Publications from this research unit

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Zuallaert, J, Godin, F, Kim, M, Soete, A, Saeys, Y, De Neve, W.
SpliceRover: Interpretable Convolutional Neural: Networks for Improved Splice Site Prediction
Bioinformatics 34, 4180-4188, 2018. (Epub 2018 Jun 21)

Davison, A, McDowell, Gary S, Holden, Jennifer M, Johnson, Harriet F, Koutsovoulos, Georgios D, Liu, MM, Hulpiau, P, Van Roy, F, Wade, Christopher M, Banerjee, R, Yang, F, Chiba, S, Davey, John W, Jackson, Daniel J, Levin, M, Blaxter, Mark L.
Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog
Current Biology 26, 1-7, 2016. (Epub 2016 Mar 7)

Demeestere, D, Dejonckheere, E, Steeland, S, Hulpiau, P, Haustraete, J, Devoogdt, N, Wichert, R, Becker-Pauly, C, Van Wonterghem, E, Dewaele, S, Van Imschoot, G, Aerts, J, Arckens, L, Saeys, Y, Libert, C, Vandenbroucke, RE.
Development and validation of a small single domain antibody that effectively inhibits matrix metalloproteinase 8
Mol Ther 24, 890-902, 2016. (Epub 2016 Jan 18)

Hulpiau, P, Driege, Y, Staal, J, Beyaert, R.
MALT1 is not alone after all: identification of novel paracaspases
Cell Mol Life Sci 1103-1116, 73, 2016. (Epub 2015 Sep 16)

Vanden Berghe, T, Hulpiau, P, Martens, L, Vandenbroucke, RE, Van Wonterghem, E, Perry, SW, Bruggeman, I, Divert, T, Choi, SM, Vuylsteke, M, Shestopalov, VI, Libert, C, Vandenabeele, P.
Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice
Immunity 43, 200-209, 2015. (Epub 2015 Jul 21)

Dondelinger, Y, Declercq, W, Montessuit, S, Roelandt, R, Goncalves, A, Bruggeman, I, Hulpiau, P, Weber, K, Sehon, CA, Marquis, RW, Bertin, J, Gough, PJ, Savvides, S, Martinou, JC, Bertrand, MJ, Vandenabeele, P.
MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates
Cell Rep 7, 971–981, 2014. (Epub 2014 May 7)

Lin, YC, Boone, M, Meuris, L, Lemmens, I, Van Roy, N, Soete, A, Reumers, J, Moisse, M, Plaisance, S, Drmanac, R, Chen, J, Speleman, F, Lambrechts, D, Van de Peer, Y, Tavernier, J, Callewaert, N.
Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations
Nat Commun 5, 4767, 2014. (Epub 2014 Sep 3)

Steeland, S, Puimege, L, Vandenbroucke, RE, Van Hauwermeiren, F, Haustraete, J, Devoogdt, N, Hulpiau, P, Leroux-Roels, G, Laukens, D, Meuleman, P, De Vos, M, Libert, C.
Generation and characterization of small single domain antibodies inhibiting human TNF receptor 1
J Biol Chem 290, 4022-4037, 2014. (Epub 2014 Dec 23)

Farhang Ghahremani, M, Goossens, S, Nittner, D, Bisteau, X, Bartunkova, S, Zwolinska, A, Hulpiau, P, Haigh, K, Haenebalcke, L, Drogat, B, Jochemsen, A, Roger, PP, Marine, JC, Haigh, JJ.
p53 promotes VEGF expression and angiogenesis in the absence of an intact p21-RB pathway
Cell Death Differ 20, 888-897, 2013. (Epub 2013 Mar 1)

Hulpiau, P, Van Roy, F.
Cadherin family members in embryonic development, morphogenesis, and disease
In Encyclopedia of Metalloproteins (Kretsinger, RH, Uversky, VN, Permyakov, EA, eds.), New York, Springer, pp. 319-332, 2013. (Epub 2013 )

van Hengel, J, Calore, M, Bauce, B, Dazzo, E, Mazzotti, E, De Bortoli, M, Lorenzon, A, Li Mura, IEA, Beffagna, G, Rigato, I, Vleeschouwers, M, Tyberghein, K, Hulpiau, P, van Hamme, E, Zaglia, T, Corrado, D, Basso, C, Thiene, G, Daliento, L, Nava, A, van Roy, F, Rampazzo, A.
Mutations in the area composita protein alpha-T-catenin are associated with arrhythmogenic right ventricular cardiomyopathy
Eur Heart J 34, 201-210, 2013. (Epub 2012 Nov 7)

