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Beyaert, R, Vanhaesebroeck, B, Heyninck, K, Boone, E, De Valck, D, Schulze-Osthoff, K, Haegeman, G, Van Roy, F, Fiers, W.
Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine
Cancer Res 53, 2623-2630, 1993. (Epub ---)

Bracke, ME, Vyncke, BM, Bruyneel, EA, Vermeulen, SJ, De Bruyne, GK, Van Larebeke, NA, Vleminckx, K, Van Roy, FM, Mareel, MM.
Insulin-like growth factor I activates the invasion suppressor function of E-cadherin in MCF-7 human mammary carcinoma cells in vitro
Br J Cancer 68, 282-289, 1993. (Epub ---)

Broekhuijsen, MP, Mattern, IE, Contreras, R, Kinghorn, JR, van den Hondel, CAMJJ.
Secretion of heterologous proteins by Aspergillus niger: Production of active human interleukin-6 in a protease-deficient mutant by KEX2-like processing of a glucoamylase-hIL6 fusion protein
J Biotechnol 31, 135-145, 1993. (Epub ---)

Brouckaert, P, Everaerdt, B, Libert, C, Takahashi, N, Cauwels, A, Fiers, W.
Strategies to broaden the therapeutic margin of tumor necrosis factor
In Tumor Necrosis Factor: Molecular and Cellular Biology and Clinical Relevance. (Fiers, W, Buurman, WA, eds.), Basel, Karger, pp. 226-232, 1993. (Epub ---)

Brouckaert, PG, Libert, C.
Tumor necrosis factor
In Acute Phase Proteins Molecular Biology, Biochemistry, and Clinical Applications. (Mackiewicz, A, Kushner, I, Baumann, H, eds.), Boca Raton, CRC Press, pp. 329-342, 1993. (Epub ---)

Brouckaert, P, Libert, C, Everaerdt, B, Takahashi, N, Cauwels, A, Fiers, W.
Tumor necrosis factor, its receptors and the connection with interleukin 1 and interleukin 6
Immunobiology 187, 317-329, 1993. (Epub ---)

Chastre, E, Empereur, S, Di Gioia, Y, El Mahdani, N, Mareel, M, Vleminckx, K, Van Roy, F, Bex, V, Emami, S, Spandidos, DA, Gespach, C.
Neoplastic progression of human and rat intestinal cell lines after transfer of the ras and polyoma middle T oncogenes
Gastroenterology 105, 1776-1789, 1993. (Epub ---)

Demolder, J, De Backer, M, Fiers, W, Contreras, R.
Phenotypic effects in Saccharomyces cerevisiae after regulated expression of beta-(1,3)-glucanase from Nicotiana plumbaginifolia
J Biotechnol 27, 295-305, 1993. (Epub ---)

De Valck, D, Beyaert, R, Van Roy, F, Fiers, W.
Tumor necrosis factor cytotoxicity is associated with activation of cellular phospholipases
In New Developments in Lipid-Protein Interactions and Receptor Function. (Wirtz, KWA, Packer, L, Gustafsson, JÅ, Evangelopoulos, AE, Changeux, JP, eds.), NATO ASI Series, Vol. A 246, New York-London, Plenum Press, pp. 29-37, 1993. (Epub ---)

De Valck, D, Beyaert, R, Van Roy, F, Fiers, W.
Tumor necrosis factor cytotoxicity is associated with phospholipase D activation
Eur J Biochem 212, 491-497, 1993. (Epub ---)

Devos, R, Guisez, Y, Cornelis, S, Verhee, A, Van der Heyden, J, Manneberg, M, Lahm, H-W, Fiers, W, Tavernier, J, Plaetinck, G.
Recombinant soluble human interleukin-5 (hIL-5) receptor molecules. Cross-linking and stoichiometry of binding to IL-5
J Biol Chem 268, 6581-6587, 1993. (Epub ---)

Fiers, W.
Tumour necrosis factor
In The Natural Immune System: Humoral Factors. (Sim, E, ed.), Oxford, IRL Press, pp. 65-119, 1993. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Cauwels, A, Declercq, W, De Valck, D, Everaerdt, B, Goossens, V, Grooten, J, Haegeman, G, Libert, C, Schulze-Osthoff, K, Takahashi, N, Vandenabeele, P, Vanhaesebroeck, B, Van Ostade, X, Van Roy, F.
Two pathways of tumor necrosis factor signal transduction: In vitro and in vivo implications
In Tumor Necrosis Factor: Molecular and Cellular Biology and Clinical Relevance. (Fiers, W, Buurman, WA, eds.), Basel, Karger (Shugar, D, Rode, W, Borowski, E, eds.), Warszawa-Berlin, Polish Scientific Publishers PWN/Springer-Verlag, pp. 58-65, 1993. (Epub ---)

