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Publications from this research unit
This page shows only publications with IRC as the affiliation of at least one author.
Publications by IRC members mentioning other affiliations are not in our database. Sorry.
See "Extra muros" papers of the units.
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Ballegeer, M, Vandewalle, J, Eggermont, M, Van Isterdael, G, Dejager, L, De Bus, L, Decruyenaere, J, Vandenbroucke, RE, Libert, C. Overexpression of Gilz Protects Mice Against Lethal Septic Peritonitis Shock , in press, 2018. (Epub 2018 Aug 17) 
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Ballegeer, M, Van Looveren, K, Timmermans, S, Eggermont, M, Vandevyver, S, Thery, F, Dendoncker, K, Souffriau, J, Vandewalle, J, Van Wyngene, L, De Rycke, R, Takahashi, N, Vandenabeele, P, Tuckermann, J, Reichardt, HM, Impens, F, Beyaert, R, De Bosscher, K, Vandenbroucke, RE, et al.. Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice J Clin Invest 128, 3265-3279, 2018. (Epub 2018 May 10)
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Gorle, N, Blaecher, C, Bauwens, E, Vandendriessche, C, Balusu, S, Vandewalle, J, Van Cauwenberghe, C, Van Wonterghem, E, Van Imschoot, G, Liu, C, Ducatelle, R, Libert, C, Haesebrouck, F, Smet, A, Vandenbroucke, RE. The choroid plexus epithelium as a novel player in the stomach-brain axis during Helicobacter infection Brain Behav Immun 69, 35-47, 2018. (Epub 2017 Dec 16)
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Steeland, S, Gorle, N, Vandendriessche, C, Balusu, S, Brkic, M, Van Cauwenberghe, C, Van Imschoot, G, Van Wonterghem, E, De Rycke, R, Kremer, A, Lippens, S, Stopa, E, Johanson, CE, Libert, C, Vandenbroucke, RE. Counteracting the effects of TNF receptor-1 has therapeutic potential in Alzheimer's disease EMBO Mol Med 10, UNSP e8300, 2018. (Epub 2018 Feb 22)
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Steeland, S, Libert, C, Vandenbroucke, RE. A New Venue of TNF Targeting Int J Mol Sci 19, e1442, 2018. (Epub 2018 May 11)
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Steeland, S, Van Ryckeghem, S, Vandewalle, J, Ballegeer, M, Van Wonterghem, E, Eggermont, M, Decruyenaere, J, De Bus, L, Libert, C, Vandenbroucke, RE. Simultaneous Inhibition of Tumor Necrosis Factor Receptor 1 and Matrix Metalloproteinase 8 Completely Protects Against Acute Inflammation and Sepsis Crit Care Med 46, e67–e75, 2018. (Epub 2017 Oct 31)
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Voet, S, Mc Guire, C, Hagemeyer, N, Martens, A, Schroeder, A, Wieghofer, P, Daems, C, Staszewski, O, Vande Walle, L, Jordao, MJC, Sze, M, Vikkula, HK, Demeestere, D, Van Imschoot, G, Scott, CL, Hoste, E, Goncalves, A, Guilliams, M, Lippens, S, Libert, C, Vandenbroucke, RE, et al., Lamkanfi, M, Prinz, M, van Loo, G. A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation Nat Commun 9, 2036, 2018. (Epub 2018 May 23)
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Zagato, E, Vermeulen, L, Dewitte, H, Van Imschoot, G, Vandenbroucke, RE, Demeester, J, De Schmedt, SC, Neyts, K, Remaut, K, Braeckmans, K. Quantifying the average number of nucleic acid therapeutics per nanocarrier by Single Particle Tracking microscopy Mol Pharm 15, 1142-1149, 2018. (Epub 2018 Feb 12)
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Greenwood, J, Hammarlund-Udenaes, M, Jones, HC, Stitt, AW, Vandenbroucke, RE, Romero, IA, Campbell, M, Fricker, G, Brodin, B, Manninga, H, Gaillard, PJ, Schwaninger, M, Webster, C, Wicher, KB, Khrestchatisky, M. Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017 Fluids Barriers CNS 14, 31, 2017. (Epub 2017 Nov 7)
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Holvoet, T, Devriese, S, Castermans, K, Boland, S, Leysen, D, Vandewynckel, YP, Devisscher, L, Van den Bossche, L, Van Welden, S, Dullaers, M, Vandenbroucke, RE, De Rycke, R, Geboes, K, Bourin, A, Defert, O, Hindryckx, P, De Vos, M, Laukens, D. Treatment of intestinal fibrosis in experimental inflammatory bowel disease by the pleiotropic actions of a local Rho kinase inhibitor Gastroenterology 153, 1054-1067, 2017. (Epub 2017 Jun 19)
