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Aegerter, H, Smole, U, Heyndrickx, I, Verstraete, K, Savvides, SN, Hammad, H, Lambrecht, BN.
Charcot-Leyden crystals and other protein crystals driving type 2 immunity and allergy
Curr Opin Immunol 72, 72-78, 2021. (Epub 2021 Apr 16)

Delaney, C, Farrell, M, Doherty, CP, Brennan, K, O'Keeffe, E, Greene, C, Byrne, K, Kelly, E, Birmingham, N, Hickey, P, Cronin, S, Savvides, SN, Doyle, SL, Campbell, M.
Attenuated CSF-1R signalling drives cerebrovascular pathology
EMBO Mol Med 13, e12889, 2021. (Epub 2020 Dec 22)

Pannecoucke, E, Raes, L, Savvides, SN.
Engineering and crystal structure of a monomeric FLT3 ligand variant
Acta Crystallogr F Struct Biol Commun 77, 121-127, 2021. (Epub 2021 Apr 6)

Pannecoucke, E, Van Trimpont, M, Desmet, J, Pieters, T, Reunes, L, Demoen, L, Vuylsteke, M, Loverix, S, Vandenbroucke, K, Alard, P, Henderikx, P, Deroo, S, Baatz, F, Lorent, E, Thiolloy, S, Somers, K, McGrath, Y, Van Vlierberghe, P, Lasters, I, et al..
Cell-penetrating Alphabody protein scaffolds for intracellular drug targeting
Sci Adv 7, eabe1682, 2021. (Epub 2021 Mar 28)

Robakiewicz, S, Bridot, C, Serna, S, Gimeno, A, Echeverria, B, Delgado, S, Ruyck, J, Semwal, S, Charro, D, Dansercoer, A, Verstraete, K, Azkargorta, M, Noort, K, Wilbers, R, Savvides, SN, Abrescia, NGA, Arda, A, Reichardt, NC, Jimenez-Barbero, J, et al..
Minimal epitope for Mannitou IgM on paucimannose-carrying glycoproteins
Glycobiology , in press, 2021. (Epub 2021 Apr 28)

Yperman, K, Papageorgiou, AC, Merceron, R, De Munck, S, Bloch, Y, Eeckhout, D, Jiang, Q, Tack, P, Grigoryan, R, Evangelidis, T, Van Leene, J, Vincze, L, Vandenabeele, P, Vanhaecke, F, Potocky, M, De Jaeger, G, Savvides, SN, Tripsianes, K, Pleskot, R, et al..
Distinct EH domains of the endocytic TPLATE complex confer lipid and protein binding
Nat Commun 12, 3050, 2021. (Epub 2021 May 24)

Yperman, K, Wang, J, Eeckhout, D, Winkler, J, Vu, LD, Vandorpe, M, Grones, P, Mylle, E, Kraus, M, Merceron, R, Nolf, J, Mor, E, De Bruyn, P, Loris, R, Potocky, M, Savvides, SN, De Rybel, B, De Jaeger, G, Van Damme, D, et al..
Molecular architecture of the endocytic TPLATE complex
Sci Adv 7, eabe7999, 2021. (Epub 2021 Feb 26)

D'Anna, F, Van Dyck, L, Xiong, J, Zhao, H, Berrens, RV, Qian, J, Bieniasz-Krzywiec, P, Chandra, V, Schoonjans, L, Matthews, J, De Smedt, J, Minnoye, L, Amorim, R, Khorasanizadeh, S, Yu, Q, Zhao, L, De Borre, M, Savvides, SN, Simon, MC, et al..
DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance
Genome Biol 21, 182, 2020. (Epub 2020 Jul 27)

Gevaert, E, Delemarre, T, De Volder, J, Zhang, N, Holtappels, G, De Ruyck, N, Persson, E, Heyndrickx, I, Verstraete, K, Aegerter, H, Nauwynck, H, Savvides, SN, Lambrecht, BN, Bachert, C.
Charcot-Leyden crystals promote neutrophilic inflammation in patients with nasal polyposis
J Allergy Clin Immunol 145, 427-430, 2020. (Epub 2019 Sep 4)

Holgado, A, Braun, H, Verstraete, K, Vanneste, D, Callewaert, N, Savvides, SN, Afonina, IS, Beyaert, R.
Single-Chain Soluble Receptor Fusion Proteins as Versatile Cytokine Inhibitors
Front Immunol 11, 1422, 2020. (Epub 2020 Jul 13)

