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Martens, S, Bridelance, J, Roelandt, R, Vandenabeele, P, Takahashi, N.
MLKL in cancer: more than a necroptosis regulator
Cell Death Differ 28, 1757-1772, 2021. (Epub 2021 May 5)

Oltean, T, Van San, E, Divert, T, Vanden Berghe, T, Saelens, X, Maelfait, J, Takahashi, N, Vandenabeele, P.
Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL
Cell Death Dis 12, 471, 2021. (Epub 2021 May 11)

Vetters, J, van Helden, MJ, Wahlen, S, Tavernier, SJ, Martens, A, Fayazpour, F, Vergote, K, Vanheerswynghels, M, Deswarte, K, Van Moorleghem, J, De Prijck, S, Takahashi, N, Vandenabeele, P, Boon, L, van Loo, G, Vivier, E, Lambrecht, BN, Janssens, S.
The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF
J Exp Med 216, 2010-2023, 2019. (Epub 2019 Jul 11)

Webb, LV, Barbarulo, A, Huysentruyt, J, Vanden Berghe, T, Takahashi, N, Ley, S, Vandenabeele, P, Seddon, B.
Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-kappaB
Immunity 50, 348-361, 2019. (Epub 2019 Jan 23)

Ballegeer, M, Van Looveren, K, Timmermans, S, Eggermont, M, Vandevyver, S, Thery, F, Dendoncker, K, Souffriau, J, Vandewalle, J, Van Wyngene, L, De Rycke, R, Takahashi, N, Vandenabeele, P, Tuckermann, J, Reichardt, HM, Impens, F, Beyaert, R, De Bosscher, K, Vandenbroucke, RE, et al..
Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice
J Clin Invest 128, 3265-3279, 2018. (Epub 2018 May 10)

Hofmans, S, Devisscher, L, Martens, S, Van Rompaey, D, Goossens, K, Divert, T, Nerinckx, W, Takahashi, N, De Winter, H, Van der Veken, P, Goossens, V, Vandenabeele, P, Augustyns, K.
Tozasertib analogues as inhibitors of necroptotic cell death
J Med Chem 61, 1895-1920, 2018. (Epub 2018 Feb 13)

Martens, S, Goossens, V, Devisscher, L, Hofmans, S, Claeys, P, Vuylsteke, M, Takahashi, N, Augustyns, K, Vandenabeele, P.
RIPK1-dependent cell death: a novel target of the Aurora kinase inhibitor Tozasertib (VX-680)
Cell Death Dis 9, 211, 2018. (Epub 2018 Feb 12)

Saavedra, PHV, Huang, L, Ghazavi, F, Kourula, S, Vanden Berghe, T, Takahashi, N, Vandenabeele, P, Lamkanfi, M.
Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis
Nat Commun 9, 4846, 2018. (Epub 2018 Nov 19)

Scott, CL, T'Jonck, W, Martens, L, Todorov, H, Sichien, D, Soen, B, Bonnardel, J, De Prijck, S, Vandamme, N, Cannoodt, R, Saelens, W, Vanneste, B, Toussaint, W, De Bleser, P, Takahashi, N, Vandenabeele, P, et al., Lambrecht, BN, De Baetselier, P, Milling, SWF, Van Ginderachter, JA, Malissen, B, Berx, G, Beschin, A, Saeys, Y, Guilliams, M.
The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages
Immunity 49, 312-325, 2018. (Epub 2018 Jul 31)

Martens, S, Jeong, M, Tonnus, W, Feldmann, F, Hofmans, S, Goossens, V, Takahashi, N, Brasen, JH, Lee, EW, Van der Veken, P, Joossens, J, Augustyns, K, Fulda, S, Linkermann, A, Song, J, Vandenabeele, P.
Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury
Cell Death Dis 8, e2904, 2017. (Epub 2017 Jun 29)

Grootaert, MO, Schrijvers, DM, Van Spaendonk, H, Breynaert, A, Hermans, N, Van Hoof, VO, Takahashi, N, Vandenabeele, P, Kim, SH, De Meyer, GR, Martinet, W.
NecroX-7 reduces necrotic core formation in atherosclerotic plaques of Apoe knockout mice
Atherosclerosis 252, 166-174, 2016. (Epub 2016 Sep)

Tortola, L, Nitsch, R, Bertrand, MJ, Kogler, M, Redouane, Y, Kozieradzki, I, Uribesalgo, I, Fennell, LM, Daugaard, M, Klug, H, Wirnsberger, G, Wimmer, R, Perlot, T, Sarao, R, Rao, S, Hanada, T, Takahashi, N, Kernbauer, E, Vandenabeele, P, et al..
The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate
Cell Rep 15, 1481-1492, 2016. (Epub 2016 May 17)

