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Cochet, F, Facchini, FA, Zaffaroni, L, Billod, JM, Coelho, H, Holgado, A, Braun, H, Beyaert, R, Jerala, R, Jimenez-Barbero, J, Martin-Santamaria, S, Peri, F.
Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties
Sci Rep 9, 919, 2019. (Epub 2019 Jan 29)

Dendoncker, K, Timmermans, S, Vandewalle, J, Eggermont, M, Lempiainen, J, Van Hamme, E, Dewaele, S, Vandevyver, S, Ballegeer, M, Souffriau, J, Van Wyngene, L, Van Looveren, K, Vanderhaeghen, T, Beyaert, R, De Bosscher, K, Palvimo, JJ, Van Montagu, M, Libert, C.
TNF-alpha inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile
Proc Natl Acad Sci U S A , in press, 2019. (Epub 2019 Jun 10)

Gilis, E, Gaublomme, D, Staal, J, Venken, K, Dhaenens, M, Lambrecht, S, Coudenys, J, Decruy, T, Schryvers, N, Driege, Y, Dumas, E, Demeyer, A, De Muynck, A, van Hengel, J, Van Hoorebeke, L, Deforce, D, Beyaert, R, Elewaut, D.
MALT1-deletion in T-cells protects against the development of auto-immune arthritis, but causes spontaneous osteoporosis
Arthritis Rheumatol , in press, 2019. (Epub 2019 Jul 1)

Holgado, A, Braun, H, Van Nuffel, E, Detry, S, Schuijs, MJ, Deswarte, K, Vergote, K, Haegman, M, Baudelet, G, Haustraete, J, Hammad, H, Lambrecht, BN, Savvides, SN, Afonina, IS, Beyaert, R.
IL-33trap is a novel IL-33 neutralizing biologic that inhibits allergic airway inflammation
J Allergy Clin Immunol , in press, 2019. (Epub 2019 Mar 12)

Lork, M, Staal, J, Beyaert, R.
Ubiquitination and phosphorylation of the CARD11-BCL10-MALT1 signalosome in T cells
Cell Immunol 340, 103877, 2019. (Epub 2018 Nov 9)

Pauwels, AM, Hartlova, A, Peltier, J, Driege, Y, Baudelet, G, Brodin, P, Trost, M, Beyaert, R, Hoffmann, E.
Spatiotemporal changes of the phagosomal proteome in dendritic cells in response to LPS stimulation
Mol Cell Proteomics 18, 909-922, 2019. (Epub 2019 Feb 26)

Staal, J, Alci, K, De Schamphelaire, W, Vanhoucke, M, Beyaert, R.
Engineering a minimal cloning vector from a pUC18 plasmid backbone with an extended multiple cloning site
Biotechniques 66, 254-259, 2019. (Epub 2019 May 24)

Adanitsch, F, Shi, J, Shao, F, Beyaert, R, Heine, H, Zamyatina, A.
Synthetic glycan-based TLR4 agonists targeting caspase-4/11 for the development of adjuvants and immunotherapeutics
Chem Sci 9, 3957-3963, 2018. (Epub 2018 Mar 15)

Andersson, P, Yang, Y, Hosaka, K, Zhang, Y, Fischer, C, Braun, H, Liu, S, Yu, G, Liu, S, Beyaert, R, Chang, M, Li, Q, Cao, Y.
Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis
JCI Insight 3, e122375, 2018. (Epub 2018 Oct 18)

Ballegeer, M, Van Looveren, K, Timmermans, S, Eggermont, M, Vandevyver, S, Thery, F, Dendoncker, K, Souffriau, J, Vandewalle, J, Van Wyngene, L, De Rycke, R, Takahashi, N, Vandenabeele, P, Tuckermann, J, Reichardt, HM, Impens, F, Beyaert, R, De Bosscher, K, Vandenbroucke, RE, et al..
Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice
J Clin Invest 128, 3265-3279, 2018. (Epub 2018 May 10)

Beyaert, R, Libert, C.
How Good Roommates Can Protect against Microbial Sepsis
Cell Host Microbe 23, 283-285, 2018. (Epub 2018 Mar 14)

Borghi, A, Haegman, M, Fischer, R, Carpentier, I, Bertrand, MJM, Libert, C, Afonina, IS, Beyaert, R.
The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2-induced canonical NF-kappaB signaling
Biochem Pharmacol 153, 292-298, 2018. (Epub 2018 Jan 26)

