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Publications from this research unit

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De Galan, C, Gonzales, GB, Van Welden, S, Tavernier, SJ, Lobaton, T, Van Moerkercke, W, Strubbe, B, Peeters, H, Macken, E, De Vos, M, Laukens, D, Hindryckx, P.
Role of integrin expression in the prediction of response to vedolizumab: A prospective real-life multicentre cohort study
Clin Transl Med 12, e769, 2022. (Epub 2022 Apr 5)

Hoste, L, Roels, L, Naesens, L, Bosteels, V, Vanhee, S, Dupont, S, Bosteels, C, Browaeys, R, Vandamme, N, Verstaen, K, Roels, J, Van Damme, KFA, Maes, B, De Leeuw, E, Declercq, J, Aegerter, H, Seys, L, Smole, U, De Prijck, S, et al..
TIM3+ TRBV11-2 T cells and IFNgamma signature in patrolling monocytes and CD16+ NK cells delineate MIS-C
J Exp Med 219, e20211381, 2022. (Epub 2021 Dec 16)

Kim, SW, Alci, K, Van Gaever, F, Driege, Y, Bicalho, K, Goeminne, G, Libert, C, Goossens, A, Beyaert, R, Staal, J.
Engineering a highly sensitive biosensor for abscisic acid in mammalian cells
FEBS Lett , in press, 2022. (Epub 2022 Jun 21)

Kos, K, Aslam, MA, van de Ven, R, Wellenstein, MD, Pieters, W, van Weverwijk, A, Duits, DEM, van Pul, K, Hau, CS, Vrijland, K, Kaldenbach, D, Raeven, EAM, Quezada, SA, Beyaert, R, Jacobs, H, de Gruijl, TD, de Visser, KE.
Tumor-educated Tregs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche
Cell Rep 38, 110447, 2022. (Epub 2022 Mar 1)

Naesens, L, Nemegeer, J, Roelens, F, Vallaeys, L, Meuwissen, M, Janssens, K, Verloo, P, Ogunjimi, B, Hemelsoet, D, Program for Undiagnosed Rare, D, Hoste, L, Roels, L, De Bruyne, M, De Baere, E, Van Dorpe, J, Dendooven, A, Sieben, A, Rice, GI, Kerre, T, et al..
Mutations in RNU7-1 Weaken Secondary RNA Structure, Induce MCP-1 and CXCL10 in CSF, and Result in Aicardi-Goutieres Syndrome with Severe End-Organ Involvement
J Clin Immunol 42, 962-974, 2022. (Epub 2022 Mar 23)

Sun, X, He, X, Zhang, Y, Hosaka, K, Andersson, P, Wu, J, Wu, J, Jing, X, Du, Q, Hui, X, Ding, B, Guo, Z, Hong, A, Liu, X, Wang, Y, Ji, Q, Beyaert, R, Yang, Y, Li, Q, et al..
Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism
Gut 71, 129-147, 2022. (Epub 2021 Feb 10)

Team, FJE, Beyaert, R.
Editor Profile: Rudi Beyaert
FEBS J 289, 3926-3931, 2022. (Epub 2022 Jul 19)

Vanderhaeghen, T, Timmermans, S, Watts, D, Paakinaho, V, Eggermont, M, Vandewalle, J, Wallaeys, C, Van Wyngene, L, Van Looveren, K, Nuyttens, L, Dewaele, S, Vanden Berghe, J, Lemeire, K, De Backer, J, Dirkx, L, Vanden Berghe, W, Caljon, G, Ghesquiere, B, De Bosscher, K, et al..
Reprogramming of glucocorticoid receptor function by hypoxia
EMBO Rep 23, e53083, 2022. (Epub 2021 Oct 26)

Vanneste, D, Staal, J, Haegman, M, Driege, Y, Carels, M, Van Nuffel, E, De Bleser, P, Saeys, Y, Beyaert, R, Afonina, IS.
CARD14 Signalling Ensures Cell Survival and Cancer Associated Gene Expression in Prostate Cancer Cells
Biomedicines 10, 2008, 2022. (Epub 2022 Aug 18)