Jouan-Lanhouet, S, Riquet, F, Duprez, L, Vanden Berghe, T, Takahashi, N, Vandenabeele, P.
Necroptosis, in vivo detection in experimental disease models
Semin Cell Dev Biol 35C, 2-13, 2014. (Epub 2014 Aug 23)

Remijsen, Q, Goossens, V, Grootjans, S, Van den Haute, C, Vanlangenakker, N, Dondelinger, Y, Roelandt, R, Bruggeman, I, Goncalves, A, Bertrand, MJ, Baekelandt, V, Takahashi, N, Vanden Berghe, T, Vandenabeele, P.
Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis
Cell Death Dis 5, e1004, 2014. (Epub 2014 Jan 16)

Takahashi, N, Vereecke, L, Bertrand, MJ, Duprez, L, Berger, SB, Divert, T, Goncalves, A, Sze, M, Gilbert, B, Kourula, S, Goossens, V, Lefebvre, S, Gunther, C, Becker, C, Bertin, J, Gough, PJ, Declercq, W, van Loo, G, Vandenabeele, P.
RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis
Nature 513, 95-99, 2014. (Epub 2014 Sep 4)

Vanden Berghe, T, Demon, D, Bogaert, P, Vandendriessche, B, Goethals, A, Depuydt, B, Vuylsteke, M, Roelandt, R, Van Wonterghem, E, Vandenbroecke, J, Choi, SM, Meyer, E, Krautwald, S, Declercq, W, Takahashi, N, Cauwels, A, Vandenabeele, P.
Simultaneous targeting of Interleukin-1 and -18 is required for protection against inflammatory and septic shock
Am J Respir Crit Care Med 189, 282-291, 2014. (Epub 2014 Jan 23)

Vandenabeele, P, Grootjans, S, Callewaert, N, Takahashi, N.
Necrostatin-1 blocks both RIPK1 and IDO: consequences for the study of cell death in experimental disease models
Cell Death Differ 20, 185-187 , 2013. (Epub 2012 Nov 30)

Vanden Berghe, T, Grootjans, S, Goossens, V, Dondelinger, Y, Krysko, DV, Takahashi, N, Vandenabeele, P.
Determination of apoptotic and necrotic cell death in vitro and in vivo
Methods 61, 117-129, 2013. (Epub 2013 Mar 6)

Jouan-Lanhouet, S, Arshad, MI, Piquet-Pellorce, C, Martin-Chouly, C, Le Moigne-Muller, G, Van Herreweghe, F, Takahashi, N, Sergent, O, Lagadic-Gossmann, D, Vandenabeele, P, Samson, M, Dimanche-Boitrel, MT.
TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation
Cell Death Differ 19, 2003-2014, 2012. (Epub 2012 Jul 20)

Takahashi, N, Duprez, L, Grootjans, S, Cauwels, A, Nerinckx, W, Duhadaway, JB, Goossens, V, Roelandt, R, Van Hauwermeiren, F, Libert, C, Declercq, W, Callewaert, N, Prendergast, GC, Degterev, A, Yuan, J, Vandenabeele, P.
Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models
Cell Death Dis 3, e437, 2012. (Epub 2012 Nov 29)

Tucci, P, Agostini, M, Grespi, F, Markert, EK, Terrinoni, A, Vousden, KH, Muller, PA, Dotsch, V, Kehrloesser, S, Sayan, BS, Giaccone, G, Lowe, SW, Takahashi, N, Vandenabeele, P, Knight, RA, Levine, AJ, Melino, G.
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer
Proc Natl Acad Sci USA 109, 15312-15327, 2012. (Epub 2012 Sep 4)

Wejda, M, Impens, F, Takahashi, N, Van Damme, P, Gevaert, K, Vandenabeele, P.
Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike
J Biol Chem 287, 33983-33995 , 2012. (Epub 2012 Jul 23)

Declercq, W, Takahashi, N, Vandenabeele, P.
Dual face apoptotic machinery: from initiator of apoptosis to guardian of necroptosis
Immunity 35, 493-495, 2011. (Epub 2011 Oct 28)

Duprez, L, Takahashi, N, Van Hauwermeiren, F, Vandendriessche, B, Goossens, V, Vanden Berghe, T, Declercq, W, Libert, C, Cauwels, A, Vandenabeele, P.
RIP Kinase-dependent necroptosis drives lethal systemic inflammatory response syndrome
Immunity 35, 908-918, 2011. (Epub 2011 Dec 23)

