Research Field: Untangling molecular crosstalk in the skin
Team leader: Prof. Dr. Esther Hoste
Tel: +32 9 33 13 763 - Fax: +32 9 221 76 73
Our team focusses on understanding the cellular and molecular crosstalk between keratinocytes- the epithelial cells of the skin- and their microenvironment in health and disease. During injury, fast repair mechanisms are critical to maintain the skinís barrier function and we study how epidermal stem cells communicate with fibroblasts and immune cells to orchestrate inflammation and subsequent tissue regeneration. Wound repair can however predispose tissues to cancer initiation and we aim to identify novel molecular mechanisms through which inflammation, cell death and fibrosis modulate epidermal stem cells and impact on skin regeneration and neoplasia.
To dissect how intercellular crosstalk in the skin orchestrates inflammation, injury repair and/or tumour initiation, we are addressing four key questions: