart, C, Quemener, S, Dehondt, H, Tougaard, P, Staels, B, Bachert, C, Vandenabeele, P, Van Loo, G, Staumont-Salle, D, Declercq, W, Dombrowicz, D.
Keratinocyte expression of A20/TNFAIP3 controls skin inflammation associated with atopic dermatitis and psoriasis
J Invest Dermatol 139, 135-145, 2019. (Epub 2018 Aug 14)

Kavcic, N, Pegan, K, Vandenabeele, P, Turk, B.
Comparative study of the differential cell death protecting effect of various ROS scavengers
Biol Chem 400, 149-160, 2019. (Epub 2018 Sep 19)

Webb, LV, Barbarulo, A, Huysentruyt, J, Vanden Berghe, T, Takahashi, N, Ley, S, Vandenabeele, P, Seddon, B.
Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-kappaB
Immunity , in press, 2019. (Epub 2019 Jan 23)

Annibaldi, A, Wicky John, S, Vanden Berghe, T, Swatek, KN, Ruan, J, Liccardi, G, Bianchi, K, Elliott, PR, Choi, SM, Van Coillie, S, Bertin, J, Wu, H, Komander, D, Vandenabeele, P, Silke, J, Meier, P.
Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2
Mol Cell 69, 566-580, 2018. (Epub 2018 Feb 15)

Ballegeer, M, Van Looveren, K, Timmermans, S, Eggermont, M, Vandevyver, S, Thery, F, Dendoncker, K, Souffriau, J, Vandewalle, J, Van Wyngene, L, De Rycke, R, Takahashi, N, Vandenabeele, P, Tuckermann, J, Reichardt, HM, Impens, F, Beyaert, R, De Bosscher, K, Vandenbroucke, RE, et al..
Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice
J Clin Invest 128, 3265-3279, 2018. (Epub 2018 May 10)

Borghi, A, Haegman, M, Fischer, R, Carpentier, I, Bertrand, MJM, Libert, C, Afonina, IS, Beyaert, R.
The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2-induced canonical NF-kappaB signaling
Biochem Pharmacol 153, 292-298, 2018. (Epub 2018 Jan 26)

Deckers, J, Bougarne, N, Mylka, V, Desmet, S, Luypaert, A, Devos, M, Tanghe, G, Van Moorleghem, J, Vanheerswynghels, M, De Cauwer, L, Thommis, J, Vuylsteke, M, Tavernier, J, Lambrecht, B, Hammad, H, De Bosscher, K.
Co-activation of GR and PPARgamma in murine skin prevents worsening of atopic march
J Invest Dermatol 138, 1360-1370, 2018. (Epub 2017 Dec 27)

Delvaeye, T, Vandenabeele, P, Bultynck, G, Leybaert, L, Krysko, DV.
Therapeutic Targeting of Connexin Channels: New Views and Challenges
Trends Mol Med 24, 1036-1053, 2018. (Epub 2018 Nov 10)

Delvaeye, T, Wyffels, L, Deleye, S, Lemeire, K, Goncalves, A, Decrock, E, Staelens, S, Leybaert, L, Vandenabeele, P, Krysko, DV.
Noninvasive whole-body imaging of phosphatidylethanolamine as a cell death marker using (99m)Tc-duramycin during TNF-induced SIRS
J Nucl Med , in press, 2018. (Epub 2018 Feb 1)

De Samber, B, Meul, E, Laforce, B, De Paepe, B, Smet, J, De Bruyne, M, De Rycke, R, Bohic, S, Cloetens, P, Van Coster, R, Vandenabeele, P, Vanden Berghe, T.
Nanoscopic X-ray fluorescence imaging and quantification of intracellular key-elements in cryofrozen Friedreich's ataxia fibroblasts
PLoS One 13, e0190495, 2018. (Epub 2018 Jan 17)

Devisscher, L, Van Coillie, S, Hofmans, S, Van Rompaey, D, Goossens, K, Meul, E, Maes, L, De Winter, H, Van Der Veken, P, Vandenabeele, P, Vanden Berghe, T, Augustyns, K.
Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy
J Med Chem 61, 10126-10140, 2018. (Epub 2018 Nov 21)

D'Hondt, S, Guillemyn, B, Syx, D, Symoens, S, De Rycke, R, Vanhoutte, L, Toussaint, W, Lambrecht, BN, De Paepe, A, Keene, DR, Ishikawa, Y, Bachinger, HP, Janssens, S, Bertrand, MJM, Malfait, F.
Type III collagen affects dermal and vascular collagen fibrillogenesis and tissue integrity in a mutant Col3a1 transgenic mouse model
Matrix Biol 70, 72-83, 2018. (Epub 2018 Mar 15)

