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Publications from this research unit

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Naert, T, Dimitrakopoulou, D, Tulkens, D, Demuynck, S, Carron, M, Noelanders, R, Eeckhout, L, Van Isterdael, G, Deforce, D, Vanhove, C, Van Dorpe, J, Creytens, D, Vleminckx, K.
RBL1 (p107) functions as tumor suppressor in glioblastoma and small-cell pancreatic neuroendocrine carcinoma in Xenopus tropicalis
Oncogene 39, 2692-2706, 2020. (Epub 2020 Jan 30)

Naert, T, Tulkens, D, Edwards, NA, Carron, M, Shaidani, NI, Wlizla, M, Boel, A, Demuynck, S, Horb, ME, Coucke, P, Willaert, A, Zorn, AM, Vleminckx, K.
Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos
Sci Rep 10, 14662, 2020. (Epub 2020 Sep 04)

Dimitrakopoulou, D, Tulkens, D, Van Vlierberghe, P, Vleminckx, K.
Xenopus tropicalis: Joining the Armada in the Fight Against Blood Cancer
Frontiers in Physiology 10, 48, 2019. (Epub 2019 Feb 1)

Haas, M, Gomez Vazquez, JL, Sun, DI, Tran, HT, Brislinger, M, Tasca, A, Shomroni, O, Vleminckx, K, Walentek, P.
DeltaN-Tp63 Mediates Wnt/beta-Catenin-Induced Inhibition of Differentiation in Basal Stem Cells of Mucociliary Epithelia
Cell Rep 28, 3338-3352, 2019. (Epub 2019 Sep 24)

Kariminejad, A, Szenker-Ravi, E, Lekszas, C, Tajsharghi, H, Moslemi, AR, Naert, T, Tran, HT, Ahangari, F, Rajaei, M, Nasseri, M, Haaf, T, Azad, A, Superti-Furga, A, Maroofian, R, Ghaderi-Sohi, S, Najmabadi, H, Abbaszadegan, MR, Vleminckx, K, Nikuei, P, et al..
Homozygous Null TBX4 Mutations Lead to Posterior Amelia with Pelvic and Pulmonary Hypoplasia
Am J Hum Genet 105, 1294-1301, 2019. (Epub 2019 Nov 21)

Li, J, Perfetto, M, Materna, C, Li, R, Thi Tran, H, Vleminckx, K, Duncan, MK, Wei, S.
A new transgenic reporter line reveals Wnt-dependent Snai2 re-expression and cranial neural crest differentiation in Xenopus
Sci Rep 9, 11191, 2019. (Epub 2019 Aug 1)

Borday, C, Parain, K, Thi Tran, H, Vleminckx, K, Perron, M, Monsoro-Burq, AH.
An atlas of Wnt activity during embryogenesis in Xenopus tropicalis
PLoS One 13, e0193606, 2018. (Epub 2018 Apr 19)

Naert, T, Vleminckx, K.
CRISPR/Cas9 disease models in zebrafish and Xenopus: The genetic renaissance of fish and frogs
Drug Discov Today Technol 28, 41-52, 2018. (Epub 2018 Jul 31)

Naert, T, Vleminckx, K.
Cancer Models in Xenopus tropicalis by CRISPR/Cas9 Mediated Knockout of Tumor Suppressors
Methods Mol Biol 1865, 147-161, 2018. (Epub 2018 Aug 28)

Naert, T, Vleminckx, K.
CRISPR/Cas9-Mediated Knockout of Rb1 in Xenopus tropicalis
Methods Mol Biol 1726, 177-193, 2018. (Epub 2018 Feb 22)

Naert, T, Vleminckx, K.
Genotyping of CRISPR/Cas9 Genome Edited Xenopus tropicalis
Methods Mol Biol 1865, 67-82, 2018. (Epub 2018 Aug 28)

Naert, T, Vleminckx, K.
Methods for CRISPR/Cas9 Xenopus tropicalis Tissue-Specific Multiplex Genome Engineering
Methods Mol Biol 1865, 33-54, 2018. (Epub 2018 Aug 28)

Noelanders, R, Vleminckx, K.
Cell Cycle Analysis of the Embryonic Brain of Fluorescent Reporter Xenopus tropicalis by Flow Cytometry
Methods Mol Biol 1865, 243-250, 2018. (Epub 2018 Aug 28)

