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Everaerdt, B, Brouckaert, P, Fiers, W.
Recombinant IL-1 receptor antagonist protects against TNF-induced lethality in mice
J Immunol 152, 5041-5049, 1994. (Epub ---)

Feldmann, H, Aigle, M, Aljinovic, G, André, B, Baclet, MC, Barthe, C, Baur, A, Bécam, A-M, Biteau, N, Boles, E, Brandt, T, Brendel, M, Brückner, M, Bussereau, F, Christiansen, C, Contreras, R, Crouzet, M, Cziepluch, C, Démolis, N, et al..
Complete DNA sequence of yeast chromosome II
EMBO J 13, 5795-5809, 1994. (Epub ---)

Flamand, V, Donckier, V, Abramowicz, D, Goldman, M, Vandenabeele, P, Urbain, J, Moser, M, Leo, O.
In vivo immunosuppression induced by a weakly mitogenic antibody to mouse CD3: Evidence that induction of long-lasting in vivo unresponsiveness requires TcR signaling
Cell Immunol 157, 239-248, 1994. (Epub ---)

Goldman, GH, Vasseur, V, Contreras, R, Van Montagu, M.
Sequence analysis and expression studies of a gene encoding a novel serine + alanine-rich protein in Trichoderma harzianum
Gene 144, 113-117, 1994. (Epub ---)

Libert, C, Brouckaert, P, Fiers, W.
Protection by a1-acid glycoprotein against tumor necrosis factor-induced lethality
J Exp Med 180, 1571-1575, 1994. (Epub ---)

Libert, C, Takahashi, N, Cauwels, A, Brouckaert, P, Bluethmann, H, Fiers, W.
Response of interleukin-6-deficient mice to tumor necrosis factor-induced metabolic changes and lethality
Eur J Immunol 24, 2237-2242, 1994. (Epub ---)

Logghe, M, Molemans, F, Fiers, W, Contreras, R.
The two genes encoding yeast ribosomal protein S8 reside on different chromosomes, and are closely linked to the hsp70 stress protein genes SSA3 and SSA4
Yeast 10, 1093-1100, 1994. (Epub ---)

Marchant, A, Bruyns, C, Vandenabeele, P, Abramowicz, D, Gérard, C, Delvaux, A, Ghezzi, P, Velu, T, Goldman, M.
The protective role of interleukin-10 in endotoxin shock
Prog Clin Biol Res 388, 417-423, 1994. (Epub ---)

Marchant, A, Bruyns, C, Vandenabeele, P, Ducarme, M, Gérard, C, Delvaux, A, De Groote, D, Abramowicz, D, Velu, T, Goldman, M.
Interleukin-10 controls interferon-gamma and tumor necrosis factor production during experimental endotoxemia
Eur J Immunol 24, 1167-1171, 1994. (Epub ---)

Mareel, M, Bracke, M, Van Roy, F.
Invasion promoter versus invasion suppressor molecules: the paradigm of E-cadherin
Mol Biol Rep 19, 45-67, 1994. (Epub ---)

Mareel, MM, Vleminckx, K, Vermeulen, S, Gao, Y, Bracke, M, van Roy, F.
Downregulation in vivo of the invasion-suppressor molecule E-cadherin in experimental and clinical cancer
In Proceedings of the 24th International Symposium of the Princess Takamatsu Cancer Research Fund. Princeton, The Princeton Scientific Publishing Co., pp. 63-80 , 1994. (Epub ---)

Mareel, M, Van Roy, F, De Baetselier, P, Vakaet, L.
Invasiveness in development and neoplasia
In Developmental Biology and Cancer. (Hodges, GM, Rowlatt, C, eds.), New Jersey, The Telford Press, pp. 389-416, 1994. (Epub ---)

Steidler, L, Fiers, W, Remaut, E.
Efficient specific release of periplasmic proteins from Escherichia coli using temperature induction of cloned kil gene of pMB9
Biotechnol Bioeng 44, 1074-1082, 1994. (Epub ---)