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Steeland, S, Van Ryckeghem, S, Van Imschoot, G, De Rycke, R, Toussaint, W, Vanhoutte, L, Vanhove, C, De Vos, F, Vandenbroucke, RE, Libert, C. TNFR1 inhibition with a Nanobody protects against EAE development in mice Sci Rep 7, 13646, 2017. (Epub 2017 Oct 20)
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Balusu, S, Brkic, M, Libert, C, Vandenbroucke, RE. The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease: more than just a barrier Neural Regen Res 11, 534-537, 2016. (Epub 2016 Apr)
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Balusu, S, Van Wonterghem, E, De Rycke, R, Raemdonck, K, Stremersch, S, Gevaert, K, Brkic, M, Demeestere, D, Vanhooren, V, Hendrix, A, Libert, C, Vandenbroucke, RE. Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles EMBO Mol Med 8, 1162-1183, 2016. (Epub 2016 Oct 4)
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De Bock, M, Van Haver, V, Vandenbroucke, RE, Decrock, E, Wang, N, Leybaert, L. Into rather unexplored terrain-transcellular transport across the blood-brain barrier Glia 64, 1097-1123, 2016. (Epub 2016 Feb 8)
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Demeestere, D, Dejonckheere, E, Steeland, S, Hulpiau, P, Haustraete, J, Devoogdt, N, Wichert, R, Becker-Pauly, C, Van Wonterghem, E, Dewaele, S, Van Imschoot, G, Aerts, J, Arckens, L, Saeys, Y, Libert, C, Vandenbroucke, RE. Development and validation of a small single domain antibody that effectively inhibits matrix metalloproteinase 8 Mol Ther 24, 890-902, 2016. (Epub 2016 Jan 18)
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Drechsler, S, Lynch, MA, Novella, S, Gonzalez-Navarro, H, Hecimovic, S, Barini, E, Tucci, V, Castro, RE, Vandenbroucke, RE, Osuchowski, M, Potter, PK. With mouse age comes wisdom: a review and suggestions of relevant mouse models for age-related conditions Mech Ageing Dev 160, 54-68, 2016. (Epub 2016 Jul 20)
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Gorlé, N, Van Cauwenberghe, C, Libert, C, Vandenbroucke, RE. The effect of aging on brain barriers and the consequences for Alzheimer's disease development Mamm Genome 27, 407-420, 2016. (Epub 2016 May 3)
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Grine, L, Libert, C, Vandenbroucke, R. Comment on "Tumour necrosis factor alpha plays a significant role in the Aldara-induced skin inflammation in mice" Br J Dermatol 174, 1419-1419, 2016. (Epub 2016 Feb 6)
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Grine, L, Steeland, S, Van Ryckeghem, S, Ballegeer, M, Lienenklaus, S, Weiss, S, Sanders, NN, Vandenbroucke, RE, Libert, C. Topical imiquimod yields systemic effects due to unintended oral uptake Sci Rep 6, 20134, 2016. (Epub 2016 Jan 28)
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Kessler, SM, Laggai, S, Van Wonterghem, E, Gemperlein, K, Muller, R, Haybaeck, J, Vandenbroucke, RE, Ogris, M, Libert, C, Kiemer, AK. Transient Hepatic Overexpression of Insulin-Like Growth Factor 2 Induces Free Cholesterol and Lipid Droplet Formation Front Physiol 7, 147, 2016. (Epub 2016 Apr 25)
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Koks, S, Dogan, S, Tuna, BG, Gonzalez-Navarro, H, Potter, P, Vandenbroucke, RE. Mouse models of ageing and their relevance to disease Mech Ageing Dev 160, 41-53, 2016. (Epub 2016 Oct 4)
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Steeland, S, Timmermans, S, Van Ryckeghem, S, Hulpiau, P, Saeys, Y, Van Montagu, M, Vandenbroucke, RE, Libert, C. Efficient analysis of mouse genome sequences reveal many nonsense variants Proc Natl Acad Sci U S A 113, 5670-5675, 2016. (Epub 2016 May 17)
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Steeland, S, Vandenbroucke, RE, Libert, C. Nanobodies as therapeutics: big opportunities for small antibodies Drug Discov Today 21, 1076-1113, 2016. (Epub 2016 Apr 11)