Dondelinger, Y, Delanghe, T, Bertrand, MJM.
MK2 puts an additional brake on RIPK1 cytotoxic potential
Cell Death Differ 25, 457-459, 2018. (Epub 2018 Jan 9)

Estornes, Y, Dondelinger, Y, Weber, K, Bruggeman, I, Peall, A, MacFarlane, M, Lebecque, S, Vandenabeele, P, Bertrand, MJM.
N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis
Cell Death Dis 9, 494, 2018. (Epub 2018 May 2)

Galluzzi, L, Vitale, I, Aaronson, SA, Abrams, JM, Adam, D, Agostinis, P, Alnemri, ES, et al., Bertrand, MJM, et al., Vanden Berghe, T, Vandenabeele, P, et al., Kroemer,G.
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Cell Death Differ 25, 486-541, 2018. (Epub 2018 Jan 23)

Geric, I, Tyurina, YY, Krysko, O, Krysko, DV, De Schryver, E, Kagan, VE, Van Veldhoven, PP, Baes, M, Verheijden, S.
Lipid homeostasis and inflammatory activation are disturbed in classically activated macrophages with peroxisomal beta-oxidation deficiency
Immunology 153, 342-356, 2018. (Epub 2017 Sep 22)

Hassannia, B, Wiernicki, B, Ingold, I, Qu, F, Van Herck, S, Tyurina, YY, Bayir, H, Abhari, BA, Angeli, JPF, Choi, SM, Meul, E, Heyninck, K, et al., Lahtela-Kakkonen, M, Van Camp, G, Krysko, DV, Ekert, PG, Fulda, S,De Geest, B.G., Vanden Berghe, W., Vandenabeele, P., Vanden Berghe, T.
Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma
J Clin Invest 128, 3341-3355, 2018. (Epub 2018 Jun 25)

Hofmans, S, Devisscher, L, Martens, S, Van Rompaey, D, Goossens, K, Divert, T, Nerinckx, W, Takahashi, N, De Winter, H, Van der Veken, P, Goossens, V, Vandenabeele, P, Augustyns, K.
Tozasertib analogues as inhibitors of necroptotic cell death
J Med Chem 61, 1895-1920, 2018. (Epub 2018 Feb 13)

Krysko, DV, Ravichandran, KS, Vandenabeele, P.
Macrophages regulate the clearance of living cells by calreticulin
Nat Commun 9, 4644, 2018. (Epub 2018 Nov 7)

Martens, S, Goossens, V, Devisscher, L, Hofmans, S, Claeys, P, Vuylsteke, M, Takahashi, N, Augustyns, K, Vandenabeele, P.
RIPK1-dependent cell death: a novel target of the Aurora kinase inhibitor Tozasertib (VX-680)
Cell Death Dis 9, 211, 2018. (Epub 2018 Feb 12)

Priem, D, Dondelinger, Y, Bertrand, MJM.
Monitoring RIPK1 Phosphorylation in the TNFR1 Signaling Complex
Methods Mol Biol 1857, 171-179, 2018. (Epub 2018 Aug 23)

Saavedra, PHV, Huang, L, Ghazavi, F, Kourula, S, Vanden Berghe, T, Takahashi, N, Vandenabeele, P, Lamkanfi, M.
Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis
Nat Commun 9, 4846, 2018. (Epub 2018 Nov 19)

Scott, CL, T'Jonck, W, Martens, L, Todorov, H, Sichien, D, Soen, B, Bonnardel, J, De Prijck, S, Vandamme, N, Cannoodt, R, Saelens, W, Vanneste, B, Toussaint, W, De Bleser, P, Takahashi, N, Vandenabeele, P, et al., Lambrecht, BN, De Baetselier, P, Milling, SWF, Van Ginderachter, JA, Malissen, B, Berx, G, Beschin, A, Saeys, Y, Guilliams, M.
The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages
Immunity 49, 312-325, 2018. (Epub 2018 Jul 31)

Tanghe, G, Urwyler-Rosselet, C, De Groote, P, Dejardin, E, De Bock, PJ, Gevaert, K, Vandenabeele, P, Declercq, W.
RIPK4 activity in keratinocytes is controlled by the SCF(beta-TrCP) ubiquitin ligase to maintain cortical actin organization
Cell Mol Life Sci 75, 2827-2841, 2018. (Epub 2018 Feb 12)