Borio, A, Holgado, A, Beyaert, R, Heine, H, Zamyatina, A.
Disaccharide-based Anionic Amphiphiles as Potent Inhibitors of LPS-induced Inflammation
ChemMedChem 13, 2317-2331, 2018. (Epub 2018 Oct 1)

Braun, H, Afonina, IS, Mueller, C, Beyaert, R.
Dichotomous function of IL-33 in health and disease: from biology to clinical implications
Biochem Pharmacol 148, 238-252, 2018. (Epub 2018 Jan 5)

Casillo, A, Ziaco, M, Lindner, B, Parrilli, E, Schwudke, D, Holgado, A, Beyaert, R, Lanzetta, R, Tutino, ML, Corsaro, MM.
Lipid A structural characterization from the LPS of the Siberian psychro-tolerant Psychrobacter arcticus 273-4 grown at low temperature
Extremophiles 22, 955-963, 2018. (Epub 2018 Aug 20)

De Bruyne, M, Hoste, L, Bogaert, DJ, Van den Bossche, L, Tavernier, SJ, Parthoens, E, et al., Lambrecht, BN, van Daele, S, Alves de Medeiros, AK, Brochez, L, Beyaert, R, De Baere, E, Puel, A, Casanova, JL, Goffard, JC, Savvides, SN, et al., Staal, J, et al.
A CARD9 Founder Mutation Disrupts NF-kappaB Signaling by Inhibiting BCL10 and MALT1 Recruitment and Signalosome Formation
Front Immunol 9, 2366, 2018. (Epub 2018 Oct 31)

De Grove, KC, Provoost, S, Braun, H, Blomme, EE, Teufelberger, AR, Krysko, O, Beyaert, R, Brusselle, GG, Joos, GF, Maes, T.
IL-33 signalling contributes to pollutant-induced allergic airway inflammation
Clin Exp Allergy 48, 1665-1675, 2018. (Epub 2018 Aug 30)

Facchini, FA, Zaffaroni, L, Minotti, A, Rapisarda, S, Calabrese, V, Forcella, M, Fusi, P, Airoldi, C, Ciaramelli, C, Billod, JM, Schromm, A, Braun, H, Palmer, C, Beyaert, R, Lapenta, F, Jerala, R, Pirianov, G, Martin-Santamaria, S, Peri, F.
Structure-Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists
J Med Chem 61, 2895-2909, 2018. (Epub 2018 Mar 12)

Gul, IS, Staal, J, Hulpiau, P, De Keuckelaere, E, Kamm, K, Deroo, T, Sanders, E, Staes, K, Driege, Y, Saeys, Y, Beyaert, R, Technau, U, Schierwater, B, Van Roy, F.
GC content of early metazoan genes and its impact on gene expression levels in mammalian cell lines
Genome biology and Evolution 10, 909917, 2018. (Epub 2018 Feb 21)

Kip, E, Staal, J, Tima, HG, Verstrepen, L, Romano, M, Lemeire, K, Suin, V, Hamouda, A, Baens, M, Libert, C, Kalai, M, Van Gucht, S, Beyaert, R.
Inhibition of MALT1 decreases neuroinflammation and pathogenicity of virulent rabies virus in mice
J Virol 92, e00720-18, 2018. (Epub 2018 Aug 29)

Kip, E, Staal, J, Verstrepen, L, Tima, HG, Terryn, S, Romano, M, Lemeire, K, Suin, V, Hamouda, A, Kalai, M, Beyaert, R, Van Gucht, S.
MALT1 controls attenuated rabies virus by inducing early inflammation and T cell activation in the brain
J Virol 92, e02029-17, 2018. (Epub 2018 Jan 26)

Lan, F, Zhang, N, Holtappels, G, De Ruyck, N, Krysko, O, Van Crombruggen, K, Braun, H, Johnston, SL, Papadopoulos, NG, Zhang, L, Bachert, C.
Staphylococcus aureus Induces a Mucosal Type 2 Immune Response via Epithelial Cell-derived Cytokines
Am J Respir Crit Care Med 198, 452-463, 2018. (Epub 2018 Aug 15)

Lembo-Fazio, L, Billod, JM, Di Lorenzo, F, Paciello, I, Pallach, M, Vaz-Francisco, S, Holgado, A, Beyaert, R, Fresno, M, Shimoyama, A, Lanzetta, R, Fukase, K, Gully, D, Giraud, E, Martin-Santamaria, S, Bernardini, ML, Silipo, A.
Bradyrhizobium Lipid A: Immunological Properties and Molecular Basis of Its Binding to the Myeloid Differentiation Protein-2/Toll-Like Receptor 4 Complex
Front Immunol 9, e1888, 2018. (Epub 2018 Aug 14)

