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Click the UGent logo to retrieve publications of Rudi Beyaert in the UGent bibliography

Casillo, A, Ziaco, M, Lindner, B, Parrilli, E, Schwudke, D, Holgado, A, Verstrepen, L, Sannino, F, Beyaert, R, Lanzetta, R, Tutino, ML,Corsaro, MM.
Unusual Lipid A from a cold adapted bacterium: detailed structural characterization
Chembiochem 18, 1845-1854, 2017. (Epub 2017 Jun 26)

Cruz, JA, Childs, EE, Amatya, N, Garg, AV, Beyaert, R, Lawrence, PK, Aneskievich, BJ, Ma, A, Gaffen, SL.
IL-17 Signaling Triggers Degradation of the Constitutive NF-kB Inhibitor ABIN-1
ImmunoHorizons 1, 133-141, 2017. (Epub 2017 Sep 1)

De Wilde, K, Martens, A, Lambrecht, S, Jacques, P, Drennan, MB, Debusschere, K, Govindarajan, S, Coudenys, J, Verheugen, E, Windels, F, Catrysse, L, Lories, R, McGonagle, D, Beyaert, R, van Loo, G, Elewaut, D.
A20 inhibition of STAT1 expression in myeloid cells: a novel endogenous regulatory mechanism preventing development of enthesitis
Ann Rheum Dis 76, 585-592, 2017. (Epub 2016 Aug 22)

Fischer, JC, Otten, V, Kober, M, Drees, C, Rosenbaum, M, Schmickl, M, Heidegger, S, Beyaert, R, van Loo, G, Li, XC, Peschel, C, Schmidt-Supprian, M, Haas, T, Spoerl, S, Poeck, H.
A20 Restrains Thymic Regulatory T Cell Development
J Immunol 199, 2356-2365, 2017. (Epub 2017 Aug 25)

Fischer, JC, Otten, V, Steiger, K, Schmickl, M, Slotta-Huspenina, J, Beyaert, R, van Loo, G, Peschel, C, Poeck, H, Haas, T, Spoerl, S.
A20 deletion in T cells modulates acute graft-versus-host disease in mice
Eur J Immunol 47, 1982-1988, 2017. (Epub 2017 Aug 22)

Kip, E, Naze, F, Suin, V, Vanden Berghe, T, Francart, A, Lamoral, S, Vandenabeele, P, Beyaert, R, Van Gucht, S, Kalai, M.
Impact of caspase-1/11, -3, -7, or IL-1beta/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease
Cell Death Discov 3, 17012, 2017. (Epub 2017 Mar 6)

Lievens, L, Pollier, J, Goossens, A, Beyaert, R, Staal, J.
Abscisic Acid as Pathogen Effector and Immune Regulator
Front Plant Sci 8, 587, 2017. (Epub 2017 Apr 19)

Lork, M, Verhelst, K, Beyaert, R.
CYLD, A20 and OTULIN deubiquitinases in NF-kappaB signaling and cell death: so similar, yet so different
Cell Death Differ 24, 1172-1183, 2017. (Epub 2017 Mar 31)

Pauwels, AM, Trost, M, Beyaert, R, Hoffmann, E.
Patterns, Receptors, and Signals: Regulation of Phagosome Maturation
Trends Immunol 38, 407-422, 2017. (Epub 2017 Apr 14)

Tima, HG, Al Dulayymi, JR, Denis, O, Lehebel, P, Baols, KS, Mohammed, MO, L'Homme, L, Sahb, MM, Potemberg, G, Legrand, S, Lang, R, Beyaert, R, Piette, J, Baird, MS, Huygen, K, Romano, M.
Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of Mycobacterium tuberculosis
J Innate Immun 9, 162-180, 2017. (Epub 2016 Nov 18)

Van Nuffel, E, Schmitt, A, Afonina, IS, Schulze-Osthoff, K, Beyaert, R, Hailfinger, S.
CARD14-Mediated Activation of Paracaspase MALT1 in Keratinocytes: Implications for Psoriasis
J Invest Dermatol 137, 569-575, 2017. (Epub 2016 Dec 8)

Verstraete, K, Peelman, F, Braun, H, Lopez, J, Van Rompaey, D, Dansercoer, A, Vandenberghe, I, Pauwels, K, Tavernier, J, Lambrecht, BN, Hammad, H, De Winter, H, Beyaert, R, Lippens, G, Savvides, SN.
Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma
Nat Commun 8, 14937, 2017. (Epub 2017 Apr 3)

