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Click the UGent logo to retrieve publications of Peter Brouckaert in the UGent bibliography

Atochin, DN, Yuzawa, I, Li, Q, Rauwerdink, KM, Malhotra, R, Chang, J, Brouckaert, P, Ayata, C, Moskowitz, MA, Bloch, KD, Huang, PL, Buys, ES.
Soluble Guanylate Cyclase alpha1beta1 limits stroke size and attenuates neurological injury
Stroke 41, 1815-1819, 2010. (Epub 2010 Jul 1)

Cauwels, A, Rogge, E, Janssen, B, Brouckaert, P.
Reactive oxygen species and small conductance calcium-dependent potassium channels are key mediators of inflammation-induced hypotension and shock
J Mol Med 88, 921-930, 2010. (Epub 2010 May 25)

Decaluwe, K, Nimmegeers, S, Thoonen, R, Buys, E, Brouckaert, P, Van de Voorde, J.
In vitro and in vivo studies on the importance of the soluble guanylyl cyclase alpha1 subunit in penile erection
World J Urol 28, 643-650, 2010. (Epub 2010 Jan 23)

Houthuys, E, Movahedi, K, De Baetselier, P, Van Ginderachter, JA, Brouckaert, P.
A method for the isolation and purification of mouse peripheral blood monocytes
J Immunol Methods 359, 1-10, 2010. (Epub 2010 May 7)

Ni, J, McLoughlin, RM, Brodovitch, A, Moulin, P, Brouckaert, P, Casadei, B, Feron, O, Topley, N, Balligand, J-L, Devuyst, O.
Nitric oxide synthase isoforms play distinct roles during acute peritonitis
Nephrol Dial Transplant 25, 86-96, 2010. (Epub 2009 Aug 25)

Buys, ES, Cauwels, A, Raher, MJ, Passeri, JJ, Hobai, I, Cawley, SM, Rauwerdink, KM, Thibault, HB, Sips, PY, Thoonen, R, Scherrer-Crosbie, M, Ichinose, F, Brouckaert, P, Bloch, KD.
sGCalpha1beta1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models
Am J Physiol Heart Circ Physiol 297, H654-H663, 2009. (Epub 2009 Jun 5)

Cauwels, A, Buys, ES, Thoonen, R, Geary, L, Delanghe, J, Shiva, S, Brouckaert, P.
Nitrite protects against morbidity and mortality associated with TNF or LPS-induced shock in a soluble guanylate cyclase–dependent manner
J Exp Med 206, 2915-2924, 2009. (Epub 2009 Nov 23)

Dhaese, I, Vanneste, G, Sips, P, Buys, E, Brouckaert, P, Lefebvre, RA.
Small intestinal motility in soluble guanylate cyclase a1 knockout mice
Naunyn S Arch Pharmacol 379, 473-487, 2009. (Epub 2008 Dec 4)

Nishida, T, Yu, JD, Minamishima, S, Sips, P, Searles, RJ, Buys, ES, Janssens, S, Brouckaert, P, Bloch, KD, Ichinose, F.
Impact of nitric oxide synthase 3 and soluble guanylate cyclase on the outcome of cardiac arrest and cardiopulmonary resuscitation in mice
Crit Care Med 37, 256-262, 2009. (Epub 2008 Nov 28)

Vanholder, R, Abou-Deif, O, Argiles, A, Baurmeister, U, Beige, J, Brouckaert, P, Brunet, P, Cohen, G, De Deyn, PP, Drueke, TB, Fliser, D, Glorieux, G, Herget-Rosenthal, S, Horl, WH, Jankowski, J, Jorres, A, Massy, ZA, Mischak, H, Perna, AF, et al..
The role of EUTox in uremic toxin research
Semin Dialysis 22, 323-328, 2009. (Epub ---)

