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De Bosscher, K, Vanden Berghe, W, Haegeman, G.
Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: Negative interference of activated glucocorticoid receptor with transcription factors
J Neuroimmunol 109, 16-22, 2000. (Epub ---)

De Bosscher, K, Vanden Berghe, W, Vermeulen, L, Plaisance, S, Boone, E, Haegeman, G.
Glucocorticoids repress NF-kB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell
Proc Natl Acad Sci USA 97, 3919-3924, 2000. (Epub ---)

Declercq, W, Logghe, M, Fiers, W, Contreras, R.
Cloning and expression of cytokine genes
In Cytokine Molecular Biology A Practical Approach. (Balkwill, F, ed.), Oxford, University Press, pp. 1-20, 2000. (Epub ---)

de Hoogt, R, Luyten, WHML, Contreras, R, De Backer, MD.
PCR- and ligation-mediated synthesis of split-marker cassettes with long flanking homology regions for gene disruption in Candida albicans
BioTechniques 28, 1112-1116, 2000. (Epub ---)

Denecker, G, Dooms, H, van Loo, G, Vercammen, D, Grooten, J, Fiers, W, Declercq, W, Vandenabeele, P.
Phosphatidyl serine exposure during apoptosis precedes release of cytochrome c and decrease in mitochondrial transmembrane potential
FEBS Lett 465, 47-52, 2000. (Epub ---)

De Vos, K, Severin, F, Van Herreweghe, F, Vancompernolle, K, Goossens, V, Hyman, A, Grooten, J.
Tumor necrosis factor induces hyperphosphorylation of kinesin light chain and inhibits kinesin-mediated transport of mitochondria
J Cell Biol 149, 1207-1214, 2000. (Epub ---)

D'Herde, K, De Prest, B, Mussche, S, Schotte, P, Beyaert, R, Van Coster, R, Roels, F.
Ultrastructural localization of cytochrome c in apoptosis demonstrates mitochondrial heterogeneity
Cell Death Differ 7, 331-337, 2000. (Epub ---)

Dooms, H, Van Belle, T, Desmedt, M, Rottiers, P, Grooten, J.
Interleukin-15 redirects the outcome of a tolerizing T-cell stimulus from apoptosis to anergy
Blood 96, 1006-1012, 2000. (Epub ---)

Eckhart, L, Declercq, W, Ban, J, Rendl, M, Lengauer, B, Mayer, C, Lippens, S, Vandenabeele, P, Tschachler, E.
Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation
J Invest Dermatol 115, 1148-1151, 2000. (Epub ---)

Goossens, V, De Vos, K, Vercammen, D, Steemans, M, Vancompernolle, K, Fiers, W, Vandenabeele, P, Grooten, J.
Role of reactive oxygen species in tumor necrosis factor toxicity
In Antioxidant and Redox Regulation of Genes. (Sen, CK, Sies, H, Baeuerle, PA, eds.), San Diego, Academic Press, pp. 245-264 , 2000. (Epub ---)

Hecht, A, Vleminckx, K, Stemmler, MP, van Roy, F, Kemler, R.
The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates
EMBO J 19, 1839-1850, 2000. (Epub ---)

Hochepied, T, Ameloot, P, Brouckaert, P, Van Leuven, F, Libert, C.
Differential response of a2-macroglobulin-deficient mice in models of lethal TNF-induced inflammation
Eur Cytokine Netw 11, 597-601, 2000. (Epub ---)

Hochepied, T, Van Molle, W, Berger, FG, Baumann, H, Libert, C.
Involvement of the acute phase protein a1-acid glycoprotein in nonspecific resistance to a lethal Gram-negative infection
J Biol Chem 275, 14903-14909, 2000. (Epub ---)

Huston, E, Beard, M, McCallum, F, Pyne, NJ, Vandenabeele, P, Scotland, G, Houslay, MD.
The cAMP-specific phosphodiesterase PDE4A5 is cleaved downstream of its SH3 interaction domain by caspase-3. Consequences for altered intracellular distribution
J Biol Chem 275, 28063-28074, 2000. (Epub ---)

Keilhack, H, Hellman, U, van Hengel, J, van Roy, F, Godovac-Zimmermann, J, Böhmer, F-D.
The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates p120 catenin
J Biol Chem 275, 26376-26384, 2000. (Epub ---)

Kools, P, Van Imschoot, G, van Roy, F.
Characterization of three novel human cadherin genes clustered on chromosome 18q22-23 and with high homology to chicken cadherin-7
Genomics 68, 283-295, 2000. (Epub ---)

