Publications from this research unit

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Puttemans, J, Stijlemans, B, Keyaerts, M, Vander Meeren, S, Renmans, W, Fostier, K, Debie, P, Hanssens, H, Rodak, M, Pruszynski, M, De Veirman, K, Vanderkerken, K, Lahoutte, T, Morgenstern, A, Bruchertseifer, F, Devoogdt, N, D'Huyvetter, M.
The Road to Personalized Myeloma Medicine: Patient-specific Single-domain Antibodies for Anti-idiotypic Radionuclide Therapy
Mol Cancer Ther 21, 159-169, 2022. (Epub 2021 Oct 19)

Ackaert, C, Smiejkowska, N, Xavier, C, Sterckx, YGJ, Denies, S, Stijlemans, B, Elkrim, Y, Devoogdt, N, Caveliers, V, Lahoutte, T, Muyldermans, S, Breckpot, K, Keyaerts, M.
Immunogenicity Risk Profile of Nanobodies
Front Immunol 12, 632687, 2021. (Epub 2021 Mar 9)

Andries, L, Masin, L, Navarro, MS, Zaunz, S, Claes, M, Bergmans, S, Brouwers, V, Lefevere, E, Verfaillie, C, Movahedi, K, De Groef, L, Moons, L.
MMP2 Modulates Inflammatory Response during Axonal Regeneration in the Murine Visual System
Cells 10, 1672, 2021. (Epub 2021 Jul 2)

Awad, RM, Lecocq, Q, Zeven, K, Ertveldt, T, De Beck, L, Ceuppens, H, Broos, K, De Vlaeminck, Y, Goyvaerts, C, Verdonck, M, Raes, G, Van Parys, A, Cauwels, A, Keyaerts, M, Devoogdt, N, Breckpot, K.
Formatting and gene-based delivery of a human PD-L1 single domain antibody for immune checkpoint blockade
Mol Ther Methods Clin Dev 22, 172-182, 2021. (Epub 2021 Sep 10)

Baudhuin, H, Cousaert, J, Vanwolleghem, P, Raes, G, Caveliers, V, Keyaerts, M, Lahoutte, T, Xavier, C.
(68)Ga-Labeling: Laying the Foundation for an Anti-Radiolytic Formulation for NOTA-sdAb PET Tracers
Pharmaceuticals (Basel) 14, 448, 2021. (Epub 2021 May 10)

Baudhuin, H, Puttemans, J, Hanssens, H, Vanwolleghem, P, Hernot, S, Raes, G, Xavier, C, Lahoutte, T, Debie, P.
Decorating sdAbs with Chelators: Effect of Conjugation on Biodistribution and Functionality
Pharmaceuticals (Basel) 14, 407, 2021. (Epub 2021 Apr 25)

Baudhuin, H, Van Bockstal, PJ, De Beer, T, Vaneycken, I, Bridoux, J, Raes, G, Caveliers, V, Keyaerts, M, Devoogdt, N, Lahoutte, T, Xavier, C.
Lyophilization of NOTA-sdAbs: first step towards a cold diagnostic kit for (68)Ga-labeling
Eur J Pharm Biopharm , in press, 2021. (Epub 2021 Jun 26)

Bolli, E, Scherger, M, Arnouk, SM, Pombo Antunes, AR, Strassburger, D, Urschbach, M, Stickdorn, J, De Vlaminck, K, Movahedi, K, Rader, HJ, Hernot, S, Besenius, P, Van Ginderachter, JA, Nuhn, L.
Targeted Repolarization of Tumor-Associated Macrophages via Imidazoquinoline-Linked Nanobodies
Adv Sci (Weinh) 8, 2004574, 2021. (Epub 2021 Mar 8)

Carbo, JM, Leon, TE, Font-Diaz, J, De la Rosa, JV, Castrillo, A, Picard, FR, Staudenraus, D, Huber, M, Cedo, L, Escola-Gil, JC, Campos, L, Bakiri, L, Wagner, EF, Caelles, C, Stratmann, T, Van Ginderachter, JA, Valledor, AF.
Pharmacological activation of LXR alters the expression profile of tumor-associated macrophages and the abundance of regulatory T cells in the tumor microenvironment
Cancer Res 81, 968-985, 2021. (Epub 2020 Dec 23)

De Vlaminck, K, Romao, E, Puttemans, J, Pombo Antunes, AR, Kancheva, D, Scheyltjens, I, Van Ginderachter, JA, Muyldermans, S, Devoogdt, N, Movahedi, K, Raes, G.
Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha
Front Immunol 12, 777524, 2021. (Epub 2021 Nov 30)

