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Publications from this research unit

This page shows only publications with IRC as the affiliation of at least one author.
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See "Extra muros" papers of the units.

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Boeltz, S, Amini, P, Anders, HJ, Andrade, F, Bilyy, R, Chatfield, S, Cichon, I, Clancy, DM, Desai, J, et al., Maueroder, C, et al. , Vanden Berghe, T, Vandenabeele, P, Hahn, J, Hidalgo, A, Hoffmann, MH, Kaplan, MJ, Knight, JS, Kolaczkowska, E, Kubes, P, et al..
To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps
Cell Death Differ 26, 395-408, 2019. (Epub 2019 Jan 8)

Dejonghe, W, Sharma, I, Denoo, B, De Munck, S, Lu, Q, Mishev, K, Bulut, H, Mylle, E, De Rycke, R, Vasileva, M, Savatin, DV, Nerinckx, W, Staes, A, Drozdzecki, A, Audenaert, D, Yperman, K, Madder, A, Friml, J, Van Damme, D, et al..
Disruption of endocytosis through chemical inhibition of clathrin heavy chain function
Nat Chem Biol , in press, 2019. (Epub 2019 Apr 22)

Detry, S, Skladanowska, K, Vuylsteke, M, Savvides, SN, Bloch, Y.
Revisiting the combinatorial potential of cytokine subunits in the IL-12 family
Biochem Pharmacol , in press, 2019. (Epub 2019 Mar 15)

Dondelinger, Y, Delanghe, T, Priem, D, Wynosky-Dolfi, MA, Sorobetea, D, Rojas-Rivera, D, Giansanti, P, Roelandt, R, Gropengiesser, J, Ruckdeschel, K, Savvides, SN, Heck, AJR, Vandenabeele, P, Brodsky, IE, Bertrand, MJM.
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
Nat Commun 10, 1729, 2019. (Epub 2019 Apr 15)

Holgado, A, Braun, H, Van Nuffel, E, Detry, S, Schuijs, MJ, Deswarte, K, Vergote, K, Haegman, M, Baudelet, G, Haustraete, J, Hammad, H, Lambrecht, BN, Savvides, SN, Afonina, IS, Beyaert, R.
IL-33trap is a novel IL-33 neutralizing biologic that inhibits allergic airway inflammation
J Allergy Clin Immunol , in press, 2019. (Epub 2019 Mar 12)

Slowicka, K, Serramito-Gomez, I, Boada-Romero, E, Martens, A, Sze, M, Petta, I, Vikkula, HK, De Rycke, R, Parthoens, E, Lippens, S, Savvides, SN, Wullaert, A, Vereecke, L, Pimentel-Muinos, FX, van Loo, G.
Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis
Nat Commun 10, 1834, 2019. (Epub 2019 Apr 23)

Verschueren, KHG, Blanchet, C, Felix, J, Dansercoer, A, De Vos, D, Bloch, Y, Van Beeumen, J, Svergun, D, Gutsche, I, Savvides, SN, Verstraete, K.
Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle
Nature 568, 571-575, 2019. (Epub 2019 Apr 3)

De Bruyne, M, Hoste, L, Bogaert, DJ, Van den Bossche, L, Tavernier, SJ, Parthoens, E, et al., Lambrecht, BN, van Daele, S, Alves de Medeiros, AK, Brochez, L, Beyaert, R, De Baere, E, Puel, A, Casanova, JL, Goffard, JC, Savvides, SN, et al., Staal, J, et al.
A CARD9 Founder Mutation Disrupts NF-kappaB Signaling by Inhibiting BCL10 and MALT1 Recruitment and Signalosome Formation
Front Immunol 9, 2366, 2018. (Epub 2018 Oct 31)

Fulara, A, Vandenberghe, I, Read, RJ, Devreese, B, Savvides, SN.
Structure and oligomerization of the periplasmic domain of GspL from the type II secretion system of Pseudomonas aeruginosa
Sci Rep 8, 16760, 2018. (Epub 2018 Nov 13)

Govindarajan, S, Gaublomme, D, Van der Cruyssen, R, Verheugen, E, Van Gassen, S, Saeys, Y, Tavernier, S, Iwawaki, T, Bloch, Y, Savvides, SN, Lambrecht, BN, Janssens, S, Elewaut, D, Drennan, MB.
Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha
Nat Commun 9, 5340, 2018. (Epub 2018 Dec 17)

Krols, M, Detry, S, Asselbergh, B, Almeida-Souza, L, Kremer, A, Lippens, S, De Rycke, R, De Winter, V, Muller, FJ, Kurth, I, McMahon, HT, Savvides, SN, Timmerman, V, Janssens, S.
Sensory-Neuropathy-Causing Mutations in ATL3 Cause Aberrant ER Membrane Tethering
Cell Rep 23, 2026-2038, 2018. (Epub 2018 May 15)

Lienart, S, Merceron, R, Vanderaa, C, Lambert, F, Colau, D, Stockis, J, van der Woning, B, De Haard, H, Saunders, M, Coulie, PG, Savvides, SN, Lucas, S.
Structural basis of latent TGF-beta1 presentation and activation by GARP on human regulatory T cells
Science 362, 952-956, 2018. (Epub 2018 Nov 23)

Mishev, K, Lu, Q, Denoo, B, et al., Dejonghe, W, Hullaert, J, De Rycke, RM, Boeren, S, Bretou, M, De Munck, S, Sharma, IS, Goodman, K, Kalinowska, K, Storme, V, Nguyen, L, Drozdzecki, A, Martins, S, Nerinckx, W, Audenaert, D, Savvides, S, et al..
Nonselective chemical inhibition of Sec7 domain-containing ARF GEFs in Arabidopsis
Plant Cell 30, 2573-2593, 2018. (Epub 2018 Jul 17)