Verhelst, J, Hulpiau, P, Saelens, X.
Mx proteins: antiviral gatekeepers that restrain the uninvited
Microbiol Mol Biol Rev 77, 551-566, 2013. (Epub 2013 Dec)

Gheldof, A, Hulpiau, P, van Roy, F, De Craene, B, Berx, G.
Evolutionary functional analysis and molecular regulation of the ZEB transcription factors
Cell Mol Life Sci 69, 2527-2541, 2012. (Epub 2012 Feb 21)

Hooghe, B, Broos, S, van Roy, F, De Bleser, P.
A flexible integrative approach based on random forest improves prediction of transcription factor binding sites
Nucleic Acids Res 40, e106, 2012. (Epub 2012 Apr 5)

Tiels, P, Baranova, E, Piens, K, De Visscher, C, Pynaert, G, Nerinckx, W, Stout, J, Fudalej, F, Hulpiau, P, Tannler, S, Geysens, S, Van Hecke, A, Valevska, A, Vervecken, W, Remaut, H, Callewaert, N.
A bacterial glycosidase enables mannose-6-phosphate modification and improved cellular uptake of yeast-produced recombinant human lysosomal enzymes
Nat Biotechnol 30, 1225-1231, 2012. (Epub 2012 Nov 18)

Broos, S, Hulpiau, P, Galle, J, Hooghe, B, Van Roy, F, De Bleser, P.
ConTra v2: a tool to identify transcription factor binding sites across species, update 2011
Nucl Acids Res 39, W74-W78, 2011. (Epub 2011 May 16)

Hulpiau, P, van Roy, F.
New insights into the evolution of metazoan cadherins
Mol Biol Evol 28, 647-657, 2011. (Epub 2010 Sep 3)

Schepens, B, Ibanez, LI, De Baets, S, Hultberg, A, Bogaert, P, De Bleser, P, Vervalle, F, Verrips, T, Melero, J, Vandevelde, W, Vanlandschoot, P, Saelens, X.
Nanobodies(R) specific for Respiratory Syncytial Virus fusion protein protect against infection by inhibition of fusion
J Infect Dis 204, 1692-1701, 2011. (Epub 2011 Oct 12)

Hulpiau, P, van Roy, F.
Molecular evolution of the cadherin superfamily
Int J Biochem Cell Biol 42, 349-369, 2009. (Epub 2008 Oct 4)

Daenen, F, van Roy, F, De Bleser, PJ.
Low nucleosome occupancy is encoded around functional human transcription factor binding sites
BMC Genomics 9, 332, 2008. (Epub 2008 Jul 15)

Hooghe, B, Hulpiau, P, van Roy, F, De Bleser, P.
ConTra: a promoter alignment analysis tool for identification of transcription factor binding sites across species
Nucleic Acids Res 36, W128-132 , 2008. (Epub 2008 May 5)

van Hengel, J, D'hooge, P, Hooghe, B, Wu, X, Libbrecht, L, De Vos, R, Quondamatteo, F, Klempt, M, Brakebusch, C, van Roy, F.
Continuous cell injury promotes hepatic tumorigenesis in Cdc42-deficient mouse liver
Gastroenterology 134, 781-792, 2008. (Epub 2008 Jan 9)

De Bleser, PJ, Hooghe, B, Vlieghe, D, van Roy, F.
A distance difference matrix approach to the identification of transcription factors that regulate differential gene expression
Genome Biology 8, R83, 2007. (Epub 2007 May 16)

Vlieghe, D, Sandelin, A, De Bleser, P, Vleminckx, K, van Roy, F, Wasserman, W, Lenhard, B.
A new generation of JASPAR, the open-access repository for transcription factor binding site profiles
Nucl Acids Res 34, D95-D97, 2006. (Epub 2006 Jan 1)

Ameloot, P, Fiers, W, De Bleser, P, Ware, CF, Vandenabeele, P, Brouckaert, P.
Identification of tumor necrosis factor (TNF) amino acids crucial for binding to the murine p75 TNF receptor and construction of receptor-selective mutants
J Biol Chem 276, 37426-37430, 2001. (Epub 2001 Jul 11)