Lork, M, Kreike, M, Staal, J, Beyaert, R.
Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies-T Cell Receptor-Induced CYLD Phosphorylation by IKKepsilon/TBK1 as a Case Study
Front Cell Dev Biol 6, 40, 2018. (Epub 2018 Apr 10)

Meloni, L, Verstrepen, L, Kreike, M, Staal, J, Driege, Y, Afonina, IS, Beyaert, R.
Mepazine Inhibits RANK-Induced Osteoclastogenesis Independent of Its MALT1 Inhibitory Function
Molecules 23, 3144, 2018. (Epub 2018 Nov 30)

Souffriau, J, Eggermont, M, Van Ryckeghem, S, Van Looveren, K, Van Wyngene, L, Van Hamme, E, Vuylsteke, M, Beyaert, R, De Bosscher, K, Libert, C.
A screening assay for Selective Dimerizing Glucocorticoid Receptor Agonists and Modulators (SEDIGRAM) that are effective against acute inflammation
Sci Rep 8, 12894, 2018. (Epub 2018 Aug 27)

Staal, J, Beyaert, R.
Inflammation and NF-kappaB Signaling in Prostate Cancer: Mechanisms and Clinical Implications
Cells 7, 122, 2018. (Epub 2018 Aug 29)

Staal, J, Driege, Y, Haegman, M, Borghi, A, Hulpiau, P, Lievens, L, Gul, IS, Sundararaman, S, Goncalves, A, Dhondt, I, Pinzon, JH, Braeckman, BP, Technau, U, Saeys, Y, van Roy, F, Beyaert, R.
Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions
Front Immunol 9, 1136, 2018. (Epub 2018 May 24)

Teufelberger, AR, Nordengrun, M, Braun, H, Maes, T, De Grove, K, Holtappels, G, O'Brien, C, Provoost, S, Hammad, H, Goncalves, A, Beyaert, R, Declercq, W, Vandenabeele, P, Krysko, DV, Broker, BM, Bachert, C, Krysko, O.
The IL-33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus-derived serine protease-like protein D.
J Allergy Clin Immunol 141, 549-559, 2018. (Epub 2017 May 19)

Van Nuffel, E, Afonina, IS, Beyaert, R.
Psoriasis Plays a Wild CARD
J Invest Dermatol 138, 1903-1905, 2018. (Epub 2018 Aug 22)

Afonina, IS, Zhong, Z, Karin, M, Beyaert, R.
Limiting inflammation-the negative regulation of NF-kappaB and the NLRP3 inflammasome
Nat Immunol 18, 861-869, 2017. (Epub 2017 Jul 19)

Casillo, A, Ziaco, M, Lindner, B, Parrilli, E, Schwudke, D, Holgado, A, Verstrepen, L, Sannino, F, Beyaert, R, Lanzetta, R, Tutino, ML,Corsaro, MM.
Unusual Lipid A from a cold adapted bacterium: detailed structural characterization
Chembiochem 18, 1845-1854, 2017. (Epub 2017 Jun 26)

Cruz, JA, Childs, EE, Amatya, N, Garg, AV, Beyaert, R, Lawrence, PK, Aneskievich, BJ, Ma, A, Gaffen, SL.
IL-17 Signaling Triggers Degradation of the Constitutive NF-kB Inhibitor ABIN-1
ImmunoHorizons 1, 133-141, 2017. (Epub 2017 Sep 1)

De Wilde, K, Martens, A, Lambrecht, S, Jacques, P, Drennan, MB, Debusschere, K, Govindarajan, S, Coudenys, J, Verheugen, E, Windels, F, Catrysse, L, Lories, R, McGonagle, D, Beyaert, R, van Loo, G, Elewaut, D.
A20 inhibition of STAT1 expression in myeloid cells: a novel endogenous regulatory mechanism preventing development of enthesitis
Ann Rheum Dis 76, 585-592, 2017. (Epub 2016 Aug 22)

Fischer, JC, Otten, V, Kober, M, Drees, C, Rosenbaum, M, Schmickl, M, Heidegger, S, Beyaert, R, van Loo, G, Li, XC, Peschel, C, Schmidt-Supprian, M, Haas, T, Spoerl, S, Poeck, H.
A20 Restrains Thymic Regulatory T Cell Development
J Immunol 199, 2356-2365, 2017. (Epub 2017 Aug 25)

