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Steidler, L, Yu, W, Fiers, W, Remaut, E.
The expression of the Photinus pyralis luciferase gene in Staphylococcus aureus Cowan I allows the development of a live amplifiable tool for immunodetection
Appl Environ Microbiol 62, 2356-2359, 1996. (Epub ---)

Van Criekinge, W, Beyaert, R, Van de Craen, M, Vandenabeele, P, Schotte, P, De Valck, D, Fiers, W.
Functional characterization of the prodomain of interleukin-1b-converting enzyme
J Biol Chem 271, 27245-27248, 1996. (Epub ---)

Van den Broecke, C, Vleminckx, K, De Bruyne, G, Van Hoorde, L, Vakaet, L, van Roy, F, Mareel, M.
Morphotypic plasticity in vitro and in nude mice of epithelial mouse mammary cells (NMuMG) displaying an epithelioid (e) or an fibroblastic (f) morphotype in culture
Clin Exp Metastas 14, 282-296, 1996. (Epub ---)

Vanlandschoot, P, Beirnaert, E, Neirynck, S, Saelens, X, Min Jou, W, Fiers, W.
Molecular and immunological characterization of soluble aggregated A/Victoria/3/75 (H3N2) influenza haemagglutinin expressed in insect cells
Arch Virol 141, 1715-1726, 1996. (Epub ---)

Vermeulen, S, Van Marck, V, Van Hoorde, L, van Roy, F, Bracke, M, Mareel, M.
Regulation of the invasion suppressor function of the cadherin/catenin complex
Pathol Res Pract 192, 694-707, 1996. (Epub ---)

Berx, G, Cleton-Jansen, A-M, Nollet, F, de Leeuw, WJF, van de Vijver, MJ, Cornelisse, C, van Roy, F.
E-cadherin is a tumor/invasion suppressor gene mutated in human lobular breast cancers
EMBO J 14, 6107-6115, 1995. (Epub ---)

Berx, G, Staes, K, van Hengel, J, Molemans, F, Bussemakers, MJG, van Bokhoven, A, van Roy, F.
Cloning and characterization of the human invasion suppressor gene E-cadherin (CDH1)
Genomics 26, 281-289, 1995. (Epub ---)

Beyaert, R, Vanhaesebroeck, B, Declercq, W, Van Lint, J, Vandenabeele, P, Agostinis, P, Vandenheede, JR, Fiers, W.
Casein kinase-1 phosphorylates the p75 tumor necrosis factor receptor and negatively regulates tumor necrosis factor signaling for apoptosis
J Biol Chem 270, 23293-23299, 1995. (Epub ---)

Cauwels, A, Brouckaert, P, Grooten, J, Huang, S, Aguet, M, Fiers, W.
Involvement of IFN-g in Bacillus Calmette-Guérin-induced but not in tumor-induced sensitization to TNF-induced lethality
J Immunol 154, 2753-2763, 1995. (Epub ---)

Contreras, R, Demolder, J, Fiers, W.
Cloning and expression of cytokine genes
In Cytokines A Practical Approach. (Balkwill, FR, ed.), 2nd ed., Oxford, IRL Press, pp. 1-18, 1995. (Epub ---)

Cornelis, S, Faché, I, Van der Heyden, J, Guisez, Y, Tavernier, J, Devos, R, Fiers, W, Plaetinck, G.
Characterization of critical residues in the cytoplasmic domain of the human interleukin-5 receptor a chain required for growth signal transduction
Eur J Immunol 25, 1857-1864, 1995. (Epub ---)

Cornelis, S, Plaetinck, G, Devos, R, Van der Heyden, J, Tavernier, J, Sanderson, CJ, Guisez, Y, Fiers, W.
Detailed analysis of the IL-5-IL-5Ra interaction: Characterization of crucial residues on the ligand and the receptor
EMBO J 14, 3395-3402, 1995. (Epub ---)

Declercq, W, Vandenabeele, P, Fiers, W.
Dimerization of chimeric erythropoietin/75 kDa tumour necrosis factor (TNF) receptors transduces TNF signals: Necessity for the 75 kDa-TNF receptor transmembrane domain
Cytokine 7, 701-709, 1995. (Epub ---)

Decoster, E, Vanhaesebroeck, B, Vandenabeele, P, Grooten, J, Fiers, W.
Generation and biological characterization of membrane-bound, uncleavable murine tumor necrosis factor
J Biol Chem 270, 18473-18478, 1995. (Epub ---)

Depraetere, S, Vanhaesebroeck, B, Fiers, W, Willems, J, Joniau, M.
Polar agents with differentiation inducing capacity potentiate tumor necrosis factor-mediated cytotoxicity in human myeloid cell lines
J Leukocyte Biol 57, 141-151, 1995. (Epub ---)

Fiers, W.
Biologic therapy with TNF: Preclinical studies
In Biologic Therapy of Cancer. (DeVita Jr., VT, Hellman, S, Rosenberg, SA, eds.), 2nd ed., Philadelphia, J.B. Lippincott, pp. 295-327 , 1995. (Epub ---)