Afonina, IS, Beyaert, R.
Trabid epigenetically drives expression of IL-12 and IL-23
Nat Immunol 17, 227-228, 2016. (Epub 2016 Feb 16)

Afonina, IS, Van Nuffel, E, Baudelet, G, Driege, Y, Kreike, M, Staal, J, Beyaert, R.
The paracaspase MALT1 mediates CARD14-induced signaling in keratinocytes
EMBO Rep 17, 914-927, 2016. (Epub 2016 Apr 25)

Borghi, A, Verstrepen, L, Beyaert, R.
TRAF2 multitasking in TNF receptor-induced signaling to NF-kappaB, MAP kinases and cell death
Biochem Pharmacol 116, 1-10, 2016. (Epub 2016 Mar 16)

Catrysse, L, Farhang Ghahremani, M, Vereecke, L, Youssef, SA, Mc Guire, C, Sze, M, Weber, A, Heikenwalder, M, de Bruin, A, Beyaert, R, van Loo, G.
A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death
Cell Death Dis 7, e2250, 2016. (Epub 2016 Jun 2)

de Kleer, IM, Kool, M, de Bruijn, MJ, Willart, M, van Moorleghem, J, Schuijs, MJ, Plantinga, M, Beyaert, R, Hams, E, Fallon, PG, Hammad, H, Hendriks, RW, Lambrecht, BN.
Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung
Immunity 45, 1285-1298, 2016. (Epub 2016 Dec 5)

Demeyer, A, Staal, J, Beyaert, R.
Targeting MALT1 Proteolytic Activity in Immunity, Inflammation and Disease: Good or Bad?
Trends Mol Med 22, 135-150, 2016. (Epub 2016 Jan 16)

Drennan, MB, Govindarajan, S, Verheugen, E, Coquet, JM, Staal, J, McGuire, C, Taghon, T, Leclercq, G, Beyaert, R, van Loo, G, Lambrecht, BN, Elewaut, D.
NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20
J Exp Med 213, 1973-1981, 2016. (Epub 2016 Aug 22)

Elton, L, Carpentier, I, Staal, J, Driege, Y, Haegman, M, Beyaert, R.
MALT1 cleaves the E3 ubiquitin ligase HOIL-1 in activated T cells, generating a dominant negative inhibitor of LUBAC-induced NF-kappaB signaling
FEBS J 283, 403-412, 2016. (Epub 2015 Nov 17)

Fukaya, M, Brorsson, CA, Meyerovich, K, Catrysse, L, Delaroche, D, Vanzela, EC, Ortis, F, Beyaert, R, Nielsen, LB, Andersen, ML, Mortensen, HB, Pociot, F, van Loo, G, St Rling, J, Cardozo, AK.
A20 inhibits beta-cell Apoptosis by Multiple Mechanisms and Predicts Residual beta-cell Function in Type 1 Diabetes
Mol Endocrinol 30, 48-61, 2016. (Epub 2015 Dec 10)

Hulpiau, P, Driege, Y, Staal, J, Beyaert, R.
MALT1 is not alone after all: identification of novel paracaspases
Cell Mol Life Sci 1103-1116, 73, 2016. (Epub 2015 Sep 16)

Lambert, B, Carron, P, D'Asseler, Y, Bacher, K, Van den Bosch, F, Elewaut, D, Verbruggen, G, Beyaert, R, Dumolyn, C, De Vos, F.
99mTc-labelled S-HYNIC certolizumab pegol in rheumatoid arthritis and spondyloarthritis patients: a biodistribution and dosimetry study
EJNMMI Res 6, 88, 2016. (Epub 2016 Dec 12)

Lork, M, Delvaeye, M, Goncalves, A, Van Hamme, E, Beyaert, R.
Monitoring Ubiquitin-Coated Bacteria via Confocal Microscopy
Methods Mol Biol 1449, 243-250, 2016. (Epub 2016 Sep 10)

Maelfait, J, Roose, K, Vereecke, L, Mc Guire, C, Sze, M, Schuijs, MJ, Willart, M, Itati Ibanez, L, Hammad, H, Lambrecht, BN, Beyaert, R, Saelens, X, van Loo, G.
A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection
PLoS Pathog 12, e1005410, 2016. (Epub 2016 Jan 27)

