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Publications from this research unit

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Anderson, CJ, Medina, CB, Barron, BJ, Karvelyte, L, Aaes, TL, Lambertz, I, Perry, JSA, Mehrotra, P, Goncalves, A, Lemeire, K, Blancke, G, Andries, V, Ghazavi, F, Martens, A, van Loo, G, Vereecke, L, Vandenabeele, P, Ravichandran, KS.
Microbes exploit death-induced nutrient release by gut epithelial cells
Nature 596, 262-267, 2021. (Epub 2021 Aug 4)

Kiss, M, Vande Walle, L, Saavedra, PHV, Lebegge, E, Van Damme, H, Murgaski, A, Qian, J, Ehling, M, Pretto, S, Bolli, E, Keirsse, J, Bardet, PMR, Arnouk, SM, Elkrim, Y, Schmoetten, M, Brughmans, J, Debraekeleer, A, Fossoul, A, Boon, L, et al..
IL1beta Promotes Immune Suppression in the Tumor Microenvironment Independent of the Inflammasome and Gasdermin D
Cancer Immunol Res 9, 309-323, 2021. (Epub 2020 Dec 23)

Van Hove, L, Lecomte, K, Roels, J, Vandamme, N, Vikkula, HK, Hoorens, I, Ongenae, K, Hochepied, T, Donati, G, Saeys, Y, Quist, SR, Watt, FM, van Loo, G, Hoste, E.
Fibrotic enzymes modulate wound-induced skin tumorigenesis
EMBO Rep , e51573, 2021. (Epub 2021 Mar 29)

van Uden, D, Koudstaal, T, van Hulst, JAC, Bergen, IM, Gootjes, C, Morrell, NW, van Loo, G, von der Thusen, JH, van den Bosch, TPP, Ghigna, MR, Perros, F, Montani, D, Kool, M, Boomars, KA, Hendriks, RW.
Central Role of Dendritic Cells in Pulmonary Arterial Hypertension in Human and Mice
Int J Mol Sci 22, 1756, 2021. (Epub 2021 Feb 10)

Van Wyngene, L, Vanderhaeghen, T, Petta, I, Timmermans, S, Corbeels, K, Van der Schueren, B, Vandewalle, J, Van Looveren, K, Wallaeys, C, Eggermont, M, Dewaele, S, Catrysse, L, van Loo, G, Beyaert, R, Vangoitsenhoven, R, Nakayama, T, Tavernier, J, De Bosscher, K, Libert, C.
ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation
iScience 24, 102790, 2021. (Epub 2021 Jun 28)

Verboom, L, Hoste, E, van Loo, G.
OTULIN in NF-kappaB signaling, cell death, and disease
Trends Immunol 42, 590-603, 2021. (Epub 2021 May 29)

Koudstaal, T, van Hulst, JAC, Das, T, Neys, SFH, Merkus, D, Bergen, IM, de Raaf, MA, Bogaard, HJ, Boon, L, van Loo, G, Aerts, J, Boomars, KA, Kool, M, Hendriks, RW.
DNGR1-Cre-mediated Deletion of Tnfaip3/A20 in Conventional Dendritic Cells Induces Pulmonary Hypertension in Mice
Am J Respir Cell Mol Biol 63, 665-680, 2020. (Epub 2020 Aug 5)

Martens, A, Priem, D, Hoste, E, Vetters, J, Rennen, S, Catrysse, L, Voet, S, Deelen, L, Sze, M, Vikkula, H, Slowicka, K, Hochepied, T, Iliaki, K, Wullaert, A, Janssens, S, Lamkanfi, M, Beyaert, R, Armaka, M, Bertrand, MJM, et al..
Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities
Nat Immunol 21, 381-387, 2020. (Epub 2020 Mar 16)

Martens, A, van Loo, G.
A20 at the Crossroads of Cell Death, Inflammation, and Autoimmunity
Cold Spring Harb Perspect Biol 12, a036418, 2020. (Epub 2019 Aug 19)

Picard, M, Yonekura, S, Slowicka, K, Petta, I, Rauber, C, Routy, B, Richard, C, Iebba, V, Tidjani Alou, M, Becharef, S, Ly, P, Pizzato, E, Lehmann, CHK, Amon, L, Klein, C, Opolon, P, Gomperts Boneca, I, Scoazec, JY, Hollebecque, A, et al..
Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients
Cell Death Differ , in press, 2020. (Epub 2020 Dec 1)

Priem, D, van Loo, G, Bertrand, MJM.
A20 and Cell Death-driven Inflammation
Trends Immunol 41, 421-435, 2020. (Epub 2020 Mar 30)