Takahashi, N, Brouckaert, P, Bemelmans, MHA, Buurman, WA, Fiers, W.
Mechanism of induction of tolerance to tumour necrosis factor (TNF): No involvement of modulators of TNF bioavailability or receptor binding
Cytokine 6, 235-242, 1994. (Epub ---)

Vandenabeele, P, Goossens, V, Beyaert, R, Declercq, W, Grooten, J, Vanhaesebroeck, B, Van de Craen, M, Vercammen, D, Depuydt, B, Denecker, G, Fiers, W.
Functional requirement of the two TNF receptors for induction of apoptosis in PC60 cells and the role of mitochondria in TNF-induced cytotoxicity
Circ Shock 44, 196-200, 1994. (Epub ---)

Vandenbossche, GMR, De Bruyne, GK, Bruyneel, EA, Clemminck, G, Vleminckx, K, van Roy, FM, Mareel, MM.
Microencapsulation of MDCK-ras-e cells prevents loss of the E-cadherin invasion suppressor function in vivo
Int J Cancer 57, 73-80, 1994. (Epub ---)

Vanhoenacker, P, Fiers, W, Haegeman, G.
Studies on the induction of the interleukin-6 promoter in cell lines of human and simian origin
Eur Cytokine Netw 5, 283-291, 1994. (Epub ---)

Van Ostade, X, Tavernier, J, Fiers, W.
Structure-activity studies of human tumour necrosis factors
Protein Eng 7, 5-22, 1994. (Epub ---)

Van Ostade, X, Vandenabeele, P, Tavernier, J, Fiers, W.
Human tumor necrosis factor mutants with preferential binding to and activity on either the R55 or R75 receptor
Eur J Biochem 220, 771-779, 1994. (Epub ---)

Vleminckx, KL, Deman, JJ, Bruyneel, EA, Van den Bossche, GMR, Keirsebilck, AA, Mareel, MM, van Roy, FM.
Enlarged cell-associated proteoglycans abolish E-cadherin functionality in invasive tumor cells
Cancer Res 54, 873-877, 1994. (Epub ---)

Behrens, J, Vakaet, L, Friis, R, Winterhager, E, van Roy, F, Mareel, MM, Birchmeier, W.
Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-src gene
J Cell Biol 120, 757-766, 1993. (Epub ---)

Beyaert, R, Heyninck, K, De Valck, D, Boeykens, F, Van Roy, F, Fiers, W.
Enhancement of tumor necrosis factor cytotoxicity by lithium chloride is associated with increased inositol phosphate accumulation
J Immunol 151, 291-300, 1993. (Epub ---)

Beyaert, R, Vanhaesebroeck, B, Heyninck, K, Boone, E, De Valck, D, Schulze-Osthoff, K, Haegeman, G, Van Roy, F, Fiers, W.
Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine
Cancer Res 53, 2623-2630, 1993. (Epub ---)

Bracke, ME, Vyncke, BM, Bruyneel, EA, Vermeulen, SJ, De Bruyne, GK, Van Larebeke, NA, Vleminckx, K, Van Roy, FM, Mareel, MM.
Insulin-like growth factor I activates the invasion suppressor function of E-cadherin in MCF-7 human mammary carcinoma cells in vitro
Br J Cancer 68, 282-289, 1993. (Epub ---)

Broekhuijsen, MP, Mattern, IE, Contreras, R, Kinghorn, JR, van den Hondel, CAMJJ.
Secretion of heterologous proteins by Aspergillus niger: Production of active human interleukin-6 in a protease-deficient mutant by KEX2-like processing of a glucoamylase-hIL6 fusion protein
J Biotechnol 31, 135-145, 1993. (Epub ---)

