Publications from this research unit

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Skordos, I, Driege, Y, Haegman, M, Kreike, M, Staal, J, Demeyer, A, Beyaert, R.
Normal lymphocyte homeostasis and function in MALT1 protease-resistant HOIL-1 knock-in mice
FEBS J 290, 2032-2048, 2023. (Epub 2022 Dec 7)

Kim, SW, Alci, K, Van Gaever, F, Driege, Y, Bicalho, K, Goeminne, G, Libert, C, Goossens, A, Beyaert, R, Staal, J.
Engineering a highly sensitive biosensor for abscisic acid in mammalian cells
FEBS Lett , in press, 2022. (Epub 2022 Jun 21)

Su, J, Lu, YJ, Staal, J, Ludwikow, A.
Editorial: Protein phosphorylation and dephosphorylation in plant-microbe interactions
Front Plant Sci 13, 1020772, 2022. (Epub 2022 Sep 9)

Vanneste, D, Staal, J, Haegman, M, Driege, Y, Carels, M, Van Nuffel, E, De Bleser, P, Saeys, Y, Beyaert, R, Afonina, IS.
CARD14 Signalling Ensures Cell Survival and Cancer Associated Gene Expression in Prostate Cancer Cells
Biomedicines 10, 2008, 2022. (Epub 2022 Aug 18)

Pieters, T, T'Sas, S, Vanhee, S, Almeida, A, Driege, Y, Roels, J, Van Loocke, W, Daneels, W, Baens, M, Marchand, A, Van Trimpont, M, Matthijssens, F, Morscio, J, Lemeire, K, Lintermans, B, Reunes, L, Chaltin, P, Offner, F, Van Dorpe, J, et al..
Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice
J Exp Med 218, e20202280, 2021. (Epub 2021 Oct 4)

Beziat, V, Tavernier, SJ, Chen, YH, Ma, CS, Materna, M, Laurence, A, Staal, J, Aschenbrenner, D, Roels, L, Worley, L, Claes, K, Gartner, L, Kohn, LA, De Bruyne, M, Schmitz-Abe, K, Charbonnier, LM, Keles, S, Nammour, J, Vladikine, N, et al..
Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome
J Exp Med 217, e20191804, 2020. (Epub 2020 Mar 24)

Braun, H, Staal, J.
Stabilization of the TAK1 adaptor proteins TAB2 and TAB3 is critical for optimal NF-kappaB activation
FEBS J 287, 3161-3164, 2020. (Epub 2020 Jan 29)

Demeyer, A, Driege, Y, Skordos, I, Coudenys, J, Lemeire, K, Elewaut, D, Staal, J, Beyaert, R.
Long-Term MALT1 Inhibition in Adult Mice Without Severe Systemic Autoimmunity
iScience 23, 101557, 2020. (Epub 2020 Sep 12)

Kim, S.W, Goossens, A, Libert, C, Van Immerseel, F, Staal, J, Beyaert, R.
Phytohormones: Multifunctional nutraceuticals against metabolic syndrome and comorbid diseases
Biochem Pharmacol 175, 113866, 2020. (Epub 2020 Feb 20)

Minina, EA, Staal, J, Alvarez, VE, Berges, JA, Berman-Frank, I, Beyaert, R, Bidle, KD, Bornancin, F, Casanova, M, Cazzulo, JJ, Choi, CJ, Coll, NS, Dixit, VM, Dolinar, M, Fasel, N, Funk, C, Gallois, P, Gevaert, K, Gutierrez-Beltran, E, et al..
Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases
Mol Cell 77, 927-929, 2020. (Epub 2020 Mar 5)

Staal, J.
Fytohormonen : verschillende bioactieve moleculen die metabolisme en ontsteking beïnvloeden in de mens
Bloedvaten, Hart, Longen 25, 32 - 35, 2020. (Epub 2020)

Van Nuffel, E, Staal, J, Baudelet, G, Haegman, M, Driege, Y, Hochepied, T, Afonina, IS, Beyaert, R.
MALT1 targeting suppresses CARD14-induced psoriatic dermatitis in mice
EMBO Rep 21, e49237, 2020. (Epub 2020 Apr 28)

Demeyer, A, Skordos, I, Driege, Y, Kreike, M, Hochepied, T, Baens, M, Staal, J, Beyaert, R.
MALT1 Proteolytic Activity Suppresses Autoimmunity in a T Cell Intrinsic Manner
Front Immunol 10, 1898, 2019. (Epub 2019 Aug 14)

Demeyer, A, Van Nuffel, E, Baudelet, G, Driege, Y, Kreike, M, Muyllaert, D, Staal, J, Beyaert, R.
MALT1-Deficient Mice Develop Atopic-Like Dermatitis Upon Aging
Front Immunol 10, 2330, 2019. (Epub 2019 Oct 1)

