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Suffys, P, Beyaert, R, Van Roy, F, Fiers, W.
TNF in combination with interferon-gamma is cytotoxic to normal, untransformed mouse and rat embryo fibroblast-like cells
Anticancer Res 9, 167-172, 1989. (Epub ---)

Tavernier, J, Devos, R, Van der Heyden, J, Hauquier, G, Bauden, R, Faché, I, Kawashima, E, Vandekerckhove, J, Contreras, R, Fiers, W.
Expression of human and murine interleukin-5 in eukaryotic systems
DNA 8, 491-501, 1989. (Epub ---)

Unkles, SE, Campbell, EI, Carrez, D, Grieve, C, Contreras, R, Fiers, W, van den Hondel, CAMJJ, Kinghorn, JR.
Transformation of Aspergillus niger with the homologous nitrate reductase gene
Gene 78, 157-166, 1989. (Epub ---)

Van de Voorde, A, Feys, V, De Waele, P, Casneuf, P, Fiers, W.
Tailoring of an anti-human placental alkaline phosphatase immunoglobulin using genetic engineering
In Advanced Research on Animal Cell Technology. (Miller, AOA, ed.), Dordrecht, Kluwer Academic Publishers, pp. 233-249, 1989. (Epub ---)

Vanhaesebroeck, B, Grooten, J, Fiers, W.
An ongoing in vivo immune response affects the abundancy and differentiation of lymphokine-activated killer cell precursors, but does not influence their broad spectrum target reactivity
J Immunol 143, 1396-1402, 1989. (Epub ---)

Van Roy, FM, Coopman, P, Suffys, P, Liebaut, G, Vleminckx, K, Gao, J, Dragonetti, CH, Fiers, W, Mareel, MM.
Effect of oncogene transfection or passage in vivo on malignant phenotypes of rat2 cells
Anticancer Res 9, 1553-1564, 1989. (Epub ---)

Van Roy, FM, Mareel, MM.
Oncogenes and tumor progression: State of the art
In Cancer Metastasis Molecular and Cellular Biology, Host Immune Responses and Perspective for Treatment. (Schirrmacher, V, Schwartz-Albiez, R, eds.), Berlin-Heidelberg, Springer Verlag, pp. 27-35, 1989. (Epub ---)

Whitehead, MP, Unkles, SE, Ramsden, M, Campbell, EI, Gurr, SJ, Spence, D, van den Hondel, C, Contreras, R, Kinghorn, JR.
Transformation of a nitrate reductase deficient mutant of Penicillium chrysogenum with the corresponding Aspergillus niger and A. nidulans niaD genes
Mol Gen Genet 216, 408-411, 1989. (Epub ---)

Arenzana-Seisdedos, F, Mogensen, SC, Vuillier, F, Fiers, W, Virelizier, JL.
Autocrine secretion of tumor necrosis factor under the influence of interferon-gamma amplifies HLA-DR gene induction in human monocytes
Proc Natl Acad Sci USA 85, 6087-6091, 1988. (Epub ---)

Balkwill, FR, Griffin, DB, Moodie, EM, Thomas, JA, Fiers, W.
Effect of TNF-a on human ovarian cancer xenografts in nude mice
In Tumor Necrosis Factor/Cachectin and Related Cytokines. (Bonavida, B, Gifford, GE, Kirchner, H, Old, LJ, eds.), Basel, Karger, pp. 160-164, 1988. (Epub ---)

Devos, R, Tavernier, J, Fiers, W.
Slippage of DNA polymerase I during synthesis of ds-cDNA
Nucleic Acids Res 16, 1630, 1988. (Epub ---)

De Waele, P, Feys, V, Van de Voorde, A, Molemans, F, Fiers, W.
Expression in non-lymphoid cells of mouse recombinant immunoglobulin directed against the tumour marker human placental alkaline phosphatase
Eur J Biochem 176, 287-295, 1988. (Epub ---)