Krysko, DV, Kaczmarek, A, Krysko, O, Heyndrickx, L, Woznicki, J, Bogaert, P, Cauwels, A, Takahashi, N, Magez, S, Bachert, C, Vandenabeele, P.
TLR-2 and TLR-9 are sensors of apoptosis in a mouse model of doxorubicin-induced acute inflammation
Cell Death Differ 18, 1316-1325, 2011. (Epub 2011 Feb 11)

Takahashi, N, Quimbaya, M, Schubert, V, Lammens, T, Vandepoele, K, Schubert, I, Matsui, M, Inze, D, Berx, G, De Veylder, L.
The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair
PLoS Genet 6, e1000817, 2010. (Epub 2010 Jan 15)

Takahashi, N, Vanlaere, I, de Rycke, R, Cauwels, A, Joosten, LA, Lubberts, E, van den Berg, WB, Libert, C.
IL-17 produced by Paneth cells drives TNF-induced shock
J Exp Med 205, 1755-1761, 2008. (Epub 2008 Jul 28)

Brouckaert, P, Takahashi, N, van Tiel, S, Hostens, J, Eggermont, AaLB, Seynhaeve, A, Fiers, W, Timo, L.
Tumour Necrosis Factor-alpha augmented tumour response in B16BL6 melanoma-bearing mice treated with Stealth liposomal doxorubicin (Doxil) correlates with altered Doxil pharmacokinetics
Int J Cancer 109, 442-448, 2004. (Epub ---)

Levi, B, Sica, A, Müller-Newen, G, Takahashi, N, Vandenabeele, P, Fish, E.
Jerusalem of cytokines
Cytokine Growth Factor Rev 10, 159-171, 1999. (Epub ---)

Takahashi, N, Waelput, W, Guisez, Y.
Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor
J Exp Med 189, 207-212, 1999. (Epub ---)

Benigni, F, Faggioni, R, Sironi, M, Fantuzzi, G, Vandenabeele, P, Takahashi, N, Sacco, S, Fiers, W, Buurman, WA, Ghezzi, P.
TNF receptor p55 plays a major role in centrally mediated increases of serum IL-6 and corticosterone after intracerebroventricular injection of TNF
J Immunol 157, 5563-5568, 1996. (Epub ---)

Brouckaert, P, Libert, C, Cauwels, A, Everaerdt, B, Van Molle, W, Ameloot, P, Gansemans, Y, Grijalba, B, Takahashi, N, Truong, M-J, Van Leuven, P, Fiers, W.
Inhibition of and sensitization to the lethal effects of tumor necrosis factor
J Inflamm 47, 18-26, 1996. (Epub ---)

Takahashi, N, Brouckaert, P, Fiers, W.
Mechanism of tolerance to tumor necrosis factor: Receptor-specific pathway and selectivity
Am J Physiol 269, R398-R405, 1995. (Epub ---)

Takahashi, N, Fiers, W, Brouckaert, P.
Anti-tumor activity of tumor necrosis factor in combination with interferon-gamma is not affected by prior tolerization
Int J Cancer 63, 846-854, 1995. (Epub ---)

Brouckaert, P, Ameloot, P, Cauwels, A, Everaerdt, B, Libert, C, Takahashi, N, Van Molle, W, Fiers, W.
Receptor-selective mutants of tumour necrosis factor in the therapy of cancer: Preclinical studies
Circ Shock 43, 185-190, 1994. (Epub ---)

Libert, C, Takahashi, N, Cauwels, A, Brouckaert, P, Bluethmann, H, Fiers, W.
Response of interleukin-6-deficient mice to tumor necrosis factor-induced metabolic changes and lethality
Eur J Immunol 24, 2237-2242, 1994. (Epub ---)

Takahashi, N, Brouckaert, P, Bemelmans, MHA, Buurman, WA, Fiers, W.
Mechanism of induction of tolerance to tumour necrosis factor (TNF): No involvement of modulators of TNF bioavailability or receptor binding
Cytokine 6, 235-242, 1994. (Epub ---)

Brouckaert, P, Everaerdt, B, Libert, C, Takahashi, N, Cauwels, A, Fiers, W.
Strategies to broaden the therapeutic margin of tumor necrosis factor
In Tumor Necrosis Factor: Molecular and Cellular Biology and Clinical Relevance. (Fiers, W, Buurman, WA, eds.), Basel, Karger, pp. 226-232, 1993. (Epub ---)