Fischer, JC, Otten, V, Steiger, K, Schmickl, M, Slotta-Huspenina, J, Beyaert, R, van Loo, G, Peschel, C, Poeck, H, Haas, T, Spoerl, S.
A20 deletion in T cells modulates acute graft-versus-host disease in mice
Eur J Immunol 47, 1982-1988, 2017. (Epub 2017 Aug 22)

Kip, E, Naze, F, Suin, V, Vanden Berghe, T, Francart, A, Lamoral, S, Vandenabeele, P, Beyaert, R, Van Gucht, S, Kalai, M.
Impact of caspase-1/11, -3, -7, or IL-1beta/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease
Cell Death Discov 3, 17012, 2017. (Epub 2017 Mar 6)

Lievens, L, Pollier, J, Goossens, A, Beyaert, R, Staal, J.
Abscisic Acid as Pathogen Effector and Immune Regulator
Front Plant Sci 8, 587, 2017. (Epub 2017 Apr 19)

Lork, M, Verhelst, K, Beyaert, R.
CYLD, A20 and OTULIN deubiquitinases in NF-kappaB signaling and cell death: so similar, yet so different
Cell Death Differ 24, 1172-1183, 2017. (Epub 2017 Mar 31)

Pauwels, AM, Trost, M, Beyaert, R, Hoffmann, E.
Patterns, Receptors, and Signals: Regulation of Phagosome Maturation
Trends Immunol 38, 407-422, 2017. (Epub 2017 Apr 14)

Staal, J.
Applied Cultural and Social Studies are Needed for a Sustainable Reduction of Genetic Disease Incidence
European Journal of Sociology and Anthropology 2, 1, 2017. (Epub 2017 Jun 15)

Tima, HG, Al Dulayymi, JR, Denis, O, Lehebel, P, Baols, KS, Mohammed, MO, L'Homme, L, Sahb, MM, Potemberg, G, Legrand, S, Lang, R, Beyaert, R, Piette, J, Baird, MS, Huygen, K, Romano, M.
Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of Mycobacterium tuberculosis
J Innate Immun 9, 162-180, 2017. (Epub 2016 Nov 18)

Van Nuffel, E, Schmitt, A, Afonina, IS, Schulze-Osthoff, K, Beyaert, R, Hailfinger, S.
CARD14-Mediated Activation of Paracaspase MALT1 in Keratinocytes: Implications for Psoriasis
J Invest Dermatol 137, 569-575, 2017. (Epub 2016 Dec 8)

Verstraete, K, Peelman, F, Braun, H, Lopez, J, Van Rompaey, D, Dansercoer, A, Vandenberghe, I, Pauwels, K, Tavernier, J, Lambrecht, BN, Hammad, H, De Winter, H, Beyaert, R, Lippens, G, Savvides, SN.
Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma
Nat Commun 8, 14937, 2017. (Epub 2017 Apr 3)

Afonina, IS, Beyaert, R.
Trabid epigenetically drives expression of IL-12 and IL-23
Nat Immunol 17, 227-228, 2016. (Epub 2016 Feb 16)

Afonina, IS, Van Nuffel, E, Baudelet, G, Driege, Y, Kreike, M, Staal, J, Beyaert, R.
The paracaspase MALT1 mediates CARD14-induced signaling in keratinocytes
EMBO Rep 17, 914-927, 2016. (Epub 2016 Apr 25)

Afschar, S, Toivonen, JM, Hoffmann, JM, Tain, LS, Wieser, D, Finlayson, AJ, Driege, Y, Alic, N, Emran, S, Stinn, J, Froehlich, J, Piper, MD, Partridge, L.
Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila
Proc Natl Acad Sci U S A 113, 1321-1326, 2016. (Epub 2016 Feb 2)

Borghi, A, Verstrepen, L, Beyaert, R.
TRAF2 multitasking in TNF receptor-induced signaling to NF-kappaB, MAP kinases and cell death
Biochem Pharmacol 116, 1-10, 2016. (Epub 2016 Mar 16)

Catrysse, L, Farhang Ghahremani, M, Vereecke, L, Youssef, SA, Mc Guire, C, Sze, M, Weber, A, Heikenwalder, M, de Bruin, A, Beyaert, R, van Loo, G.
A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death
Cell Death Dis 7, e2250, 2016. (Epub 2016 Jun 2)

de Kleer, IM, Kool, M, de Bruijn, MJ, Willart, M, van Moorleghem, J, Schuijs, MJ, Plantinga, M, Beyaert, R, Hams, E, Fallon, PG, Hammad, H, Hendriks, RW, Lambrecht, BN.
Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung
Immunity 45, 1285-1298, 2016. (Epub 2016 Dec 5)

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