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Publications from this research unit
This page shows only publications with IRC as the affiliation of at least one author.
Publications by IRC members mentioning other affiliations are not in our database. Sorry.
See "Extra muros" papers of the units.
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Lichawska-Cieslar, A, Konieczny, P, Szukala, W, Declercq, W, Fu, M, Jura, J. Loss of keratinocyte Mcpip1 abruptly activates the IL-23/Th17 and Stat3 pathways in skin inflammation Biochim Biophys Acta Mol Cell Res , in press, 2021. (Epub 2020 Sep 29) 
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Aaes, TL, Verschuere, H, Kaczmarek, A, Heyndrickx, L, Wiernicki, B, Delrue, I, De Craene, B, Taminau, J, Delvaeye, T, Bertrand, MJM, Declercq, W, Berx, G, Krysko, DV, Adjemian, S, Vandenabeele, P. Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection J Immunol 204, 775-787, 2020. (Epub 2020 Jan 3)
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Devos, M, Tanghe, G, Gilbert, B, Dierick, E, Verheirstraeten, M, Nemegeer, J, de Reuver, R, Lefebvre, S, De Munck, J, Rehwinkel, J, Vandenabeele, P, Declercq, W, Maelfait, J. Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation J Exp Med 217, e20191913, 2020. (Epub 2020 Apr 21)
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Martens, S, Hofmans, S, Declercq, W, Augustyns, K, Vandenabeele, P. Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs Trends Pharmacol Sci 41, 209-224, 2020. (Epub 2020 Feb 5)
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Teufelberger, AR, Van Nevel, S, Hulpiau, P, Nordengrun, M, Savvides, SN, De Graeve, S, Akula, S, Holtappels, G, De Ruyck, N, Declercq, W, Vandenabeele, P, Hellman, L, Broker, BM, Krysko, DV, Bachert, C, Krysko, O. Mouse Strain-Dependent Difference Toward the Staphylococcus aureus Allergen Serine Protease-Like Protein D Reveals a Novel Regulator of IL-33 Front Immunol 11, 582044, 2020. (Epub 2020 Sep 25)
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Thyssen, JP, Jakasa, I, Riethmuller, C, Schon, MP, Braun, A, Haftek, M, Fallon, PG, Wroblewski, J, Jakubowski, H, Eckhart, L, Declercq, W, Koppes, S, Engebretsen, KA, Bonefeld, C, Irvine, AD, Keita-Alassane, S, Simon, M, Kawasaki, H, Kubo, A, et al.. Filaggrin Expression and Processing Deficiencies Impair Corneocyte Surface Texture and Stiffness in Mice J Invest Dermatol 140, 615-623, 2020. (Epub 2019 Aug 31)
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Delvaeye, T, De Smet, MAJ, Verwaerde, S, Decrock, E, Czekaj, A, Vandenbroucke, RE, Lemeire, K, Goncalves, A, Declercq, W, Vandenabeele, P, Krysko, DV, Leybaert, L. Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock Sci Rep 9, 16623, 2019. (Epub 2019 Nov 12)
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Devos, M, Mogilenko, DA, Fleury, S, Gilbert, B, Becquart, C, Quemener, S, Dehondt, H, Tougaard, P, Staels, B, Bachert, C, Vandenabeele, P, Van Loo, G, Staumont-Salle, D, Declercq, W, Dombrowicz, D. Keratinocyte expression of A20/TNFAIP3 controls skin inflammation associated with atopic dermatitis and psoriasis J Invest Dermatol 139, 135-145, 2019. (Epub 2018 Aug 14)
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Hoste, E, Maueroder, C, van Hove, L, Catrysse, L, Vikkula, HK, Sze, M, Maes, B, Karjosukarso, D, Martens, L, Goncalves, A, Parthoens, E, Roelandt, R, Declercq, W, Fuentes, I, Palisson, F, Gonzalez, S, Salas-Alanis, JC, Boon, L, Huebener, P, et al.. Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils for NET Formation Cell Rep 29, 2689-2701, 2019. (Epub 2019 Nov 26)