Afonina, IS, Van Nuffel, E, Beyaert, R.
Immune responses and therapeutic options in psoriasis
Cell Mol Life Sci 78, 2709–2727, 2021. (Epub 2021 Jan 2)

Backers, L, Parton, B, De Bruyne, M, Tavernier, SJ, Van Den Bogaert, K, Lambrecht, BN, Haerynck, F, Claes, KBM.
Missing heritability in Bloom syndrome: First report of a deep intronic variant leading to pseudo-exon activation in the BLM gene
Clin Genet 99, 292-297, 2021. (Epub 2020 Oct 9)

Heine, H, Adanitsch, F, Peternelj, TT, Haegman, M, Kasper, C, Ittig, S, Beyaert, R, Jerala, R, Zamyatina, A.
Tailored Modulation of Cellular Pro-inflammatory Responses With Disaccharide Lipid A Mimetics
Front Immunol 12, 631797, 2021. (Epub 2021 Mar 18)

Iliaki, S, Beyaert, R, Afonina, IS.
Polo-like kinase 1 (PLK1) signaling in cancer and beyond
Biochem Pharmacol 193, 114747, 2021. (Epub 2021 Aug 26)

Joeris, T, Gomez-Casado, C, Holmkvist, P, Tavernier, SJ, Silva-Sanchez, A, Klotz, L, Randall, TD, Mowat, AM, Kotarsky, K, Malissen, B, Agace, WW.
Intestinal cDC1 drive cross-tolerance to epithelial-derived antigen via induction of FoxP3(+)CD8(+) Tregs
Sci Immunol 6, eabd3774, 2021. (Epub 2021 Jun 4)

Klionsky, DJ, Abdel-Aziz, AK, Abdelfatah, S, Abdellatif, M, Abdoli, A, Abel, S, Abeliovich, H, Abildgaard, MH, Abudu, YP, Acevedo-Arozena, A, Adamopoulos, IE, Adeli, K, Adolph, TE, Adornetto, A, Aflaki, E, Agam, G, Agarwal, A, Aggarwal, BB, Agnello, M, et al..
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Autophagy 1, 1-382, 2021. (Epub 2021 Feb 8)

Meireson, A, Tavernier, SJ, Van Gassen, S, Sundahl, N, Demeyer, A, Spaas, M, Kruse, V, Ferdinande, L, Van Dorpe, J, Hennart, B, Allorge, D, Haerynck, F, Decaestecker, K, Rottey, S, Saeys, Y, Ost, P, Brochez, L.
Immune Monitoring in Melanoma and Urothelial Cancer Patients Treated with Anti-PD-1 Immunotherapy and SBRT Discloses Tumor Specific Immune Signatures
Cancers (Basel) 13, 2630, 2021. (Epub 2021 May 27)

Meyts, I, Bucciol, G, Quinti, I, Neven, B, Fischer, A, Seoane, E, Lopez-Granados, E, Gianelli, C, Robles-Marhuenda, A, Jeandel, PY, Paillard, C, Sankaran, VG, Demirdag, YY, et al, Bosteels, C, Lambrecht, BN, et al..
Coronavirus Disease 2019 in patients with inborn errors of immunity: an international study
J Allergy Clin Immunol 147, 520-531, 2021. (Epub 2020 Sep 24)

Percier, P, De Prins, S, Tima, G, Beyaert, R, Grooten, J, Romano, M, Denis, O.
Aspergillus fumigatus Recognition by Dendritic Cells Negatively Regulates Allergic Lung Inflammation Through a TLR2/MyD88 Pathway
Am J Respir Cell Mol Biol 64, 39-49, 2021. (Epub 2020 Sep 24)

Pieters, T, T'Sas, S, Vanhee, S, Almeida, A, Driege, Y, Roels, J, Van Loocke, W, Daneels, W, Baens, M, Marchand, A, Van Trimpont, M, Matthijssens, F, Morscio, J, Lemeire, K, Lintermans, B, Reunes, L, Chaltin, P, Offner, F, Van Dorpe, J, et al..
Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice
J Exp Med 218, e20202280, 2021. (Epub 2021 Oct 4)

