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Click the UGent logo to retrieve publications of Rudi Beyaert in the UGent bibliography

Vande Walle, L, Van Opdenbosch, N, Jacques, P, Fossoul, A, Verheugen, E, Vogel, P, Beyaert, R, Elewaut, D, Kanneganti, TV, van Loo, G, Lamkanfi, M.
Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis
Nature 512, 69-73, 2014. (Epub 2014 Jun 29)

Vereecke, L, Vieira-Silva, S, Billiet, T, van Es, JH, Mc Guire, C, Slowicka, K, Sze, M, van den Born, M, De Hertogh, G, Clevers, H, Raes, J, Rutgeerts, P, Vermeire, S, Beyaert, R, van Loo, G.
A20 controls intestinal homeostasis through cell-specific activities
Nat Comm 5, 5103, 2014. (Epub 2014 Sep 30)

Verhelst, K, van Loo, G, Beyaert, R.
A20: attractive without showing cleavage
EMBO Rep 15, 734-735, 2014. (Epub 2014 May 30)

Verstrepen, L, Beyaert, R.
Receptor proximal kinases in NF-?B signaling as potential therapeutic targets in cancer and inflammation
Biochem Pharmacol 92, 519-529, 2014. (Epub 2014 Nov 27)

Verstrepen, L, Carpentier, I, Beyaert, R.
The biology of A20-binding inhibitors of NF-kappaB activation (ABINs)
In The multiple therapeutic targets of A20 (Ferran, C, ed.), Landes Bioscience and Springer Science+Business Media , Adv Exp Med Biol 809, 13-31, 2014. (Epub 2014 Jan)

Beyaert, R, Beaugerie, L, Van Assche, G, Brochez, L, Renauld, JC, Viguierg, M, Cocquyth, V, Jerusalemi, G, Machiels, JP, Prenenk, H, Masson, P, Louis, E, De Keyser, F.
Cancer risk in immune-mediated inflammatory diseases
Mol Cancer 12, 98, 2013. (Epub 2013 Aug 29)

Mc Guire, C, Prinz, M, Beyaert, R, van Loo, G.
Nuclear Factor-kB in multiple sclerosis pathology
Trends Mol Med 19, 604-613, 2013. (Epub 2023 Sep 2)

Mc Guire, C, Rahman, M, Schwaninger, M, Beyaert, R, van Loo, G.
The ubiquitin editing enzyme A20 (TNFAIP3) is upregulated during permanent middle cerebral artery occlusion but does not influence disease outcome
Cell Death Dis 4, e531, 2013. (Epub 2013 Mar 7)

Mc Guire, C, Wieghofer, P, Elton, L, Muyllaert, D, Prinz, M, Beyaert, R, van Loo, G.
Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination
J Immunol 190, 2896-2903, 2013. (Epub 2013 Feb 11)

Peluffo, H, Gonzalez, P, Acarin, L, Aris, A, Beyaert, R, Villaverde, A, Gonzalez, B.
Overexpression of the nuclear factor kappaB inhibitor A20 is neurotoxic after an excitotoxic injury to the immature rat brain
Neurol Res 35, 308-319, 2013. (Epub 2012 Dec 26)

Verhelst, K, Verstrepen, L, Carpentier, I, Beyaert, R.
IkappaB kinase epsilon (IKKepsilon): A therapeutic target in inflammation and cancer
Biochem Pharmacol 57, 873-880, 2013. (Epub 2012 Jan 17)

Aksoy, E, Taboubi, S, Torres, D, Delbauve, S, Hachani, A, Whitehead, MA, Pearce, WP, Berenjeno, IM, Nock, G, Filloux, A, Beyaert, R, Flamand, V, Vanhaesebroeck, B.
The p110delta isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock
Nat Immunol 13, 1045-1054, 2012. (Epub 2012 Sep 30)

Bovijn, C, Ulrichts, P, De Smet, AS, Catteeuw, D, Beyaert, R, Tavernier, J, Peelman, F.
Identification of interaction sites for dimerization and adapter recruitment in the TOLL/Interleukin-1 domain of toll-like receptor 4
J Biol Chem 287, 4088-4098, 2012. (Epub 2011 Dec 2)

Chu, Y, Soberon, V, Glockner, L, Beyaert, R, Massoumi, R, van Loo, G, Krappmann, D, Schmidt-Supprian, M.
A20 and CYLD do not share significant overlapping functions during B cell development and activation
J Immunol 189, 4437-4443, 2012. (Epub 2012 Sep 21)

Galle, M, Carpentier, I, Beyaert, R.
Structure and function of the Type III secretion system of Pseudomonas aeruginosa
Curr Protein Pept Sci 13, 831-842, 2012. (Epub 2012 Dec 10)

Galle, M, Jin, S, Bogaert, P, Haegman, M, Vandenabeele, P, Beyaert, R.
The Pseudomonas aeruginosa type III secretion system has an exotoxin S/T/Y independent pathogenic role during acute lung infection
PLoS One 7, e41547, 2012. (Epub 2012 Jul 23)