Slowicka, K, Petta, I, Blancke, G, Hoste, E, Dumas, E, Sze, M, Vikkula, H, Radaelli, E, Haigh, J, Jonckheere, S, Taminau, J, Vandamme, N, Wullaert, A, Tulchinsky, E, Nittner, D, Van Vlierberghe, P, De Hertogh, G, Baldin, P, Etlioglu, E, et al. Berx, G, Vereecke, L, van Loo,G.
Zeb2 drives invasive and microbiota-dependent colon carcinoma
Nature Cancer 1, 620-634, 2020. (Epub 2020 Jun 15)

Verboom, L, Martens, A, Priem, D, Hoste, E, Sze, M, Vikkula, HK, Van Hove, L, Voet, S, Roels, J, Maelfait, J, Bongiovanni, L, de Bruin, A, Scott, CL, Saeys, Y, Pasparakis, M, Bertrand, MJM, van Loo, G.
OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis
Cell Rep 30, 2237-2247, 2020. (Epub 2020 Feb 18)

Vroman, H, van Uden, D, Bergen, IM, van Hulst, JAC, Lukkes, M, van Loo, G, Clausen, BE, Boon, L, Lambrecht, BN, Hammad, H, Hendriks, RW, Kool, M.
Tnfaip3 expression in pulmonary conventional type 1 Langerin-expressing dendritic cells regulates T helper 2-mediated airway inflammation in mice
Allergy 75, 2587-2598, 2020. (Epub 2020 Apr 23)

Das, T, Bergen, IM, Koudstaal, T, van Hulst, JAC, van Loo, G, Boonstra, A, Vanwolleghem, T, Leung, PSC, Gershwin, ME, Hendriks, RW, Kool, M.
DNGR1-mediated deletion of A20/Tnfaip3 in dendritic cells alters T and B-cell homeostasis and promotes autoimmune liver pathology
J Autoimmun 102, 167-178, 2019. (Epub 2019 May 28)

Devos, M, Mogilenko, DA, Fleury, S, Gilbert, B, Becquart, C, Quemener, S, Dehondt, H, Tougaard, P, Staels, B, Bachert, C, Vandenabeele, P, Van Loo, G, Staumont-Salle, D, Declercq, W, Dombrowicz, D.
Keratinocyte expression of A20/TNFAIP3 controls skin inflammation associated with atopic dermatitis and psoriasis
J Invest Dermatol 139, 135-145, 2019. (Epub 2018 Aug 14)

Dubois, H, Sorgeloos, F, Sarvestani, ST, Martens, L, Saeys, Y, Mackenzie, JM, Lamkanfi, M, van Loo, G, Goodfellow, I, Wullaert, A.
Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection
PLoS Pathog 15, e1007709, 2019. (Epub 2019 Apr 24)

Dubois, H, van Loo, G, Wullaert, A.
Nucleic Acid Induced Interferon and Inflammasome Responses in Regulating Host Defense to Gastrointestinal Viruses
Int Rev Cell Mol Biol 345, 137-171, 2019. (Epub 2018 Oct 3)

Hoste, E, Maueroder, C, van Hove, L, Catrysse, L, Vikkula, HK, Sze, M, Maes, B, Karjosukarso, D, Martens, L, Goncalves, A, Parthoens, E, Roelandt, R, Declercq, W, Fuentes, I, Palisson, F, Gonzalez, S, Salas-Alanis, JC, Boon, L, Huebener, P, et al..
Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils for NET Formation
Cell Rep 29, 2689-2701, 2019. (Epub 2019 Nov 26)

Mamantopoulos, M, Frising, UC, Asaoka, T, van Loo, G, Lamkanfi, M, Wullaert, A.
El Tor Biotype Vibrio cholerae Activates the Caspase-11-Independent Canonical Nlrp3 and Pyrin Inflammasomes
Front Immunol 10, 2463, 2019. (Epub 2019 Oct 29)

Martens, A, van Loo, G.
A20 phosphorylation controls A20 function
Nat Immunol 20, 1261-1262, 2019. (Epub 2019 Sep 18)

Masuda, T, Sankowski, R, Staszewski, O, Bottcher, C, Amann, L, Scheiwe, C, Nessler, S, Kunz, P, van Loo, G, Coenen, VA, Reinacher, PC, Michel, A, Sure, U, Gold, R, Priller, J, Stadelmann, C, Prinz, M.
Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution
Nature 566, 388-392, 2019. (Epub 2019 Feb 15)

Oules, B, Rognoni, E, Hoste, E, Goss, G, Fiehler, R, Natsuga, K, Quist, S, Mentink, R, Donati, G, Watt, FM.
Mutant Lef1 controls Gata6 in sebaceous gland development and cancer
EMBO J 38, e100526, 2019. (Epub 2019 Mar 20)