Jian, Y, Merceron, R, De Munck, S, Forbes, HE, Hulpia, F, Risseeuw, MDP, Van Hecke, K, Savvides, SN, Munier-Lehmann, H, Boshoff, HIM, Van Calenbergh, S.
Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents
Eur J Med Chem 206, 112659, 2020. (Epub 2020 Jul 24)

Kozak, S, Bloch, Y, De Munck, S, Mikula, A, Bento, I, Savvides, SN, Meijers, R.
Homogeneously N-glycosylated proteins derived from the GlycoDelete HEK293 cell line enable diffraction-quality crystallogenesis
Acta Crystallogr D Struct Biol 76, 1244-1255, 2020. (Epub 2020 Dec 1)

Markovic, I, Savvides, SN.
Modulation of Signaling Mediated by TSLP and IL-7 in Inflammation, Autoimmune Diseases, and Cancer
Front Immunol 11, 1557, 2020. (Epub 2020 Jul 21)

Savvides, SN, Elewaut, D.
Small-molecule inhibitors get pro-inflammatory TNF into shape
Nat Rev Rheumatol 16, 189-190, 2020. (Epub 2020 Feb 14)

Teufelberger, AR, Van Nevel, S, Hulpiau, P, Nordengrun, M, Savvides, SN, De Graeve, S, Akula, S, Holtappels, G, De Ruyck, N, Declercq, W, Vandenabeele, P, Hellman, L, Broker, BM, Krysko, DV, Bachert, C, Krysko, O.
Mouse Strain-Dependent Difference Toward the Staphylococcus aureus Allergen Serine Protease-Like Protein D Reveals a Novel Regulator of IL-33
Front Immunol 11, 582044, 2020. (Epub 2020 Sep 25)

Boeltz, S, Amini, P, Anders, HJ, Andrade, F, Bilyy, R, Chatfield, S, Cichon, I, Clancy, DM, Desai, J, et al., Maueroder, C, et al. , Vanden Berghe, T, Vandenabeele, P, Hahn, J, Hidalgo, A, Hoffmann, MH, Kaplan, MJ, Knight, JS, Kolaczkowska, E, Kubes, P, et al..
To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps
Cell Death Differ 26, 395-408, 2019. (Epub 2019 Jan 8)

Dejonghe, W, Sharma, I, Denoo, B, De Munck, S, Lu, Q, Mishev, K, Bulut, H, Mylle, E, De Rycke, R, Vasileva, M, Savatin, DV, Nerinckx, W, Staes, A, Drozdzecki, A, Audenaert, D, Yperman, K, Madder, A, Friml, J, Van Damme, D, et al..
Disruption of endocytosis through chemical inhibition of clathrin heavy chain function
Nat Chem Biol 15, 641649, 2019. (Epub 2019 Apr 22)

Detry, S, Skladanowska, K, Vuylsteke, M, Savvides, SN, Bloch, Y.
Revisiting the combinatorial potential of cytokine subunits in the IL-12 family
Biochem Pharmacol 165, 240-248, 2019. (Epub 2019 Mar 15)

Dondelinger, Y, Delanghe, T, Priem, D, Wynosky-Dolfi, MA, Sorobetea, D, Rojas-Rivera, D, Giansanti, P, Roelandt, R, Gropengiesser, J, Ruckdeschel, K, Savvides, SN, Heck, AJR, Vandenabeele, P, Brodsky, IE, Bertrand, MJM.
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
Nat Commun 10, 1729, 2019. (Epub 2019 Apr 15)

Durham, BH, Lopez Rodrigo, E, Picarsic, J, Abramson, D, Rotemberg, V, De Munck, S, Pannecoucke, E, Lu, SX, Pastore, A, Yoshimi, A, Mandelker, D, Ceyhan-Birsoy, O, Ulaner, GA, Walsh, M, Yabe, M, Petrova-Drus, K, Arcila, ME, Ladanyi, M, Solit, DB, et al..
Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms
Nat Med 25, 1839-1842, 2019. (Epub 2019 Nov 25)

Holgado, A, Braun, H, Van Nuffel, E, Detry, S, Schuijs, MJ, Deswarte, K, Vergote, K, Haegman, M, Baudelet, G, Haustraete, J, Hammad, H, Lambrecht, BN, Savvides, SN, Afonina, IS, Beyaert, R.
IL-33trap is a novel IL-33 neutralizing biologic that inhibits allergic airway inflammation
J Allergy Clin Immunol 144, 204-215, 2019. (Epub 2019 Mar 12)

Nguyen, CT, Bloch, Y, Skladanowska, K, Savvides, SN, Adamopoulos, IE.
Pathophysiology and inhibition of IL-23 signaling in psoriatic arthritis: A molecular insight
Clin Immunol 206, 15-22, 2019. (Epub 2018 Sep 6)