Maelfait, J, Beyaert, R.
Emerging role of ubiquitination in antiviral RIG-I signaling
Microbiol Mol Biol Rev 76, 33-45, 2012. (Epub 2012 Mar)

Maelfait, J, Roose, K, Bogaert, P, Sze, M, Saelens, X, Pasparakis, M, Carpentier, I, van Loo, G, Beyaert, R.
A20 (Tnfaip3) deficiency in myeloid cells protects against Influenza A virus infection
PLoS Pathog 8, e1002570, 2012. (Epub 2012 Mar 1)

Staal, J, Beyaert, R.
A two-step activation mechanism of MALT1 paracaspase: Commentary on 'Structural determinants of MALT1 protease activity' by Wiesmann et al
J Mol Biol 419, 1-3, 2012. (Epub 2012 Mar 15)

Verhelst, K, Carpentier, I, Kreike, M, Meloni, L, Verstrepen, L, Kensche, T, Dikic, I, Beyaert, R.
A20 inhibits LUBAC-mediated NF-?B activation by binding linear polyubiquitin chains via its zinc finger 7
EMBO J 31, 3845-3855, 2012. (Epub 2012 Aug 28)

Verstrepen, L, Beyaert, R.
No ubiquitin anchors and fully RIGged
Immunity 36, 897-899, 2012. (Epub 2012 Jun 29)

Willart, MA, Deswarte, K, Pouliot, P, Braun, H, Beyaert, R, Lambrecht, BN, Hammad, H.
Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33
J Exp Med 209, 1505-1517, 2012. (Epub 2012 Jul 16)

Abdulkhalek, S, Amith, SR, Franchuk, SL, Jayanth, P, Guo, M, Finlay, T, Gilmour, A, Guzzo, C, Gee, K, Beyaert, R, Szewczuk, MR.
Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for TOLL-like receptor activation and cellular signaling
J Biol Chem 286, 36532-36549, 2011. (Epub 2011 Aug 26)

Beyaert, R.
SHP works a double shift to control TLR signaling
Nat Immunol 12, 725-727, 2011. (Epub 2011 Jul 19)

Chu, Y, Vahl, JC, Kumar, D, Heger, K, Bertossi, A, Wojtowicz, E, Soberon, V, Schenten, D, Mack, B, Reutelshöfer, M, Beyaert, R, Amann, K, van Loo, G, Schmidt-Supprian, M.
B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation, hyperactivation and cause inflammation and autoimmunity in aged mice
Blood 117, 2227-2236, 2011. (Epub 2010 Nov 18)

Gardam, S, Beyaert, R.
The kinase NIK as a therapeutic target in multiple myeloma
Expert Opin Ther Targets 15, 207-218, 2011. (Epub 2011 Jan 5)

Kool, M, van Loo, G, Waelput, W, De Prijck, S, Muskens, F, Sze, M, van Praet, J, Branco-Madeira, F, Janssens, S, Reizis, B, Elewaut, D, Beyaert, R, Hammad, H, Lambrecht, B.
The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells and systemic autoimmunity
Immunity 35, 82-96, 2011. (Epub 2011 Jun 30)

Lippens, S, Lefebvre, S, Gilbert, B, Sze, M, Devos, M, Verhelst, K, Vereecke, L, Mc Guire, C, Guerin, C, Vandenabeele, P, Pasparakis, M, Mikkola, ML, Beyaert, R, Declercq, W, van Loo, G.
Keratinocyte-specific ablation of the NF-?B regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis
Cell Death Differ 18, 1845-1853, 2011. (Epub 2011 May 13)

Matmati, M, Jacques, P, Maelfait, J, Verheugen, E, Kool, M, Sze, M, Geboes, L, Louagie, E, Mc Guire, C, Vereecke, L, Chu, Y, Boon, L, Staelens, S, Matthys, P, Lambrecht, B, Schmidt-Supprian, M, Pasparakis, M, Elewaut, D, Beyaert, R, van Loo, G.
A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis
Nature Genetics 43, 908-912, 2011. (Epub 2011 Aug 14)

Mc Guire, C, Beyaert, R, van Loo, G.
Death receptor signalling in central nervous system inflammation and demyelination
Trends Neurosci 34, 619-628, 2011. (Epub 2011 Oct 13)

Staal, J, Bekaert, T, Beyaert, R.
Regulation of NF-kB signalling by caspases and MALT1 paracaspase
Cell Res 21, 40-54, 2011. (Epub 2010 Nov 30)

Staal, J, Driege, Y, Bekaert, T, Demeyer, A, Muyllaert, D, Van Damme, P, Gevaert, K, Beyaert, R.
T cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1
EMBO J 30, 1742-1752, 2011. (Epub 2011 Mar 29)

van Loo, G, Beyaert, R.
Negative regulation of NF-kappaB and its involvement in rheumatoid arthritis
Arthritis Res Ther 13, 221, 2011. (Epub 2011 May 31)

Vereecke, L, Beyaert, R, van Loo, G.
Enterocyte death and intestinal barrier maintenance in homeostasis and disease
Trends Mol Med 17, 584-593, 2011. (Epub 2011 Jul 6)