Skordos, I, Demeyer, A, Beyaert, R.
Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry
STAR Protoc 2, 100351, 2021. (Epub 2021 Feb 20)

Staal, J, Driege, Y, Haegman, M, Kreike, M, Iliaki, S, Vanneste, D, Lork, M, Afonina, IS, Braun, H, Beyaert, R.
Defining the combinatorial space of PKC::CARD-CC signal transduction nodes
FEBS J 288, 1630-1647, 2021. (Epub 2020 Aug 13)

Vanderhaeghen, T, Beyaert, R, Libert, C.
Bidirectional Crosstalk Between Hypoxia Inducible Factors and Glucocorticoid Signalling in Health and Disease
Front Immunol 12, 684085, 2021. (Epub 2021 Jun 4)

Van Hove, I, Van Bergen, T, Etienne, I, Holgado, A, Afonina, IS, Beyaert, R, Feyen, JH, Hu, TT.
IL-33trap-mediated IL-33 neutralization does not exacerbate choroidal neovascularization, but fails to protect against retinal degeneration in a dry age-related macular degeneration model
Exp Eye Res 207, 108608, 2021. (Epub 2021 Apr 27)

Van Wyngene, L, Vanderhaeghen, T, Petta, I, Timmermans, S, Corbeels, K, Van der Schueren, B, Vandewalle, J, Van Looveren, K, Wallaeys, C, Eggermont, M, Dewaele, S, Catrysse, L, van Loo, G, Beyaert, R, Vangoitsenhoven, R, Nakayama, T, Tavernier, J, De Bosscher, K, Libert, C.
ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation
iScience 24, 102790, 2021. (Epub 2021 Jun 28)

Beziat, V, Tavernier, SJ, Chen, YH, Ma, CS, Materna, M, Laurence, A, Staal, J, Aschenbrenner, D, Roels, L, Worley, L, Claes, K, Gartner, L, Kohn, LA, De Bruyne, M, Schmitz-Abe, K, Charbonnier, LM, Keles, S, Nammour, J, Vladikine, N, et al..
Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome
J Exp Med 217, e20191804, 2020. (Epub 2020 Mar 24)

Bogaert, DJ, Laureys, G, Naesens, L, Mazure, D, De Bruyne, M, Hsu, AP, Bordon, V, Wouters, E, Tavernier, SJ, Lambrecht, BN, De Baere, E, Haerynck, F, Kerre, T.
GATA2 deficiency and haematopoietic stem cell transplantation: challenges for the clinical practitioner
Br J Haematol 188, 768-773, 2020. (Epub 2019 Nov 11)

Braun, H, Staal, J.
Stabilization of the TAK1 adaptor proteins TAB2 and TAB3 is critical for optimal NF-kappaB activation
FEBS J 287, 3161-3164, 2020. (Epub 2020 Jan 29)

Demeyer, A, Beyaert, R.
Fragility can be a good thing in cancer
Nat Immunol 21, 11-13, 2020. (Epub 2019 Dec 10)

Demeyer, A, Driege, Y, Skordos, I, Coudenys, J, Lemeire, K, Elewaut, D, Staal, J, Beyaert, R.
Long-Term MALT1 Inhibition in Adult Mice Without Severe Systemic Autoimmunity
iScience 23, 101557, 2020. (Epub 2020 Sep 12)

Holgado, A, Braun, H, Verstraete, K, Vanneste, D, Callewaert, N, Savvides, SN, Afonina, IS, Beyaert, R.
Single-Chain Soluble Receptor Fusion Proteins as Versatile Cytokine Inhibitors
Front Immunol 11, 1422, 2020. (Epub 2020 Jul 13)

Kim, S.W, Goossens, A, Libert, C, Van Immerseel, F, Staal, J, Beyaert, R.
Phytohormones: Multifunctional nutraceuticals against metabolic syndrome and comorbid diseases
Biochem Pharmacol 175, 113866, 2020. (Epub 2020 Feb 20)