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Konieczny, P, Lichawska-Cieslar, A, Kwiecinska, P, Cichy, J, Pietrzycka, R, Szukala, W, Declercq, W, Devos, M, Paziewska, A, Rumienczyk, I, Kulecka, M, Mikula, M, Fu, M, Borowczyk, J, Santamaria-Babi, LF, Jura, J. Keratinocyte-specific ablation of Mcpip1 impairs skin integrity and promotes local and systemic inflammation J Mol Med (Berl) 97, 1669-1684, 2019. (Epub 2019 Nov 30)
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Priem, D, Devos, M, Druwe, S, Martens, A, Slowicka, K, Ting, AT, Pasparakis, M, Declercq, W, Vandenabeele, P, van Loo, G, Bertrand, MJM. A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms Cell Death Dis 10, 692, 2019. (Epub 2019 Sep 18)
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Tanc, M, Cleenewerck, M, Kurdi, A, Roelandt, R, Declercq, W, De Meyer, G, Augustyns, K, Martinet, W, Van der Veken, P. Synthesis and evaluation of novel benzotropolones as Atg4B inhibiting autophagy blockers Bioorg Chem 87, 163-168, 2019. (Epub 2019 Mar 13)
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Van Hoecke, L, Raes, L, Stremersch, S, Brans, T, Fraire, JC, Roelandt, R, Declercq, W, Vandenabeele, P, Raemdonck, K, Braeckmans, K, Saelens, X. Delivery of Mixed-Lineage Kinase Domain-Like Protein by Vapor Nanobubble Photoporation Induces Necroptotic-Like Cell Death in Tumor Cells International Journal of Molecular Sciences 20, E4254, 2019. (Epub 2019 Aug 30)
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Deckers, J, Bougarne, N, Mylka, V, Desmet, S, Luypaert, A, Devos, M, Tanghe, G, Van Moorleghem, J, Vanheerswynghels, M, De Cauwer, L, Thommis, J, Vuylsteke, M, Tavernier, J, Lambrecht, B, Hammad, H, De Bosscher, K. Co-activation of GR and PPARgamma in murine skin prevents worsening of atopic march J Invest Dermatol 138, 1360-1370, 2018. (Epub 2017 Dec 27)
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Tanghe, G, Urwyler-Rosselet, C, De Groote, P, Dejardin, E, De Bock, PJ, Gevaert, K, Vandenabeele, P, Declercq, W. RIPK4 activity in keratinocytes is controlled by the SCF(beta-TrCP) ubiquitin ligase to maintain cortical actin organization Cell Mol Life Sci 75, 2827-2841, 2018. (Epub 2018 Feb 12)
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Teufelberger, AR, Nordengrun, M, Braun, H, Maes, T, De Grove, K, Holtappels, G, O'Brien, C, Provoost, S, Hammad, H, Goncalves, A, Beyaert, R, Declercq, W, Vandenabeele, P, Krysko, DV, Broker, BM, Bachert, C, Krysko, O. The IL-33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus-derived serine protease-like protein D. J Allergy Clin Immunol 141, 549-559, 2018. (Epub 2017 May 19)
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Urwyler-Rosselet, C, Tanghe, G, Leurs, K, Gilbert, B, De Rycke, R, De Bruyne, M, Lippens, S, Bartunkova, S, De Groote, P, Niessen, C, Haftek, M, Vandenabeele, P, Declercq, W. Keratinocyte-specific ablation of RIPK4 allows epidermal cornification but impairs skin barrier formation J Invest Dermatol 138, 1268-1278, 2018. (Epub 2018 Jan 6)
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Vandenabeele, P, Declercq, W, Roelandt, R, Vanden Berghe, T. MLKL Reveals Its Friendly Face: A Role in Nerve Regeneration Mol Cell 72, 397-399, 2018. (Epub 2018 Nov 1)