Feys, V, De Waele, P, Van de Voorde, A, Casneuf, P, Fiers, W.
Expression of functional mouse antibodies directed against the tumour marker human placental alkaline phosphatase in non-lymphoid cells
Int J Cancer 41 (Suppl. 2), 26-27, 1988. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Everaerdt, B, Haegeman, G, Suffys, P, Tavernier, J, Vanhaesebroeck, B, Van Roy, F.
TNF. Its potential as an antitumour agent
In Developments in Biological Standardization. (Gearing, AJH, Hennessen, W, eds.), Vol. 69, Basel, Karger, pp. 143-151, 1988. (Epub ---)

Fiers, W, Leemans, R, Mertens, N, Sablon, E, Stanssens, P, Steidler, L, Van Mechelen, E, Remaut, E.
Engineering maximal expression of heterologous genes in gram-negative bacteria
In Proceedings of the 8th International Biotechnology Symposium, Paris, 1988. (Durand, G, Bobichon, L, Florent, J, eds.), Vol. II, Paris, Société Française de Microbiologie, pp. 680-694, 1988. (Epub ---)

Gresser, I, Belardelli, F, Tavernier, J, Fiers, W, Podo, F, Woodrow, D, Moss, J, Proietti, E.
Similarities and dissimilarities in the effects of tumor necrosis factor and interferon-alpha/beta on transplantable tumors and on suckling mice
In Tumor Necrosis Factor/Cachectin and Related Cytokines. (Bonavida, B, Gifford, GE, Kirchner, H, Old, LJ, eds.), Basel, Karger, pp. 165-170, 1988. (Epub ---)

Havell, EA, Fiers, W, North, RJ.
The antitumor function of tumor necrosis factor (TNF). 1. Therapeutic action of TNF against an established murine sarcoma is indirect, immunologically dependent, and limited by severe toxicity
J Exp Med 167, 1067-1085, 1988. (Epub ---)

Hepburn, A, Demolle, D, Boeynaems, JM, Fiers, W, Dumont, GE.
Rapid phosphorylation of a 27 kDa protein induced by tumor necrosis factor
FEBS Lett 227, 175-178, 1988. (Epub ---)

Huylebroeck, D, Maertens, G, Fiers, W, Stunnenberg, H, Fuller, S, Liljestroem, P, Garoff, H.
Viral delivery systems for heterologous antigens and epitopes
In Technological Advances in Vaccine Development. (Lasky, L, ed.), New York, Alan R. Liss, pp. 279-293, 1988. (Epub ---)

Huylebroeck, D, Maertens, G, Verhoeyen, M, Lopez, C, Raeymakers, A, Min Jou, W, Fiers, W.
High-level transient expression of influenza virus proteins from a series of SV40 late and early replacement vectors
Gene 66, 163-181, 1988. (Epub ---)

Krief, P, Azzarone, B, Boucheix, C, Billard, C, Chang, C, Fiers, W, Carloni, G.
Different levels of interferon-gamma induction of class I and class II major histocompatibility antigens in human hepatoma cell lines
In Viral Hepatitis and Liver Disease. New York, Alan R. Liss, pp. 217-220, 1988. (Epub ---)

Lapierre, LA, Fiers, W, Pober, JS.
Three distinct classes of regulatory cytokines control endothelial cell MHC antigen expression. Interactions with immune gamma interferon differentiate the effects of tumor necrosis factor and lymphotoxin from those of leukocyte a and fibroblast beta interferons
J Exp Med 167, 794-804, 1988. (Epub ---)

Lewit-Bentley, A, Fourme, R, Kahn, R, Prangé, T, Vachette, P, Tavernier, J, Hauquier, G, Fiers, W.
Structure of tumour necrosis factor by X-ray solution scattering and preliminary studies by single crystal X-ray diffraction
J Mol Biol 199, 389-392, 1988. (Epub ---)

Mareel, M, Coopman, P, Dragonetti, C, Fiers, W, Gao, J, Messiaen, L, Van Roy, F.
Spontaneous and oncogene-mediated acquisition of the invasive phenotype by cells in culture
In Tumor Progression and Metastasis. (Nicolson, GL, Fidler, IJ, eds.), UCLA Symposia on Molecular and Cellular Biology, New Series, Vol. 78, New York, Alan R. Liss, pp. 179-188, 1988. (Epub ---)