Martens, A, Priem, D, Hoste, E, Vetters, J, Rennen, S, Catrysse, L, Voet, S, Deelen, L, Sze, M, Vikkula, H, Slowicka, K, Hochepied, T, Iliaki, K, Wullaert, A, Janssens, S, Lamkanfi, M, Beyaert, R, Armaka, M, Bertrand, MJM, et al..
Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities
Nat Immunol 21, 381-387, 2020. (Epub 2020 Mar 16)

Minina, EA, Staal, J, Alvarez, VE, Berges, JA, Berman-Frank, I, Beyaert, R, Bidle, KD, Bornancin, F, Casanova, M, Cazzulo, JJ, Choi, CJ, Coll, NS, Dixit, VM, Dolinar, M, Fasel, N, Funk, C, Gallois, P, Gevaert, K, Gutierrez-Beltran, E, et al..
Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases
Mol Cell 77, 927-929, 2020. (Epub 2020 Mar 5)

Souffriau, J, Timmermans, S, Vanderhaeghen, T, Wallaeys, C, Van Looveren, K, Aelbrecht, L, Dewaele, S, Vandewalle, J, et al., Eggermont, M, De Rycke, R, De Bruyne, M, Ballegeer, M, Vandevyver, S, Hochepied, T, Beyaert, R, Libert, C.
Zinc inhibits lethal inflammatory shock by preventing microbe-induced interferon signature in intestinal epithelium
EMBO Mol Med , e11917, 2020. (Epub 2020 Sep 11)

Staal, J.
Fytohormonen : verschillende bioactieve moleculen die metabolisme en ontsteking beïnvloeden in de mens
Bloedvaten, Hart, Longen 25, 32 - 35, 2020. (Epub 2020)

Van Damme, KFA, Tavernier, S, Van Roy, N, De Leeuw, E, Declercq, J, Bosteels, C, Maes, B, De Bruyne, M, Bogaert, D, Bosteels, V, Hoste, L, Naesens, L, Maes, P, Grifoni, A, Weiskopf, D, Sette, A, Depuydt, P, Van Braeckel, E, Haerynck, F, et al..
Case Report: Convalescent Plasma, a Targeted Therapy for Patients with CVID and Severe COVID-19
Front Immunol 11, 596761, 2020. (Epub 2020 Nov 20)

Van der Jeught, K, Sun, Y, Fang, Y, Zhou, Z, Jiang, H, Yu, T, Yang, J, Kamocka, MM, So, KM, Li, Y, Eyvani, H, Sandusky, GE, Frieden, M, Braun, H, Beyaert, R, He, X, Zhang, X, Zhang, C, Paczesny, S, et al..
ST2 as checkpoint target for colorectal cancer immunotherapy
JCI Insight 5, 136073, 2020. (Epub 2020 May 7)

Vandewalle, J, Vanderhaeghen, T, Beyaert, R, Libert, C.
Taking the STING Out of Sepsis?
Cell Host Microbe 27, 491-493, 2020. (Epub 2020 Apr 8)

Van Dingenen, J, Pieters, L, Van Nuffel, E, Lefebvre, RA.
Hemin reduces postoperative ileus in a heme oxygenase 1-dependent manner while dimethyl fumarate does without heme oxygenase 1-induction
Neurogastroenterol Motil , e13624, 2020. (Epub 2019 May 23)

Van Nuffel, E, Staal, J, Baudelet, G, Haegman, M, Driege, Y, Hochepied, T, Afonina, IS, Beyaert, R.
MALT1 targeting suppresses CARD14-induced psoriatic dermatitis in mice
EMBO Rep 21, e49237, 2020. (Epub 2020 Apr 28)

Cochet, F, Facchini, FA, Zaffaroni, L, Billod, JM, Coelho, H, Holgado, A, Braun, H, Beyaert, R, Jerala, R, Jimenez-Barbero, J, Martin-Santamaria, S, Peri, F.
Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties
Sci Rep 9, 919, 2019. (Epub 2019 Jan 29)