Persson, EK, Verstraete, K, Heyndrickx, I, Gevaert, E, Aegerter, H, Percier, JM, Deswarte, K, Verschueren, KHG, Dansercoer, A, Gras, D, Chanez, P, Bachert, C, Goncalves, A, Van Gorp, H, De Haard, H, Blanchetot, C, Saunders, M, Hammad, H, Savvides, SN, Lambrecht, BN.
Protein crystallization promotes type 2 immunity and is reversible by antibody treatment
Science 364, , 2019. (Epub 2019 May 24)

Slowicka, K, Serramito-Gomez, I, Boada-Romero, E, Martens, A, Sze, M, Petta, I, Vikkula, HK, De Rycke, R, Parthoens, E, Lippens, S, Savvides, SN, Wullaert, A, Vereecke, L, Pimentel-Muinos, FX, van Loo, G.
Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis
Nat Commun 10, 1834, 2019. (Epub 2019 Apr 23)

Verschueren, KHG, Blanchet, C, Felix, J, Dansercoer, A, De Vos, D, Bloch, Y, Van Beeumen, J, Svergun, D, Gutsche, I, Savvides, SN, Verstraete, K.
Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle
Nature 568, 571-575, 2019. (Epub 2019 Apr 3)

De Bruyne, M, Hoste, L, Bogaert, DJ, Van den Bossche, L, Tavernier, SJ, Parthoens, E, et al., Lambrecht, BN, van Daele, S, Alves de Medeiros, AK, Brochez, L, Beyaert, R, De Baere, E, Puel, A, Casanova, JL, Goffard, JC, Savvides, SN, et al., Staal, J, et al.
A CARD9 Founder Mutation Disrupts NF-kappaB Signaling by Inhibiting BCL10 and MALT1 Recruitment and Signalosome Formation
Front Immunol 9, 2366, 2018. (Epub 2018 Oct 31)

Fulara, A, Vandenberghe, I, Read, RJ, Devreese, B, Savvides, SN.
Structure and oligomerization of the periplasmic domain of GspL from the type II secretion system of Pseudomonas aeruginosa
Sci Rep 8, 16760, 2018. (Epub 2018 Nov 13)

Govindarajan, S, Gaublomme, D, Van der Cruyssen, R, Verheugen, E, Van Gassen, S, Saeys, Y, Tavernier, S, Iwawaki, T, Bloch, Y, Savvides, SN, Lambrecht, BN, Janssens, S, Elewaut, D, Drennan, MB.
Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha
Nat Commun 9, 5340, 2018. (Epub 2018 Dec 17)

Krols, M, Detry, S, Asselbergh, B, Almeida-Souza, L, Kremer, A, Lippens, S, De Rycke, R, De Winter, V, Muller, FJ, Kurth, I, McMahon, HT, Savvides, SN, Timmerman, V, Janssens, S.
Sensory-Neuropathy-Causing Mutations in ATL3 Cause Aberrant ER Membrane Tethering
Cell Rep 23, 2026-2038, 2018. (Epub 2018 May 15)

Lienart, S, Merceron, R, Vanderaa, C, Lambert, F, Colau, D, Stockis, J, van der Woning, B, De Haard, H, Saunders, M, Coulie, PG, Savvides, SN, Lucas, S.
Structural basis of latent TGF-beta1 presentation and activation by GARP on human regulatory T cells
Science 362, 952-956, 2018. (Epub 2018 Nov 23)

Mishev, K, Lu, Q, Denoo, B, et al., Dejonghe, W, Hullaert, J, De Rycke, RM, Boeren, S, Bretou, M, De Munck, S, Sharma, IS, Goodman, K, Kalinowska, K, Storme, V, Nguyen, L, Drozdzecki, A, Martins, S, Nerinckx, W, Audenaert, D, Savvides, S, et al..
Nonselective chemical inhibition of Sec7 domain-containing ARF GEFs in Arabidopsis
Plant Cell 30, 2573-2593, 2018. (Epub 2018 Jul 17)

Song, L, Merceron, R, Gracia, B, Quintana, AL, Risseeuw, MDP, Hulpia, F, Cos, P, Ainsa, JA, Munier-Lehmann, H, Savvides, SN, Van Calenbergh, S.
Structure Guided Lead Generation towards non-chiral M. tuberculosis Thymidylate Kinase Inhibitors
J Med Chem 61, 2753-2775, 2018. (Epub 2018 Mar 6)

Bloch, Y, Bouchareychas, L, Merceron, R, Skladanowska, K, Van den Bossche, L, Detry, S, Govindarajan, S, Elewaut, D, Haerynck, F, Dullaers, M, Adamopoulos, IE, Savvides, SN.
Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12Rbeta1
Immunity 48, 45-58, 2017. (Epub 2017 Dec 21)

Devos, S, Van Putte, W, Vitse, J, Van Driessche, G, Stremersch, S, Van Den Broek, W, Raemdonck, K, Braeckmans, K, Stahlberg, H, Kudryashev, M, Savvides, SN, Devreese, B.
Membrane vesicle secretion and prophage induction in multidrug-resistant Stenotrophomonas maltophilia in response to ciprofloxacin stress
Environ Microbiol 19, 3930-3937, 2017. (Epub 2017 May 10)

Elegheert, J, Brige, A, Van Beeumen, J, Savvides, SN.
Structural dissection of Shewanella oneidensis old yellow enzyme 4 bound to a Meisenheimer complex and (nitro)phenolic ligands
FEBS Lett 591, 3391-3401, 2017. (Epub 2017 Sep 4)

Felix, J, Savvides, SN.
Mechanisms of immunomodulation by mammalian and viral decoy receptors: insights from structures
Nat Rev Immunol 17, 112-129, 2017. (Epub 2016 Dec 28)

Hammad, H, Vanderkerken, M, Pouliot, P, Deswarte, K, Toussaint, W, Vergote, K, Vandersarren, L, Janssens, S, Ramou, I, Savvides, SN, Haigh, JJ, Hendriks, R, Kopf, M, Craessaerts, K, de Strooper, B, Kearney, JF, Conrad, DH, Lambrecht, BN.
Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10
Nat Immunol 18, 313320, 2017. (Epub 2017 Jan 9)

Szaruga, M, Munteanu, B, Lismont, S, Veugelen, S, Horre, K, Mercken, M, Saido, TC, Ryan, NS, De Vos, T, Savvides, SN, Gallardo, R, Schymkowitz, J, Rousseau, F, Fox, NC, Hopf, C, De Strooper, B, Chavez-Gutierrez, L.
Alzheimer's-Causing Mutations Shift Abeta Length by Destabilizing gamma-Secretase-Abetan Interactions
Cell 170, 443-456, 2017. (Epub 2017 Jul 27)

Van Rompaey, D, Verstraete, K, Peelman, F, Savvides, SN, Augustyns, K, Van Der Veken, P, De Winter, H.
Virtual screening for inhibitors of the human TSLP:TSLPR interaction
Sci Rep 7, 17211, 2017. (Epub 2017 Dec 8)

Verstraete, K, Peelman, F, Braun, H, Lopez, J, Van Rompaey, D, Dansercoer, A, Vandenberghe, I, Pauwels, K, Tavernier, J, Lambrecht, BN, Hammad, H, De Winter, H, Beyaert, R, Lippens, G, Savvides, SN.
Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma
Nat Commun 8, 14937, 2017. (Epub 2017 Apr 3)

Felix, J, Kandiah, E, De Munck, S, Bloch, Y, van Zundert, GC, Pauwels, K, Dansercoer, A, Novanska, K, Read, RJ, Bonvin, AM, Vergauwen, B, Verstraete, K, Gutsche, I, Savvides, SN.
Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF
Nat Commun 7, 13228, 2016. (Epub 2016 Nov 7)

Felix, J, De Munck, S, Verstraete, K, Meuris, L, Callewaert, N, Elegheert, J, Savvides, SN.
Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1
Structure 23, 1621-1631, 2015. (Epub 2015 Jul 21)

Al Atalah, B, Vanderschaeghe, D, Bloch, Y, Proost, P, Plas, K, Callewaert, N, Savvides, SN, Van Damme, EJ.
Characterization of a type D1A EUL-related lectin from rice expressed in Pichia pastoris
Biol Chem 395, 413-424, 2014. (Epub 2013 Nov 15)

Dondelinger, Y, Declercq, W, Montessuit, S, Roelandt, R, Goncalves, A, Bruggeman, I, Hulpiau, P, Weber, K, Sehon, CA, Marquis, RW, Bertin, J, Gough, PJ, Savvides, S, Martinou, JC, Bertrand, MJ, Vandenabeele, P.
MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates
Cell Rep 7, 971981, 2014. (Epub 2014 May 7)

Elegheert, J, Bracke, N, Pouliot, P, Gutsche, I, Shkumatov, AV, Tarbouriech, N, Verstraete, K, Bekaert, A, Burmeister, WP, Svergun, DI, Lambrecht, BN, Vergauwen, B, Savvides, SN.
Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1
Nat Struct Mol Biol 19, 938-947, 2012. (Epub 2012 Aug 19)

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