Slowicka, K, Vereecke, L, McGuire, C, Sze, M, Maelfait, J, Kolpe, A, Saelens, X, Beyaert, R, van Loo, G.
Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-kappaB signaling
Eur J Immunol 46, 971-980, 2016. (Epub 2015 Dec 17)

van de Laar, L, Saelens, W, De Prijck, S, Martens, L, Scott, CL, Van Isterdael, G, Hoffmann, E, Beyaert, R, Saeys, Y, Lambrecht, BN, Guilliams, M.
Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages
Immunity 44, 755-768, 2016. (Epub 2016 Apr 19)

Yang, Y, Andersson, P, Hosaka, K, Zhang, Y, Cao, R, Iwamoto, H, Yang, X, Nakamura, M, Wang, J, Zhuang, R, Morikawa, H, Xue, Y, Braun, H, Beyaert, R, Samani, N, Nakae, S, Hams, E, Dissing, S, Fallon, PG, et al..
The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages
Nat Commun 7, 11385, 2016. (Epub 2016 May 6)

Afonina, IS, Elton, L, Carpentier, I, Beyaert, R.
MALT1 - a universal soldier: multiple strategies to ensure NF-kappaB activation and target gene expression
FEBS J 282, 3286-3297, 2015. (Epub 2015 May 21)

Afonina, IS, Muller, C, Martin, SJ, Beyaert, R.
Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme
Immunity 42, 991-1004, 2015. (Epub 2015 Jun 16)

Alloatti, A, Kotsias, F, Pauwels, AM, Carpier, JM, Jouve, M, Timmerman, E, Pace, L, Vargas, P, Maurin, M, Gehrmann, U, Joannas, L, Vivar, OI, Lennon-Dumenil, AM, Savina, A, Gevaert, K, Beyaert, R, Hoffmann, E, Amigorena, S.
Toll-like Receptor 4 Engagement on Dendritic Cells Restrains Phago-Lysosome Fusion and Promotes Cross-Presentation of Antigens
Immunity 43, 1087-1100, 2015. (Epub 2015 Dec 15)

Catrysse, L, Fukaya, M, Sze, M, Meyerovich, K, Beyaert, R, Cardozo, AK, van Loo, G.
A20 deficiency sensitizes pancreatic beta cells to cytokine-induced apoptosis in vitro but does not influence type 1 diabetes development in vivo
Cell Death Dis 6, e1918, 2015. (Epub 2015 Oct 15)

Coquet, JM, Schuijs, MJ, Smyth, MJ, Deswarte, K, Beyaert, R, Braun, H, Boon, L, Karlsson Hedestam, GB, Nutt, SL, Hammad, H, Lambrecht, BN.
Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites
Immunity 43, 318-30, 2015. (Epub 2015 Aug 18)

De Ceuleneer, M, Vanhoucke, M, Beyaert, R.
Role of the Bacterial Type VI Secretion System in the Modulation of Mammalian Host Cell Immunity
Curr Med Chem 22, 1734-1744, 2015. (Epub 2015 Apr)

Elton, L, Carpentier, I, Verhelst, K, Staal, J, Beyaert, R.
The multifaceted role of the E3 ubiquitin ligase HOIL-1: beyond linear ubiquitination
Immunol Rev 266, 208-221, 2015. (Epub 2015 Jul)

Garate, JA, Stockl, J, Del Carmen Fernandez-Alonso, M, Artner, D, Haegman, M, Oostenbrink, C, Jimenez-Barbero, J, Beyaert, R, Heine, H, Kosma, P, Zamyatina, A.
Anti-endotoxic activity and structural basis for human MD-2.TLR4 antagonism of tetraacylated lipid A mimetics based on betaGlcN(1<-->1)alphaGlcN scaffold
Innate Immun 21, 490-503, 2015. (Epub 2014 Nov 13)

Hollaus, R, Ittig, S, Hofinger, A, Haegman, M, Beyaert, R, Kosma, P, Zamyatina, A.
Chemical Synthesis of Burkholderia Lipid A Modified with Glycosyl Phosphodiester-Linked 4-Amino-4-deoxy-beta-L-arabinose and Its Immunomodulatory Potential
Chemistry 21, 4102-4114, 2015. (Epub 2015 Jan 28)

