Publications from this research unit

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de Reuver, R, Verdonck, S, Dierick, E, Nemegeer, J, Hessmann, E, Ahmad, S, Jans, M, Blancke, G, Van Nieuwerburgh, F, Botzki, A, Vereecke, L, van Loo, G, Declercq, W, Hur, S, Vandenabeele, P, Maelfait, J.
ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation
Nature 607, 784-789, 2022. (Epub 2022 Jul 20)

Naesens, L, Muppala, S, Acharya, D, Nemegeer, J, Bogaert, D, Lee, JH, Staes, K, Debacker, V, De Bleser, P, De Bruyne, M, De Baere, E, van Gent, M, Liu, G, Lambrecht, BN, Staal, J, Kerre, T, Beyaert, R, Maelfait, J, Tavernier, SJ, et al..
GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141
Sci Immunol 7, eabq4531, 2022. (Epub 2022 Nov 25)

Naesens, L, Nemegeer, J, Roelens, F, Vallaeys, L, Meuwissen, M, Janssens, K, Verloo, P, Ogunjimi, B, Hemelsoet, D, Program for Undiagnosed Rare, D, Hoste, L, Roels, L, De Bruyne, M, De Baere, E, Van Dorpe, J, Dendooven, A, Sieben, A, Rice, GI, Kerre, T, et al..
Mutations in RNU7-1 Weaken Secondary RNA Structure, Induce MCP-1 and CXCL10 in CSF, and Result in Aicardi-Goutieres Syndrome with Severe End-Organ Involvement
J Clin Immunol 42, 962-974, 2022. (Epub 2022 Mar 23)

Nemegeer, J, Lemeire, K, Vandenabeele, P, Maelfait, J.
Tyramide Signal Amplification for the Immunofluorescent Staining of ZBP1-dependent Phosphorylation of RIPK3 and MLKL After HSV-1 Infection in Human Cells
J Vis Exp , in press, 2022. (Epub 2022 Oct 20)

Oltean, T, Ibanez, LI, Divert, T, Ysenbaert, T, Van Eeckhoutte, H, Goossens, V, Schotsaert, M, Bracke, K, Schepens, B, Maelfait, J, Takahashi, N, Saelens, X, Vandenabeele, P.
Reduced protection of RIPK3-deficient mice against influenza by matrix protein 2 ectodomain targeted active and passive vaccination strategies
Cell Death Dis 13, 280, 2022. (Epub 2022 Mar 29)

Peng, R, Wang, CK, Wang-Kan, X, Idorn, M, Kjaer, M, Zhou, FY, Fiil, BK, Timmermann, F, Orozco, SL, McCarthy, J, Leung, CS, Lu, X, Bagola, K, Rehwinkel, J, Oberst, A, Maelfait, J, Paludan, SR, Gyrd-Hansen, M.
Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1
EMBO Rep , e55839, 2022. (Epub 2022 Oct 21)

Verdonck, S, Nemegeer, J, Vandenabeele, P, Maelfait, J.
Viral manipulation of host cell necroptosis and pyroptosis
Trends Microbiol 30, 593-605, 2022. (Epub 2021 Dec 18)

de Reuver, R, Dierick, E, Wiernicki, B, Staes, K, Seys, L, De Meester, E, Muyldermans, T, Botzki, A, Lambrecht, BN, Van Nieuwerburgh, F, Vandenabeele, P, Maelfait, J.
ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation
Cell Rep 36, 109500, 2021. (Epub 2021 Aug 10)

Oltean, T, Van San, E, Divert, T, Vanden Berghe, T, Saelens, X, Maelfait, J, Takahashi, N, Vandenabeele, P.
Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL
Cell Death Dis 12, 471, 2021. (Epub 2021 May 11)

Devos, M, Tanghe, G, Gilbert, B, Dierick, E, Verheirstraeten, M, Nemegeer, J, de Reuver, R, Lefebvre, S, De Munck, J, Rehwinkel, J, Vandenabeele, P, Declercq, W, Maelfait, J.
Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation
J Exp Med 217, e20191913, 2020. (Epub 2020 Apr 21)

Maelfait, J, Liverpool, L, Rehwinkel, J.
Nucleic Acid Sensors and Programmed Cell Death
J Mol Biol 432, 552-568, 2020. (Epub 2019 Nov 28)

Verboom, L, Martens, A, Priem, D, Hoste, E, Sze, M, Vikkula, HK, Van Hove, L, Voet, S, Roels, J, Maelfait, J, Bongiovanni, L, de Bruin, A, Scott, CL, Saeys, Y, Pasparakis, M, Bertrand, MJM, van Loo, G.
OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis
Cell Rep 30, 2237-2247, 2020. (Epub 2020 Feb 18)

Maelfait, J, Roose, K, Vereecke, L, Mc Guire, C, Sze, M, Schuijs, MJ, Willart, M, Itati Ibanez, L, Hammad, H, Lambrecht, BN, Beyaert, R, Saelens, X, van Loo, G.
A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection
PLoS Pathog 12, e1005410, 2016. (Epub 2016 Jan 27)

Slowicka, K, Vereecke, L, McGuire, C, Sze, M, Maelfait, J, Kolpe, A, Saelens, X, Beyaert, R, van Loo, G.
Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-kappaB signaling
Eur J Immunol 46, 971-980, 2016. (Epub 2015 Dec 17)

Maelfait, J, Beyaert, R.
Emerging role of ubiquitination in antiviral RIG-I signaling
Microbiol Mol Biol Rev 76, 33-45, 2012. (Epub 2012 Mar)

Maelfait, J, Roose, K, Bogaert, P, Sze, M, Saelens, X, Pasparakis, M, Carpentier, I, van Loo, G, Beyaert, R.
A20 (Tnfaip3) deficiency in myeloid cells protects against Influenza A virus infection
PLoS Pathog 8, e1002570, 2012. (Epub 2012 Mar 1)

Matmati, M, Jacques, P, Maelfait, J, Verheugen, E, Kool, M, Sze, M, Geboes, L, Louagie, E, Mc Guire, C, Vereecke, L, Chu, Y, Boon, L, Staelens, S, Matthys, P, Lambrecht, B, Schmidt-Supprian, M, Pasparakis, M, Elewaut, D, Beyaert, R, van Loo, G.
A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis
Nature Genetics 43, 908-912, 2011. (Epub 2011 Aug 14)

Bloor, S, Maelfait, J, Krumbach, R, Beyaert, R, Randow, F.
The endoplasmic reticulum chaperone gp96 is essential for infection with vesicular stomatitis virus
Proc Natl Acad Sci USA 107, 6970-6975, 2010. (Epub 2010 Mar 29)

Maelfait, J, Beyaert, R.
Non-apoptotic functions of caspase-8
Biochem Pharmacol 76, 1365-1373, 2008. (Epub 2008 Aug 6)

Maelfait, J, Vercammen, E, Janssens, S, Schotte, P, Haegman, M, Magez, S, Beyaert, R.
Stimulation of Toll-like receptor 3 and 4 induces Interleukin-1beta maturation by Caspase-8
J Exp Med 205, 1967-1973, 2008. (Epub 2008 Aug 25)