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Selected IRC publications
The IRC publications that match your query are listed below.
For copyright reasons, PDF-versions of our publications are available on the intranet only (login required 
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Devos, R, Tavernier, J, Plaetinck, G, Van der Heyden, J, Rolink, A, Fiers, W. Expression of the murine interleukin-5 receptor on Xenopus laevis oocytes Biochem Biophys Res Commun 172, 570-575, 1990. (Epub ---) 
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De Wachter, R, Maniloff, J, Fiers, W. Two-dimensional gel electrophoresis of nucleic acids In Gel Electrophoresis of Nucleic Acids A Practical Approach. (Rickwood, D, Hames, BD, eds.), 2nd ed., Oxford-New York-Tokyo, IRL Press, pp. 151-200, 1990. (Epub ---) 
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Fiers, W. De impact van de 'genetic engineering' in de biomedische sector Ingenieursblad 59, 33-38, 1990. (Epub ---)
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Fiers, W, Beyaert, R, Brouckaert, P, Everaerdt, B, Haegeman, G, Libert, C, Suffys, P, Takahashi, N, Tavernier, J, Van Bladel, S, Vanhaesebroeck, B, Van Ostade, X, Van Roy, F. In vitro and in vivo action of tumor necrosis factor In Tumor Necrosis Factor: Structure, Mechanism of Action, Role in Disease and Therapy. (Bonavida, B, Granger, G, eds.), Basel, Karger, pp. 77-81, 1990. (Epub ---)
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Fiers, W, Beyaert, R, Brouckaert, P, Everaerdt, B, Libert, C, Suffys, P, Takahashi, N, Vanhaesebroeck, B, Van Roy, F. Mechanism of action of tumor necrosis factor and its implications for synergizing and antagonizing drugs In Endotoxin From Pathophysiology to Therapeutic Approaches. (Baumgartner, J-D, Calandra, T, Carlet, J, eds.), Paris, Médecine-Sciences/Flammarion, pp. 59-68, 1990. (Epub ---)
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Goldman, M, Vandenabeele, P, Moulart, J, Amraoui, Z, Abramowicz, D, Nortier, J, Vanherweghem, JL, Fiers, W. Intraperitoneal secretion of interleukin-6 during continuous ambulatory peritoneal dialysis Nephron 56, 277-280, 1990. (Epub ---)
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Grunfeld, C, Adi, S, Soued, M, Moser, A, Fiers, W, Feingold, KR. Search for mediators of the lipogenic effects of tumor necrosis factor: Potential role for interleukin 6 Cancer Res 50, 4233-4238, 1990. (Epub ---)
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Kallinowski, F, Friis, RR, Van Roy, F, Vaupel, P. Oxygenation of tumors derived from ras transformed cells Adv Exp Med Biol 277, 907-916, 1990. (Epub ---)
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Libert, C, Brouckaert, P, Shaw, A, Fiers, W. Induction of interleukin 6 by human and murine recombinant interleukin 1 in mice Eur J Immunol 20, 691-694, 1990. (Epub ---)
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Mahadevan, V, Malik, STA, Meager, A, Fiers, W, Lewis, GP, Hart, IR. Role of tumor necrosis factor in flavone acetic acid-induced tumor vasculature shutdown Cancer Res 50, 5537-5542, 1990. (Epub ---)
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Malik, STA, Griffin, DB, Naylor, MS, Fiers, W, Oliff, A, Balkwill, FR. The complex effects of recombinant tumour necrosis factor-alpha (rhTNF-alpha) in human ovarian cancer xenograft models In Cytokines and Lipocortins in Inflammation and Differentiation. New York, Wiley-Liss, pp. 393-403, 1990. (Epub ---)
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Mareel, MM, Van Roy, FM, De Baetselier, P. The invasive phenotypes Cancer Metast Rev 9, 45-62, 1990. (Epub ---)
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Parant, F, Tavernier, J, Fiers, W, Parant, M. Comparative activity of human and murine tumor necrosis factor in toxicity and anti-infectious assays in mice Microb Pathogen 8, 143-149, 1990. (Epub ---)
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Plaetinck, G, Van der Heyden, J, Tavernier, J, Faché, I, Tuypens, T, Fischkoff, S, Fiers, W, Devos, R. Characterization of interleukin 5 receptors on eosinophilic sublines from human promyelocytic leukemia (HL-60) cells J Exp Med 172, 683-691, 1990. (Epub ---)
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Tavernier, J, Marmenout, A, Bauden, R, Hauquier, G, Van Ostade, X, Fiers, W. Analysis of the structure-function relationship of tumour necrosis factor. Human/mouse chimeric TNF proteins: General properties and epitope analysis J Mol Biol 211, 493-501, 1990. (Epub ---)
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Vandenabeele, P, Declercq, W, Libert, C, Fiers, W. Development of a simple, sensitive and specific bioassay for interleukin-1 based on the proliferation of RPMI 1788 cells. Comparison with other bioassays for IL-1 J Immunol Methods 135, 25-32, 1990. (Epub ---)