Polykratis, A, Martens, A, Eren, RO, Shirasaki, Y, Yamagishi, M, Yamaguchi, Y, Uemura, S, Miura, M, Holzmann, B, Kollias, G, Armaka, M, van Loo, G, Pasparakis, M.
A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain
Nat Cell Biol 21, 731-742, 2019. (Epub 2019 May 13)

Priem, D, Devos, M, Druwe, S, Martens, A, Slowicka, K, Ting, AT, Pasparakis, M, Declercq, W, Vandenabeele, P, van Loo, G, Bertrand, MJM.
A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms
Cell Death Dis 10, 692, 2019. (Epub 2019 Sep 18)

Rogiers, O, Frising, UC, Kucharikova, S, Jabra-Rizk, MA, van Loo, G, Van Dijck, P, Wullaert, A.
Candidalysin Crucially Contributes to Nlrp3 Inflammasome Activation by Candida albicans Hyphae
MBio 10, e02221-18, 2019. (Epub 2019 Jan 8)

Serramito-Gomez, I, Boada-Romero, E, Slowicka, K, Vereecke, L, van Loo, G, Pimentel-Muinos, FX.
The anti-inflammatory protein TNFAIP3/A20 binds the WD40 domain of ATG16L1 to control the autophagic response, NFKB/NF-kappaB activation and intestinal homeostasis
Autophagy 15, 1657-1659, 2019. (Epub 2019 Jun 11)

Slowicka, K, Serramito-Gomez, I, Boada-Romero, E, Martens, A, Sze, M, Petta, I, Vikkula, HK, De Rycke, R, Parthoens, E, Lippens, S, Savvides, SN, Wullaert, A, Vereecke, L, Pimentel-Muinos, FX, van Loo, G.
Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis
Nat Commun 10, 1834, 2019. (Epub 2019 Apr 23)

Vetters, J, van Helden, MJ, Wahlen, S, Tavernier, SJ, Martens, A, Fayazpour, F, Vergote, K, Vanheerswynghels, M, Deswarte, K, Van Moorleghem, J, De Prijck, S, Takahashi, N, Vandenabeele, P, Boon, L, van Loo, G, Vivier, E, Lambrecht, BN, Janssens, S.
The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF
J Exp Med 216, 2010-2023, 2019. (Epub 2019 Jul 11)

Voet, S, Prinz, M, van Loo, G.
Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology
Trends Mol Med 25, 112-123, 2019. (Epub 2018 Dec 18)

Voet, S, Srinivasan, S, Lamkanfi, M, van Loo, G.
Inflammasomes in neuroinflammatory and neurodegenerative diseases
EMBO Mol Med 11, e10248, 2019. (Epub 2019 Apr 23)

Catrysse, L, van Loo, G.
Adipose tissue macrophages and their polarization in health and obesity
Cell Immunol 330, 114-119, 2018. (Epub 2018 Mar 5)

Deckers, J, Hammad, H, Hoste, E.
Langerhans Cells: Sensing the Environment in Health and Disease
Frontiers in Immunology 9, 93, 2018. (Epub 2018 Feb 1)

Muliaditan, T, Caron, J, Okesola, M, Opzoomer, JW, Kosti, P, Georgouli, M, Gordon, P, Lall, S, Kuzeva, DM, Pedro, L, Shields, JD, Gillett, CE, Diebold, SS, Sanz-Moreno, V, Ng, T, Hoste, E, Arnold, JN.
Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis
Nat Commun 9, e2951, 2018. (Epub 2018 Jul 27)

Prabakaran, T, Bodda, C, Krapp, C, Zhang, BC, Christensen, MH, Sun, C, Reinert, L, Cai, Y, Jensen, SB, Skouboe, MK, Nyengaard, JR, Thompson, CB, Lebbink, RJ, Sen, GC, van Loo, G, Nielsen, R, Komatsu, M, Nejsum, LN, Jakobsen, MR, et al.
Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1
EMBO J 37, UNSP e97858, 2018. (Epub 2018 Mar 1)

Slowicka, K, van Loo, G.
Optineurin Functions for Optimal Immunity
Front Immunol 9, 769, 2018. (Epub 2018 Apr 10)

Van Quickelberghe, E, De Sutter, D, van Loo, G, Eyckerman, S, Gevaert, K.
A protein-protein interaction map of the TNF-induced NF-kappaB signal transduction pathway
Sci Data 5, 180289, 2018. (Epub 2018 Dec 18)

Van Quickelberghe, E, Martens, A, Goeminne, LJE, Clement, L, van Loo, G, Gevaert, K.
Identification of Immune-Responsive Gene 1 (IRG1) as a Target of A20
J Proteome Res 17, 2182-2191, 2018. (Epub 2018 May 11)