Nguyen, CT, Bloch, Y, Skladanowska, K, Savvides, SN, Adamopoulos, IE.
Pathophysiology and inhibition of IL-23 signaling in psoriatic arthritis: A molecular insight
Clin Immunol , in press, 2018. (Epub 2018 Sep 6)

Song, L, Merceron, R, Gracia, B, Quintana, AL, Risseeuw, MDP, Hulpia, F, Cos, P, Ainsa, JA, Munier-Lehmann, H, Savvides, SN, Van Calenbergh, S.
Structure Guided Lead Generation towards non-chiral M. tuberculosis Thymidylate Kinase Inhibitors
J Med Chem 61, 2753-2775, 2018. (Epub 2018 Mar 6)

Bloch, Y, Bouchareychas, L, Merceron, R, Skladanowska, K, Van den Bossche, L, Detry, S, Govindarajan, S, Elewaut, D, Haerynck, F, Dullaers, M, Adamopoulos, IE, Savvides, SN.
Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12Rbeta1
Immunity 48, 45-58, 2017. (Epub 2017 Dec 21)

Devos, S, Van Putte, W, Vitse, J, Van Driessche, G, Stremersch, S, Van Den Broek, W, Raemdonck, K, Braeckmans, K, Stahlberg, H, Kudryashev, M, Savvides, SN, Devreese, B.
Membrane vesicle secretion and prophage induction in multidrug-resistant Stenotrophomonas maltophilia in response to ciprofloxacin stress
Environ Microbiol 19, 3930-3937, 2017. (Epub 2017 May 10)

Elegheert, J, Brige, A, Van Beeumen, J, Savvides, SN.
Structural dissection of Shewanella oneidensis old yellow enzyme 4 bound to a Meisenheimer complex and (nitro)phenolic ligands
FEBS Lett 591, 3391-3401, 2017. (Epub 2017 Sep 4)

Felix, J, Savvides, SN.
Mechanisms of immunomodulation by mammalian and viral decoy receptors: insights from structures
Nat Rev Immunol 17, 112-129, 2017. (Epub 2016 Dec 28)

Hammad, H, Vanderkerken, M, Pouliot, P, Deswarte, K, Toussaint, W, Vergote, K, Vandersarren, L, Janssens, S, Ramou, I, Savvides, SN, Haigh, JJ, Hendriks, R, Kopf, M, Craessaerts, K, de Strooper, B, Kearney, JF, Conrad, DH, Lambrecht, BN.
Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10
Nat Immunol 18, 313320, 2017. (Epub 2017 Jan 9)

Szaruga, M, Munteanu, B, Lismont, S, Veugelen, S, Horre, K, Mercken, M, Saido, TC, Ryan, NS, De Vos, T, Savvides, SN, Gallardo, R, Schymkowitz, J, Rousseau, F, Fox, NC, Hopf, C, De Strooper, B, Chavez-Gutierrez, L.
Alzheimer's-Causing Mutations Shift Abeta Length by Destabilizing gamma-Secretase-Abetan Interactions
Cell 170, 443-456, 2017. (Epub 2017 Jul 27)

Van Rompaey, D, Verstraete, K, Peelman, F, Savvides, SN, Augustyns, K, Van Der Veken, P, De Winter, H.
Virtual screening for inhibitors of the human TSLP:TSLPR interaction
Sci Rep 7, 17211, 2017. (Epub 2017 Dec 8)

Verstraete, K, Peelman, F, Braun, H, Lopez, J, Van Rompaey, D, Dansercoer, A, Vandenberghe, I, Pauwels, K, Tavernier, J, Lambrecht, BN, Hammad, H, De Winter, H, Beyaert, R, Lippens, G, Savvides, SN.
Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma
Nat Commun 8, 14937, 2017. (Epub 2017 Apr 3)

Felix, J, Kandiah, E, De Munck, S, Bloch, Y, van Zundert, GC, Pauwels, K, Dansercoer, A, Novanska, K, Read, RJ, Bonvin, AM, Vergauwen, B, Verstraete, K, Gutsche, I, Savvides, SN.
Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF
Nat Commun 7, 13228, 2016. (Epub 2016 Nov 7)

Felix, J, De Munck, S, Verstraete, K, Meuris, L, Callewaert, N, Elegheert, J, Savvides, SN.
Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1
Structure 23, 1621-1631, 2015. (Epub 2015 Jul 21)

Al Atalah, B, Vanderschaeghe, D, Bloch, Y, Proost, P, Plas, K, Callewaert, N, Savvides, SN, Van Damme, EJ.
Characterization of a type D1A EUL-related lectin from rice expressed in Pichia pastoris
Biol Chem 395, 413-424, 2014. (Epub 2013 Nov 15)

Dondelinger, Y, Declercq, W, Montessuit, S, Roelandt, R, Goncalves, A, Bruggeman, I, Hulpiau, P, Weber, K, Sehon, CA, Marquis, RW, Bertin, J, Gough, PJ, Savvides, S, Martinou, JC, Bertrand, MJ, Vandenabeele, P.
MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates
Cell Rep 7, 971981, 2014. (Epub 2014 May 7)

Elegheert, J, Bracke, N, Pouliot, P, Gutsche, I, Shkumatov, AV, Tarbouriech, N, Verstraete, K, Bekaert, A, Burmeister, WP, Svergun, DI, Lambrecht, BN, Vergauwen, B, Savvides, SN.
Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1
Nat Struct Mol Biol 19, 938-947, 2012. (Epub 2012 Aug 19)

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