Cossarizza, A, Chang, HD, Radbruch, A, Acs, A, Adam, D, Adam-Klages, S, Agace, WW, Aghaeepour, N, Akdis, M, Allez, M, Almeida, LN, Alvisi, G, Anderson, G, Andra, I, Annunziato, F, Anselmo, A, Bacher, P, Baldari, CT, Bari, S, et al..
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
Eur J Immunol 49, 1457-1973, 2019. (Epub 2019 Oct)

Demeyer, A, Skordos, I, Driege, Y, Kreike, M, Hochepied, T, Baens, M, Staal, J, Beyaert, R.
MALT1 Proteolytic Activity Suppresses Autoimmunity in a T Cell Intrinsic Manner
Front Immunol 10, 1898, 2019. (Epub 2019 Aug 14)

Demeyer, A, Van Nuffel, E, Baudelet, G, Driege, Y, Kreike, M, Muyllaert, D, Staal, J, Beyaert, R.
MALT1-Deficient Mice Develop Atopic-Like Dermatitis Upon Aging
Front Immunol 10, 2330, 2019. (Epub 2019 Oct 1)

Dendoncker, K, Timmermans, S, Vandewalle, J, Eggermont, M, Lempiainen, J, Van Hamme, E, Dewaele, S, Vandevyver, S, Ballegeer, M, Souffriau, J, Van Wyngene, L, Van Looveren, K, Vanderhaeghen, T, Beyaert, R, De Bosscher, K, Palvimo, JJ, Van Montagu, M, Libert, C.
TNF-alpha inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile
Proc Natl Acad Sci U S A 116, 12942-12951, 2019. (Epub 2019 Jun 10)

Drutman, SB, Haerynck, F, Zhong, FL, Hum, D, Hernandez, NJ, Belkaya, S, Rapaport, F, de Jong, SJ, Creytens, D, Tavernier, SJ, Bonte, K, De Schepper, S, van der Werff Ten Bosch, J, Lorenzo-Diaz, L, Wullaert, A, Bossuyt, X, Orth, G, Bonagura, VR, Beziat, V, et al..
Homozygous NLRP1 gain-of-function mutation in siblings with a syndromic form of recurrent respiratory papillomatosis
Proc Natl Acad Sci U S A 116, 19055-19063, 2019. (Epub 2019 Sep 4)

Emmaneel, A, Bogaert, DJ, Van Gassen, S, Tavernier, SJ, Dullaers, M, Haerynck, F, Saeys, Y.
A Computational Pipeline for the Diagnosis of CVID Patients
Frontiers in Immunology 10, 2009, 2019. (Epub 2019 Aug 30)

Gilis, E, Gaublomme, D, Staal, J, Venken, K, Dhaenens, M, Lambrecht, S, Coudenys, J, Decruy, T, Schryvers, N, Driege, Y, Dumas, E, Demeyer, A, De Muynck, A, van Hengel, J, Van Hoorebeke, L, Deforce, D, Beyaert, R, Elewaut, D.
Deletion of Mucosa‐Associated Lymphoid Tissue Lymphoma Translocation Protein 1 in Mouse T Cells Protects Against Development of Autoimmune Arthritis but Leads to Spontaneous Osteoporosis
Arthritis Rheumatol 71, 2005-2015, 2019. (Epub 2019 Jul 1)

Holgado, A, Braun, H, Van Nuffel, E, Detry, S, Schuijs, MJ, Deswarte, K, Vergote, K, Haegman, M, Baudelet, G, Haustraete, J, Hammad, H, Lambrecht, BN, Savvides, SN, Afonina, IS, Beyaert, R.
IL-33trap is a novel IL-33 neutralizing biologic that inhibits allergic airway inflammation
J Allergy Clin Immunol 144, 204-215, 2019. (Epub 2019 Mar 12)

Lork, M, Staal, J, Beyaert, R.
Ubiquitination and phosphorylation of the CARD11-BCL10-MALT1 signalosome in T cells
Cell Immunol 340, 103877, 2019. (Epub 2018 Nov 9)

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