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Vandenabeele, P, Grooten, J, Fiers, W. IL-4 acts synergistically on the IL-2 response of an autoreactive T-cell clone; synergism correlates with increased intracellular IL-2, but not with a modified IL-2 receptor expression Cell Immunol 130, 79-91, 1990. (Epub ---)
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Vandenabeele, P, Guisez, Y, Declercq, W, Bauw, G, Vandekerckhove, J, Fiers, W. Response of murine cell lines to an IL-1/IL-2-induced factor in a rat/mouse T hybridoma (PC60): Differential induction of cytokines by human IL-1a and IL-1b and partial amino acid sequence of rat GM-CSF Lymphokine Res 9, 381-389, 1990. (Epub ---)
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Vanhaesebroeck, B, Cragoe Jr., EJ, Pouysségur, J, Beyaert, R, Van Roy, F, Fiers, W. Cytotoxic activity of tumor necrosis factor is inhibited by amiloride derivatives without involvement of the Na+/H+ antiporter FEBS Lett 261, 319-322, 1990. (Epub ---)
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Vanhaesebroeck, B, Timmers, HTM, Pronk, GJ, Van Roy, F, van der Eb, AJ, Fiers, W. Modulation of cellular susceptibility to the cytotoxic/cytostatic action of tumor necrosis factor by adenovirus E1 gene expression is cell type-dependent Virology 176, 362-368, 1990. (Epub ---)
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van Hinsbergh, VWM, van den Berg, EA, Fiers, W, Dooijewaard, G. Tumor necrosis factor induces the production of urokinase-type plasminogen activator by human endothelial cells Blood 75, 1991-1998, 1990. (Epub ---)
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Van Roy, F, Liebaut, G, Mareel, M, Fiers, W. Partial transformation of human tumor cell lines showing defective interaction between unusual p53 gene product and SV40 large-T antigen Oncogene 5, 207-218, 1990. (Epub ---)
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Van Roy, F, Mareel, M, Vleminckx, K, Beyaert, R, Fiers, W, Devleeschouwer, N, Muquardt, C, Legros, N, Bracke, M, Leclercq, G. Hormone sensitivity in vitro and in vivo of v-ras-transfected MCF-7 cell derivatives Int J Cancer 46, 522-532, 1990. (Epub ---)
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Balkwill, FR, Fiers, W. Introduction Cancer Surveys 8, 711-712, 1989. (Epub ---)
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Behrens, J, Mareel, MM, van Roy, FM, Birchmeier, W. Dissecting tumor cell invasion: Epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion J Cell Biol 108, 2435-2447, 1989. (Epub ---)
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Bereta, J, Kurdowska, A, Koj, A, Hirano, T, Kishimoto, T, Content, J, Fiers, W, Van Damme, J, Gauldie, J. Different preparations of natural and recombinant human interleukin-6 (IFN-beta2, BSF-2) similarly stimulate acute phase protein synthesis and uptake of alpha-aminoisobutyric acid by cultured rat hepatocytes Int J Biochem 21, 361-366, 1989. (Epub ---)
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Beyaert, R, Vanhaesebroeck, B, Suffys, P, Van Roy, F, Fiers, W. Lithium chloride potentiates tumor necrosis factor-mediated cytotoxicity in vitro and in vivo Proc Natl Acad Sci USA 86, 9494-9498, 1989. (Epub ---)
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Brouckaert, PG, Everaerdt, B, Libert, C, Takahashi, N, Fiers, W. Species specificity and involvement of other cytokines in endotoxic shock action of recombinant tumour necrosis factor in mice Agents Actions 26, 196-198, 1989. (Epub ---)
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Brouckaert, PG, Libert, C, Everaerdt, B, Takahashi, N, Fiers, W. A role for interleukin 1 in the in vivo actions of tumor necrosis factor Lymphokine Res 8, 269-274, 1989. (Epub ---)
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Brouckaert, P, Spriggs, DR, Demetri, G, Kufe, DW, Fiers, W. Circulating interleukin 6 during a continuous infusion of tumor necrosis factor and interferon g J Exp Med 169, 2257-2262, 1989. (Epub ---)
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Campbell, EI, Unkles, SE, Macro, JA, van den Hondel, C, Contreras, R, Kinghorn, JR. Improved transformation efficiency of Aspergillus niger using the homologous niaD gene for nitrate reductase Curr Genet 16, 53-56, 1989. (Epub ---)
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Coopman, P, Van Roy, F, Dragonetti, C, Gao, J, Fiers, W, Meneguzzi, G, Mareel, M. Tumorigenicity, invasiveness and metastatic capability of FR3T3 rat cells before and after transfection with bovine papilloma virus type 1 DNA Clin Exp Metastas 7, 69-84, 1989. (Epub ---)
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de Ruiter-Jacobs, YM, Broekhuijsen, M, Unkles, SE, Campbell, EI, Kinghorn, JR, Contreras, R, Pouwels, PH, van den Hondel, CA. A gene transfer system based on the homologous pyrG gene and efficient expression of bacterial genes in Aspergillus oryzae Curr Genet 16, 159-163, 1989. (Epub ---)
