Esther Hoste team - Keratinocyte microenvironment lab

Research Field: Untangling molecular crosstalk in the skin

Team leader: Prof. Dr. Esther Hoste

Tel: +32 9 33 13 763 - Fax: +32 9 221 76 73
Email: Esther.Hoste.spam.detractor@irc.vib-ugentspam.corruptor.be

Research topic

Our team focusses on understanding the cellular and molecular crosstalk between keratinocytes- the epithelial cells of the skin- and their microenvironment in health and disease. During injury, fast repair mechanisms are critical to maintain the skinís barrier function and we study how epidermal stem cells communicate with fibroblasts and immune cells to orchestrate inflammation and subsequent tissue regeneration. Wound repair can however predispose tissues to cancer initiation and we aim to identify novel molecular mechanisms through which inflammation, cell death and fibrosis modulate epidermal stem cells and impact on skin regeneration and neoplasia.

To dissect how intercellular crosstalk in the skin orchestrates inflammation, injury repair and/or tumour initiation, we are addressing four key questions:

  1. What are the molecules that are released during cutaneous injury repair and how do they modulate regenerative and neoplastic responses?
  2. Which molecular pathways control the activation of epidermal stem cells?
  3. How do different modalities of keratinocyte cell death influence the skinís tissue response?
  4. Can we manipulate molecular signaling pathways in the skin to improve tissue regeneration, while preventing tumour initiation?

Areas of expertise

  • Mouse models of skin inflammation, regeneration and keratinocyte-derived tumorigenesis
  • Innate immunity
  • Epidermal stem cell assays

Technology transfer potential

  • Novel treatments to improve chronic and diabetic cutaneous wound healing
  • Identifying targeting strategies to prevent non-melanoma skin cancer

Recent publications

  1. Hoste, E., et al. Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils for NET Formation.
    Cell Reports. 29(9): p. 2689-2701 e4. 2019.
  2. Hoste, E., et al. Innate sensing of microbial products promotes wound-induced skin cancer.
    Nature Communications. 6: p. 5932. 2015.
  3. Cipolat, S., Hoste E. et al. Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility.
    Elife. 3: p. e01888. 2014.
  4. Arwert, E.N., E. Hoste, and F.M. Watt, Epithelial stem cells, wound healing and cancer.
    Nature Reviews Cancer. 12(3): p. 170-80. 2012.
  5. Driskell, R.R., Hoste E. et al. Distinct fibroblast lineages determine dermal architecture in skin development and repair.
    Nature. 504(7479): p. 277-281. 2013.
Image depicting tail wholemounts of normal (left) and inflamed (right) skin stained for cleaved caspase-3 (red) and nuclear counterstain (blue). A clear increase in apoptotic cells is observed in inflamed tail skin. Scale bar: 100 Ķm.

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