Vermeersch, P, Buys, E, Sips, P, Pokreisz, P, Marsboom, G, Gillijns, H, Pellens, M, Dewerchin, M, Bloch, KD, Brouckaert, P, Janssens, S.
Gender-specific modulation of the response to arterial injury by soluble Guanylate Cyclase alpha1
Open Cardiovasc Med J 3, 98-104, 2009. (Epub 2009 Aug 31)

Buys, ES, Sips, P, Vermeersch, P, Raher, MJ, Rogge, E, Ichinose, F, Dewerchin, M, Bloch, KD, Janssens, S, Brouckaert, P.
Gender-specific hypertension and responsiveness to nitric oxide in sGC{alpha}1 knockout mice
Cardiovasc Res 79, 179-186, 2008. (Epub 2008 Mar 13)

Cauwels, A, Brouckaert, P.
Critical role for small and large conductance calcium-dependent potassium channels in endotoxemia and TNF toxicity
Shock 29, 577-582, 2008. (Epub 2007 Aug 16)

De Backer, O, Elinck, E, Sips, P, Buys, E, Brouckaert, P, Lefebvre, RA.
Role of the soluble guanylyl cyclase alpha1/alpha2 subunits in the relaxant effect of CO and CORM-2 in murine gastric fundus
Naunyn S Arch Pharmacol 378, 493-502, 2008. (Epub 2008 Jun 19)

Dhaese, I, Vanneste, G, Sips, P, Buys, E, Brouckaert, P, Lefebvre, RA.
Involvement of soluble guanylate cyclase alpha1 and alpha2, and SKCa channels in NANC relaxation of mouse distal colon
Eur J Pharmacol 589, 251-259, 2008. (Epub 2008 May 23)

Nimmegeers, S, Sips, P, Buys, E, De Caluwé, K, Brouckaert, P, Van de Voorde, J.
Role of the soluble guanylyl cyclase-alpha-1 subunit in mice corpus cavernosum smooth muscle relaxation
Int J Impot Res 20, 278-284, 2008. (Epub 2007 Dec 6)

Rivas, MA, Carnevale, RP, Proietti, CJ, Rosemblit, C, Beguelin, W, Salatino, M, Charreau, EH, Frahm, I, Sapia, S, Brouckaert, P, Elizalde, PV, Schillaci, R.
TNFalpha acting on TNFR1 promotes breast cancer growth via p42/P44 MAPK, JNK, Akt and NF-kappaB-dependent pathways
Exp Cell Res 314, 509-529, 2008. (Epub 2007 Oct 13)

Cauwels, A, Brouckaert, P.
Survival of TNF toxicity: dependence on caspases and NO
Arch Biochem Biophys 462, 132-139, 2007. (Epub 2007 Feb 8)

Nimmegeers, S, Sips, P, Buys, E, Brouckaert, P, Van de Voorde, J.
Functional role of the soluble guanylyl cyclase alpha1 subunit in vascular smooth muscle relaxation
Cardiovasc Res 76, 149-159, 2007. (Epub 2007 Jun 12)

Vanneste, G, Dhaese, I, Sips, P, Buys, E, Brouckaert, P, Lefebvre, RA.
Gastric motility in soluble guanylate cyclase alpha1 knock-out mice
J Physiol 584, 907-920, 2007. (Epub 2007 Aug 23)

Vermeersch, P, Buys, E, Pokreisz, P, Marsboom, G, Ichinose, F, Sips, P, Pellens, M, Gillijns, H, Swinnen, M, Graveline, A, Collen, D, Dewerchin, M, Brouckaert, P, Bloch, KD, Janssens, S.
Soluble guanylate cyclase-alpha1 deficiency selectively inhibits the pulmonary vasodilator response to nitric oxide and increases the pulmonary vascular remodeling response to chronic hypoxia
Circulation 116, 936-943, 2007. (Epub 2007 Aug 6)

Bultinck, J, Brouckaert, P, Cauwels, A.
The in vivo contribution of hematopoietic cells to systemic TNF and IL-6 production during endotoxemia
Cytokine 36, 160-166, 2006. (Epub 2007 Jan 3)