Mareel, M, Dragonetti, C, Tavernier, J, Fiers, W.
Tumor-selective cytotoxic effects of murine tumor necrosis factor (TNF) and interferon-gamma (IFN-gamma) in organ culture of B16 melanoma cells and heart tissue
Int J Cancer 42, 470-473, 1988. (Epub ---)

Mareel, MM, Van Roy, FM, Messiaen, L, Van Laerebeke, N, Boghaert, E.
Correlations of malignancy in cultured cells
In New Frontiers in Cytology Modern Aspects of Research and Practice. (Goerttler, K, Feichter, GE, Witte, S, eds.), Berlin-Heidelberg, Springer Verlag, pp. 27-31, 1988. (Epub ---)

Marquet, RL, Eggermont, AMM, de Bruin, RWF, Fiers, W, Jeekel, J.
Combined treatment of colon adenocarcinoma in rats with tumor necrosis factor and the interferon inducer ABPP
J Interferon Res 8, 319-323, 1988. (Epub ---)

Mosselmans, R, Hepburn, A, Dumont, JE, Fiers, W, Galand, P.
Endocytic pathway of recombinant murine tumor necrosis factor in L-929 cells
J Immunol 141, 3096-3100, 1988. (Epub ---)

Proietti, E, Belardelli, F, Carpinelli, G, Di Vito, M, Woodrow, D, Moss, J, Sestili, P, Fiers, W, Gresser, I, Podo, F.
Tumor necrosis factor a induces early morphologic and metabolic alterations in Friend leukemia cell tumors and fibrosarcomas in mice
Int J Cancer 42, 582-591, 1988. (Epub ---)

Reuter, A, Bernier, J, Vrindts-Gevaert, Y, Meuleman-Gathy, R, Malaise, M, Fiers, W, Franchimont, P.
Production of interferon gamma by peripheral blood mononuclear cells from normal subjects and from patients with rheumatoid arthritis
Clin Exp Rheumatol 6, 347-354, 1988. (Epub ---)

Suffys, P, Beyaert, R, Van Roy, F, Fiers, W.
Involvement of a serine protease in tumour-necrosis-factor-mediated cytotoxicity
Eur J Biochem 178, 257-265, 1988. (Epub ---)

Suffys, P, Van Roy, F, Fiers, W.
Tumor necrosis factor and interleukin 1 activate phospholipase in rat chondrocytes
FEBS Lett 232, 24-28, 1988. (Epub ---)

Tovey, MG, Content, J, Gresser, I, Gugenheim, J, Blanchard, B, Guymarho, J, Poupart, P, Gigou, M, Shaw, A, Fiers, W.
Genes for IFN-b-2 (IL-6), tumor necrosis factor, and IL-1 are expressed at high levels in the organs of normal individuals
J Immunol 141, 3106-3110, 1988. (Epub ---)

Vandenabeele, P, Jayaram, B, Devos, R, Shaw, A, Fiers, W.
Interleukin 1a acts as an autocrine growth factor for RPMI 1788, an Epstein-Barr virus-transformed human B cell line
Eur J Immunol 18, 1027-1031, 1988. (Epub ---)

van Hinsbergh, VWM, Kooistra, T, van den Berg, EA, Princen, HMG, Fiers, W, Emeis, JJ.
Tumor necrosis factor increases the production of plasminogen activator inhibitor in human endothelial cells in vitro and in rats in vivo
Blood 72, 1467-1473, 1988. (Epub ---)

Van Ostade, X, Tavernier, J, Fiers, W.
Two conserved tryptophan residues of tumor necrosis factor and lymphotoxin are not involved in the biological activity
FEBS Lett 238, 347-352, 1988. (Epub ---)

Vink, A, Vandenabeele, P, Uyttenhove, C, Cayphas, S, Van Snick, J.
Plasmacytoma growth factor activity of murine granulocyte-macrophage colony-stimulating factor
J Immunol 141, 1996-1999, 1988. (Epub ---)

Balkwill, F, Osborne, R, Burke, F, Naylor, S, Talbot, D, Durbin, H, Tavernier, J, Fiers, W.
Evidence for tumour necrosis factor/cachectin production in cancer
Lancet ii, 1229-1232, 1987. (Epub ---)