Brouckaert, P, Libert, C, Everaerdt, B, Takahashi, N, Cauwels, A, Fiers, W.
Tumor necrosis factor, its receptors and the connection with interleukin 1 and interleukin 6
Immunobiology 187, 317-329, 1993. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Cauwels, A, Declercq, W, De Valck, D, Everaerdt, B, Goossens, V, Grooten, J, Haegeman, G, Libert, C, Schulze-Osthoff, K, Takahashi, N, Vandenabeele, P, Vanhaesebroeck, B, Van Ostade, X, Van Roy, F.
Two pathways of tumor necrosis factor signal transduction: In vitro and in vivo implications
In Tumor Necrosis Factor: Molecular and Cellular Biology and Clinical Relevance. (Fiers, W, Buurman, WA, eds.), Basel, Karger (Shugar, D, Rode, W, Borowski, E, eds.), Warszawa-Berlin, Polish Scientific Publishers PWN/Springer-Verlag, pp. 58-65, 1993. (Epub ---)

Libert, C, Everaerdt, B, Takahashi, N, Cauwels, A, Brouckaert, P, Fiers, W.
Protection against tumor necrosis factor-induced lethality
In Tumor Necrosis Factor: Molecular and Cellular Biology and Clinical Relevance. (Fiers, W, Buurman, WA, eds.), Basel, Karger, pp. 126-131, 1993. (Epub ---)

Takahashi, N, Brouckaert, P, Fiers, W.
Cyclooxygenase inhibitors prevent the induction of tolerance to the toxic effects of tumor necrosis factor
J Immunother 14, 16-21, 1993. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Decoster, E, De Valck, D, Everaerdt, B, Grooten, J, Lenaerts, A, Libert, C, Schulze-Osthoff, K, Takahashi, N, Tavernier, J, Van Bladel, S, Van Dorpe, C, Vanhaesebroeck, B, Van Ostade, X, Van Roy, F.
Tumor necrosis factor: Mechanism of action at the molecular, cellular and in vivo level
In Tumor Necrosis Factor: Structure-function Relationship and Clinical Application. (Osawa, T, Bonavida, B, eds.), Basel, Karger, pp. 66-73, 1992. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Decoster, E, De Valck, D, Everaerdt, B, Grooten, J, Lenaerts, A, Libert, C, Schulze-Osthoff, K, Takahashi, N, Van Bladel, S, Van Dorpe, C, Vanhaesebroeck, B, Van Ostade, X, Van Roy, F.
Tumor necrosis factor: Mechanism of action and its potential for anticancer therapy
In Molecular Aspects of Chemotherapy. , pp. 119-125, 1992. (Epub ---)

Takahashi, N, Brouckaert, P, Fiers, W.
Induction of tolerance allows separation of lethal and antitumor activities of tumor necrosis factor in mice
Cancer Res 51, 2366-2372, 1991. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Everaerdt, B, Haegeman, G, Libert, C, Suffys, P, Takahashi, N, Tavernier, J, Van Bladel, S, Vanhaesebroeck, B, Van Ostade, X, Van Roy, F.
In vitro and in vivo action of tumor necrosis factor
In Tumor Necrosis Factor: Structure, Mechanism of Action, Role in Disease and Therapy. (Bonavida, B, Granger, G, eds.), Basel, Karger, pp. 77-81, 1990. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Everaerdt, B, Libert, C, Suffys, P, Takahashi, N, Vanhaesebroeck, B, Van Roy, F.
Mechanism of action of tumor necrosis factor and its implications for synergizing and antagonizing drugs
In Endotoxin From Pathophysiology to Therapeutic Approaches. (Baumgartner, J-D, Calandra, T, Carlet, J, eds.), Paris, Médecine-Sciences/Flammarion, pp. 59-68, 1990. (Epub ---)

Brouckaert, PG, Everaerdt, B, Libert, C, Takahashi, N, Fiers, W.
Species specificity and involvement of other cytokines in endotoxic shock action of recombinant tumour necrosis factor in mice
Agents Actions 26, 196-198, 1989. (Epub ---)

Brouckaert, PG, Libert, C, Everaerdt, B, Takahashi, N, Fiers, W.
A role for interleukin 1 in the in vivo actions of tumor necrosis factor
Lymphokine Res 8, 269-274, 1989. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Everaerdt, B, Grooten, J, Haegeman, G, Libert, C, Suffys, P, Takahashi, N, Tavernier, J, Van Bladel, S, Vanhaesebroeck, B, Van Ostade, X, Van Roy, F.
Tumour necrosis factor and interleukin-6: Structure and mechanism of action of the molecular, cellular and in vivo level
In Vectors as Tools for the Study of Normal and Abnormal Growth and Differentiation. (Lother, H, Dernick, R, Ostertag, W, eds.), NATO ASI Series, Vol. H 34, Berlin, Springer-Verlag, pp. 229-240, 1989. (Epub ---)

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