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Storck, SE, Meister, S, Nahrath, J, Meissner, JN, Schubert, N, Di Spiezio, A, Baches, S, Vandenbroucke, RE, Bouter, Y, Prikulis, I, Korth, C, Weggen, S, Heimann, A, Schwaninger, M, Bayer, TA, Pietrzik, CU. Endothelial LRP1 transports amyloid-beta1-42 across the blood-brain barrier J Clin Invest 126, 123-136, 2016. (Epub 2015 Nov 30)
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Stremersch, S, Vandenbroucke, RE, Van Wonterghem, E, Hendrix, A, De Smedt, SC, Raemdonck, K. Comparing exosome-like vesicles with liposomes for the functional cellular delivery of small RNAs J Control Release 232, 51-61, 2016. (Epub 2016 Apr 9)
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Van Cauwenberghe, C, Vandendriessche, C, Libert, C, Vandenbroucke, RE. Caloric restriction: beneficial effects on brain aging and Alzheimer's disease Mamm Genome 27, 300-319, 2016. (Epub 2016 May 30)
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Vandenbroucke, RE. A Hidden Epithelial Barrier in the Brain with a Central Role in Regulating Brain Homeostasis. Implications for Aging Ann Am Thorac Soc 13, S407-S410, 2016. (Epub 2016 Dec 13)
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Van Hove, I, Lefevere, E, De Groef, L, Sergeys, J, Salinas-Navarro, M, Libert, C, Vandenbroucke, R, Moons, L. MMP-3 Deficiency Alleviates Endotoxin-Induced Acute Inflammation in the Posterior Eye Segment Int J Mol Sci 17, E1825, 2016. (Epub 2016 Nov 1)
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Xiong, R, Vandenbroucke, RE, Broos, K, Brans, T, Van Wonterghem, E, Libert, C, Demeester, J, De Smedt, SC, Braeckmans, K. Sizing nanomaterials in bio-fluids by cFRAP enables protein aggregation measurements and diagnosis of bio-barrier permeability Nat Commun 7, 12982, 2016. (Epub 2016 Sep 22)
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Aerts, J, Vandenbroucke, RE, Dera, R, Balusu, S, Van Wonterghem, E, Moons, L, Libert, C, Dehaen, W, Arckens, L. Synthesis and Validation of a Hydroxypyrone-Based, Potent, and Specific Matrix Metalloproteinase-12 Inhibitor with Anti-Inflammatory Activity In Vitro and In Vivo Mediators Inflamm 2015, 510679, 2015. (Epub 2015 Aug 13)
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Brkic, M, Balusu, S, Libert, C, Vandenbroucke, RE. Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases Mediators Inflamm 2015, 620581, 2015. (Epub 2015 Oct 11)
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Brkic, M, Balusu, S, Van Wonterghem, E, Gorle, N, Benilova, I, Kremer, A, Van Hove, I, Moons, L, De Strooper, B, Kanazir, S, Libert, C, Vandenbroucke, RE. Amyloid beta Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases J Neurosci 35, 12766-78, 2015. (Epub 2015 Sep 16)
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De Groef, L, Salinas-Navarro, M, Van Imschoot, G, Libert, C, Vandenbroucke, RE, Moons, L. Decreased TNF Levels and Improved Retinal Ganglion Cell Survival in MMP-2 Null Mice Suggest a Role for MMP-2 as TNF Sheddase Mediators Inflamm 2015, 108617, 2015. (Epub 2015 Sep 15)
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Demeestere, D, Libert, C, Vandenbroucke, RE. Clinical implications of leukocyte infiltration at the choroid plexus in (neuro)inflammatory disorders Drug Discov Today 20, 928-941, 2015. (Epub 2015 May 13)
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Demeestere, D, Libert, C, Vandenbroucke, RE. Therapeutic implications of the choroid plexus-cerebrospinal fluid interface in neuropsychiatric disorders Brain Behav Immun 50, 1-13, 2015. (Epub 2015 Jun 23)
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Grine, L, Dejager, L, Libert, C, Vandenbroucke, RE. Dual Inhibition of TNFR1 and IFNAR1 in Imiquimod-Induced Psoriasiform Skin Inflammation in Mice J Immunol 194, 5094-5102, 2015. (Epub 2015 Apr 24)
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Puimege, L, Van Hauwermeiren, F, Steeland, S, Van Ryckeghem, S, Vandewalle, J, Lodens, S, Dejager, L, Vandevyver, S, Staelens, J, Timmermans, S, Vandenbroucke, RE, Libert, C. Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1 EMBO Mol Med 7, 1004-1017, 2015. (Epub 2015 May 20)