Teufelberger, AR, Nordengrun, M, Braun, H, Maes, T, De Grove, K, Holtappels, G, O'Brien, C, Provoost, S, Hammad, H, Goncalves, A, Beyaert, R, Declercq, W, Vandenabeele, P, Krysko, DV, Broker, BM, Bachert, C, Krysko, O.
The IL-33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus-derived serine protease-like protein D.
J Allergy Clin Immunol 141, 549-559, 2018. (Epub 2017 May 19)

Urwyler-Rosselet, C, Tanghe, G, Leurs, K, Gilbert, B, De Rycke, R, De Bruyne, M, Lippens, S, Bartunkova, S, De Groote, P, Niessen, C, Haftek, M, Vandenabeele, P, Declercq, W.
Keratinocyte-specific ablation of RIPK4 allows epidermal cornification but impairs skin barrier formation
J Invest Dermatol 138, 1268-1278, 2018. (Epub 2018 Jan 6)

Vandenabeele, P, Declercq, W, Roelandt, R, Vanden Berghe, T.
MLKL Reveals Its Friendly Face: A Role in Nerve Regeneration
Mol Cell 72, 397-399, 2018. (Epub 2018 Nov 1)

Vanden Berghe, T, Hoste, E.
Paving the way for precision medicine v2.0 in intensive care by profiling necroinflammation in biofluids
Cell Death Differ , in press, 2018. (Epub 2018 Sep 10)

Van Hoecke, L, Van Lint, S, Roose, K, Van Parys, A, Vandenabeele, P, Grooten, J, Tavernier, J, De Koker, S, Saelens, X.
Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes
Nat Commun 9, 3417, 2018. (Epub 2018 Aug 24)

Weber, K, Roelandt, R, Bruggeman, I, Estornes, Y, Vandenabeele, P.
Nuclear RIPK3 and MLKL contribute to cytosolic necrosome formation and necroptosis
Commun Biol 1, e6, 2018. (Epub 2018 Jan 22)

Breyne, K, Steenbrugge, J, Demeyere, K, Vanden Berghe, T, Meyer, E.
Preconditioning with Lipopolysaccharide or Lipoteichoic Acid Protects against Staphylococcus aureus Mammary Infection in Mice
Front Immunol 8, 833, 2017. (Epub 2017 Jul 24)

De Beule, N, Menu, E, Bertrand, MJ, Favreau, M, De Bruyne, E, Maes, K, De Veirman, K, Radwanska, M, Samali, A, Magez, S, Vanderkerken, K, De Trez, C.
Experimental African trypanosome infection suppresses the development of multiple myeloma in mice by inducing intrinsic apoptosis of malignant plasma cells
Oncotarget 8, 52016-52025, 2017. (Epub 2017 May 24)

Decrock, E, Hoorelbeke, D, Ramadan, R, Delvaeye, T, De Bock, M, Wang, N, Krysko, DV, Baatout, S, Bultynck, G, Aerts, A, Vinken, M, Leybaert, L.
Calcium, oxidative stress and connexin channels, a harmonious orchestra directing the response to radiotherapy treatment?
Biochim Biophys Acta 1864, 1099-1120, 2017. (Epub 2017 Feb 11)

Delehouze, C, Leverrier-Penna, S, Le Cann, F, Comte, A, Jacquard-Fevai, M, Delalande, O, Desban, N, Baratte, B, Gallais, I, Faurez, F, Bonnet, MC, Hauteville, M, Goekjian, PG, Thuillier, R, Favreau, F, Vandenabeele, P, Hauet, T, Dimanche-Boitrel, MT, Bach, S.
6E11, a highly selective inhibitor of Receptor-Interacting Protein Kinase 1, protects cells against cold hypoxia-reoxygenation injury
Sci Rep 7, 12931, 2017. (Epub 2017 Oct 10)

Demeautis, C, Sipieter, F, Roul, J, Chapuis, C, Padilla-Parra, S, Riquet, FB, Tramier, M.
Multiplexing PKA and ERK1&2 kinases FRET biosensors in living cells using single excitation wavelength dual colour FLIM
Sci Rep 7, 41026, 2017. (Epub 2017 Jan 20)

Devos, M, Gilbert, B, Denecker, G, Leurs, K, Mc Guire, C, Lemeire, K, Hochepied, T, Vuylsteke, M, Lambert, J, Van Den Broecke, C, Libbrecht, L, Haigh, J, Berx, G, Lippens, S, Vandenabeele, P, Declercq, W.
Elevated DeltaNp63alpha levels facilitate epidermal and biliary oncogenic transformation
J Invest Dermatol 137, 494-505, 2017. (Epub 2016 Oct 7)