Geeraerts, X, Fernandez-Garcia, J, Hartmann, FJ, de Goede, KE, Martens, L, Elkrim, Y, Debraekeleer, A, Stijlemans, B, Vandekeere, A, Rinaldi, G, De Rycke, R, Planque, M, Broekaert, D, Meinster, E, Clappaert, E, Bardet, P, Murgaski, A, Gysemans, C, Nana, FA, et al..
Macrophages are metabolically heterogeneous within the tumor microenvironment
Cell Rep 37, 110171, 2021. (Epub 2021 Dec 28)

Germanova, D, Keirsse, J, Kohler, A, Hastir, JF, Demetter, P, Delbauve, S, Elkrim, Y, Verset, L, Larbanoix, L, Preyat, N, Laurent, S, Nedospasov, S, Donckier, V, Van Ginderachter, JA, Flamand, V.
Myeloid TNF and HO-1 regulate the progression of colorectal liver metastases during hepatic ischemia-reperfusion
Int J Cancer 148, 1276–1288, 2021. (Epub 2020 Oct 10)

Kim, JS, Kolesnikov, M, Peled-Hajaj, S, Scheyltjens, I, Xia, Y, Trzebanski, S, Haimon, Z, Shemer, A, Lubart, A, Van Hove, H, Chappell-Maor, L, Boura-Halfon, S, Movahedi, K, Blinder, P, Jung, S.
A Binary Cre Transgenic Approach Dissects Microglia and CNS Border-Associated Macrophages
Immunity 54, 176-190, 2021. (Epub 2020 Dec 16)

Kiss, M, Vande Walle, L, Saavedra, PHV, Lebegge, E, Van Damme, H, Murgaski, A, Qian, J, Ehling, M, Pretto, S, Bolli, E, Keirsse, J, Bardet, PMR, Arnouk, SM, Elkrim, Y, Schmoetten, M, Brughmans, J, Debraekeleer, A, Fossoul, A, Boon, L, et al..
IL1beta Promotes Immune Suppression in the Tumor Microenvironment Independent of the Inflammasome and Gasdermin D
Cancer Immunol Res 9, 309-323, 2021. (Epub 2020 Dec 23)

Lahmar, Q, Schouppe, E, Morias, Y, Van Overmeire, E, De Baetselier, P, Movahedi, K, Laoui, D, Sarukhan, A, Van Ginderachter, JA.
Monocytic myeloid-derived suppressor cells home to tumor-draining lymph nodes via CCR2 and locally modulate the immune response
Cell Immunol 362, 104296, 2021. (Epub 2021 Jan 30)

Lecocq, Q, Awad, RM, De Vlaeminck, Y, De Mey, W, Ertveldt, T, Goyvaerts, C, Raes, G, Thielemans, K, Keyaerts, M, Devoogdt, N, Breckpot, K.
Nanobody nuclear imaging allows noninvasive quantification of LAG-3 expression by tumor-infiltrating leukocytes and predicts response of immune checkpoint blockade
J Nucl Med , in press, 2021. (Epub 2021 Mar 12)

Lecocq, Q, Debie, P, Puttemans, J, Awad, RM, De Beck, L, Ertveldt, T, De Vlaeminck, Y, Goyvaerts, C, Raes, G, Keyaerts, M, Breckpot, K, Devoogdt, N.
Evaluation of single domain antibodies as nuclear tracers for imaging of the immune checkpoint receptor human lymphocyte activation gene-3 in cancer
EJNMMI Res 11, 115, 2021. (Epub 2021 Nov 2)

Lodder, C, Scheyltjens, I, Stancu, IC, Botella Lucena, P, Gutierrez de Rave, M, Vanherle, S, Vanmierlo, T, Cremers, N, Vanrusselt, H, Brone, B, Hanseeuw, B, Octave, JN, Bottelbergs, A, Movahedi, K, Dewachter, I.
CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia
Acta Neuropathol Commun 9, 108, 2021. (Epub 2021 Jun 8)

Pombo Antunes, AR, Scheyltjens, I, Lodi, F, Messiaen, J, Antoranz, A, Duerinck, J, Kancheva, D, Martens, L, De Vlaminck, K, Van Hove, H, Kjolner Hansen, SS, Bosisio, FM, Van der Borght, K, De Vleeschouwer, S, Sciot, R, Bouwens, L, Verfaillie, M, Vandamme, N, Vandenbroucke, RE, et al..
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization
Nat Neurosci 24, 595-610, 2021. (Epub 2021 Mar 29)

