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Guisez, Y, Tison, B, Vandekerckhove, J, Demolder, J, Bauw, G, Haegeman, G, Fiers, W, Contreras, R.
Production and purification of recombinant human interleukin-6 secreted by the yeast Saccharomyces cerevisiae
Eur J Biochem 198, 217-222, 1991. (Epub ---)

Haegeman, G, Vandevoorde, V, Fiers, W.
Tumor necrosis factor-induced gene expression and cytotoxicity share a signal transduction pathway
In Cellular Regulation by Protein Phosphorylation. (Heilmeyer Jr., LMG, ed.), NATO ASI Series, Vol. H 56, Berlin, Springer,, pp. 471-475, 1991. (Epub ---)

Kordula, T, Rokita, H, Koj, A, Fiers, W, Gauldie, J, Baumann, H.
Effects of interleukin-6 and leukemia inhibitory factor on the acute phase response and DNA synthesis in cultured rat hepatocytes
Lymphokine Cytokine Res 10, 23-26, 1991. (Epub ---)

Langeler, EG, Fiers, W, van Hinsbergh, VWM.
Effects of tumor necrosis factor on prostacyclin production and the barrier function of human endothelial cell monolayers
Arteriosclerosis Thrombosis 11, 872-881, 1991. (Epub ---)

Libert, C, Van Bladel, S, Brouckaert, P, Fiers, W.
The influence of modulating substances on tumor necrosis factor and interleukin-6 levels after injection of murine tumor necrosis factor or lipopolysaccharide in mice
J Immunother 10, 227-235, 1991. (Epub ---)

Libert, C, Van Bladel, S, Brouckaert, P, Shaw, A, Fiers, W.
Involvement of the liver, but not of IL-6, in IL-1-induced desensitization to the lethal effects of tumor necrosis factor
J Immunol 146, 2625-2632, 1991. (Epub ---)

Mareel, M, Bracke, M, Gao, Y, Van Roy, F.
Normal and chimeric avian embryo ecosystems of invasion
Eur Arch Biol 102, 185-188, 1991. (Epub ---)

Mareel, MM, Behrens, J, Birchmeier, W, De Bruyne, GK, Vleminckx, K, Hoogewijs, A, Fiers, WC, Van Roy, FM.
Down-regulation of E-cadherin expression in Madin Darby canine kidney (MDCK) cells inside tumors of nude mice
Int J Cancer 47, 922-928, 1991. (Epub ---)

Mareel, MM, De Baetselier, P, Van Roy, FM.
Mechanisms of Invasion and Metastasis
Boca Raton, UniScience Books , 651 pages, 1991. (Epub ---)

Messiaen, L, Qian, S, De Bruyne, G, Boghaert, E, Moens, T, Rabaey, M, Van Roy, F, Mareel, M.
Spontaneous acquisition of tumorigenicity and invasiveness by mouse lens explant cells during culture in vitro
In Vitro Cell Devel Biol 27A, 369-380, 1991. (Epub ---)

Nortier, J, Vandenabeele, P, Noel, E, Bosseloir, Y, Goldman, M, Deschodt-Lanckman, M.
Enzymatic degradation of tumor necrosis factor by activated human neutrophils: Role of elastase
Life Sci 49, 1879-1886, 1991. (Epub ---)

Robaye, B, Mosselmans, R, Fiers, W, Dumont, JE, Galand, P.
Tumor necrosis factor induces apoptosis (programmed cell death) in normal endothelial cells in vitro
Am J Pathol 138, 447-453, 1991. (Epub ---)

Schulze-Osthoff, K, Fiers, W.
Die Rolle des Tumor-Nekrose-Faktors im septischen Schock
Die Gelben Hefte 31, 61-67, 1991. (Epub ---)

Schulze-Osthoff, K, Fiers, W.
Oxygen radicals as second messengers
Trends Cell Biol 1, 150, 1991. (Epub ---)

Suffys, P, Beyaert, R, De Valck, D, Vanhaesebroeck, B, Van Roy, F, Fiers, W.
Tumour-necrosis-factor-mediated cytotoxicity is correlated with phospholipase-A2 activity, but not with arachidonic acid release per se
Eur J Biochem 195, 465-475, 1991. (Epub ---)

Takahashi, N, Brouckaert, P, Fiers, W.
Induction of tolerance allows separation of lethal and antitumor activities of tumor necrosis factor in mice
Cancer Res 51, 2366-2372, 1991. (Epub ---)

Tavernier, J, Devos, R, Cornelis, S, Tuypens, T, Van der Heyden, J, Fiers, W, Plaetinck, G.
A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific a chain and a b chain shared with the receptor for GM-CSF
Cell 66, 1175-1184, 1991. (Epub ---)