Bultinck, J, Sips, P, Vakaet, L, Brouckaert, P, Cauwels, A.
Systemic NO production during (septic) shock depends on parenchymal and not on hematopoietic cells: in vivo iNOS expression pattern in (septic) shock
FASEB J 20, 2363-2365, 2006. (Epub 2006 Oct 4)

Cauwels, A, Janssen, B, Buys, E, Sips, P, Brouckaert, P.
Anaphylactic shock depends on PI3K and eNOS-derived NO
J Clin Invest 116, 2244-2251, 2006. (Epub ---)

Heirman, I, Ginneberge, D, Brigelius-Flohé, R, Hendrickx, N, Agostinis, P, Brouckaert, P, Rottiers, P, Grooten, J.
Blocking tumor cell eicosanoid synthesis by GPx4 impedes tumor growth and malignancy
Free Radical Biol Med 40, 285-294, 2006. (Epub ---)

Rahman, MM, Barrett, JW, Brouckaert, P, McFadden, G.
Variation in ligand binding specificities of a novel class of poxvirus-encoded Tumor Necrosis Factor-binding protein
J Biol Chem 281, 22517-22526, 2006. (Epub 2006 Jun 16)

Waelput, W, Brouckaert, P, Broekaert, D, Tavernier, J.
A role for leptin in the systemic inflammatory response syndrome (SIRS) and in immune response, an update
Curr Med Chem 13, 465-475, 2006. (Epub ---)

Cauwels, A, Bultinck, J, Brouckaert, P.
Dual role of endogenous nitric oxide in tumor necrosis factor shock: induced NO tempers oxidative stress
Cell Mol Life Sci 62, 1632-1640, 2005. (Epub 2005 Jun 30)

Ameloot, P, Brouckaert, P.
Production and characterization of receptor-specific TNF muteins
Methods Mol Med 98, 33-46, 2004. (Epub ---)

Brouckaert, P, Takahashi, N, van Tiel, S, Hostens, J, Eggermont, AaLB, Seynhaeve, A, Fiers, W, Timo, L.
Tumour Necrosis Factor-alpha augmented tumour response in B16BL6 melanoma-bearing mice treated with Stealth liposomal doxorubicin (Doxil) correlates with altered Doxil pharmacokinetics
Int J Cancer 109, 442-448, 2004. (Epub ---)

Magez, S, Truyens, C, Merimi, M, Radwanska, M, Stijlemans, B, Brouckaert, P, Brombacher, F, Pays, E, De Baetselier, P.
P75 TNF-receptor shedding occurs as a protective host response during African trypanosomiasis
J Infect Dis 189, 527-539, 2004. (Epub 2004 Jan 23)

Wu, G, Brouckaert, P, Olivecrona, T.
Rapid down-regulation of adipose tissue lipoprotein lipase activity on food deprivation. Evidence that TNF- is involved
Am J Physiol Endocrinol Metab 286, E711–E717, 2004. (Epub 2003 Dec 23)

Cauwels, A, Janssen, B, Waeytens, A, Cuvelier, C, Brouckaert, P.
Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2
Nat Immunol 4, 387-393, 2003. (Epub ---)

Ameloot, P, Fiers, W, Buurman, WA, De Baetselier, P, Brouckaert, P.
Characterization of the interaction between murine tumour necrosis factor and monoclonal antibodies
Cytokine 18, 158-163, 2002. (Epub ---)

Ameloot, P, Takahashi, T, Everaerdt, B, Hostens, J, Eugster, H-P, Fiers, W, Brouckaert, P.
Bioavailability of recombinant tumor necrosis factor determines its lethality in mice
Eur J Immunol 32, 2759-2765, 2002. (Epub ---)

Dick, JMC, Van Molle, W, Brouckaert, P, Lefebvre, RA.
Relaxation by vasoactive intestinal polypeptide in the gastric fundus of nitric oxide synthase-deficient mice
J Physiol 538, 133-143, 2002. (Epub ---)