Laroy, W, Contreras, R.
Cloning of Trypanosoma cruzi trans-sialidase and expression in Pichia pastoris
Protein Expr Purif 20, 389-393, 2000. (Epub ---)

Lippens, S, Kockx, M, Knaapen, M, Mortier, L, Polakowska, R, Verheyen, A, Garmyn, M, Zwijsen, A, Formstecher, P, Huylebroeck, D, Vandenabeele, P, Declercq, W.
Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing
Cell Death Differ 7, 1218-1224, 2000. (Epub ---)

Maras, M, Callewaert, N, Piens, K, Claeyssens, M, Martinet, W, Dewaele, S, Contreras, H, Dewerte, I, Penttilä, M, Contreras, R.
Molecular cloning and enzymatic characterization of a Trichoderma reesei 1,2-a-D-mannosidase
J Biotechnol 77, 255-263, 2000. (Epub ---)

Nollet, F, Kools, P, van Roy, F.
Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members
J Mol Biol 299, 551-572, 2000. (Epub ---)

O'Neil, D.
Web alert. Gene therapy in cancer treatment
Curr Opin Mol Ther 2, 359, 2000. (Epub ---)

O'Neil, D.
Web alert. Viruses as vectors for gene transfer
Curr Opin Mol Ther 2, 484-485, 2000. (Epub ---)

O'Neil, D, Jones, D.
Web alert. Genomics and proteomics
Curr Opin Mol Ther 2, 621-622, 2000. (Epub ---)

Penning, L, Denecker, G, Vercammen, D, Declercq, W, Schipper, RG, Vandenabeele, P.
A role for potassium in TNF-induced apoptosis and gene-induction in human and rodent tumour cell lines
Cytokine 12, 747-750, 2000. (Epub ---)

Peppelenbosch, MP, Desmedt, M, Pynaert, G, van Deventer, SJH, Grooten, J.
Macrophages present pinocytosed exogenous antigen via MHC class I whereas antigen ingested by receptor-mediated endocytosis is presented via MHC class II
J Immunol 165, 1984-1991, 2000. (Epub ---)

Pype, S, Declercq, W, Ibrahimi, A, Michiels, C, Van Rietschoten, JGL, Dewulf, N, de Boer, M, Vandenabeele, P, Huylebroeck, D, Remacle, JE.
TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kB activation
J Biol Chem 275, 18586-18593, 2000. (Epub ---)

Schoonjans, R, Willems, A, Grooten, J, Mertens, N.
Efficient heterodimerization of recombinant bi- and trispecific antibodies
Bioseparation 9, 179-183, 2000. (Epub ---)

Schoonjans, R, Willems, A, Schoonooghe, S, Fiers, W, Grooten, J, Mertens, N.
Fab chains as an efficient heterodimerization scaffold for the production of recombinant bispecific and trispecific antibody derivatives
J Immunol 165, 7050-7057, 2000. (Epub ---)

Schotte, L, Steidler, L, Vandekerckhove, J, Remaut, E.
Secretion of biologically active murine interleukin-10 by Lactococcus lactis
Enzyme Microb Technol 27, 761-765, 2000. (Epub ---)

Steidler, L, Hans, W, Schotte, L, Neirynck, S, Obermeier, F, Falk, W, Fiers, W, Remaut, E.
Treatment of murine colitis by Lactococcus lactis secreting interleukin-10
Science 289, 1352-1355, 2000. (Epub ---)

Vancompernolle, K, Boonefaes, T, Mann, M, Fiers, W, Grooten, J.
Tumor necrosis factor-induced microtubule stabilization mediated by hyperphosphorylated oncoprotein 18 promotes cell death
J Biol Chem 275, 33876-33882, 2000. (Epub ---)

Van Craenenbroeck, K, Vanhoenacker, P, Duchau, H, Haegeman, G.
Molecular integrity and usefulness of episomal expression vectors derived from BK and Epstein-Barr virus
Gene 253, 293-301, 2000. (Epub ---)

Van Craenenbroeck, K, Vanhoenacker, P, Haegeman, G.
Episomal vectors for gene expression in mammalian cells
Eur J Biochem 267, 5665-5678, 2000. (Epub ---)

Vanden Berghe, W, Vermeulen, L, De Wilde, G, De Bosscher, K, Boone, E, Haegeman, G.
Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6
Biochem Pharmacol 60, 1185-1195, 2000. (Epub ---)