Reijmen, E, De Mey, S, Van Damme, H, De Ridder, K, Gevaert, T, De Blay, E, Bouwens, L, Collen, C, Decoster, L, De Couck, M, Laoui, D, De Greve, J, De Ridder, M, Gidron, Y, Goyvaerts, C.
Transcutaneous Vagal Nerve Stimulation Alone or in Combination With Radiotherapy Stimulates Lung Tumor Infiltrating Lymphocytes But Fails to Suppress Tumor Growth
Front Immunol 12, 772555, 2021. (Epub 2021 Dec 1)

Van Damme, H, Dombrecht, B, Kiss, M, Roose, H, Allen, E, Van Overmeire, E, Kancheva, D, Martens, L, Murgaski, A, Bardet, PMR, Blancke, G, Jans, M, Bolli, E, Martins, MS, Elkrim, Y, Dooley, J, Boon, L, Schwarze, JK, Tacke, F, Movahedi, K, Vandamme, N, Neyns, B, Ocak, S, Scheyltjens, I, Vereecke, L, Nana, FA, Merchiers, P, Laoui, D, Van Ginderachter, JA.
Therapeutic depletion of CCR8(+) tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy
J Immunother Cancer 9, e001749, 2021. (Epub 2021 Feb)

Virga, F, Cappellesso, F, Stijlemans, B, Henze, AT, Trotta, R, Van Audenaerde, J, Mirchandani, AS, Sanchez-Garcia, MA, Vandewalle, J, Orso, F, Riera-Domingo, C, Griffa, A, Ivan, C, Smits, E, Laoui, D, Martelli, F, Langouche, L, Van den Berghe, G, Feron, O, et al..
Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation
Sci Adv 7, eabf0466, 2021. (Epub 2021 May 7)

Zheng, F, Zhou, J, Ouyang, Z, Zhang, J, Wang, X, Muyldermans, S, Van Ginderachter, J, Devoogdt, N, Wen, Y, Schoonooghe, S, Raes, G.
Development and Characterization of Nanobodies Targeting the Kupffer Cell
Front Immunol 12, 641819, 2021. (Epub 2021 Feb 22)

Bridoux, J, Broos, K, Lecocq, Q, Debie, P, Martin, C, Ballet, S, Raes, G, Neyt, S, Vanhove, C, Breckpot, K, Devoogdt, N, Caveliers, V, Keyaerts, M, Xavier, C.
Anti-human PD-L1 Nanobody for Immuno-PET Imaging: Validation of a Conjugation Strategy for Clinical Translation
Biomolecules 10, E1388, 2020. (Epub 2020 Sep 29)

Deschoemaeker, S, Laoui, D.
IFNgamma signaling response in peripheral blood monocytes: A new prognostic biomarker for breast cancer?
EBioMedicine 53, 102690, 2020. (Epub 2020 Feb 25)

De Trez, C, Stijlemans, B, Bockstal, V, Cnops, J, Korf, H, Van Snick, J, Caljon, G, Muraille, E, Humphreys, IR, Boon, L, Van Ginderachter, JA, Magez, S.
A Critical Blimp-1-Dependent IL-10 Regulatory Pathway in T Cells Protects From a Lethal Pro-inflammatory Cytokine Storm During Acute Experimental Trypanosoma brucei Infection
Front Immunol 11, 1085, 2020. (Epub 2020 Jun 4)

De Vlaeminck, Y, Bonelli, S, Awad, RM, Dewilde, M, Rizzolio, S, Lecocq, Q, Bolli, E, Santos, AR, Laoui, D, Schoonooghe, S, Tamagnone, L, Goyvaerts, C, Mazzone, M, Breckpot, K, Van Ginderachter, JA.
Targeting Neuropilin-1 with Nanobodies Reduces Colorectal Carcinoma Development
Cancers (Basel) 12, 3582, 2020. (Epub 2020 Nov 30)

D'Huyvetter, M, De Vos, J, Caveliers, V, Vaneycken, I, Heemskerk, J, Duhoux, FP, Fontaine, C, Vanhoeij, M, Windhorst, AD, van der Aa, F, Hendrikse, NH, Eersels, JLE, Everaert, H, Gykiere, P, Devoogdt, N, Raes, G, Lahoutte, T, Keyaerts, M.
Phase I trial of (131)I-GMIB-Anti-HER2-VHH1, a new promising candidate for HER2-targeted radionuclide therapy in breast cancer patients
J Nucl Med , in press, 2020. (Epub 2020 Dec 4)