Brouckaert, P, Everaerdt, B, Libert, C, Takahashi, N, Cauwels, A, Fiers, W.
Strategies to broaden the therapeutic margin of tumor necrosis factor
In Tumor Necrosis Factor: Molecular and Cellular Biology and Clinical Relevance. (Fiers, W, Buurman, WA, eds.), Basel, Karger, pp. 226-232, 1993. (Epub ---)

Brouckaert, PG, Libert, C.
Tumor necrosis factor
In Acute Phase Proteins Molecular Biology, Biochemistry, and Clinical Applications. (Mackiewicz, A, Kushner, I, Baumann, H, eds.), Boca Raton, CRC Press, pp. 329-342, 1993. (Epub ---)

Brouckaert, P, Libert, C, Everaerdt, B, Takahashi, N, Cauwels, A, Fiers, W.
Tumor necrosis factor, its receptors and the connection with interleukin 1 and interleukin 6
Immunobiology 187, 317-329, 1993. (Epub ---)

Chastre, E, Empereur, S, Di Gioia, Y, El Mahdani, N, Mareel, M, Vleminckx, K, Van Roy, F, Bex, V, Emami, S, Spandidos, DA, Gespach, C.
Neoplastic progression of human and rat intestinal cell lines after transfer of the ras and polyoma middle T oncogenes
Gastroenterology 105, 1776-1789, 1993. (Epub ---)

Demolder, J, De Backer, M, Fiers, W, Contreras, R.
Phenotypic effects in Saccharomyces cerevisiae after regulated expression of beta-(1,3)-glucanase from Nicotiana plumbaginifolia
J Biotechnol 27, 295-305, 1993. (Epub ---)

De Valck, D, Beyaert, R, Van Roy, F, Fiers, W.
Tumor necrosis factor cytotoxicity is associated with activation of cellular phospholipases
In New Developments in Lipid-Protein Interactions and Receptor Function. (Wirtz, KWA, Packer, L, Gustafsson, JÅ, Evangelopoulos, AE, Changeux, JP, eds.), NATO ASI Series, Vol. A 246, New York-London, Plenum Press, pp. 29-37, 1993. (Epub ---)

De Valck, D, Beyaert, R, Van Roy, F, Fiers, W.
Tumor necrosis factor cytotoxicity is associated with phospholipase D activation
Eur J Biochem 212, 491-497, 1993. (Epub ---)

Devos, R, Guisez, Y, Cornelis, S, Verhee, A, Van der Heyden, J, Manneberg, M, Lahm, H-W, Fiers, W, Tavernier, J, Plaetinck, G.
Recombinant soluble human interleukin-5 (hIL-5) receptor molecules. Cross-linking and stoichiometry of binding to IL-5
J Biol Chem 268, 6581-6587, 1993. (Epub ---)

Fiers, W.
Tumour necrosis factor
In The Natural Immune System: Humoral Factors. (Sim, E, ed.), Oxford, IRL Press, pp. 65-119, 1993. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Cauwels, A, Declercq, W, De Valck, D, Everaerdt, B, Goossens, V, Grooten, J, Haegeman, G, Libert, C, Schulze-Osthoff, K, Takahashi, N, Vandenabeele, P, Vanhaesebroeck, B, Van Ostade, X, Van Roy, F.
Two pathways of tumor necrosis factor signal transduction: In vitro and in vivo implications
In Tumor Necrosis Factor: Molecular and Cellular Biology and Clinical Relevance. (Fiers, W, Buurman, WA, eds.), Basel, Karger (Shugar, D, Rode, W, Borowski, E, eds.), Warszawa-Berlin, Polish Scientific Publishers PWN/Springer-Verlag, pp. 58-65, 1993. (Epub ---)

Goldman, GH, Temmerman, W, Jacobs, D, Contreras, R, Van Montagu, M, Herrera-Estrella, A.
A nucleotide substitution in one of the beta-tubulin genes of Trichoderma viride confers resistance to the antimitotic drug methyl benzimidazole-2-yl-carbamate
Mol Gen Genet 240, 73-80, 1993. (Epub ---)

