Research Field: Role of intestinal microbiota in inflammatory pathologies
Team leader: Prof. Dr. Lars Vereecke
Tel: +32 9 33 264 04
The ‘Host-Microbiota Interaction’ lab (HMI) studies the complex interplay between the intestinal microbiota and the host immune system, both locally and systemically. The lab investigates the fundamental mechanisms underlying immune pathologies including spondyloarthritis (SpA) and IBD using genetic mouse models, and studies the role of the intestinal microbiota during disease development. We have a strong interest in immune-modulating functions of enteric bacteria, fungi and helminths. The HMI lab is embedded in the department or Rheumatology (headed by Prof. Dirk Elewaut) at the Ghent University Hospital, and has a special focus on the mechanistic link between intestinal and joint inflammation (the gut-joint axis). The lab coordinates the Ghent Germfree and Gnotobiotic mouse facility and is part of the ‘Ghent Gut Inflammation Group’, a research consortium around intestinal inflammation at Ghent University.
Areas of expertise
Technology transfer potential
Schematic overview HMI lab. Click to enlarge.
Mucus produced by intestinal goblet cells preventing bacterial adhesion in the colon