Vereecke, L, Beyaert, R, van Loo, G.
Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimmune disease
Biochem Soc Trans 39, 1086-1091, 2011. (Epub 2011 Aug 1)

Verhelst, K, Carpentier, I, Beyaert, R.
Regulation of TNF-induced NF-?B activation by different cytoplasmic ubiquitination events
Cytok Growth Factor Rev 22, 277-286, 2011. (Epub 2011 Nov 23)

Verhelst, K, Verstrepen, L, Carpentier, I, Beyaert, R.
Linear ubiquitination in NF-kappaB signaling and inflammation: What we do understand and what we do not
Biochem Pharmacol 82, 1057-1065, 2011. (Epub 2011 Jul 20)

Verstrepen, L, Verhelst, K, Carpentier, I, Beyaert, R.
TAX1BP1, a ubiquitin-binding adaptor protein in innate immunity and beyond
Trends Biochem Sci 36, 347-354, 2011. (Epub 2011 May 4)

Amith, SR, Jayanth, P, Franchuk, S, Finlay, T, Seyrantepe, V, Beyaert, R, Pshezhetsky, AV, Szewczuk, MR.
Neu1 desialylation of sialyl alpha-2,3-linked beta-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling
Cell Signal 22, 314-324, 2010. (Epub 2009 Sep 29)

Bloor, S, Maelfait, J, Krumbach, R, Beyaert, R, Randow, F.
The endoplasmic reticulum chaperone gp96 is essential for infection with vesicular stomatitis virus
Proc Natl Acad Sci USA 107, 6970-6975, 2010. (Epub 2010 Mar 29)

De Boever, S, Neirinckx, EA, Meyer, E, de Baere, S, Beyaert, R, De Backer, P, Croubels, S.
Pharmacodynamics of tepoxalin, sodium-salicylate and ketoprofen in an intravenous lipopolysaccharide inflammation model in broiler chickens
J Vet Pharmacol Therap 33, 564-572, 2010. (Epub 2010 Jun 18)

Finlay, TM, Abdulkhalek, S, Gilmour, A, Guzzo, C, Jayanth, P, Amith, SR, Gee, K, Beyaert, R, Szewczuk, MR.
Thymoquinone-induced Neu4 sialidase activates NFkappaB in macrophage cells and pro-inflammatory cytokines in vivo
Glycoconj J 27, 583-600, 2010. (Epub 2010 Aug 10)

Finlay, TM, Jayanth, P, Amith, SR, Gilmour, A, Guzzo, C, Gee, K, Beyaert, R, Szewczuk, MR.
Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9
Glycoconj J 27, 329-348, 2010. (Epub 2010 Mar 6)

Fradejas, N, Pastor, MD, Burgos, M, Beyaert, R, Tranque, P, Calvo, S.
Caspase-11 mediates ischemia-induced astrocyte death: involvement of endoplasmic reticulum stress and C/EBP homologous protein.
J Neurosci Res 88, 1094-1105, 2010. (Epub 2009 Nov 3)

Hoffmann, C, Galle, M, Dilling, S, Kappeli, R, Muller, AJ, Songhet, P, Beyaert, R, Hardt, WD.
In macrophages, Caspase-1 activation by SopE and the type III secretion system-1 of S. Typhimurium can proceed in the absence of flagellin
PLoS One 5, e12477, 2010. (Epub 2010 Aug 30)

Malinverni, C, Unterreiner, A, Staal, J, Demeyer, A, Galaup, M, Luyten, M, Beyaert, R, Bornancin, F.
Cleavage by MALT1 induces cytosolic release of A20
Biochem Biophys Res Commun 400, 543-547, 2010. (Epub 2010 Aug 27)

Mc Guire, C, Volckaert, T, Wolke, U, Sze, M, De Rycke, R, Waisman, A, Prinz, M, Beyaert, R, Pasparakis, M, van Loo, G.
Oligodendrocyte-specific FADD deletion protects mice from autoimmune-mediated demyelination
J Immunol 185, 7646-7653, 2010. (Epub 2010 Nov 10)

Ulrichts, P, Bovijn, C, Lievens, S, Beyaert, R, Tavernier, J, Peelman, F.
Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site
J Cell Sci 123, 256-265, 2010. (Epub 2010 Jan 5)

van Loo, G, Sze, M, Bougarne, N, Praet, J, McGuire, C, Ullrich, A, Haegeman, G, Prinz, M, Beyaert, R, De Bosscher, K.
Anti-inflammatory properties of a plant-derived nonsteroidal, dissociated glucocorticoid receptor (GR) modulator in experimental autoimmune encephalomyelitis
Mol Endocrinol 24, 310-322, 2010. (Epub 2009 Dec 4)

Vereecke, L, Sze, M, Mc Guire, C, Rogiers, B, Chu, Y, Schmidt-Supprian, M, Pasparakis, M, Beyaert, R, van Loo, G.
Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis
J Exp Med 207, 1513-1523, 2010. (Epub 2010 Jun 7)

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