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Berx, G, Cleton-Jansen, A-M, Strumane, K, de Leeuw, WJF, Nollet, F, van Roy, FM, Cornelisse, C.
E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain
Oncogene 13, 1919-1925, 1996. (Epub ---)

Beyaert, R, Cuenda, A, Vanden Berghe, W, Plaisance, S, Lee, JC, Haegeman, G, Cohen, P, Fiers, W.
The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumour necrosis factor
EMBO J 15, 1914-1923, 1996. (Epub ---)

Bracke, ME, Van Roy, FM, Castronovo, V, Mareel, MM.
Tamoxifen and the E-cadherin/catenin complex
In Tamoxifen - Beyond the Antiestrogen. (Kellen, JA, ed.), Boston-Basel-Berlin, Birkhäuser, pp. 267-284, 1996. (Epub ---)

Bracke, ME, van Roy, FM, Mareel, MM.
The E-cadherin/catenin complex in invasion and metastasis
Curr Top Microbiol Immunol 213, 123-161, 1996. (Epub ---)

Brouckaert, P, Fiers, W.
Tumor necrosis factor and the systemic inflammatory response syndrome
Curr Top Microbiol Immunol 216, 167-187, 1996. (Epub ---)

Brouckaert, P, Libert, C, Cauwels, A, Everaerdt, B, Van Molle, W, Ameloot, P, Gansemans, Y, Grijalba, B, Takahashi, N, Truong, M-J, Van Leuven, P, Fiers, W.
Inhibition of and sensitization to the lethal effects of tumor necrosis factor
J Inflamm 47, 18-26, 1996. (Epub ---)

Cappelletti, M, Alonzi, T, Fattori, E, Libert, C, Poli, V.
C/EBPb is required for the late phases of acute phase genes induction in the liver and for tumour necrosis factor-alpha, but not interleukin-6, regulation
Cell Death Differ 3, 29-35, 1996. (Epub ---)

Carbó, N, López-Soriano, FJ, Fiers, W, Argilés, JM.
Tumour growth results in changes in placental amino acid transport in the rat: A tumour necrosis factor alpha-mediated effect
Biochem J 313, 77-82, 1996. (Epub ---)

Cauwels, A, Fiers, W, Brouckaert, P.
Murine IL-12 is involved in Calmette-Guérin bacillus-induced sensitization and is by itself sufficient to sensitize mice to the lethal effects of human TNF
J Immunol 156, 4686-4690, 1996. (Epub ---)

Clauss, M, Grell, M, Fangmann, C, Fiers, W, Scheurich, P, Risau, W.
Synergistic induction of endothelial tissue factor by tumor necrosis factor and vascular endothelial growth factor: Functional analysis of the tumor necrosis factor receptors
FEBS Lett 390, 334-338, 1996. (Epub ---)

Deroo, T, Min Jou, W, Fiers, W.
Recombinant neuraminidase vaccine protects against lethal influenza
Vaccine 14, 561-569, 1996. (Epub ---)

De Valck, D, Heyninck, K, Van Criekinge, W, Contreras, R, Beyaert, R, Fiers, W.
A20, an inhibitor of cell death, self-associates by its zinc finger domain
FEBS Lett 384, 61-64, 1996. (Epub ---)

Engers, R, van Roy, F, Heymer, T, Ramp, U, Moll, R, Dienst, M, Friebe, U, Pohl, A, Gabbert, HE, Gerharz, C-D.
Growth inhibition in clonal subpopulations of a human epithelioid sarcoma cell line by retinoic acid and tumour necrosis factor alpha
Br J Cancer 73, 491-498, 1996. (Epub ---)

Fiers, W, Beyaert, R, Boone, E, Cornelis, S, Declercq, W, Decoster, E, Denecker, G, Depuydt, B, De Valck, D, De Wilde, G, Goossens, V, Grooten, J, Haegeman, G, Heyninck, K, Penning, L, Plaisance, S, Vancompernolle, K, Van Criekinge, W, Vandenabeele, P, et al..
TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis
J Inflamm 47, 67-75, 1996. (Epub ---)

Goossens, V, Grooten, J, Fiers, W.
The oxidative metabolism of glutamine. A modulator of reactive oxygen intermediate-mediated cytotoxicity of tumor necrosis factor in L929 fibrosarcoma cells
J Biol Chem 271, 192-196, 1996. (Epub ---)

Hack, V, Gross, A, Kinscherf, R, Bockstette, M, Fiers, W, Berke, G, Dröge, W.
Abnormal glutathione and sulfate levels after interleukin 6 treatment and in tumor-induced cachexia
FASEB J 10, 1219-1226, 1996. (Epub ---)

Lassalle, P, Molet, S, Janin, A, Van der Heyden, J, Tavernier, J, Fiers, W, Devos, R, Tonnel, A-B.
ESM-1 is a novel human endothelial cell-specific molecule expressed in lung and regulated by cytokines
J Biol Chem 271, 20458-20464, 1996. (Epub ---)