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Sklyarova, T, van Hengel, J, Van Wonterghem, E, Libert, C, van Roy, F, Vandenbroucke, RE. Hematopoietic plakophilin-3 regulates acute tissue-specific and systemic inflammation in mice Eur J Immunol 45, 2898-2910, 2015. (Epub 2015 Jul 14)
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Timmermans, S, Van Hauwermeiren, F, Puimege, L, Dejager, L, Van Wonterghem, E, Vanhooren, V, Mestdagh, P, Libert, C, Vandenbroucke, RE. Determining differentially expressed miRNAs and validating miRNA-target relationships using the SPRET/Ei mouse strain Mamm Genome 26, 94-107, 2015. (Epub 2014 Dec 10)
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Vanden Berghe, T, Hulpiau, P, Martens, L, Vandenbroucke, RE, Van Wonterghem, E, Perry, SW, Bruggeman, I, Divert, T, Choi, SM, Vuylsteke, M, Shestopalov, VI, Libert, C, Vandenabeele, P. Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice Immunity 43, 200-209, 2015. (Epub 2015 Jul 21)
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De Bock, M, Vandenbroucke, RE, Decrock, E, Culot, M, Cecchelli, R, Leybaert, L. A new angle on blood-CNS interfaces: A role for connexins? FEBS Lett 588, 1259-1270, 2014. (Epub 2014 Mar 12)
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De Temmerman, ML, Soenen, SJ, Symens, N, Lucas, B, Vandenbroucke, RE, Libert, C, Demeester, J, De Smedt, SC, Himmelreich, U, Rejman, J. Magnetic layer-by-layer coated particles for efficient MRI of dendritic cells and mesenchymal stem cells Nanomedicine (Lond) 9, 1363-1376, 2014. (Epub 2013 Oct 9)
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Dewitte, H, Verbeke, R, Breckpot, K, Vandenbroucke, RE, Libert, C, De Smedt, SC, Lentacker, I. Choose your models wisely: How different murine bone marrow-derived dendritic cell protocols influence the success of nanoparticulate vaccines in vitro J Control Release 195, 138-146, 2014. (Epub 2014 Jun 21)
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Grine, L, Dejager, L, Libert, C, Vandenbroucke, RE. An inflammatory triangle in psoriasis: TNF, type I IFNs and IL-17 Cytok Growth Factor Rev 26, 25-33, 2014. (Epub 2014 Oct 31)
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Laukens, D, Devisscher, L, Van den Bossche, L, Hindryckx, P, Vandenbroucke, RE, Vandewynckel, YP, Cuvelier, C, Brinkman, BM, Libert, C, Vandenabeele, P, De Vos, M. Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death Lab Invest 94, 1419-1430, 2014. (Epub 2014 Oct 13)
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Steeland, S, Puimege, L, Vandenbroucke, RE, Van Hauwermeiren, F, Haustraete, J, Devoogdt, N, Hulpiau, P, Leroux-Roels, G, Laukens, D, Meuleman, P, De Vos, M, Libert, C. Generation and characterization of small single domain antibodies inhibiting human TNF receptor 1 J Biol Chem 290, 4022-4037, 2014. (Epub 2014 Dec 23)
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Vandenbroucke, RE, Libert, C. Is there new hope for therapeutic matrix metalloproteinase inhibition? Nat Rev Drug Discov , 904-927, 2014. (Epub 2014 Nov 7)
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Vandenbroucke, RE, Vanlaere, I, Van Hauwermeiren, F, Van Wonterghem, E, Wilson, C, Libert, C. Pro-inflammatory effects of matrix metalloproteinase 7 in acute inflammation Mucosal Immunol 7, 579-588, 2014. (Epub 2013 Oct 16)
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Vandevyver, S, Dejager, L, Vandenbroucke, RE, Libert, C. An acute phase protein ready to go therapeutic in sepsis EMBO Mol Med 6, 2-3, 2014. (Epub 2014 Jan 9)
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Van Hauwermeiren, F, Vandenbroucke, RE, Grine, L, Lodens, S, Van Wonterghem, E, De Rycke, R, De Geest, N, Hassan, B, Libert, C. TNFR1-induced lethal inflammation is mediated by goblet and Paneth cell dysfunction Mucosal Immunol 8, 828-840, 2014. (Epub 2014 Nov 26)
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