Vakaet Jr., L, Vleminckx, K, Van Roy, F, Mareel, M.
Numerical evaluation of the invasion of closely related cell lines into collagen type I gels
Invasion Metastasis 11, 469-484, 1991. (Epub ---)

Van Bladel, S, Libert, C, Fiers, W.
Interleukin-6 enhances the expression of tumor necrosis factor receptors on hepatoma cells and hepatocytes
Cytokine 3, 149-154, 1991. (Epub ---)

Vandenabeele, P, Fiers, W.
Is amyloidogenesis during Alzheimer's disease due to an IL-1/IL-6-mediated 'acute phase response' in the brain?
Immunol Today 12, 217-219, 1991. (Epub ---)

Van der Heyden, J, Devos, R, Plaetinck, G, Faché, I, Fiers, W, Tavernier, J.
Characterization of the murine IL-5 receptor complex with the use of a panel of monoclonal antibodies. Relationship to the murine IL-3 receptor
J Immunol 147, 3413-3418, 1991. (Epub ---)

Vandevoorde, V, Haegeman, G, Fiers, W.
Tumor necrosis factor-induced interleukin-6 expression and cytotoxicity follow a common signal transduction pathway in L929 cells
Biochem Biophys Res Commun 178, 993-1001, 1991. (Epub ---)

Vanhaesebroeck, B, Mareel, M, Van Roy, F, Grooten, J, Fiers, W.
Expression of the tumor necrosis factor gene in tumor cells correlates with reduced tumorigenicity and reduced invasiveness in vivo
Cancer Res 51, 2229-2238, 1991. (Epub ---)

Vanhaesebroeck, B, Van Bladel, S, Lenaerts, A, Suffys, P, Beyaert, R, Lucas, R, Van Roy, F, Fiers, W.
Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line
Cancer Res 51, 2469-2477, 1991. (Epub ---)

Van Ostade, X, Tavernier, J, Prangé, T, Fiers, W.
Localization of the active site of human tumour necrosis factor (hTNF) by mutational analysis
EMBO J 10, 827-836, 1991. (Epub ---)

Vleminckx, K, Vakaet Jr., L, Mareel, M, Fiers, W, Van Roy, F.
Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role
Cell 66, 107-119, 1991. (Epub ---)

Abramowicz, D, Vandervorst, P, Bruyns, C, Doutrelepont, JM, Vandenabeele, P, Goldman, M.
Persistence of anti-donor allohelper T cells after neonatal induction of allotolerance in mice
Eur J Immunol 20, 1647-1653, 1990. (Epub ---)

Alegre, M, Depierreux, M, Florquin, S, Najdovski, T, Vandenabeele, P, Abramowicz, D, Leo, O, Deschodt-Lanckman, M, Goldman, M.
Acute toxicity of anti-CD3 monoclonal antibody in mice: A model for OKT3 first dose reactions
Transplant Proc 22, 1920-1921, 1990. (Epub ---)

Alegre, M, Vandenabeele, P, Flamand, V, Moser, M, Leo, O, Abramowicz, D, Urbain, J, Fiers, W, Goldman, M.
Hypothermia and hypoglycemia induced by anti-CD3 monoclonal antibody in mice: Role of tumor necrosis factor
Eur J Immunol 20, 707-710, 1990. (Epub ---)

Bereta, J, Szuba, K, Fiers, W, Gauldie, J, Koj, A.
Transforming growth factor-b and epidermal growth factor modulate basal and interleukin-6-induced amino acid uptake and acute phase protein synthesis in cultured rat hepatocytes
FEBS Lett 266, 48-50, 1990. (Epub ---)

Beyaert, R, Suffys, P, Van Roy, F, Fiers, W.
Inhibition by glucocorticoids of tumor necrosis factor-mediated cytotoxicity. Evidence against lipocortin involvement
FEBS Lett 262, 93-96, 1990. (Epub ---)

Carlo-Stella, C, Mangoni, L, Almici, C, Frassoni, F, Fiers, W, Rizzoli, V.
Growth of CD34+ acute myeloblastic leukemia colony-forming cells in response to recombinant hematopoietic growth factors
Leukemia 4, 561-566, 1990. (Epub ---)

Carrez, D, Janssens, W, Degrave, P, van den Hondel, CAMJJ, Kinghorn, JR, Fiers, W, Contreras, R.
Heterologous gene expression by filamentous fungi: Secretion of human interleukin-6 by Aspergillus nidulans
Gene 94, 147-154, 1990. (Epub ---)

Devos, R, Tavernier, J, Plaetinck, G, Van der Heyden, J, Rolink, A, Fiers, W.
Expression of the murine interleukin-5 receptor on Xenopus laevis oocytes
Biochem Biophys Res Commun 172, 570-575, 1990. (Epub ---)