Leppä, S, Vleminckx, K, Van Roy, F, Jalkanen, M.
Syndecan-1 expression in mammary epithelial tumor cells is E-cadherin-dependent
J Cell Sci 109, 1393-1403, 1996. (Epub ---)

Leysen, JE, Gommeren, W, Heylen, L, Luyten, WHML, Van de Weyer, I, Vanhoenacker, P, Haegeman, G, Schotte, A, Van Gompel, P, Wouters, R, Lesage, AS.
Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: Ligand-binding properties of human 5-hydroxytryptamine1Da, human 5-hydroxytryptamine1Db, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan
Mol Pharmacol 50, 1567-1580, 1996. (Epub ---)

Libert, C, Van Molle, W, Brouckaert, P, Fiers, W.
a1-Antitrypsin inhibits the lethal response to TNF in mice
J Immunol 157, 5126-5129, 1996. (Epub ---)

Libert, C, Van Molle, W, Brouckaert, P, Fiers, W.
Platelet-activating factor is a mediator in tumor necrosis factor/galactosamine-induced lethality
J Inflamm 46, 139-143, 1996. (Epub ---)

Marchant, A, Amraoui, Z, Gueydan, C, Bruyns, C, Le Moine, O, Vandenabeele, P, Fiers, W, Buurman, WA, Goldman, M.
Methylprednisolone differentially regulates interleukin-10 and tumor necrosis factor production during murine endotoxemia
Clin Exp Immunol 106, 91-96, 1996. (Epub ---)

Mareel, M, Berx, G, Van Roy, F, Bracke, M.
The cadherin/catenin complex: a target for antiinvasive therapy?
J Cell Biochem 61, 524-530, 1996. (Epub ---)

Mertens, N, Remaut, E, Fiers, W.
Increased stability of phage T7g10 mRNA is mediated by either a 5'- or a 3'-terminal stem-loop structure
Biol Chem 377, 811-817, 1996. (Epub ---)

Niki, T, Schuppan, D, de Bleser, PJ, Vrijsen, R, Pipeleers-Marichal, M, Beyaert, R, Wisse, E, Geerts, A.
Dexamethasone alters messenger RNA levels but not synthesis of collagens, fibronectin, or laminin by cultured rat fat-storing cells
Hepatology 23, 1673-1681, 1996. (Epub ---)

Nollet, F, Berx, G, Molemans, F, van Roy, F.
Genomic organization of the human beta-catenin gene (CTNNB1)
Genomics 32, 413-424, 1996. (Epub ---)

Ostermeier, M, De Sutter, K, Georgiou, G.
Eukaryotic protein disulfide isomerase complements Escherichia coli dsbA mutants and increases the yield of a heterologous secreted protein with disulfide bonds
J Biol Chem 271, 10616-10622, 1996. (Epub ---)

Steidler, L, Fiers, W, Remaut, E.
Expression of human and murine interleukins in Lactococcus lactis
In Lactic Acid Bacteria: Current Advances in Metabolism, Genetics and Applications. (Bozoglu, TF, Ray, B, eds.), NATO ASI Series, Vol. H 98, Berlin-Heidelberg, Springer, pp. 63-79, 1996. (Epub ---)

Steidler, L, Yu, W, Fiers, W, Remaut, E.
The expression of the Photinus pyralis luciferase gene in Staphylococcus aureus Cowan I allows the development of a live amplifiable tool for immunodetection
Appl Environ Microbiol 62, 2356-2359, 1996. (Epub ---)

Van Criekinge, W, Beyaert, R, Van de Craen, M, Vandenabeele, P, Schotte, P, De Valck, D, Fiers, W.
Functional characterization of the prodomain of interleukin-1b-converting enzyme
J Biol Chem 271, 27245-27248, 1996. (Epub ---)

Van den Broecke, C, Vleminckx, K, De Bruyne, G, Van Hoorde, L, Vakaet, L, van Roy, F, Mareel, M.
Morphotypic plasticity in vitro and in nude mice of epithelial mouse mammary cells (NMuMG) displaying an epithelioid (e) or an fibroblastic (f) morphotype in culture
Clin Exp Metastas 14, 282-296, 1996. (Epub ---)

Vanlandschoot, P, Beirnaert, E, Neirynck, S, Saelens, X, Min Jou, W, Fiers, W.
Molecular and immunological characterization of soluble aggregated A/Victoria/3/75 (H3N2) influenza haemagglutinin expressed in insect cells
Arch Virol 141, 1715-1726, 1996. (Epub ---)

Vermeulen, S, Van Marck, V, Van Hoorde, L, van Roy, F, Bracke, M, Mareel, M.
Regulation of the invasion suppressor function of the cadherin/catenin complex
Pathol Res Pract 192, 694-707, 1996. (Epub ---)