Kumar, M, Sahu, SK, Kumar, R, Subuddhi, A, Maji, RK, Jana, K, Gupta, P, Raffetseder, J, Lerm, M, Ghosh, Z, van Loo, G, Beyaert, R, Gupta, UD, Kundu, M, Basu, J.
MicroRNA let-7 Modulates the Immune Response to Mycobacterium tuberculosis Infection via Control of A20, an Inhibitor of the NF-kappaB Pathway
Cell Host Microbe 17, 345-356, 2015. (Epub 2015 Feb 11)

Schuijs, MJ, Willart, MA, Vergote, K, Gras, D, Deswarte, K, Ege, MJ, Branco Madeira, F, Beyaert, R, van Loo, G, Bracher, F, von Mutius, E, Chanez, P, Lambrecht, BN, Hammad, H.
Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells
Science 349, 1106-1110, 2015. (Epub 2015 Sep 4)

Tyteca, D, Nishino, T, Debaix, H, Van Der Smissen, P, N'Kuli, F, Hoffmann, D, Cnops, Y, Rabolli, V, van Loo, G, Beyaert, R, Huaux, F, Devuyst, O, Courtoy, PJ.
Regulation of macrophage motility by the water channel aquaporin-1: crucial role of m0/m2 phenotype switch
PLoS One 10, e0117398, 2015. (Epub 2015 Feb 26)

Verhelst, K, Gardam, S, Borghi, A, Kreike, M, Carpentier, I, Beyaert, R.
XEDAR activates the non-canonical NF-kappaB pathway
Biochem Biophys Res Commun 465, 275-280, 2015. (Epub 2015 Aug 7)

Adanitsch, F, Ittig, S, Stockl, J, Oblak, A, Haegman, M, Jerala, R, Beyaert, R, Kosma, P, Zamyatina, A.
Development of alphaGlcN(1<-->1)alphaMan-Based Lipid A Mimetics as a Novel Class of Potent Toll-like Receptor 4 Agonists
J Med Chem 57, 8056-8071, 2014. (Epub 2014 Sep 25)

Beyaert, R.
An E3 ubiquitin ligase-independent role of LUBAC
Blood 123, 2131-2133, 2014. (Epub 2014 Apr 3)

Catrysse, L, Vereecke, L, Beyaert, R, van Loo, G.
A20 in inflammation and autoimmunity
Trends Immunol 35, 22-31, 2014. (Epub 2013 Nov 15)

Giordano, M, Roncagalli, R, Bourdely, P, Chasson, L, Buferne, M, Yamasaki, S, Beyaert, R, van Loo, G, Auphan-Anezin, N, Schmitt-Verhulst, AM, Verdeil, G.
The tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells
Proc Natl Acad Sci USA 111, 11115-11120, 2014. (Epub 2014 Jul 14)

Guabiraba, R, Besnard, AG, Menezes, GB, Secher, T, Jabir, MS, Amaral, SS, Braun, H, Lima-Junior, RC, Ribeiro, RA, Cunha, FQ, Teixeira, MM, Beyaert, R, Graham, GJ, Liew, FY.
IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice
Mucosal Immunol 7, 1079-1093, 2014. (Epub 2014 Jan 15)

Heger, K, Fierens, K, Vahl, C, Aszodi, A, Peschke, K, Schenten, D, Hammad, H, Beyaert, R, Saur, D, van Loo, G, Roers, A, Lambrecht, BN, Kool, M, Schmidt-Supprian, M.
A20-deficient mast cells exacerbate inflammatory responses in vivo
PLoS Biol 12, e1001762, 2014. (Epub 2014 Jan 14)

Ley, SC, Beyaert, R.
Priming IKKbeta kinase for action
Biochem J 463, e1-2, 2014. (Epub 2014 Oct 1)

Mc Guire, C, Elton, L, Wieghofer, P, Staal, J, Voet, S, Demeyer, A, Nagel, D, Krappmann, D, Prinz, M, Beyaert, R, van Loo, G.
Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis
J Neuroinflamm 11, 124, 2014. (Epub 2014 Jul 21)

Vande Walle, L, Van Opdenbosch, N, Jacques, P, Fossoul, A, Verheugen, E, Vogel, P, Beyaert, R, Elewaut, D, Kanneganti, TV, van Loo, G, Lamkanfi, M.
Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis
Nature 512, 69-73, 2014. (Epub 2014 Jun 29)

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