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Everaerdt, B, Brouckaert, P, Shaw, A, Fiers, W. Four different interleukin-1 species sensitize to the lethal action of tumour necrosis factor Biochem Biophys Res Commun 163, 378-385, 1989. (Epub ---)
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Fiers, W. TNF: Mechanism of action in vitro and in vivo In Influence of Molecular Biology on Drug Discovery. (Udaka, K, Furuichi, Y, Drews, J, eds.), Clinical Pharmacology, Vol. 1, München, W. Zuckschwerdt Verlag, pp. 17-24, 1989. (Epub ---)
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Fiers, W, Balkwill, FR. Future prospects and problems Cancer Surveys 8, 921-927, 1989. (Epub ---)
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Fiers, W, Beyaert, R, Brouckaert, P, Everaerdt, B, Grooten, J, Haegeman, G, Libert, C, Suffys, P, Takahashi, N, Tavernier, J, Van Bladel, S, Vanhaesebroeck, B, Van Ostade, X, Van Roy, F. Tumour necrosis factor and interleukin-6: Structure and mechanism of action of the molecular, cellular and in vivo level In Vectors as Tools for the Study of Normal and Abnormal Growth and Differentiation. (Lother, H, Dernick, R, Ostertag, W, eds.), NATO ASI Series, Vol. H 34, Berlin, Springer-Verlag, pp. 229-240, 1989. (Epub ---)
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Fiers, W, Brouckaert, P, Content, J, Contreras, R, Everaerdt, B, Guisez, Y, Libert, C, Spriggs, D, Takahashi, N, Tison, B, Vandenabeele, P, Van Snick, J. Interleukin-6: Biological function and regulation of the gene expression in vitro and in vivo In Advances in Immunopharmacology. (Hadden, JW, Spreafico, F, Yamamura, Y, Austen, KF, Dukor, P, Masek, K, eds.), Vol. 4, Oxford, Pergamon Press, pp. 185-190, 1989. (Epub ---)
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Grooten, J, Fiers, W. Acquisition by the murine host of responsiveness toward various neoplastic cell lines, but not toward self, through adoptive transfer of a helper T-lymphocyte clone with antiself specificity Cancer Res 49, 3872-3878, 1989. (Epub ---)
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Jayaram, B, Devos, R, Guisez, Y, Fiers, W. Purification of human interleukin-4 produced in Escherichia coli Gene 79, 345-354, 1989. (Epub ---)
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Leemans, R, Remaut, E, Fiers, W. Correlation between temperature-dependent cytoplasmic solubility and periplasmic export of a heterologous protein in Escherichia coli Gene 85, 99-108, 1989. (Epub ---)
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Malik, STA, Griffin, DB, Fiers, W, Balkwill, FR. Paradoxical effects of tumour necrosis factor in experimental ovarian cancer Int J Cancer 44, 918-925, 1989. (Epub ---)
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Rampart, M, De Smet, W, Fiers, W, Herman, AG. Inflammatory properties of recombinant tumor necrosis factor in rabbit skin in vivo J Exp Med 169, 2227-2232, 1989. (Epub ---)
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Rampart, M, Fiers, W, De Smet, W, Herman, AG. Different pro-inflammatory profiles of interleukin 1 (IL1) and tumor necrosis factor (TNF) in an in vivo model of inflammation Agents Actions 26, 186-188, 1989. (Epub ---)
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Robaye, B, Hepburn, A, Lecocq, R, Fiers, W, Boeynaems, JM, Dumont, JE. Tumor necrosis factor-alpha induces the phosphorylation of 28kDa stress proteins in endothelial cells: Possible role in protection against cytotoxicity? Biochem Biophys Res Commun 163, 301-308, 1989. (Epub ---)
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Saelens, X, Van Haute, E, Fiers, W. A simple and sensitive test reaction for cDNA synthesis Colloquium Boehringer Mannheim 2, 10-11, 1989. (Epub ---)
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Suffys, P, Beyaert, R, Van Roy, F, Fiers, W. TNF in combination with interferon-gamma is cytotoxic to normal, untransformed mouse and rat embryo fibroblast-like cells Anticancer Res 9, 167-172, 1989. (Epub ---)
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Tavernier, J, Devos, R, Van der Heyden, J, Hauquier, G, Bauden, R, Faché, I, Kawashima, E, Vandekerckhove, J, Contreras, R, Fiers, W. Expression of human and murine interleukin-5 in eukaryotic systems DNA 8, 491-501, 1989. (Epub ---)
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Unkles, SE, Campbell, EI, Carrez, D, Grieve, C, Contreras, R, Fiers, W, van den Hondel, CAMJJ, Kinghorn, JR. Transformation of Aspergillus niger with the homologous nitrate reductase gene Gene 78, 157-166, 1989. (Epub ---)
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Van de Voorde, A, Feys, V, De Waele, P, Casneuf, P, Fiers, W. Tailoring of an anti-human placental alkaline phosphatase immunoglobulin using genetic engineering In Advanced Research on Animal Cell Technology. (Miller, AOA, ed.), Dordrecht, Kluwer Academic Publishers, pp. 233-249, 1989. (Epub ---)
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