Szenker-Ravi, E, Altunoglu, U, Leushacke, M, Bosso-Lefevre, C, Khatoo, M, Thi Tran, H, Naert, T, Noelanders, R, Hajamohideen, A, Beneteau, C, de Sousa, SB, Karaman, B, Latypova, X, Basaran, S, Yucel, EB, Tan, TT, Vlaeminck, L, Nayak, SS, Shukla, A, et al..
RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6
Nature 557, 564-569, 2018. (Epub 2018 May 16)

Van Nieuwenhuysen, T, Vleminckx, K.
Targeted Genome Engineering in Xenopus Using the Transcription Activator-Like Effector Nuclease (TALEN) Technology
Methods Mol Biol 1865, 55-65, 2018. (Epub 2018 Aug 28)

Naert, T, Van Nieuwenhuysen, T, Vleminckx, K.
TALENs and CRISPR/Cas9 fuel genetically engineered clinically relevant Xenopus tropicalis tumor models
Genesis 55, 1-2, 2017. (Epub 2017 Jan 29)

Noelanders, R, Vleminckx, K.
How Wnt Signaling Builds the Brain: Bridging Development and Disease
Neuroscientist 23, 314-329, 2017. (Epub 2016 Sep 13)

Song, J, Liu, XM, Li, JD, Liu, HD, Peng, Z, Liu, YL, Mei, LY, He, CF, Cai, XZ, Chen, HS, Vleminckx, K, Feng, Y.
Mechanism underlying synergic activation of Tyrosinase promoter by MITF and IRF4
International Journal of Clinical and Experimental Medicine 10, 4, 2017. (Epub 2017 Apr 15)

Tran, HT, Fransen, M, Dimitrakopoulou, D, Van Imschoot, G, Willemarck, N, Vleminckx, K.
Caspase-9 has a non-apoptotic function in Xenopus embryonic primitive blood formation
J Cell Sci 130, 2371-2381, 2017. (Epub 2017 Jun 2)

Naert, T, Colpaert, R, Van Nieuwenhuysen, T, Dimitrakopoulou, D, Leoen, J, Haustraete, J, Boel, A, Steyaert, W, Lepez, T, Deforce, D, Willaert, A, Creytens, D, Vleminckx, K.
CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis
Sci Rep 6, 35264, 2016. (Epub 2016 Oct 14)

Song, J, Feng, Y, Acke, FR, Coucke, P, Vleminckx, K, Dhooge, IJ.
Hearing loss in Waardenburg syndrome: a systematic review
Clin Genet 89, 416-425, 2015. (Epub 2015 Jun 22)

Symoens, S, Barnes, AM, Gistelinck, C, Malfait, F, Guillemyn, B, Steyaert, W, Syx, D, D'Hondt, S, Biervliet, M, De Backer, J, Witten, EP, Leikin, S, Makareeva, E, Gillessen-Kaesbach, G, Huysseune, A, Vleminckx, K, Willaert, A, De Paepe, A, Marini, JC, et al..
Genetic Defects in TAPT1 Disrupt Ciliogenesis and Cause a Complex Lethal Osteochondrodysplasia
Am J Hum Genet 97, 521-534, 2015. (Epub 2015 Oct 1)

Van Nieuwenhuysen, T, Naert, T, Tran, HT, Van Imschoot, G, Geurs, S, Sanders, E, Creytens, D, Van Roy, F, Vleminckx, K.
TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis
Oncoscience 2, 555-566, 2015. (Epub 2015 May 19)

De Groote, P, Tran, HT, Fransen, M, Tanghe, G, Urwyler, C, De Craene, B, Leurs, K, Gilbert, B, Van Imschoot, G, De Rycke, R, Guerin, CJ, Holland, P, Berx, G, Vandenabeele, P, Lippens, S, Vleminckx, K, Declercq, W.
A novel RIPK4-IRF6 connection is required to prevent epithelial fusions characteristic for popliteal pterygium syndromes
Cell Death Differ 22, 1012-1024, 2014. (Epub 2014 Nov 28)