Gilis, E, Gaublomme, D, Staal, J, Venken, K, Dhaenens, M, Lambrecht, S, Coudenys, J, Decruy, T, Schryvers, N, Driege, Y, Dumas, E, Demeyer, A, De Muynck, A, van Hengel, J, Van Hoorebeke, L, Deforce, D, Beyaert, R, Elewaut, D.
Deletion of Mucosa‐Associated Lymphoid Tissue Lymphoma Translocation Protein 1 in Mouse T Cells Protects Against Development of Autoimmune Arthritis but Leads to Spontaneous Osteoporosis
Arthritis Rheumatol 71, 2005-2015, 2019. (Epub 2019 Jul 1)

Lork, M, Staal, J, Beyaert, R.
Ubiquitination and phosphorylation of the CARD11-BCL10-MALT1 signalosome in T cells
Cell Immunol 340, 103877, 2019. (Epub 2018 Nov 9)

Staal, J, Alci, K, De Schamphelaire, W, Vanhoucke, M, Beyaert, R.
Engineering a minimal cloning vector from a pUC18 plasmid backbone with an extended multiple cloning site
Biotechniques 66, 254-259, 2019. (Epub 2019 May 24)

Tavernier, SJ, Athanasopoulos, V, Verloo, P, Behrens, G, Staal, J, Bogaert, DJ, Naesens, L, De Bruyne, M, Van Gassen, S, Parthoens, E, Ellyard, J, Cappello, J, Morris, LX, Van Gorp, H, Van Isterdael, G, Saeys, Y, Lamkanfi, M, Schelstraete, P, Dehoorne, J, et al..
A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation
Nat Commun 10, 4779, 2019. (Epub 2019 oct 21)

De Bruyne, M, Hoste, L, Bogaert, DJ, Van den Bossche, L, Tavernier, SJ, Parthoens, E, et al., Lambrecht, BN, van Daele, S, Alves de Medeiros, AK, Brochez, L, Beyaert, R, De Baere, E, Puel, A, Casanova, JL, Goffard, JC, Savvides, SN, et al., Staal, J, et al.
A CARD9 Founder Mutation Disrupts NF-kappaB Signaling by Inhibiting BCL10 and MALT1 Recruitment and Signalosome Formation
Front Immunol 9, 2366, 2018. (Epub 2018 Oct 31)

Gul, IS, Staal, J, Hulpiau, P, De Keuckelaere, E, Kamm, K, Deroo, T, Sanders, E, Staes, K, Driege, Y, Saeys, Y, Beyaert, R, Technau, U, Schierwater, B, Van Roy, F.
GC content of early metazoan genes and its impact on gene expression levels in mammalian cell lines
Genome biology and Evolution 10, 909–917, 2018. (Epub 2018 Feb 21)

Kip, E, Staal, J, Tima, HG, Verstrepen, L, Romano, M, Lemeire, K, Suin, V, Hamouda, A, Baens, M, Libert, C, Kalai, M, Van Gucht, S, Beyaert, R.
Inhibition of MALT1 decreases neuroinflammation and pathogenicity of virulent rabies virus in mice
J Virol 92, e00720-18, 2018. (Epub 2018 Aug 29)

Kip, E, Staal, J, Verstrepen, L, Tima, HG, Terryn, S, Romano, M, Lemeire, K, Suin, V, Hamouda, A, Kalai, M, Beyaert, R, Van Gucht, S.
MALT1 controls attenuated rabies virus by inducing early inflammation and T cell activation in the brain
J Virol 92, e02029-17, 2018. (Epub 2018 Jan 26)

Lork, M, Kreike, M, Staal, J, Beyaert, R.
Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies-T Cell Receptor-Induced CYLD Phosphorylation by IKKepsilon/TBK1 as a Case Study
Front Cell Dev Biol 6, 40, 2018. (Epub 2018 Apr 10)

Meloni, L, Verstrepen, L, Kreike, M, Staal, J, Driege, Y, Afonina, IS, Beyaert, R.
Mepazine Inhibits RANK-Induced Osteoclastogenesis Independent of Its MALT1 Inhibitory Function
Molecules 23, 3144, 2018. (Epub 2018 Nov 30)

Staal, J, Beyaert, R.
Inflammation and NF-kappaB Signaling in Prostate Cancer: Mechanisms and Clinical Implications
Cells 7, 122, 2018. (Epub 2018 Aug 29)

Staal, J, Driege, Y, Haegman, M, Borghi, A, Hulpiau, P, Lievens, L, Gul, IS, Sundararaman, S, Goncalves, A, Dhondt, I, Pinzon, JH, Braeckman, BP, Technau, U, Saeys, Y, van Roy, F, Beyaert, R.
Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions
Front Immunol 9, 1136, 2018. (Epub 2018 May 24)

Lievens, L, Pollier, J, Goossens, A, Beyaert, R, Staal, J.
Abscisic Acid as Pathogen Effector and Immune Regulator
Front Plant Sci 8, 587, 2017. (Epub 2017 Apr 19)

Staal, J.
Applied Cultural and Social Studies are Needed for a Sustainable Reduction of Genetic Disease Incidence
European Journal of Sociology and Anthropology 2, 1, 2017. (Epub 2017 Jun 15)