Voet, S, Mc Guire, C, Hagemeyer, N, Martens, A, Schroeder, A, Wieghofer, P, Daems, C, Staszewski, O, Vande Walle, L, Jordao, MJC, Sze, M, Vikkula, HK, Demeestere, D, Van Imschoot, G, Scott, CL, Hoste, E, Goncalves, A, Guilliams, M, Lippens, S, Libert, C, Vandenbroucke, RE, et al., Lamkanfi, M, Prinz, M, van Loo, G.
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation
Nat Commun 9, 2036, 2018. (Epub 2018 May 23)

Voytyuk, I, Mueller, SA, Herber, J, Snellinx, A, Moechars, D, van Loo, G, Lichtenthaler, SF, De Strooper, B.
BACE2 distribution in major brain cell types and identification of novel substrates
Life Science Alliance 1, e201800026 , 2018. (Epub 2018 Feb 15)

Vroman, H, Bergen, IM, van Hulst, JAC, van Nimwegen, M, van Uden, D, Schuijs, MJ, Pillai, SY, van Loo, G, Hammad, H, Lambrecht, BN, Hendriks, RW, Kool, M.
TNFAIP3 levels in lung dendritic cells instruct Th2 or Th17 cell differentiation in eosinophilic or neutrophilic asthma
J Allergy Clin Immunol 141, 1620-1633, 2018. (Epub 2017 Sep 6)

Vroman, H, Das, T, Bergen, IM, van Hulst, JAC, Ahmadi, F, van Loo, G, Lubberts, E, Hendriks, RW, Kool, M.
House dust mite-driven neutrophilic airway inflammation in mice with TNFAIP3-deficient myeloid cells is IL-17-independent
Clin Exp Allergy 48, 1705-1714, 2018. (Epub 2018 Sep 1)

Catrysse, L, van Loo, G.
Inflammation and the Metabolic Syndrome: The Tissue-Specific Functions of NF-kappaB
Trends Cell Biol 27, 417-429, 2017. (Epub 2017 Feb 22)

Deckers, J, Sichien, D, Plantinga, M, Van Moorleghem, J, Vanheerswynghels, M, Hoste, E, Malissen, B, Dombrowicz, D, Guilliams, M, De Bosscher, K, Lambrecht, BN, Hammad, H.
Epicutaneous sensitization to house dust mite allergen requires IRF4-dependent dermal dendritic cells
J Allergy Clin Immunol 140, 1364-1377, 2017. (Epub 2017 Feb 9)

De Wilde, K, Martens, A, Lambrecht, S, Jacques, P, Drennan, MB, Debusschere, K, Govindarajan, S, Coudenys, J, Verheugen, E, Windels, F, Catrysse, L, Lories, R, McGonagle, D, Beyaert, R, van Loo, G, Elewaut, D.
A20 inhibition of STAT1 expression in myeloid cells: a novel endogenous regulatory mechanism preventing development of enthesitis
Ann Rheum Dis 76, 585-592, 2017. (Epub 2016 Aug 22)

Donati, G, Rognoni, E, Hiratsuka, T, Liakath-Ali, K, Hoste, E, Kar, G, Kayikci, M, Russell, R, Kretzschmar, K, Mulder, KW, Teichmann, SA, Watt, FM.
Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties
Nat Cell Biol 19, 603-613, 2017. (Epub 2017 May 15)

Fischer, JC, Otten, V, Kober, M, Drees, C, Rosenbaum, M, Schmickl, M, Heidegger, S, Beyaert, R, van Loo, G, Li, XC, Peschel, C, Schmidt-Supprian, M, Haas, T, Spoerl, S, Poeck, H.
A20 Restrains Thymic Regulatory T Cell Development
J Immunol 199, 2356-2365, 2017. (Epub 2017 Aug 25)

Fischer, JC, Otten, V, Steiger, K, Schmickl, M, Slotta-Huspenina, J, Beyaert, R, van Loo, G, Peschel, C, Poeck, H, Haas, T, Spoerl, S.
A20 deletion in T cells modulates acute graft-versus-host disease in mice
Eur J Immunol 47, 1982-1988, 2017. (Epub 2017 Aug 22)

Kaushal, G, Rognoni, E, Lichtenberger, BM, Driskell, RR, Kretzschmar, K, Hoste, E, Watt, FM.
Stabilization of beta-Catenin Does Not Increase Dermal Papilla Cell Number in the Hair Follicle Reply
J Invest Dermatol 137, 247-248, 2017. (Epub 2017 Jan)

Lee, JH, Jung, SM, Yang, KM, Bae, E, Ahn, SG, Park, JS, Seo, D, Kim, M, Ha, J, Lee, J, Kim, JH, Kim, JH, Ooshima, A, Park, J, Shin, D, Lee, YS, Lee, S, van Loo, G, Jeong, J, et al..
A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1
Nat Cell Biol 19, 1260-1273, 2017. (Epub 2017 Sep 11)

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