Rankin, SA, Thi Tran, H, Wlizla, M, Mancini, P, Shifley, ET, Bloor, SD, Han, L, Vleminckx, K, Wert, SE, Zorn, AM.
A molecular atlas of Xenopus respiratory system development
Dev Dyn 244, 69-85, 2014. (Epub 2014 Aug 26)

Tran, HT, Vleminckx, K.
Design and use of transgenic reporter strains for detecting activity of signaling pathways in Xenopus
Methods 66, 422-432, 2014. (Epub 2013 Jun 28)

Zhang, S, Li, J, Lea, R, Vleminckx, K, Amaya, E.
Fezf2 promotes neuronal differentiation through localised activation of Wnt/beta-catenin signalling during forebrain development
Development 141, 4794-4805, 2014. (Epub 2014 Dec 15)

Janssens, S, Van Den Broek, O, Davenport, IR, Akkers, RC, Liu, F, Veenstra, GJ, Hoppler, S, Vleminckx, K, Destree, O.
The Wnt signaling mediator tcf1 is required for expression of foxd3 during Xenopus gastrulation
Int J Dev Biol 57, 49-54, 2013. (Epub 2013 Apr)

Borday, C, Cabochette, P, Parain, K, Mazurier, N, Janssens, S, Tran, HT, Sekkali, B, Bronchain, O, Vleminckx, K, Locker, M, Perron, M.
Antagonistic cross-regulation between Wnt and Hedgehog signalling pathways controls post-embryonic retinal proliferation
Development 139, 3499-3509, 2012. (Epub 2012 Aug 16)

El Yakoubi, W, Borday, C, Hamdache, J, Parain, K, Tran, HT, Vleminckx, K, Perron, M, Locker, M.
Hes4 controls proliferative properties of neural stem cells during retinal ontogenesis
Stem Cells 30, 2784-2795, 2012. (Epub 2012 Sep 11)

Munoz, WA, Kloc, M, Cho, K, Lee, M, Hofmann, I, Sater, A, Vleminckx, K, McCrea, PD.
Plakophilin-3 is required for late embryonic amphibian development, exhibiting roles in ectodermal and neural tissues
PLoS One 7, e34342, 2012. (Epub 2012 Apr 5)

Janssens, S, Crabbe, E, Vleminckx, K.
The role of Wnt in cell signaling and cell adhesion during early vertebrate development
Front Biosci 17, 2352-2366, 2011. (Epub 2011 Jun 1)

Pourebrahim, R, Houtmeyers, R, Ghogomu, S, Janssens, S, Thelie, A, Tran, HT, Langenberg, T, Vleminckx, K, Bellefroid, E, Cassiman, JJ, Tejpar, S.
Transcription factor Zic2 inhibits Wnt/beta-catenin signaling
J Biol Chem 286, 37732-37740, 2011. (Epub 2011 Sep 9)

Tran, HT, Delvaeye, M, Verschuere, V, Descamps, E, Crabbe, E, Van Hoorebeke, L, McCrea, P, Adriaens, D, Van Roy, F, Vleminckx, K.
ARVCF depletion cooperates with Tbx1 deficiency in the development of 22q11.2DS-like phenotypes in Xenopus
Dev Dynam 240, 2680-2687, 2011. (Epub 2011 Oct 25)

Tran, HT, Vleminckx, K.
You'd better catch that Wnt: primitive hematopoiesis requires canonical Wnt signaling
Cell Cycle 10, 366-367, 2011. (Epub 2011 Feb 1)

De Schamphelaere, KA, Stubblefield, W, Rodriguez, P, Vleminckx, K, Janssen, CR.
The chronic toxicity of molybdate to freshwater organisms. I. Generating reliable effects data
Sci Total Environ 408, 5362-5371, 2010. (Epub 2010 Aug 31)

Janssens, S, Denayer, T, Deroo, T, Van Roy, F, Vleminckx, K.
Direct control of Hoxd1 and Irx3 expression by Wnt/beta-catenin signaling during anteroposterior patterning of the neural axis in Xenopus
Int J Dev Biol 54, 1435-1442, 2010. (Epub 2010 Oct 19)

Tran, HT, Sekkali, B, Van Imschoot, G, Janssens, S, Vleminckx, K.
Wnt/beta-catenin signaling is involved in the induction and maintenance of primitive hematopoiesis in the vertebrate embryo
Proc Natl Acad Sci USA 107, 16160-16165, 2010. (Epub 2010 Aug 30)