Fiers, W.
Pioneering work (Comment on Science, 1995, 269:496-512)
Science 269, 1805, 1995. (Epub ---)

Flamez, D, Remaut, E, Fiers, W.
Production in Escherichia coli of a functional murine and murine::human chimeric F(ab')2 fragment and mature antibody directed against human placental alkaline phosphatase
J Biotechnol 42, 133-143, 1995. (Epub ---)

Goossens, V, Grooten, J, De Vos, K, Fiers, W.
Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity
Proc Natl Acad Sci USA 92, 8115-8119, 1995. (Epub ---)

Haegeman, G, Fiers, W.
TNF-induced mechanisms for IL6 gene induction
In Signalling Mechanisms - From Transcription Factors to Oxidative Stress. (Packer, L, Wirtz, K, eds.), NATO ASI Series, Vol. H 92, Berlin-Heidelberg-New York, Springer, pp. 375-382, 1995. (Epub ---)

Los, M, Van de Craen, M, Penning, LC, Schenk, H, Westendorp, M, Baeuerle, PA, Dröge, W, Krammer, PH, Fiers, W, Schulze-Osthoff, K.
Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis
Nature 375, 81-83, 1995. (Epub ---)

Mareel, M, Bracke, M, Van Roy, F.
Cancer metastasis: Negative regulation by an invasion-suppressor complex
Cancer Detect Prevent 19, 451-464, 1995. (Epub ---)

Mertens, N, Remaut, E, Fiers, W.
Tight transcriptional control mechanism ensures stable high-level expression from T7 promoter-based expression plasmids
Bio/Technology 13, 175-179, 1995. (Epub ---)

Mertens, N, Remaut, E, Fiers, W.
Versatile, multi-featured plasmids for high-level expression of heterologous genes in Escherichia coli: Overproduction of human and murine cytokines
Gene 164, 9-15, 1995. (Epub ---)

Nollet, F, van Hengel, J, Berx, G, Molemans, F, van Roy, F.
Isolation and characterization of a human pseudogene (CTNNAP1) for alpha-E-catenin (CTNNA1): Assignment of the pseudogene to 5q22 and the alpha-E-catenin gene to 5q31
Genomics 26, 410-413, 1995. (Epub ---)

Nyyssönen, E, Demolder, J, Contreras, R, Keränen, S, Penttilä, M.
Protein production by the filamentous fungus Trichoderma reesei: Secretion of active antibody molecules
Can J Bot 73, S885-S890, 1995. (Epub ---)

Robbens, J, Raeymaekers, A, Steidler, L, Fiers, W, Remaut, E.
Production of soluble and active recombinant murine interleukin-2 in Escherichia coli: High level expression, kil-induced release, and purification
Protein Expr Purif 6, 481-486, 1995. (Epub ---)

Steidler, L, Fiers, W, Remaut, E.
Simultaneous light emission from cloned Vibrio fischeri lux genes and expression of LamB or LamB-protein A fusion proteins in Escherichia coli depends on using a single chimeric operon
Biotechnol Bioengin 48, 667-672, 1995. (Epub ---)

Steidler, L, Wells, JM, Raeymaekers, A, Vandekerckhove, J, Fiers, W, Remaut, E.
Secretion of biologically active murine interleukin-2 by Lactococcus lactis subsp. lactis
Appl Environ Microbiol 61, 1627-1629, 1995. (Epub ---)

Takahashi, N, Brouckaert, P, Fiers, W.
Mechanism of tolerance to tumor necrosis factor: Receptor-specific pathway and selectivity
Am J Physiol 269, R398-R405, 1995. (Epub ---)

Takahashi, N, Fiers, W, Brouckaert, P.
Anti-tumor activity of tumor necrosis factor in combination with interferon-gamma is not affected by prior tolerization
Int J Cancer 63, 846-854, 1995. (Epub ---)

Vandenabeele, P, Declercq, W, Beyaert, R, Fiers, W.
Two tumour necrosis factor receptors: Structure and function
Trends Cell Biol 5, 392-399, 1995. (Epub ---)

Vandenabeele, P, Declercq, W, Vanhaesebroeck, B, Grooten, J, Fiers, W.
Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells
J Immunol 154, 2904-2913, 1995. (Epub ---)

van Hengel, J, Nollet, F, Berx, G, van Roy, N, Speleman, F, van Roy, F.
Assignment of the human beta-catenin gene (CTNNB1) to 3p22-p21.3 by fluorescence in situ hybridization
Cytogenet Cell Genet 70, 68-70, 1995. (Epub ---)

Vanlandschoot, P, Beirnaert, E, Dewilde, S, Saelens, X, Bestebroer, T, de Jong, J, Min Jou, W, Fiers, W.
A fairly conserved epitope on the hemagglutinin of influenza A (H3N2) virus with variable accessibility to neutralizing antibody
Virology 212, 526-534, 1995. (Epub ---)

