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Publications from this research unit

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D'Hondt, S, Guillemyn, B, Syx, D, Symoens, S, De Rycke, R, Vanhoutte, L, Toussaint, W, Lambrecht, BN, De Paepe, A, Keene, DR, Ishikawa, Y, Bachinger, HP, Janssens, S, Bertrand, MJM, Malfait, F.
Type III collagen affects dermal and vascular collagen fibrillogenesis and tissue integrity in a mutant Col3a1 transgenic mouse model
Matrix Biol 70, 72-83, 2018. (Epub 2018 Mar 15)

Govindarajan, S, Gaublomme, D, Van der Cruyssen, R, Verheugen, E, Van Gassen, S, Saeys, Y, Tavernier, S, Iwawaki, T, Bloch, Y, Savvides, SN, Lambrecht, BN, Janssens, S, Elewaut, D, Drennan, MB.
Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha
Nat Commun 9, 5340, 2018. (Epub 2018 Dec 17)

Krols, M, Asselbergh, B, De Rycke, R, De Winter, V, Seyer, A, Muller, FJ, Kurth, I, Bultynck, G, Timmerman, V, Janssens, S.
Sensory neuropathy-causing mutations in ATL3 affect ER-mitochondria contact sites and impair axonal mitochondrial distribution
Hum Mol Genet , in press, 2018. (Epub 2018 Oct 18)

Krols, M, Detry, S, Asselbergh, B, Almeida-Souza, L, Kremer, A, Lippens, S, De Rycke, R, De Winter, V, Muller, FJ, Kurth, I, McMahon, HT, Savvides, SN, Timmerman, V, Janssens, S.
Sensory-Neuropathy-Causing Mutations in ATL3 Cause Aberrant ER Membrane Tethering
Cell Rep 23, 2026-2038, 2018. (Epub 2018 May 15)

Osorio, F, Lambrecht, BN, Janssens, S.
Antigen presentation unfolded: identifying convergence points between the UPR and antigen presentation pathways
Curr Opin Immunol 52, 100-107, 2018. (Epub 2018 May 10)

Tavernier, SJ, Lambrecht, BN, Janssens, S.
The Unfolded Protein Response in the Immune Cell Development: Putting the Caretaker in the Driving Seat
Curr Top Microbiol Immunol 414, 45-72, 2018. (Epub 2017 Jul 13)

Hammad, H, Vanderkerken, M, Pouliot, P, Deswarte, K, Toussaint, W, Vergote, K, Vandersarren, L, Janssens, S, Ramou, I, Savvides, SN, Haigh, JJ, Hendriks, R, Kopf, M, Craessaerts, K, de Strooper, B, Kearney, JF, Conrad, DH, Lambrecht, BN.
Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10
Nat Immunol 18, 313320, 2017. (Epub 2017 Jan 9)

Kennedy, D, Mnich, K, Oommen, D, Chakravarthy, R, Almeida-Souza, L, Krols, M, Saveljeva, S, Doyle, K, Gupta, S, Timmerman, V, Janssens, S, Gorman, AM, Samali, A.
HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis
Cell Death Dis 8, e3026, 2017. (Epub 2017 Aug 31)

Klein Geltink, RI, O'Sullivan, D, Corrado, M, Bremser, A, Buck, MD, et al., Caputa, G, Kelly, B, Warthorst, U, Rensing-Ehl, A, Kyle, RL, Vandersarren, L, et al., Janssens, S, Lambrecht BN , et al., Curtis, JD, Patterson, AE, Lawless, S, Grzes, K, et al..
Mitochondrial Priming by CD28
Cell 171, 385-397, 2017. (Epub 2017 Sep 14)

Tavernier, SJ, Osorio, F, Vandersarren, L, Vetters, J, Vanlangenakker, N, Van Isterdael, G, Vergote, K, De Rycke, R, Parthoens, E, van de Laar, L, Iwawaki, T, Del Valle, JR, Hu, CCA, Lambrecht, BN, Janssens, S.
Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival
Nat Cell Biol 19, 698-710, 2017. (Epub 2017 May 1)