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Devos, M, Gilbert, B, Denecker, G, Leurs, K, Mc Guire, C, Lemeire, K, Hochepied, T, Vuylsteke, M, Lambert, J, Van Den Broecke, C, Libbrecht, L, Haigh, J, Berx, G, Lippens, S, Vandenabeele, P, Declercq, W. Elevated DeltaNp63alpha levels facilitate epidermal and biliary oncogenic transformation J Invest Dermatol 137, 494-505, 2017. (Epub 2016 Oct 7)
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Kurdi, A, Cleenewerck, M, Vangestel, C, Lyssens, S, Declercq, W, Timmermans, JP, Stroobants, S, Augustyns, K, De Meyer, GRY, Van Der Veken, P, Martinet, W. ATG4B inhibitors with a benzotropolone core structure block autophagy and augment efficiency of chemotherapy in mice Biochem Pharmacol 138, 150-162, 2017. (Epub 2017 Jun 19)
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Latil, M, Nassar, D, Beck, B, Boumahdi, S, Wang, L, Brisebarre, A, Dubois, C, Nkusi, E, Lenglez, S, Checinska, A, Vercauteren Drubbel, A, Devos, M, Declercq, W, Yi, R, Blanpain, C. Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition Cell Stem Cell 20, 191-204, 2017. (Epub 2016 Nov 16)
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Aaes, TL, Kaczmarek, A, Delvaeye, T, De Craene, B, De Koker, S, Heyndrickx, L, Delrue, I, Taminau, J, Wiernicki, B, De Groote, P, Garg, AD, Leybaert, L, Grooten, J, Bertrand, MJ, Agostinis, P, Berx, G, Declercq, W, Vandenabeele, P, Krysko, DV. Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity Cell Rep 15, 274-287, 2016. (Epub 2016 Mar 30)
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Cleenewerck, M, Grootaert, MO, Gladysz, R, Adriaenssens, Y, Roelandt, R, Joossens, J, Lambeir, AM, De Meyer, GR, Declercq, W, Augustyns, K, Martinet, W, Van der Veken, P. Inhibitor screening and enzymatic activity determination for autophagy target Atg4B using a gel electrophoresis-based assay Eur J Med Chem 123, 631-638, 2016. (Epub 2016 Jul 31)
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De Groote, P, Grootjans, S, Lippens, S, Eichperger, C, Leurs, K, Kahr, I, Tanghe, G, Bruggeman, I, De Schamphelaire, W, Urwyler, C, Vandenabeele, P, Haustraete, J, Declercq, W. Generation of a new Gateway-compatible inducible lentiviral vector platform allowing easy derivation of co-transduced cells Biotechniques 60, 252-259, 2016. (Epub 2016 May 1)
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Panayotova-Dimitrova, D, Declercq, W. Martin Leverkus, MD (1965-2016) J Invest Dermatol 136, 891-892, 2016. (Epub 2016 May)
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Lyrio, EC, Campos-Souza, IC, Correa, C, Lechuga, G, Vericimo, M, Castro, HC, Bourguignon, SC, Faria, SC, Ratcliffe, N, Declercq, W, Santos, DO. Interaction of Mycobacterium leprae with the HaCaT human keratinocyte cell line: New frontiers in the cellular immunology of leprosy Exp Dermatol 24, 536-542, 2015. (Epub 2015 Apr 1)
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Vorhagen, S, Jackow, J, Mohor, SG, Tanghe, G, Tanrikulu, L, Skazik-Vogt, C, Tellkamp, F. Lineage tracing mediated by Cre-recombinase activity J Invest Dermatol 135, e28, 2015. (Epub 2014 Dec 12)
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De Groote, P, Tran, HT, Fransen, M, Tanghe, G, Urwyler, C, De Craene, B, Leurs, K, Gilbert, B, Van Imschoot, G, De Rycke, R, Guerin, CJ, Holland, P, Berx, G, Vandenabeele, P, Lippens, S, Vleminckx, K, Declercq, W. A novel RIPK4-IRF6 connection is required to prevent epithelial fusions characteristic for popliteal pterygium syndromes Cell Death Differ 22, 1012-1024, 2014. (Epub 2014 Nov 28)