Vercammen, D, Vandenabeele, P, Declercq, W, Van de Craen, M, Grooten, J, Fiers, W.
Cytotoxicity in L929 murine fibrosarcoma cells after triggering of transfected human p75 tumour necrosis factor (TNF) receptor is mediated by endogenous murine TNF
Cytokine 7, 463-470, 1995. (Epub ---)

Vermeulen, S, Bruyneel, E, van Roy, F, Mareel, M, Bracke, M.
Activation of the E-cadherin/catenin complex in human MCF-7 breast cancer cells by all-trans-retinoic acid
Br J Cancer 72, 1447-1453, 1995. (Epub ---)

Vermeulen, SJ, Bruyneel, EA, Bracke, ME, De Bruyne, GK, Vennekens, KM, Vleminckx, KL, Berx, GJ, van Roy, FM, Mareel, MM.
Transition from the noninvasive to the invasive phenotype and loss of alpha-catenin in human colon cancer cells
Cancer Res 55, 4722-4728, 1995. (Epub ---)

Westermarck, J, Häkkinen, L, Fiers, W, Kähäri, V-M.
TNF-R55-specific form of human tumor necrosis factor-alpha induces collagenase gene expression by human skin fibroblasts
J Invest Dermatol 105, 197-202, 1995. (Epub ---)

Barbara, JAJ, Smith, WB, Gamble, JR, Van Ostade, X, Vandenabeele, P, Tavernier, J, Fiers, W, Vadas, MA, Lopez, AF.
Dissociation of TNF-a cytotoxic and proinflammatory activities by p55 receptor- and p75 receptor-selective TNF-a mutants
EMBO J 13, 843-850, 1994. (Epub ---)

Beyaert, R, Fiers, W.
Molecular mechanisms of tumor necrosis factor-induced cytotoxicity: What we do understand and what we do not
FEBS Lett 340, 9-16, 1994. (Epub ---)

Bracke, ME, Vermeulen, SJ, Bruyneel, EA, Vennekens, KM, De Bruyne, GK, van Roy, FM, Mareel, MM.
The invasion suppressor function of E-cadherin in mammary epithelioid cells
In Prospects in Diagnosis and Treatment of Breast Cancer. (Schmitt, M, ed.), Excerpta Medica International Congress Series, Amsterdam, Elsevier, pp. 107-115, 1994. (Epub ---)

Brouckaert, P, Ameloot, P, Cauwels, A, Everaerdt, B, Libert, C, Takahashi, N, Van Molle, W, Fiers, W.
Receptor-selective mutants of tumour necrosis factor in the therapy of cancer: Preclinical studies
Circ Shock 43, 185-190, 1994. (Epub ---)

Carter, AT, Narbad, A, Pearson, BM, Beck, K-F, Baum, B, Logghe, M, Contreras, R, Schweizer, M.
Phosphoribosylpyrophosphate synthetase (PRS): A new gene family in Saccharomyces cerevisiae
Yeast 10, 1031-1044, 1994. (Epub ---)

Demolder, J, Fiers, W, Contreras, R.
Human interferon-beta, expressed in Saccharomyces cerevisiae, is predominantly directed to the vacuoles. Influence of modified co-expression of secretion factors and chaperones
J Biotechnol 32, 179-189, 1994. (Epub ---)

De Sutter, K, Fiers, W.
A bifunctional murine::human chimeric antibody with one antigen-binding arm replaced by bacterial beta-lactamase
Mol Immunol 31, 261-267, 1994. (Epub ---)

De Sutter, K, Hostens, K, Vandekerckhove, J, Fiers, W.
Production of enzymatically active rat protein disulfide isomerase in Escherichia coli
Gene 141, 163-170, 1994. (Epub ---)

Dimanche-Boitrel, MT, Vakaet Jr., L, Pujuguet, P, Chauffert, B, Martin, MS, Hammann, A, Van Roy, F, Mareel, M, Martin, F.
In vivo and in vitro invasiveness of a rat colon cancer cell line maintaining E-cadherin expression: An enhancing role of tumor-associated myofibroblasts
Int J Cancer 56, 512-521, 1994. (Epub ---)

Donckier, V, Abramowicz, D, Bruyns, C, Florquin, S, Vanderhaegen, M-L, Amraoui, Z, Dubois, C, Vandenabeele, P, Goldman, M.
IFN-g prevents Th2 cell-mediated pathology after neonatal injection of semiallogenic spleen cells in mice
J Immunol 153, 2361-2368, 1994. (Epub ---)

Donckier, V, Flament, V, Gérard, C, Abramowicz, D, Vandenabeele, P, Wissing, M, Delvaux, A, Fiers, W, Leo, O, Velu, T, Goldman, M.
Modulation of the release of cytokines and reduction of the shock syndrome induced by anti-CD3 monoclonal antibody in mice by interleukin-10
Transplantation 57, 1436-1439, 1994. (Epub ---)

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