Kiss, M, Caro, AA, Raes, G, Laoui, D.
Systemic Reprogramming of Monocytes in Cancer
Front Oncol 10, 1399, 2020. (Epub 2020 Sep 17)

Lebegge, E, Arnouk, SM, Bardet, PMR, Kiss, M, Raes, G, Van Ginderachter, JA.
Innate Immune Defense Mechanisms by Myeloid Cells That Hamper Cancer Immunotherapy
Front Immunol 11, 1395, 2020. (Epub 2020 Jul 09)

Li, Z, Pinto Torres, JE, Goossens, J, Stijlemans, B, Sterckx, YG, Magez, S.
Development of a recombinase polymerase amplification lateral flow assay for the detection of active Trypanosoma evansi infections
PLoS Negl Trop Dis 14, e0008044, 2020. (Epub 2020 Feb 18)

Nguyen, PN, Tossounian, MA, Kovacs, DS, Thu, TT, Stijlemans, B, Vertommen, D, Pauwels, J, Gevaert, K, Angenon, G, Messens, J, Tompa, P.
Dehydrin ERD14 activates glutathione transferase Phi9 in Arabidopsis thaliana under osmotic stress
Biochim Biophys Acta Gen Subj 1864, 129506, 2020. (Epub 2019 Dec 20)

Pombo Antunes, AR, Scheyltjens, I, Duerinck, J, Neyns, B, Movahedi, K, Van Ginderachter, JA.
Understanding the glioblastoma immune microenvironment as basis for the development of new immunotherapeutic strategies
Elife 9, e52176, 2020. (Epub 2020 Feb 4)

Qian, J, Olbrecht, S, Boeckx, B, Vos, H, Laoui, D, Etlioglu, E, Wauters, E, Pomella, V, Verbandt, S, Busschaert, P, Bassez, A, Franken, A, Bempt, MV, Xiong, J, Weynand, B, van Herck, Y, Antoranz, A, Bosisio, FM, Thienpont, B, et al..
A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling
Cell Res 30, 745-762, 2020. (Epub 2020 Jun 19)

Raaymakers, C, Stijlemans, B, Martin, C, Zaman, S, Ballet, S, Martel, A, Pasmans, F, Roelants, K.
A New Family of Diverse Skin Peptides from the Microhylid Frog Genus Phrynomantis
Molecules 25, 912, 2020. (Epub 2020 Feb 18)

Romao, E, Krasniqi, A, Maes, L, Vandenbrande, C, Sterckx, YG, Stijlemans, B, Vincke, C, Devoogdt, N, Muyldermans, S.
Identification of Nanobodies against the Acute Myeloid Leukemia Marker CD33
Int J Mol Sci 21, 310, 2020. (Epub 2020 Jan 2)

Scherger, M, Bolli, E, Pombo Antunes, AR, Arnouk, S, Stickdorn, J, Van Driessche, A, Schild, H, Grabbe, S, De Geest, BG, Van Ginderachter, JA, Nuhn, L.
Transient Multivalent Nanobody Targeting to CD206-Expressing Cells via PH-Degradable Nanogels
Cells 9, E2222, 2020. (Epub 2020 Oct 1)

Shemer, A, Scheyltjens, I, Frumer, GR, Kim, JS, Grozovski, J, Ayanaw, S, Dassa, B, Van Hove, H, Chappell-Maor, L, Boura-Halfon, S, Leshkowitz, D, Mueller, W, Maggio, N, Movahedi, K, Jung, S.
Interleukin-10 Prevents Pathological Microglia Hyperactivation following Peripheral Endotoxin Challenge
Immunity 53, 1033-1049 e7, 2020. (Epub 2020 Oct 12)

Stijlemans, B, Korf, H, De Baetselier, P, Brys, L, Van Ginderachter, JA, Magez, S, De Trez, C.
Hepatocyte-derived IL-10 plays a crucial role in attenuating pathogenicity during the chronic phase of T. congolense infection
PLoS Pathog 16, e1008170, 2020. (Epub 2020 Feb 3)

Tipanee, J, Di Matteo, M, Tulalamba, W, Samara-Kuko, E, Keirsse, J, Van Ginderachter, JA, Chuah, MK, VandenDriessche, T.
Validation of miR-20a as a Tumor Suppressor Gene in Liver Carcinoma Using Hepatocyte-Specific Hyperactive piggyBac Transposons
Mol Ther Nucleic Acids 19, 1309-1329, 2020. (Epub 2020 Mar 6)