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Dondelinger, Y, Declercq, W, Montessuit, S, Roelandt, R, Goncalves, A, Bruggeman, I, Hulpiau, P, Weber, K, Sehon, CA, Marquis, RW, Bertin, J, Gough, PJ, Savvides, S, Martinou, JC, Bertrand, MJ, Vandenabeele, P. MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates Cell Rep 7, 971–981, 2014. (Epub 2014 May 7)
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Kubica, M, Hildebrand, F, Brinkman, BM, Goossens, D, Del Favero, J, Vercammen, K, Cornelis, P, Schroder, JM, Vandenabeele, P, Raes, J, Declercq, W. The skin microbiome of caspase-14 deficient mice shows mild dysbiosis Exp Dermatol 23, 561-567, 2014. (Epub 2014 May 26)
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Quimbaya, M, Raspe, E, Denecker, G, De Craene, B, Roelandt, R, Declercq, W, Sagaert, X, De Veylder, L, Berx, G. Deregulation of the replisome factor MCMBP prompts oncogenesis in colorectal carcinomas through chromosomal instability Neoplasia 16, 694-709, 2014. (Epub 2014 Sep)
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Takahashi, N, Vereecke, L, Bertrand, MJ, Duprez, L, Berger, SB, Divert, T, Goncalves, A, Sze, M, Gilbert, B, Kourula, S, Goossens, V, Lefebvre, S, Gunther, C, Becker, C, Bertin, J, Gough, PJ, Declercq, W, van Loo, G, Vandenabeele, P. RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis Nature 513, 95-99, 2014. (Epub 2014 Sep 4)
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Vanden Berghe, T, Demon, D, Bogaert, P, Vandendriessche, B, Goethals, A, Depuydt, B, Vuylsteke, M, Roelandt, R, Van Wonterghem, E, Vandenbroecke, J, Choi, SM, Meyer, E, Krautwald, S, Declercq, W, Takahashi, N, Cauwels, A, Vandenabeele, P. Simultaneous targeting of Interleukin-1 and -18 is required for protection against inflammatory and septic shock Am J Respir Crit Care Med 189, 282-291, 2014. (Epub 2014 Jan 23)
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Beck, IM, Drebert, ZJ, Hoya-Arias, R, Bahar, AA, Devos, M, Clarisse, D, Desmet, S, Bougarne, N, Ruttens, B, Gossye, V, Denecker, G, Lievens, S, Bracke, M, Tavernier, J, Declercq, W, Gevaert, K, Vanden Berghe, W, Haegeman, G, De Bosscher, K. Compound A, a selective glucocorticoid receptor modulator, enhances heat shock protein hsp70 gene promoter activation PLoS One 8, e69115, 2013. (Epub 2013 Jul 30)
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Bisteau, X, Paternot, S, Colleoni, B, Ecker, K, Coulonval, K, De Groote, P, Declercq, W, Hengst, L, Roger, PP. CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point PLoS Genet 9, e1003546, 2013. (Epub 2013 May 30)
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Declercq, W. Caspase-14 In Handbook of Proteolytic Enzymes. (Rawlings, N.D. & Salvesen, G.S., eds.), Oxford, Academic Press, pp. 2280-2285, 2013. (Epub 2013 Jan)
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Devos, M, De Groote, P, Gilbert, B, Bruggeman, I, Leurs, K, Lippens, S, Vandenabeele, P, Declercq, W. Caspase-14 overexpression in hairless mice is not involved in utricle formation Exp Dermatol 22, 484-486, 2013. (Epub 2013 Jul)
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Eckhart, L, Lippens, S, Tschachler, E, Declercq, W. Cell death by cornification Biochim Biophys Acta - Mol Cell Res 1833, 3471-3480, 2013. (Epub 2013 Jun 20)
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Hoste, E, Denecker, G, Gilbert, B, Van Nieuwerburgh, F, van der Fits, L, Asselbergh, B, De Rycke, R, Hachem, JP, Deforce, D, Prens, EP, Vandenabeele, P, Declercq, W. Caspase-14-deficient mice are more prone to the development of parakeratosis J Invest Dermatol 133, 742-750, 2013. (Epub 2012 Sep 27)