Vanhoenacker, P, Haegeman, G, Leysen, JE.
5-HT7 receptors: Current knowledge and future prospects
Trends Pharmacol Sci 21, 70-77, 2000. (Epub ---)

Van Molle, W, Hochepied, T, Brouckaert, P, Libert, C.
The major acute-phase protein, serum amyloid P component, in mice is not involved in endogenous resistance against tumor necrosis factor alpha-induced lethal hepatitis, shock, and skin necrosis
Infect Immun 68, 5026-5029, 2000. (Epub ---)

Van Molle, W, Vanden Berghe, J, Brouckaert, P, Libert, C.
Tumor necrosis factor-induced lethal hepatitis: Pharmacological intervention with verapamil, tannic acid, picotamide and K76COOH
FEBS Lett 467, 201-205, 2000. (Epub ---)

Viaene, J, Tiels, P, Logghe, M, Dewaele, S, Martinet, W, Contreras, R.
MET15 as a visual selection marker for Candida albicans
Yeast 16, 1205-1215, 2000. (Epub ---)

Wijnhoven, BPL, Nollet, F, De Both, NJ, Tilanus, HW, Dinjens, WNM.
Genetic alterations involving exon 3 of the beta-catenin gene do not play a role in adenocarcinomas of the esophagus
Int J Cancer 86, 533-537, 2000. (Epub ---)

Assefa, Z, Vantieghem, A, Declercq, W, Vandenabeele, P, Vandenheede, JR, Merlevede, W, de Witte, P, Agostinis, P.
The activation of the c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways protects HeLa cells from apoptosis following photodynamic therapy with hypericin
J Biol Chem 274, 8788-8796, 1999. (Epub ---)

Baeyens, KJ, De Bondt, HL, Raeymaekers, A, Fiers, W, De Ranter, CJ.
The structure of mouse tumour-necrosis factor at 1.4 Å resolution: Towards modulation of its selectivity and trimerization
Acta Crystallogr D55, 772-778, 1999. (Epub ---)

Baxter, GT, Kuo, RC, Jupp, OJ, Vandenabeele, P, MacEwan, DJ.
Tumor necrosis factor-alpha mediates both apoptotic cell death and cell proliferation in a human hematopoietic cell line dependent on mitotic activity and receptor subtype expression
J Biol Chem 274, 9539-9547, 1999. (Epub ---)

Beyaert, R.
NF-kB as an emerging target in atopy
Expert Opin Ther Targets 3, 213-228, 1999. (Epub ---)

Beyaert, RLV.
A sensitizing function for lithium ions in tumor necrosis factor and interleukin-1 signalling
In Lithium: 50 Years of Psychopharmacology New Perspectives in Biomedical and Clinical Research. (Birch, NJ, Gallicchio, VS, Becker, RW, eds.), Cheshire, Weidner Publishing Group, pp. 168-182 , 1999. (Epub ---)

Bonné, S, van Hengel, J, Nollet, F, Kools, P, van Roy, F.
Plakophilin-3, a novel Armadillo-like protein present in nuclei and desmosomes of epithelial cells
J Cell Sci 112, 2265-2276, 1999. (Epub ---)

Carpentier, I, Beyaert, R.
TRAF1 is a TNF inducible regulator of NF-kB activation
FEBS Lett 460, 246-250, 1999. (Epub ---)

Daemen, MARC, van 't Veer, C, Denecker, G, Heemskerk, VH, Wolfs, TGAM, Clauss, M, Vandenabeele, P, Buurman, WA.
Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation
J Clin Invest 104, 541-549, 1999. (Epub ---)

De Backer, MD, Maes, D, Vandoninck, S, Logghe, M, Contreras, R, Luyten, WHML.
Transformation of Candida albicans by electroporation
Yeast 15, 1609-1618, 1999. (Epub ---)

De Bleecker, JL, Meire, VI, Declercq, W, Van Aken, EH.
Immunolocalization of tumor necrosis factor-alpha and its receptors in inflammatory myopathies
Neuromusc Disorders 9, 239-246, 1999. (Epub ---)

De Bosscher, K, Vanden Berghe, W, Boone, E, Haegeman, G.
In search of the molecular mechanism of gene repression by glucocorticoids
In Molecular Mechanisms of Transcellular Signaling From Membrane Receptors to Transcription Factors. (Thiery, JP, ed.), NATO Science Series, Vol. A 309, Amsterdam, IOS Press, pp. 53-62, 1999. (Epub ---)

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