Hochepied, T, Wullaert, A, Berger, FG, Baumann, H, Brouckaert, P, Steidler, L, Libert, C.
Overexpression of a1-acid glycoprotein in transgenic mice leads to sensitisation to acute colitis
Gut 51, 398-404, 2002. (Epub ---)

Waelput, W, Brouckaert, P, Broekaert, D, Tavernier, J.
A role for leptin in the systemic inflammatory response syndrome (SIRS) and in immune response
Current Drug Targets Inflamm Allergy 1, 277-289, 2002. (Epub ---)

Ameloot, P, Declercq, W, Fiers, W, Vandenabeele, P, Brouckaert, P.
Heterotrimers formed by tumor necrosis factors of different species or muteins
J Biol Chem 276, 27098-27103, 2001. (Epub 2001 May 22)

Ameloot, P, Fiers, W, De Bleser, P, Ware, CF, Vandenabeele, P, Brouckaert, P.
Identification of tumor necrosis factor (TNF) amino acids crucial for binding to the murine p75 TNF receptor and construction of receptor-selective mutants
J Biol Chem 276, 37426-37430, 2001. (Epub 2001 Jul 11)

Waelput, W, Broekaert, D, Vandekerckhove, J, Brouckaert, P, Tavernier, J, Libert, C.
A mediator role for metallothionein in tumor necrosis factor-induced lethal shock
J Exp Med 194, 1617-1624, 2001. (Epub ---)

Wielockx, B, Hochepied, T, Staelens, J, Van Molle, W, Brouckaert, P, Libert, C.
Detection, characterisation and purification of a murine liver factor capable of desensitising towards the lethal activity of tumour necrosis factor
Cytokine 15, 59-65, 2001. (Epub ---)

Cauwels, A, Van Molle, W, Janssen, B, Everaerdt, B, Huang, P, Fiers, W, Brouckaert, P.
Protection against TNF-induced lethal shock by soluble guanylate cyclase inhibition requires functional inducible nitric oxide synthase
Immunity 13, 223-231, 2000. (Epub ---)

Hochepied, T, Ameloot, P, Brouckaert, P, Van Leuven, F, Libert, C.
Differential response of a2-macroglobulin-deficient mice in models of lethal TNF-induced inflammation
Eur Cytokine Netw 11, 597-601, 2000. (Epub ---)

Van Molle, W, Hochepied, T, Brouckaert, P, Libert, C.
The major acute-phase protein, serum amyloid P component, in mice is not involved in endogenous resistance against tumor necrosis factor alpha-induced lethal hepatitis, shock, and skin necrosis
Infect Immun 68, 5026-5029, 2000. (Epub ---)

Van Molle, W, Vanden Berghe, J, Brouckaert, P, Libert, C.
Tumor necrosis factor-induced lethal hepatitis: Pharmacological intervention with verapamil, tannic acid, picotamide and K76COOH
FEBS Lett 467, 201-205, 2000. (Epub ---)

Libert, C, Wielockx, B, Grijalba, B, Van Molle, W, Kremmer, E, Colten, HR, Fiers, W, Brouckaert, P.
The role of complement activation in tumour necrosis factor-induced lethal hepatitis
Cytokine 11, 617-625, 1999. (Epub ---)

Libert, C, Wielockx, B, Hammond, GL, Brouckaert, P, Fiers, W, Elliott, RW.
Identification of a locus on distal mouse chromosome 12 that controls resistance to tumor necrosis factor-induced lethal shock
Genomics 55, 284-289, 1999. (Epub ---)

Van Molle, W, Brouckaert, P, Libert, C.
Caspase-1 is not involved in experimental hepatitis in mouse
FEBS Lett 445, 115-118, 1999. (Epub ---)

Van Molle, W, Denecker, G, Rodriguez, I, Brouckaert, P, Vandenabeele, P, Libert, C.
Activation of caspases in lethal experimental hepatitis and prevention by acute phase proteins
J Immunol 163, 5235-5241, 1999. (Epub ---)

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