Balkwill, FR, Ward, BG, Fiers, W.
Effects of tumour necrosis factor on human tumour xenografts in nude mice
In Tumour Necrosis Factor and Related Cytotoxins. (Bock, G, Marsh, J, eds.), Ciba Foundation Symposium, Vol. 131, Chichester, John Wiley & Sons, pp. 154-169, 1987. (Epub ---)

Balkwill, FR, Ward, BG, Fiers, W, Ramani, P.
Mechanisms of anticancer action of interferons on human tumour xenografts in nude mice
In The Biology of the Interferon System 1986. (Cantell, K, Schellekens, H, eds.), Dordrecht-Boston-Lancaster, Martinus Nijhoff Publishers, pp. 293-300, 1987. (Epub ---)

Balkwill, FR, Ward, BG, Moodie, E, Fiers, W.
Therapeutic potential of tumor necrosis factor-alpha and gamma-interferon in experimental human ovarian cancer
Cancer Res 47, 4755-4758, 1987. (Epub ---)

Bevilacqua, MP, Wheeler, ME, Pober, JS, Fiers, W, Mendrick, DL, Cotran, RS, Gimbrone, MA.
Endothelial-dependent mechanisms of leukocyte adhesion: Regulation by interleukin-1 and tumor necrosis factor
In Leukocyte Emigration and Its Sequelae. (Movat, HZ, ed.), Basel, Karger, pp. 79-93, 1987. (Epub ---)

Dealtry, GB, Naylor, MS, Fiers, W, Balkwill, FR.
DNA fragmentation and cytotoxicity caused by tumor necrosis factor is enhanced by interferon-gamma
Eur J Immunol 17, 689-693, 1987. (Epub ---)

Dealtry, GB, Naylor, MS, Fiers, W, Balkwill, FR.
The effect of recombinant human tumour necrosis factor on growth and macromolecular synthesis of human epithelial cells
Exp Cell Res 170, 428-438, 1987. (Epub ---)

Defilippi, P, Poupart, P, Haegeman, G, Tavernier, J, Fiers, W, Content, J.
Induction of 26 kDa protein mRNA in human cells treated with recombinant human tumour necrosis factor (rTNF-a)
In The Biology of the Interferon System 1986. (Cantell, K, Schellekens, H, eds.), Dordrecht-Boston-Lancaster, Martinus Nijhoff Publishers, pp. 217-222, 1987. (Epub ---)

Defilippi, P, Poupart, P, Tavernier, J, Fiers, W, Content, J.
Induction and regulation of mRNA encoding 26-kDa protein in human cell lines treated with recombinant human tumor necrosis factor
Proc Natl Acad Sci USA 84, 4557-4561, 1987. (Epub ---)

Devos, R, Cheroutre, H, Plaetinck, G, Fiers, W.
Identification and expression of cDNA plasmids corresponding to human interferon-gamma (IFN-gamma) and interleukin 2 (IL-2)
In Molecular Cloning and Analysis of Lymphokines. (Webb, DR, Goeddel, DV, eds.), Lymphokines, Vol. 13, Orlando, Academic Press, pp. 21-34, 1987. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Everaerdt, B, Haegeman, G, Suffys, P, Tavernier, J, Vandenabeele, P, Vanhaesebroeck, B, Van Ostade, X, Van Roy, F.
Gene cloning and structure-function relationship of cytokines such as TNF and interleukins
Immunol Lett 16, 219-226, 1987. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Everaerdt, B, Suffys, P, Tavernier, J, Vanhaesebroeck, B, Van Roy, F.
Tumor necrosis factor: a potential antitumor agent?
J Interferon Res 7, 627-634, 1987. (Epub ---)

Fiers, W, Brouckaert, P, Devos, R, Fransen, L, Haegeman, G, Leroux-Roels, G, Marmenout, A, Remaut, E, Suffys, P, Tavernier, J, Van der Heyden, J, Van Roy, F.
Molecular and cellular biology of tumor necrosis factor, interferon-gamma, and their synergism
In The Biology of the Interferon System 1986. (Cantell, K, Schellekens, H, eds.), Dordrecht-Boston-Lancaster, Martinus Nijhoff Publishers, pp. 205-216, 1987. (Epub ---)

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