Berx, G, Cleton-Jansen, A-M, Nollet, F, de Leeuw, WJF, van de Vijver, MJ, Cornelisse, C, van Roy, F.
E-cadherin is a tumor/invasion suppressor gene mutated in human lobular breast cancers
EMBO J 14, 6107-6115, 1995. (Epub ---)

Berx, G, Staes, K, van Hengel, J, Molemans, F, Bussemakers, MJG, van Bokhoven, A, van Roy, F.
Cloning and characterization of the human invasion suppressor gene E-cadherin (CDH1)
Genomics 26, 281-289, 1995. (Epub ---)

Beyaert, R, Vanhaesebroeck, B, Declercq, W, Van Lint, J, Vandenabeele, P, Agostinis, P, Vandenheede, JR, Fiers, W.
Casein kinase-1 phosphorylates the p75 tumor necrosis factor receptor and negatively regulates tumor necrosis factor signaling for apoptosis
J Biol Chem 270, 23293-23299, 1995. (Epub ---)

Cauwels, A, Brouckaert, P, Grooten, J, Huang, S, Aguet, M, Fiers, W.
Involvement of IFN-g in Bacillus Calmette-Guérin-induced but not in tumor-induced sensitization to TNF-induced lethality
J Immunol 154, 2753-2763, 1995. (Epub ---)

Contreras, R, Demolder, J, Fiers, W.
Cloning and expression of cytokine genes
In Cytokines A Practical Approach. (Balkwill, FR, ed.), 2nd ed., Oxford, IRL Press, pp. 1-18, 1995. (Epub ---)

Cornelis, S, Faché, I, Van der Heyden, J, Guisez, Y, Tavernier, J, Devos, R, Fiers, W, Plaetinck, G.
Characterization of critical residues in the cytoplasmic domain of the human interleukin-5 receptor a chain required for growth signal transduction
Eur J Immunol 25, 1857-1864, 1995. (Epub ---)

Cornelis, S, Plaetinck, G, Devos, R, Van der Heyden, J, Tavernier, J, Sanderson, CJ, Guisez, Y, Fiers, W.
Detailed analysis of the IL-5-IL-5Ra interaction: Characterization of crucial residues on the ligand and the receptor
EMBO J 14, 3395-3402, 1995. (Epub ---)

Declercq, W, Vandenabeele, P, Fiers, W.
Dimerization of chimeric erythropoietin/75 kDa tumour necrosis factor (TNF) receptors transduces TNF signals: Necessity for the 75 kDa-TNF receptor transmembrane domain
Cytokine 7, 701-709, 1995. (Epub ---)

Decoster, E, Vanhaesebroeck, B, Vandenabeele, P, Grooten, J, Fiers, W.
Generation and biological characterization of membrane-bound, uncleavable murine tumor necrosis factor
J Biol Chem 270, 18473-18478, 1995. (Epub ---)

Depraetere, S, Vanhaesebroeck, B, Fiers, W, Willems, J, Joniau, M.
Polar agents with differentiation inducing capacity potentiate tumor necrosis factor-mediated cytotoxicity in human myeloid cell lines
J Leukocyte Biol 57, 141-151, 1995. (Epub ---)

Fiers, W.
Biologic therapy with TNF: Preclinical studies
In Biologic Therapy of Cancer. (DeVita Jr., VT, Hellman, S, Rosenberg, SA, eds.), 2nd ed., Philadelphia, J.B. Lippincott, pp. 295-327 , 1995. (Epub ---)

Fiers, W.
Pioneering work (Comment on Science, 1995, 269:496-512)
Science 269, 1805, 1995. (Epub ---)

Flamez, D, Remaut, E, Fiers, W.
Production in Escherichia coli of a functional murine and murine::human chimeric F(ab')2 fragment and mature antibody directed against human placental alkaline phosphatase
J Biotechnol 42, 133-143, 1995. (Epub ---)

Goossens, V, Grooten, J, De Vos, K, Fiers, W.
Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity
Proc Natl Acad Sci USA 92, 8115-8119, 1995. (Epub ---)

Haegeman, G, Fiers, W.
TNF-induced mechanisms for IL6 gene induction
In Signalling Mechanisms - From Transcription Factors to Oxidative Stress. (Packer, L, Wirtz, K, eds.), NATO ASI Series, Vol. H 92, Berlin-Heidelberg-New York, Springer, pp. 375-382, 1995. (Epub ---)

Los, M, Van de Craen, M, Penning, LC, Schenk, H, Westendorp, M, Baeuerle, PA, Dröge, W, Krammer, PH, Fiers, W, Schulze-Osthoff, K.
Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis
Nature 375, 81-83, 1995. (Epub ---)

Mareel, M, Bracke, M, Van Roy, F.
Cancer metastasis: Negative regulation by an invasion-suppressor complex
Cancer Detect Prevent 19, 451-464, 1995. (Epub ---)

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