Afonina, IS, Van Nuffel, E, Baudelet, G, Driege, Y, Kreike, M, Staal, J, Beyaert, R.
The paracaspase MALT1 mediates CARD14-induced signaling in keratinocytes
EMBO Rep 17, 914-927, 2016. (Epub 2016 Apr 25)

Demeyer, A, Staal, J, Beyaert, R.
Targeting MALT1 Proteolytic Activity in Immunity, Inflammation and Disease: Good or Bad?
Trends Mol Med 22, 135-150, 2016. (Epub 2016 Jan 16)

Drennan, MB, Govindarajan, S, Verheugen, E, Coquet, JM, Staal, J, McGuire, C, Taghon, T, Leclercq, G, Beyaert, R, van Loo, G, Lambrecht, BN, Elewaut, D.
NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20
J Exp Med 213, 1973-1981, 2016. (Epub 2016 Aug 22)

Elton, L, Carpentier, I, Staal, J, Driege, Y, Haegman, M, Beyaert, R.
MALT1 cleaves the E3 ubiquitin ligase HOIL-1 in activated T cells, generating a dominant negative inhibitor of LUBAC-induced NF-kappaB signaling
FEBS J 283, 403-412, 2016. (Epub 2015 Nov 17)

Hulpiau, P, Driege, Y, Staal, J, Beyaert, R.
MALT1 is not alone after all: identification of novel paracaspases
Cell Mol Life Sci 1103-1116, 73, 2016. (Epub 2015 Sep 16)

Elton, L, Carpentier, I, Verhelst, K, Staal, J, Beyaert, R.
The multifaceted role of the E3 ubiquitin ligase HOIL-1: beyond linear ubiquitination
Immunol Rev 266, 208-221, 2015. (Epub 2015 Jul)

Mc Guire, C, Elton, L, Wieghofer, P, Staal, J, Voet, S, Demeyer, A, Nagel, D, Krappmann, D, Prinz, M, Beyaert, R, van Loo, G.
Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis
J Neuroinflamm 11, 124, 2014. (Epub 2014 Jul 21)

Oide, S, Bejai, S, Staal, J, Guan, N, Kaliff, M, Dixelius, C.
A novel role of PR2 in abscisic acid (ABA) mediated, pathogen-induced callose deposition in Arabidopsis thaliana
New Phytol 200, 1187-1199, 2013. (Epub 2013 Aug 19)

Staal, J, Beyaert, R.
A two-step activation mechanism of MALT1 paracaspase: Commentary on 'Structural determinants of MALT1 protease activity' by Wiesmann et al
J Mol Biol 419, 1-3, 2012. (Epub 2012 Mar 15)

Staal, J, Bekaert, T, Beyaert, R.
Regulation of NF-kB signalling by caspases and MALT1 paracaspase
Cell Res 21, 40-54, 2011. (Epub 2010 Nov 30)

Staal, J, Driege, Y, Bekaert, T, Demeyer, A, Muyllaert, D, Van Damme, P, Gevaert, K, Beyaert, R.
T cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1
EMBO J 30, 1742-1752, 2011. (Epub 2011 Mar 29)

Malinverni, C, Unterreiner, A, Staal, J, Demeyer, A, Galaup, M, Luyten, M, Beyaert, R, Bornancin, F.
Cleavage by MALT1 induces cytosolic release of A20
Biochem Biophys Res Commun 400, 543-547, 2010. (Epub 2010 Aug 27)

Staal, J, Dixelius, C.
Plant innate immunity
In Encyclopedia of Life Sciences. Chichester, Wiley & Sons, DOI: 10.1002/9780470015902.a0020114, 2009. (Epub 2009 Mar)

Coornaert, B, Baens, M, Heyninck, K, Bekaert, T, Haegman, M, Staal, J, Sun, L, Chen, ZJ, Marynen, P, Beyaert, R.
T cell receptor stimulation induces MALT1 paracaspase mediated cleavage of A20
Nature Immunol 9, 263-271 , 2008. (Epub 2008 Jan 27)

Staal, J, Dixelius, C.
RLM3, a potential adaptor between specific TIR-NB-LRR receptors and DZC proteins
Commun Integr Biol 1, 59-61, 2008. (Epub 2008 Jun 17)

Staal, J, Kaliff, M, Dewaele, E, Persson, M, Dixelius, C.
RLM3, a TIR domain-encoding gene involved in broad-range immunity of Arabidopsis to necrotrophic fungal pathogens
Plant J 55, 188-200, 2008. (Epub 2008 Apr 4)

Vercammen, E, Staal, J, Beyaert, R.
Sensing of viral infection and activation of innate immunity by Toll-like receptor 3 (TLR3)
Clin Microbiol Rev 21, 13-25, 2008. (Epub ---)

Vercammen, E, Staal, J, Van Den Broeke, A, Haegman, M, Vereecke, L, Schotte, P, Beyaert, R.
Prolonged exposure to IL-1b and IFNc induces necrosis of L929 tumor cells via a p38MAPK/NF-jB/NO-dependent mechanism
Oncogene 27, 3780-3788, 2008. (Epub ---)