Dondelinger, Y, Delanghe, T, Rojas-Rivera, D, Priem, D, Delvaeye, T, Bruggeman, I, Van Herreweghe, F, Vandenabeele, P, Bertrand, MJM.
MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death
Nat Cell Biol 19, 1237-1247, 2017. (Epub 2017 Sep 18)

Fearnhead, HO, Vandenabeele, P, Vanden Berghe, T.
How do we fit ferroptosis in the family of regulated cell death?
Cell Death Differ 24, 1991-1998, 2017. (Epub 2017 Oct 6)

Feldmann, F, Schenk, B, Martens, S, Vandenabeele, P, Fulda, S.
Sorafenib inhibits therapeutic induction of necroptosis in acute leukemia cells
Oncotarget 8, 68208-68220, 2017. (Epub 2017 Aug 4)

Filliol, A, Farooq, M, Piquet-Pellorce, C, Genet, V, Dimanche-Boitrel, MT, Vandenabeele, P, Bertrand, MJM, Samson, M, Le Seyec, J.
RIPK1 protects hepatocytes from death in Fas-induced hepatitis
Sci Rep 7, 9205, 2017. (Epub 2017 Aug 23)

Filliol, A, Piquet-Pellorce, C, Raguenes-Nicol, C, Dion, S, Farooq, M, Lucas-Clerc, C, Vandenabeele, P, Bertrand, MJ, Le Seyec, J, Samson, M.
RIPK1 protects hepatocytes from Kupffer cells-mediated TNF-induced apoptosis in mouse models of PAMP-induced hepatitis
J Hepatol 66, 1205-1213, 2017. (Epub 2017 Jan 11)

Gadicherla, AK, Wang, N, Bulic, M, Agullo-Pascual, E, Lissoni, A, De Smet, M, Delmar, M, Bultynck, G, Krysko, DV, Camara, A, Schluter, KD, Schulz, R, Kwok, WM, Leybaert, L.
Mitochondrial Cx43 hemichannels contribute to mitochondrial calcium entry and cell death in the heart
Basic Res Cardiol 112, 27, 2017. (Epub 2017 May)

Grootjans, S, Vanden Berghe, T, Vandenabeele, P.
Initiation and execution mechanisms of necroptosis: an overview
Cell Death Differ 24, 1184-1195, 2017. (Epub 2017 May 12)

Hariton, WVJ, Galichet, A, Vanden Berghe, T, Overmiller, AM, Mahoney, MG, Declercq, W, Muller, EJ.
Feasibility study for clinical application of caspase-3 inhibitors in Pemphigus vulgaris
Exp Dermatol 26, 1274-1277, 2017. (Epub 2017 Nov 3)

Jeong, M, Lee, EW, Seong, D, Seo, J, Kim, JH, Grootjans, S, Kim, SY, Vandenabeele, P, Song, J.
USP8 suppresses death receptor-mediated apoptosis by enhancing FLIPL stability
Oncogene 36, 458-470, 2017. (Epub 2016 Jun 20)

Kip, E, Naze, F, Suin, V, Vanden Berghe, T, Francart, A, Lamoral, S, Vandenabeele, P, Beyaert, R, Van Gucht, S, Kalai, M.
Impact of caspase-1/11, -3, -7, or IL-1beta/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease
Cell Death Discov 3, 17012, 2017. (Epub 2017 Mar 6)

Kourula, S, Ang, J, Zhao, H, Kalish, F, Vandenabeele, P, Sylvester, KG, Wong, RJ, Stevenson, DK.
Heme Oxygenase Activity and Heme Binding in a Neonatal Mouse Model
Neonatology 112, 376-383, 2017. (Epub 2017 Sep 20)

Krysko, O, Aaes, TL, Kagan, VE, D'Herde, K, Bachert, C, Leybaert, L, Vandenabeele, P, Krysko, DV.
Necroptotic cell death in anti-cancer therapy
Immunol Rev 280, 207-219, 2017. (Epub 2017 Oct 13)

Kurdi, A, Cleenewerck, M, Vangestel, C, Lyssens, S, Declercq, W, Timmermans, JP, Stroobants, S, Augustyns, K, De Meyer, GRY, Van Der Veken, P, Martinet, W.
ATG4B inhibitors with a benzotropolone core structure block autophagy and augment efficiency of chemotherapy in mice
Biochem Pharmacol 138, 150-162, 2017. (Epub 2017 Jun 19)