Willemarck, N, Rysman, E, Brusselmans, K, Van Imschoot, G, Vanderhoydonc, F, Moerloose, K, Lerut, E, Verhoeven, G, Van Roy, F, Vleminckx, K, Swinnen, J.
Aberrant activation of fatty acid synthesis suppreses primary cilium formation and distorts tissue development
Cancer Res 70, 9453-9462, 2010. (Epub 2010 Oct 1)

De Rybel, B, Audenaert, D, Vert, G, Rozhon, W, Mayerhofer, J, Peelman, F, Coutuer, S, Denayer, T, Jansen, L, Nguyen, L, Vanhoutte, I, Beemster, GT, Vleminckx, K, Jonak, C, Chory, J, Inze, D, Russinova, E, Beeckman, T.
Chemical inhibition of a subset of Arabidopsis thaliana GSK3-like kinases activates brassinosteroid signaling
Chem Biol 16, 594-604, 2009. (Epub ---)

Lyons, JP, Miller, RK, Zhou, X, Weidinger, G, Deroo, T, Denayer, T, Park, J-IJ, H., Hong, JY, Li, A, Moon, RT, Jones, EA, Vleminckx, K, Vize, PD, McCrea, PD.
Requirement of Wnt/beta-Catenin signaling in pronephric kidney development
Mech Develop 126, 142-159, 2009. (Epub 2008 Dec 7)

Crabbe, E, Vleminckx, K.
Cell migration during development
In Encyclopedia of Life Sciences. Chichester, Wiley & Sons, DOI: 10.1002/9780470015902.a0020864, 2008. (Epub 2008 Jul)

Denayer, T, Locker, M, Borday, C, Deroo, T, Janssens, S, Hecht, A, Van Roy, F, Perron, M, Vleminckx, K.
Canonical Wnt signaling controls proliferation of retinal stem/progenitor cells in post-embryonic Xenopus eyes
Stem Cells 26, 2063-2074, 2008. (Epub 2008 Jun 12)

Denayer, T, Tran, HT, Vleminckx, K.
Transgenic reporter tools tracing endogenous canonical wnt signaling in Xenopus
Methods Mol Biol 469, 381-400, 2008. (Epub 2008 Dec 25)

Sekkali, B, Tran, HT, Crabbe, E, De Beule, C, Van Roy, F, Vleminckx, K.
Chicken beta-globin insulator overcomes variegation of transgenes in Xenopus embryos
FASEB J 22, 2534-2540, 2008. (Epub 2008 Mar 21)

Vleminckx, K.
Cell Adhesion Molecules
In Encyclopedic Reference of Cancer. (Schwab, M, ed.), Heidelberg, Springer Verlag, pp. 181-187, 2008. (Epub ---)

Suykerbuyk, P, Vleminckx, K, Pasmans, F, Stragier, P, Ablordey, A, Tran, HT, Hermans, K, Fleetwood, M, Meyers, WM, Portaels, F.
Mycobacterium liflandii infection in a European laboratory colony of Silurana tropicalis
Emerg Infect Dis 13, 743-746, 2007. (Epub ---)

Denayer, T, Van Roy, F, Vleminckx, K.
In vivo tracing of canonical Wnt signaling in Xenopus tadpoles by means of an inducible transgenic reporter tool
FEBS Lett 580, 393-398, 2006. (Epub 2005 Dec 19)

Ny, A, Koch, M, Schneider, M, Neven, E, Tong, R, Maity, S, Fischer, C, Plaisance, S, Lambrechts, D, Heligon, C, Terclavers, S, Ciesiolka, M, Kaelin, R, Man, W, Senn, I, Wyns, S, Lupu, F, Braendli, A, Vleminckx, K, et al..
A genetic Xenopus laevis tadpole model to study lymphangiogenesis
Nature Medicine 11, 998-1004, 2005. (Epub 2005 Aug 22)

Park, J, Wan Kim, D, Lyons, J, Ji, H, Nguyen, T, Cho, K, Barton, M, Deroo, T, Vleminckx, K, McCrea, P.
Kaiso/p120-Catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets
Developmental Cell 8, 843-854, 2005. (Epub ---)

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