Van Hove, H, Pombo Antunes, AR, De Vlaminck, K, Scheyltjens, I, Van Ginderachter, JA, Movahedi, K.
Identifying the variables that drive tamoxifen-independent CreERT2 recombination: Implications for microglial fate mapping and gene deletions
Eur J Immunol 50, 459-463, 2020. (Epub 2019 Nov 30)

Bieniasz-Krzywiec, P, Martin-Perez, R, Ehling, M, Garcia-Caballero, M, Pinioti, S, Pretto, S, Kroes, R, Aldeni, C, Di Matteo, M, Prenen, H, Tribulatti, MV, Campetella, O, Smeets, A, Noel, A, Floris, G, Van Ginderachter, JA, Mazzone, M.
Podoplanin-Expressing Macrophages Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer
Cell Metab 30, 917-936, 2019. (Epub 2019 Aug 19)

Bolli, E, D'Huyvetter, M, Murgaski, A, Berus, D, Stange, G, Clappaert, EJ, Arnouk, S, Pombo Antunes, AR, Krasniqi, A, Lahoutte, T, Goncalves, A, Vuylsteke, M, Raes, G, Devoogdt, N, Movahedi, K, Van Ginderachter, JA.
Stromal-targeting radioimmunotherapy mitigates the progression of therapy-resistant tumors
J Control Release 314, 1-11, 2019. (Epub 2019 Oct 15)

Bonnardel, J, T'Jonck, W, Gaublomme, D, Browaeys, R, Scott, CL, Martens, L, Vanneste, B, De Prijck, S, Nedospasov, SA, Kremer, A, Van Hamme, E, Borghgraef, P, Toussaint, W, De Bleser, P, Mannaerts, I, Beschin, A, van Grunsven, LA, Lambrecht, BN, Taghon, T, et al..
Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche
Immunity 51, 638-654, 2019. (Epub 2019 Sep 24)

Broos, K, Lecocq, Q, Keersmaecker, B, Raes, G, Corthals, J, Lion, E, Thielemans, K, Devoogdt, N, Keyaerts, M, Breckpot, K.
Single Domain Antibody-Mediated Blockade of Programmed Death-Ligand 1 on Dendritic Cells Enhances CD8 T-cell Activation and Cytokine Production
Vaccines (Basel) 7, 85, 2019. (Epub 2019 Aug 7)

Broos, K, Lecocq, Q, Xavier, C, Bridoux, J, Nguyen, TT, Corthals, J, Schoonooghe, S, Lion, E, Raes, G, Keyaerts, M, Devoogdt, N, Breckpot, K.
Evaluating a Single Domain Antibody Targeting Human PD-L1 as a Nuclear Imaging and Therapeutic Agent
Cancers (Basel) 11, 6, 2019. (Epub 2019 Jun 21)

Bruger, AM, Dorhoi, A, Esendagli, G, Barczyk-Kahlert, K, van der Bruggen, P, Lipoldova, M, Perecko, T, Santibanez, J, Saraiva, M, Van Ginderachter, JA, Brandau, S.
How to measure the immunosuppressive activity of MDSC: assays, problems and potential solutions
Cancer Immunol Immunother 68, 631-644, 2019. (Epub 2018 May 21)

De Veirman, K, Menu, E, Maes, K, De Beule, N, De Smedt, E, Maes, A, Vlummens, P, Fostier, K, Kassambara, A, Moreaux, J, Van Ginderachter, JA, De Bruyne, E, Vanderkerken, K, Van Valckenborgh, E.
Myeloid-derived suppressor cells induce multiple myeloma cell survival by activating the AMPK pathway
Cancer Lett 442, 233-241, 2019. (Epub 2018 Nov 9)

De Vlaeminck, Y, Lecocq, Q, Giron, P, Heirman, C, Geeraerts, X, Bolli, E, Movahedi, K, Massa, S, Schoonooghe, S, Thielemans, K, Goyvaerts, C, Van Ginderachter, JA, Breckpot, K.
Single-domain antibody fusion proteins can target and shuttle functional proteins into macrophage mannose receptor expressing macrophages
J Control Release 299, 107-120, 2019. (Epub 2019 Feb 21)

Hanoteau, A, Newton, JM, Krupar, R, Huang, C, Liu, HC, Gaspero, A, Gartrell, RD, Saenger, YM, Hart, TD, Santegoets, SJ, Laoui, D, Spanos, C, Parikh, F, Jayaraman, P, Zhang, B, Van der Burg, SH, Van Ginderachter, JA, Melief, CJM, Sikora, AG.
Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy
J Immunother Cancer 7, 10, 2019. (Epub 2019 Jan 15)