Gérard, C, Bruyns, C, Marchant, A, Abramowicz, D, Vandenabeele, P, Delvaux, A, Fiers, W, Goldman, M, Velu, T.
Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia
J Exp Med 177, 547-550, 1993. (Epub ---)

Grooten, J, Goossens, V, Vanhaesebroeck, B, Fiers, W.
Cell membrane permeabilization and cellular collapse, followed by loss of dehydrogenase activity: Early events in tumour necrosis factor-induced cytotoxicity
Cytokine 5, 546-555, 1993. (Epub ---)

Guisez, Y, Demolder, J, Mertens, N, Raeymaekers, A, Plaetinck, G, Robbens, J, Vandekerckhove, J, Remaut, E, Fiers, W.
High-level expression, purification and renaturation of recombinant murine interleukin-2 from Escherichia coli
Protein Expr Purif 4, 240-246, 1993. (Epub ---)

Guisez, Y, Oefner, C, Winkler, FK, Schlaeger, E-J, Zulauf, M, Van der Heyden, J, Plaetinck, G, Cornelis, S, Tavernier, J, Fiers, W, Devos, R, D'Arcy, A.
Expression, purification and crystallization of fully active, glycosylated human interleukin-5
FEBS Lett 331, 49-52, 1993. (Epub ---)

Guisez, Y, Robbens, J, Remaut, E, Fiers, W.
Folding of the MS2 coat protein in Escherichia coli is modulated by translational pauses resulting from mRNA secondary structure and codon usage: A hypothesis
J Theor Biol 162, 243-252, 1993. (Epub ---)

Libert, C, Everaerdt, B, Takahashi, N, Cauwels, A, Brouckaert, P, Fiers, W.
Protection against tumor necrosis factor-induced lethality
In Tumor Necrosis Factor: Molecular and Cellular Biology and Clinical Relevance. (Fiers, W, Buurman, WA, eds.), Basel, Karger, pp. 126-131, 1993. (Epub ---)

Mareel, M, Bracke, M, Van Roy, F, Vakaet, L.
Expression of E-cadherin in embryogenetic ingression and cancer invasion
Int J Dev Biol 37, 227-235, 1993. (Epub ---)

Mareel, MM, van Roy, FM, Bracke, ME.
How and when do tumor cells metastasize?
Crit Rev Oncogenesis 4, 559-594, 1993. (Epub ---)

Patestos, NP, Haegeman, G, Vandevoorde, V, Fiers, W.
Activation of the nuclear factor kB is not sufficient for regulation of tumor necrosis factor-induced interleukin-6 gene expression
Biochimie 75, 1007-1018, 1993. (Epub ---)

Schulze-Osthoff, K, Beyaert, R, Vandevoorde, V, Haegeman, G, Fiers, W.
Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF
EMBO J 12, 3095-3104, 1993. (Epub ---)

Slowik, MR, De Luca, LG, Fiers, W, Pober, JS.
Tumor necrosis factor activates human endothelial cells through the p55 tumor necrosis factor receptor but the p75 receptor contributes to activation at low tumor necrosis factor concentration
Am J Pathol 143, 1724-1730, 1993. (Epub ---)

Steidler, L, Remaut, E, Fiers, W.
LamB as a carrier molecule for the functional exposition of IgG-binding domains of the Staphylococcus aureus protein A at the surface of Escherichia coli K12
Mol Gen Genet 236, 187-192, 1993. (Epub ---)

Steidler, L, Remaut, E, Fiers, W.
Pap pili as a vector system for surface exposition of an immunoglobulin G-binding domain of protein A of Staphylococcus aureus in Escherichia coli
J Bacteriol 175, 7639-7643, 1993. (Epub ---)

Takahashi, N, Brouckaert, P, Fiers, W.
Cyclooxygenase inhibitors prevent the induction of tolerance to the toxic effects of tumor necrosis factor
J Immunother 14, 16-21, 1993. (Epub ---)

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