Tavernier, SJ, Vanlangenakker, N, Vetters, J, Carmeliet, P, Janssens, S, Lambrecht, BN.
Opposing regulation and roles for PHD3 in lung dendritic cells and alveolar macrophages
J Leukoc Biol 102, 1115-1126, 2017. (Epub 2017 Jul 17)

Vanacker, H, Vetters, J, Moudombi, L, Caux, C, Janssens, S, Michallet, MC.
Emerging Role of the Unfolded Protein Response in Tumor Immunosurveillance
Trends Cancer 3, 491-505, 2017. (Epub 2017 Jul)

Vandersarren, L, Bosteels, C, Vanheerswynghels, M, Moon, JJ, Easton, AJ, Van Isterdael, G, Janssens, S, Lambrecht, BN, van Helden, MJ.
Epitope mapping and kinetics of CD4 T cell immunity to pneumonia virus of mice in the C57BL/6 strain
Sci Rep 7, 3472, 2017. (Epub 2017 Jun 14)

Van Welden, S, De Vos, M, Wielockx, B, Tavernier, SJ, Dullaers, M, Neyt, S, Descamps, B, Devisscher, L, Devriese, S, Van den Bossche, L, Holvoet, T, Baeyens, A, Correale, C, D'Alessio, S, Vanhove, C, De Vos, F, Verhasselt, B, Breier, G, Lambrecht, BN, et al..
Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis
J Pathol 241, 547558 , 2017. (Epub 2016 Dec 16)

Bouhy, D, Geuens, T, De Winter, V, Almeida-Souza, L, Katona, I, Weis, J, Hochepied, T, Goossens, S, Haigh, J, Janssens, S, Timmerman, V.
Characterization of New Transgenic Mouse Models for Two Charcot-Marie-Tooth-Causing HspB1 Mutations using the Rosa26 Locus
Journal of Neuromuscular Diseases 3, 183-200, 2016. (Epub 2016 May 27)

Debeuf, N, Haspeslagh, E, van Helden, M, Hammad, H, Lambrecht, BN.
Mouse Models of Asthma
Curr Protoc Mouse Biol 6, 169-184, 2016. (Epub 2016 Jun 1)

Krols, M, Bultynck, G, Janssens, S.
ER-Mitochondria contact sites: A new regulator of cellular calcium flux comes into play
J Cell Biol 214, 367-370, 2016. (Epub 2016 Aug 15)

Krols, M, van Isterdael, G, Asselbergh, B, Kremer, A, Lippens, S, Timmerman, V, Janssens, S.
Mitochondria-associated membranes as hubs for neurodegeneration
Acta Neuropathol 131, 505-523, 2016. (Epub 2016 Jan 7)

Thyrion, L, Raedt, R, Portelli, J, Van Loo, P, Wadman, WJ, Glorieux, G, Lambrecht, BN, Janssens, S, Vonck, K, Boon, P.
Uric acid is released in the brain during seizure activity and increases severity of seizures in a mouse model for acute limbic seizures
Exp Neurol 277, 244-251, 2016. (Epub 2016 Jan 8)

van de Laar, L, Guilliams, M, Tavernier, SJ.
Isolation of Conventional Dendritic Cells from Mouse Lungs
Methods Mol Biol 1423, 139-152, 2016. (Epub 2016 May 4)

Zhakupova, A, Debeuf, N, Krols, M, Toussaint, W, Vanhoutte, L, Alecu, I, Kutalik, Z, Vollenweider, P, Ernst, D, von Eckardstein, A, Lambrecht, BN, Janssens, S, Hornemann, T.
ORMDL3 expression levels have no influence on the activity of serine palmitoyltransferase
FASEB J 30, 4289-4300, 2016. (Epub 206 Sep 19)

