Publications from this research unit

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Liu, KE, Raymond, MH, Ravichandran, KS, Kucenas, S.
Clearing Your Mind: Mechanisms of Debris Clearance After Cell Death During Neural Development
Annu Rev Neurosci , in press, 2022. (Epub 2022 Feb 28)

Lucas, CD, Medina, CB, Bruton, FA, Dorward, DA, Raymond, MH, Tufan, T, Etchegaray, JI, Barron, B, Oremek, MEM, Arandjelovic, S, Farber, E, Onngut-Gumuscu, S, Ke, E, Whyte, MKB, Rossi, AG, Ravichandran, KS.
Pannexin 1 drives efficient epithelial repair after tissue injury
Sci Immunol 7, eabm4032, 2022. (Epub 2022 May 13)

Maschalidi, S, Mehrotra, P, Keceli, BN, De Cleene, HKL, Lecomte, K, Van der Cruyssen, R, Janssen, P, Pinney, J, van Loo, G, Elewaut, D, Massie, A, Hoste, E, Ravichandran, KS.
Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes
Nature 606, 776–784, 2022. (Epub 2022 May 25)

Mehrotra, P, Ravichandran, KS.
Drugging the efferocytosis process: concepts and opportunities
Nat Rev Drug Discov 21, 601–620, 2022. (Epub 2022 Jun 1)

Raymond, MH, Davidson, AJ, Shen, Y, Tudor, DR, Lucas, CD, Morioka, S, Perry, JSA, Krapivkina, J, Perrais, D, Schumacher, LJ, Campbell, RE, Wood, W, Ravichandran, KS.
Live cell tracking of macrophage efferocytosis during Drosophila embryo development in vivo
Science 375, 1182-1187, 2022. (Epub 2022 Mar 11)

Aaes, TL, Vandenabeele, P.
The intrinsic immunogenic properties of cancer cell lines, immunogenic cell death, and how these influence host antitumor immune responses
Cell Death Differ 28, 843-860, 2021. (Epub 2020 Nov 19)

Ackermann, M, Anders, HJ, Bilyy, R, Bowlin, GL, Daniel, C, De Lorenzo, R, Egeblad, M, Henneck, T, Hidalgo, A, Hoffmann, M, Hohberger, B, Kanthi, Y, Kaplan, MJ, Knight, JS, Knopf, J, Kolaczkowska, E, Kubes, P, Leppkes, M, Mahajan, A, et al..
Patients with COVID-19: in the dark-NETs of neutrophils
Cell Death Differ 28, 3125-3139, 2021. (Epub 2021 May 24)

Anderson, CJ, Medina, CB, Barron, BJ, Karvelyte, L, Aaes, TL, Lambertz, I, Perry, JSA, Mehrotra, P, Goncalves, A, Lemeire, K, Blancke, G, Andries, V, Ghazavi, F, Martens, A, van Loo, G, Vereecke, L, Vandenabeele, P, Ravichandran, KS.
Microbes exploit death-induced nutrient release by gut epithelial cells
Nature 596, 262-267, 2021. (Epub 2021 Aug 4)

Arandjelovic, S, Perry, JSA, Zhou, M, Ceroi, A, Smirnov, I, Walk, SF, Shankman, LS, Cambre, I, Onengut-Gumuscu, S, Elewaut, D, Conrads, TP, Ravichandran, KS.
ELMO1 signaling is a promoter of osteoclast function and bone loss
Nat Commun 12, 4974, 2021. (Epub 2021 Aug 17)

Catrysse, L, Maes, B, Mehrotra, P, Martens, A, Hoste, E, Martens, L, Maueroder, C, Remmerie, A, Bujko, A, Slowicka, K, Sze, M, Vikkula, H, Ghesquiere, B, Scott, CL, Saeys, Y, van de Sluis, B, Ravichandran, K, Janssens, S, van Loo, G.
A20 deficiency in myeloid cells protects mice from diet-induced obesity and insulin resistance due to increased fatty acid metabolism
Cell Rep 36, 109748, 2021. (Epub 2021 Sep 21)

Hoste, E, Lecomte, K, Annusver, K, Vandamme, N, Roels, J, Maschalidi, S, Verboom, L, Vikkula, HK, Sze, M, Van Hove, L, Verstaen, K, Martens, A, Hochepied, T, Saeys, Y, Ravichandran, K, Kasper, M, van Loo, G.
OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity
Nat Commun 12, 5913, 2021. (Epub 2021 Oct 8)

Kelley, SM, Ravichandran, KS.
Putting the brakes on phagocytosis: "don't-eat-me" signaling in physiology and disease
EMBO Rep 22, e52564, 2021. (Epub 2021 May 27)

Maschalidi, S, Ravichandran, KS.
Phagocytosis: Sweet Repulsions via the Glycocalyx
Curr Biol 31, R20-R22, 2021. (Epub 2021 Jan 11)