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Devos, M, Prawitt, J, Staumont-Salle, D, Hoste, E, Fleury, S, Bouchaert, E, Gilbert, B, Lippens, S, Vandenabeele, P, Dombrowicz, D, Declercq, W. Filaggrin degradation by Caspase-14 is required for UVB photoprotection but does not influence allergic sensitization in a mouse model of atopic dermatitis J Invest Dermatol 132, 2857-2860, 2012. (Epub 2012 Aug 30)
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Takahashi, N, Duprez, L, Grootjans, S, Cauwels, A, Nerinckx, W, Duhadaway, JB, Goossens, V, Roelandt, R, Van Hauwermeiren, F, Libert, C, Declercq, W, Callewaert, N, Prendergast, GC, Degterev, A, Yuan, J, Vandenabeele, P. Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models Cell Death Dis 3, e437, 2012. (Epub 2012 Nov 29)
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Bertrand, MJ, Lippens, S, Staes, A, Gilbert, B, Roelandt, R, De Medts, J, Gevaert, K, Declercq, W, Vandenabeele, P. cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to Receptor Interacting Protein Kinases 1 to 4 (RIP1-4) PLoS One 6, e22356, 2011. (Epub 2011 Sep 22)
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Brinkman, BM, Hildebrand, F, Kubica, M, Goosens, D, Del Favero, J, Declercq, W, Raes, J, Vandenabeele, P. Caspase deficiency alters the murine gut microbiome Cell Death Dis 2, e220, 2011. (Epub 2011 Oct 20)
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Declercq, W, Agostinis, P, Vandenabeele, P. 18th Euroconference on Apoptosis in Ghent, Belgium, 1-4 September 2010 Cell Death Differ 18, 1540-1542, 2011. (Epub 2011 Jun 3)
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Declercq, W, Takahashi, N, Vandenabeele, P. Dual face apoptotic machinery: from initiator of apoptosis to guardian of necroptosis Immunity 35, 493-495, 2011. (Epub 2011 Oct 28)
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Duprez, L, Takahashi, N, Van Hauwermeiren, F, Vandendriessche, B, Goossens, V, Vanden Berghe, T, Declercq, W, Libert, C, Cauwels, A, Vandenabeele, P. RIP Kinase-dependent necroptosis drives lethal systemic inflammatory response syndrome Immunity 35, 908-918, 2011. (Epub 2011 Dec 23)
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Hoste, E, Kemperman, P, Devos, M, Denecker, G, Kezic, S, Yau, N, Gilbert, B, Lippens, S, De Groote, P, Roelandt, R, Van Damme, P, Gevaert, K, Presland, RB, Takahara, H, Puppels, G, Caspers, P, Vandenabeele, P, Declercq, W. Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin J Invest Dermatol 131, 2233-2241, 2011. (Epub 2011 Jun 9)
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Kantyka, T, Fischer, J, Wu, Z, Declercq, W, Reiss, K, Schroder, JM, Meyer-Hoffert, U. Inhibition of Kallikrein-related peptidases by the serine protease inhibitor of Kazal-type 6 Peptides 32, 1187-1192, 2011. (Epub 2011 Mar 22)
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Lippens, S, Hoste, E, Vandenabeele, P, Declercq, W. Cell death in the skin In Apoptosis: Physiology and pathology. (Reed, JC, Green, DR, eds.), Cambridge, Cambridge University Press, pp. 323-332, 2011. (Epub 2011)
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Lippens, S, Lefebvre, S, Gilbert, B, Sze, M, Devos, M, Verhelst, K, Vereecke, L, Mc Guire, C, Guerin, C, Vandenabeele, P, Pasparakis, M, Mikkola, ML, Beyaert, R, Declercq, W, van Loo, G. Keratinocyte-specific ablation of the NF-?B regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis Cell Death Differ 18, 1845-1853, 2011. (Epub 2011 May 13)
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