Kremer, A, Lippens, S, Bartunkova, S, Asselbergh, B, Blanpain, C, Fendrych, M, Goossens, A, Holt, M, Janssens, S, Krols, M, Larsimont, JC, Mc Guire, C, Nowack, MK, Saelens, X, Schertel, A, Schepens, B, Slezak, M, Timmerman, V, Theunis, C, et al..
Developing 3D SEM in a broad biological context
J Microsc 259, 80-96, 2015. (Epub 2015 Jan 26)

Ydens, E, Demon, D, Lornet, G, De Winter, V, Timmerman, V, Lamkanfi, M, Janssens, S.
Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes
J Neuroinflammation 12, 143, 2015. (Epub 2015 Aug 8)

Janssens, S, Pulendran, B, Lambrecht, BN.
Emerging functions of the unfolded protein response in immunity
Nat Immunol 15, 910-919, 2014. (Epub 2014 Sep 18)

Osorio, F, Tavernier, SJ, Hoffmann, E, Saeys, Y, Martens, L, Vetters, J, Delrue, I, De Rycke, R, Parthoens, E, Pouliot, P, Iwawaki, T, Janssens, S, Lambrecht, BN.
The unfolded-protein-response sensor IRE-1alpha regulates the function of CD8alpha+ dendritic cells
Nat Immunol 15, 248-257, 2014. (Epub 2014 Jan 19)

Vandewynckel, YP, Laukens, D, Bogaerts, E, Paridaens, A, Van den Bussche, A, Verhelst, X, Van Steenkiste, C, Descamps, B, Vanhove, C, Libbrecht, L, De Rycke, R, Lambrecht, BN, Geerts, A, Janssens, S, Van Vlierberghe, H.
Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy
Hepatol Int 9, 93-104, 2014. (Epub 2014 Oct 1)

Vandewynckel, YP, Laukens, D, Geerts, A, Vanhove, C, Descamps, B, Colle, I, Devisscher, L, Bogaerts, E, Paridaens, A, Verhelst, X, Van Steenkiste, C, Libbrecht, L, Lambrecht, BN, Janssens, S, Van Vlierberghe, H.
Therapeutic effects of artesunate in hepatocellular carcinoma: repurposing an ancient antimalarial agent
Eur J Gastroenterol Hepatol 26, 861-870, 2014. (Epub 2014 Jul)

Almeida-Souza, L, Asselbergh, B, De Winter, V, Goethals, S, Timmerman, V, Janssens, S.
HSPB1 facilitates the formation of non-centrosomal microtubules
PLoS One 8, e66541, 2013. (Epub 2013 Jun 24)

Osorio, F, Lambrecht, B, Janssens, S.
The UPR and lung disease
Semin Immunopathol 35, 293-306, 2013. (Epub 2013 Mar 28)

Vandewynckel, YP, Laukens, D, Geerts, A, Bogaerts, E, Paridaens, A, Verhelst, X, Janssens, S, Heindryckx, F, Van Vlierberghe, H.
The paradox of the unfolded protein response in cancer
Anticancer Res 33, 4683-4694, 2013. (Epub 2013 Nov)

Ydens, E, Lornet, G, Smits, V, Goethals, S, Timmerman, V, Janssens, S.
The neuroinflammatory role of Schwann cells in disease
Neurobiol Dis 55, 95-103, 2013. (Epub 2013 Mar 21)

Ydens, E, Cauwels, A, Asselbergh, B, Goethals, S, Peeraer, L, Lornet, G, Almeida-Souza, L, Van Ginderachter, JA, Timmerman, V, Janssens, S.
Acute injury in the peripheral nervous system triggers an alternative macrophage response
J Neuroinflammation 9, 176, 2012. (Epub 2012 Jul 20)

Kool, M, van Loo, G, Waelput, W, De Prijck, S, Muskens, F, Sze, M, van Praet, J, Branco-Madeira, F, Janssens, S, Reizis, B, Elewaut, D, Beyaert, R, Hammad, H, Lambrecht, B.
The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells and systemic autoimmunity
Immunity 35, 82-96, 2011. (Epub 2011 Jun 30)