Medina, CB, Chiu, YH, Stremska, ME, Lucas, CD, Poon, I, Tung, KS, Elliott, MR, Desai, B, Lorenz, UM, Bayliss, DA, Ravichandran, KS.
Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation
Immunity 54, 1715-1727, 2021. (Epub 2021 Aug 10)

Shankman, LS, Fleury, ST, Evans, WB, Penberthy, KK, Arandjelovic, S, Blumberg, RS, Agaisse, H, Ravichandran, KS.
Efferocytosis by Paneth cells within the intestine
Curr Biol 31, 2469-2476, 2021. (Epub 2021 Apr 8)

Medina, CB, Mehrotra, P, Arandjelovic, S, Perry, JSA, Guo, Y, Morioka, S, Barron, B, Walk, SF, Ghesquiere, B, Krupnick, AS, Lorenz, U, Ravichandran, KS.
Metabolites released from apoptotic cells act as tissue messengers
Nature 580, 130-135, 2020. (Epub 2020 Mar 18)

Yao, M, Ventura, PB, Jiang, Y, Rodriguez, FJ, Wang, L, Perry, JSA, Yang, Y, Wahl, K, Crittenden, RB, Bennett, ML, Qi, L, Gong, CC, Li, XN, Barres, BA, Bender, TP, Ravichandran, KS, Janes, KA, Eberhart, CG, Zong, H.
Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth
Cell 180, 502-520, 2020. (Epub 2020 Jan 23)

Arandjelovic, S, Perry, JSA, Lucas, CD, Penberthy, KK, Kim, TH, Zhou, M, Rosen, DA, Chuang, TY, Bettina, AM, Shankman, LS, Cohen, AH, Gaultier, A, Conrads, TP, Kim, M, Elliott, MR, Ravichandran, KS.
A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis
Nat Immunol 20, 141-151, 2019. (Epub 2019 Jan 14)

Boeltz, S, Amini, P, Anders, HJ, Andrade, F, Bilyy, R, Chatfield, S, Cichon, I, Clancy, DM, Desai, J, et al., Maueroder, C, et al. , Vanden Berghe, T, Vandenabeele, P, Hahn, J, Hidalgo, A, Hoffmann, MH, Kaplan, MJ, Knight, JS, Kolaczkowska, E, Kubes, P, et al..
To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps
Cell Death Differ 26, 395-408, 2019. (Epub 2019 Jan 8)

Cossarizza, A, Chang, HD, Radbruch, A, Acs, A, Adam, D, Adam-Klages, S, Agace, WW, Aghaeepour, N, Akdis, M, Allez, M, Almeida, LN, Alvisi, G, Anderson, G, Andra, I, Annunziato, F, Anselmo, A, Bacher, P, Baldari, CT, Bari, S, et al..
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
Eur J Immunol 49, 1457-1973, 2019. (Epub 2019 Oct)

Hoste, E, Maueroder, C, van Hove, L, Catrysse, L, Vikkula, HK, Sze, M, Maes, B, Karjosukarso, D, Martens, L, Goncalves, A, Parthoens, E, Roelandt, R, Declercq, W, Fuentes, I, Palisson, F, Gonzalez, S, Salas-Alanis, JC, Boon, L, Huebener, P, et al..
Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils for NET Formation
Cell Rep 29, 2689-2701, 2019. (Epub 2019 Nov 26)

Morioka, S, Maueroder, C, Ravichandran, KS.
Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology
Immunity 50, 1149-1162, 2019. (Epub 2019 May 21)

Perry, JSA, Morioka, S, Medina, CB, Iker Etchegaray, J, Barron, B, Raymond, MH, Lucas, CD, Onengut-Gumuscu, S, Delpire, E, Ravichandran, KS.
Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway
Nat Cell Biol 21, 1532-1543, 2019. (Epub 2019 Dec 2)

Rival, CM, Xu, W, Shankman, LS, Morioka, S, Arandjelovic, S, Lee, CS, Wheeler, KM, Smith, RP, Haney, LB, Isakson, BE, Purcell, S, Lysiak, JJ, Ravichandran, KS.
Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization
Nat Commun 10, 4456, 2019. (Epub 2019 Oct 1)

Krysko, DV, Ravichandran, KS, Vandenabeele, P.
Macrophages regulate the clearance of living cells by calreticulin
Nat Commun 9, 4644, 2018. (Epub 2018 Nov 7)

Morioka, S, Perry, JSA, Raymond, MH, Medina, CB, Zhu, Y, Zhao, L, Serbulea, V, Onengut-Gumuscu, S, Leitinger, N, Kucenas, S, Rathmell, JC, Makowski, L, Ravichandran, KS.
Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release
Nature 563, 714-718, 2018. (Epub 2018 Nov 21)

Penberthy, KK, Rival, C, Shankman, LS, Raymond, MH, Zhang, J, Perry, JSA, Lee, CS, Han, CZ, Onengut-Gumuscu, S, Palczewski, K, Lysiak, JJ, Ravichandran, KS.
Context-dependent compensation among phosphatidylserine-recognition receptors
Sci Rep 7, 14623, 2017. (Epub 2017 Nov 9)