De Wachter, R, Maniloff, J, Fiers, W.
Two-dimensional gel electrophoresis of nucleic acids
In Gel Electrophoresis of Nucleic Acids A Practical Approach. (Rickwood, D, Hames, BD, eds.), 2nd ed., Oxford-New York-Tokyo, IRL Press, pp. 151-200, 1990. (Epub ---)

Fiers, W.
De impact van de 'genetic engineering' in de biomedische sector
Ingenieursblad 59, 33-38, 1990. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Everaerdt, B, Haegeman, G, Libert, C, Suffys, P, Takahashi, N, Tavernier, J, Van Bladel, S, Vanhaesebroeck, B, Van Ostade, X, Van Roy, F.
In vitro and in vivo action of tumor necrosis factor
In Tumor Necrosis Factor: Structure, Mechanism of Action, Role in Disease and Therapy. (Bonavida, B, Granger, G, eds.), Basel, Karger, pp. 77-81, 1990. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Everaerdt, B, Libert, C, Suffys, P, Takahashi, N, Vanhaesebroeck, B, Van Roy, F.
Mechanism of action of tumor necrosis factor and its implications for synergizing and antagonizing drugs
In Endotoxin From Pathophysiology to Therapeutic Approaches. (Baumgartner, J-D, Calandra, T, Carlet, J, eds.), Paris, Médecine-Sciences/Flammarion, pp. 59-68, 1990. (Epub ---)

Goldman, M, Vandenabeele, P, Moulart, J, Amraoui, Z, Abramowicz, D, Nortier, J, Vanherweghem, JL, Fiers, W.
Intraperitoneal secretion of interleukin-6 during continuous ambulatory peritoneal dialysis
Nephron 56, 277-280, 1990. (Epub ---)

Grunfeld, C, Adi, S, Soued, M, Moser, A, Fiers, W, Feingold, KR.
Search for mediators of the lipogenic effects of tumor necrosis factor: Potential role for interleukin 6
Cancer Res 50, 4233-4238, 1990. (Epub ---)

Kallinowski, F, Friis, RR, Van Roy, F, Vaupel, P.
Oxygenation of tumors derived from ras transformed cells
Adv Exp Med Biol 277, 907-916, 1990. (Epub ---)

Libert, C, Brouckaert, P, Shaw, A, Fiers, W.
Induction of interleukin 6 by human and murine recombinant interleukin 1 in mice
Eur J Immunol 20, 691-694, 1990. (Epub ---)

Mahadevan, V, Malik, STA, Meager, A, Fiers, W, Lewis, GP, Hart, IR.
Role of tumor necrosis factor in flavone acetic acid-induced tumor vasculature shutdown
Cancer Res 50, 5537-5542, 1990. (Epub ---)

Malik, STA, Griffin, DB, Naylor, MS, Fiers, W, Oliff, A, Balkwill, FR.
The complex effects of recombinant tumour necrosis factor-alpha (rhTNF-alpha) in human ovarian cancer xenograft models
In Cytokines and Lipocortins in Inflammation and Differentiation. New York, Wiley-Liss, pp. 393-403, 1990. (Epub ---)

Mareel, MM, Van Roy, FM, De Baetselier, P.
The invasive phenotypes
Cancer Metast Rev 9, 45-62, 1990. (Epub ---)

Parant, F, Tavernier, J, Fiers, W, Parant, M.
Comparative activity of human and murine tumor necrosis factor in toxicity and anti-infectious assays in mice
Microb Pathogen 8, 143-149, 1990. (Epub ---)

Plaetinck, G, Van der Heyden, J, Tavernier, J, Faché, I, Tuypens, T, Fischkoff, S, Fiers, W, Devos, R.
Characterization of interleukin 5 receptors on eosinophilic sublines from human promyelocytic leukemia (HL-60) cells
J Exp Med 172, 683-691, 1990. (Epub ---)

Tavernier, J, Marmenout, A, Bauden, R, Hauquier, G, Van Ostade, X, Fiers, W.
Analysis of the structure-function relationship of tumour necrosis factor. Human/mouse chimeric TNF proteins: General properties and epitope analysis
J Mol Biol 211, 493-501, 1990. (Epub ---)

Vandenabeele, P, Declercq, W, Libert, C, Fiers, W.
Development of a simple, sensitive and specific bioassay for interleukin-1 based on the proliferation of RPMI 1788 cells. Comparison with other bioassays for IL-1
J Immunol Methods 135, 25-32, 1990. (Epub ---)

Vandenabeele, P, Grooten, J, Fiers, W.
IL-4 acts synergistically on the IL-2 response of an autoreactive T-cell clone; synergism correlates with increased intracellular IL-2, but not with a modified IL-2 receptor expression
Cell Immunol 130, 79-91, 1990. (Epub ---)

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