Matmati, M, Jacques, P, Maelfait, J, Verheugen, E, Kool, M, Sze, M, Geboes, L, Louagie, E, Mc Guire, C, Vereecke, L, Chu, Y, Boon, L, Staelens, S, Matthys, P, Lambrecht, B, Schmidt-Supprian, M, Pasparakis, M, Elewaut, D, Beyaert, R, van Loo, G.
A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis
Nature Genetics 43, 908-912, 2011. (Epub 2011 Aug 14)

Maelfait, J, Vercammen, E, Janssens, S, Schotte, P, Haegman, M, Magez, S, Beyaert, R.
Stimulation of Toll-like receptor 3 and 4 induces Interleukin-1beta maturation by Caspase-8
J Exp Med 205, 1967-1973, 2008. (Epub 2008 Aug 25)

Dierick, I, Irobi, J, Janssens, S, Theuns, J, Lemmens, R, Jacobs, A, Corsmit, E, Hersmus, N, Van Den Bosch, L, Robberecht, W, De Jonghe, P, Van Broeckhoven, C, Timmerman, V.
Genetic variant in the HSPB1 promoter region impairs the HSP27 stress response
Hum Mutat 28, 830, 2007. (Epub ---)

Schauvliege, R, Janssens, S, Beyaert, R.
Pellino Proteins: Novel Players in TLR and IL-1R Signalling
J Cell Mol Med 11, 453-461, 2007. (Epub ---)

Schauvliege, R, Janssens, S, Beyaert, R.
Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: A role as novel RING E3-ubiquitin-ligases
FEBS Lett 580, 4697-4702, 2006. (Epub 2006 Jul 24)

Wullaert, A, Heyninck, K, Janssens, S, Beyaert, R.
Ubiquitin: tool and target for intracellular NF-kappaB inhibitors
Trends Immunol 27, 533-540, 2006. (Epub 2006 Sep 16)

Burns, K, Janssens, S, Brissoni, B, Olivos, N, Beyaert, R, Tschopp, J.
Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4
J Exp Med 197, 263-268, 2003. (Epub ---)

Carpentier, I, Janssens, S, Heyninck, K, Beyaert, R.
NF-kB activation by Tumor Necrosis Factor and Interleukin-1
In Nuclear Factor kB: Regulation and role in disease. (Beyaert, R, ed.), Dordrecht, Kluwer Academic Publishers, pp. 49-67, 2003. (Epub ---)

Janssens, S, Beyaert, R.
Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members
Mol Cell 11, 293-302, 2003. (Epub ---)

Janssens, S, Beyaert, R.
Role of Toll-like receptors in pathogen recognition
Clin Microbiol Rev 16, 637-646, 2003. (Epub ---)

Janssens, S, Burns, K, Vercammen, E, Tschopp, J, Beyaert, R.
MyD88S, a splice variant of MyD88, differentially modulates NF-kappaB- and AP-1-dependent gene expression
FEBS Lett 548, 103-107, 2003. (Epub ---)

Janssens, S, Beyaert, R.
A universal role for MyD88 in TLR/IL-1R-mediated signaling
Trends Biochem Sci 27, 474-482, 2002. (Epub ---)

Janssens, S, Burns, K, Tschopp, J, Beyaert, R.
Regulation of interleukin-1- and lipopolysaccharide-induced NF-kB activation by alternative splicing of MyD88
Curr Biol 12, 467-471, 2002. (Epub ---)

Schotte, P, Schauvliege, R, Janssens, S, Beyaert, R.
The cathepsin B inhibitor z-FA.fmk inhibits cytokine production in macrophages stimulated by lipopolysaccharide
J Biol Chem 276, 21153-21157, 2001. (Epub 2001 Apr 4)

Vandermeeren, M, Janssens, S, Wouters, H, Borghmans, I, Borgers, M, Beyaert, R, Geysen, J.
Dimethylfumarate is an inhibitor of cytokine-induced nuclear translocation of NF-kB1, but not RelA in normal human dermal fibroblast cells
J Invest Dermatol 116, 124-130, 2001. (Epub ---)

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