Research field: Pathogen sensing and inflammation
Group leader: Prof. Dr. Mohamed Lamkanfi
The major research interest of the NOD-like Receptor and Inflammasome Laboratory is how NOD-like receptors (NLRs) and inflammasomes modulate immune responses. NLRs represent a family of intracellular receptors by which immune cells detect and mount immune responses against invading pathogens. Mutations in NLR genes are associated with auto-inflammatory and -immune disorders, including Crohn’s disease, arthritis, diabetes, period fever syndromes, asthma, atopic eczema, Blau syndrome and vitiligo. While some NLRs regulate NF-κB signaling and interferon responses, another subset of the 22 NLR proteins encoded in the human genome is responsible for production of interleukin (IL)-1ß and IL-18 through activation of the cysteine proteases caspases-1 and -11 in protein complexes termed ‘inflammasomes’.
Area of expertise
Technology transfer potential
Macrophage undergoing pyroptotic cell death
Intestinal inflammation in caspase-11-deficient mice