Goldman, GH, Temmerman, W, Jacobs, D, Contreras, R, Van Montagu, M, Herrera-Estrella, A.
A nucleotide substitution in one of the beta-tubulin genes of Trichoderma viride confers resistance to the antimitotic drug methyl benzimidazole-2-yl-carbamate
Mol Gen Genet 240, 73-80, 1993. (Epub ---)

Gérard, C, Bruyns, C, Marchant, A, Abramowicz, D, Vandenabeele, P, Delvaux, A, Fiers, W, Goldman, M, Velu, T.
Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia
J Exp Med 177, 547-550, 1993. (Epub ---)

Grooten, J, Goossens, V, Vanhaesebroeck, B, Fiers, W.
Cell membrane permeabilization and cellular collapse, followed by loss of dehydrogenase activity: Early events in tumour necrosis factor-induced cytotoxicity
Cytokine 5, 546-555, 1993. (Epub ---)

Guisez, Y, Demolder, J, Mertens, N, Raeymaekers, A, Plaetinck, G, Robbens, J, Vandekerckhove, J, Remaut, E, Fiers, W.
High-level expression, purification and renaturation of recombinant murine interleukin-2 from Escherichia coli
Protein Expr Purif 4, 240-246, 1993. (Epub ---)

Guisez, Y, Oefner, C, Winkler, FK, Schlaeger, E-J, Zulauf, M, Van der Heyden, J, Plaetinck, G, Cornelis, S, Tavernier, J, Fiers, W, Devos, R, D'Arcy, A.
Expression, purification and crystallization of fully active, glycosylated human interleukin-5
FEBS Lett 331, 49-52, 1993. (Epub ---)

Guisez, Y, Robbens, J, Remaut, E, Fiers, W.
Folding of the MS2 coat protein in Escherichia coli is modulated by translational pauses resulting from mRNA secondary structure and codon usage: A hypothesis
J Theor Biol 162, 243-252, 1993. (Epub ---)

Libert, C, Everaerdt, B, Takahashi, N, Cauwels, A, Brouckaert, P, Fiers, W.
Protection against tumor necrosis factor-induced lethality
In Tumor Necrosis Factor: Molecular and Cellular Biology and Clinical Relevance. (Fiers, W, Buurman, WA, eds.), Basel, Karger, pp. 126-131, 1993. (Epub ---)

Mareel, M, Bracke, M, Van Roy, F, Vakaet, L.
Expression of E-cadherin in embryogenetic ingression and cancer invasion
Int J Dev Biol 37, 227-235, 1993. (Epub ---)

Mareel, MM, van Roy, FM, Bracke, ME.
How and when do tumor cells metastasize?
Crit Rev Oncogenesis 4, 559-594, 1993. (Epub ---)

Patestos, NP, Haegeman, G, Vandevoorde, V, Fiers, W.
Activation of the nuclear factor kB is not sufficient for regulation of tumor necrosis factor-induced interleukin-6 gene expression
Biochimie 75, 1007-1018, 1993. (Epub ---)

Schulze-Osthoff, K, Beyaert, R, Vandevoorde, V, Haegeman, G, Fiers, W.
Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF
EMBO J 12, 3095-3104, 1993. (Epub ---)

Slowik, MR, De Luca, LG, Fiers, W, Pober, JS.
Tumor necrosis factor activates human endothelial cells through the p55 tumor necrosis factor receptor but the p75 receptor contributes to activation at low tumor necrosis factor concentration
Am J Pathol 143, 1724-1730, 1993. (Epub ---)

Steidler, L, Remaut, E, Fiers, W.
LamB as a carrier molecule for the functional exposition of IgG-binding domains of the Staphylococcus aureus protein A at the surface of Escherichia coli K12
Mol Gen Genet 236, 187-192, 1993. (Epub ---)

Steidler, L, Remaut, E, Fiers, W.
Pap pili as a vector system for surface exposition of an immunoglobulin G-binding domain of protein A of Staphylococcus aureus in Escherichia coli
J Bacteriol 175, 7639-7643, 1993. (Epub ---)

Takahashi, N, Brouckaert, P, Fiers, W.
Cyclooxygenase inhibitors prevent the induction of tolerance to the toxic effects of tumor necrosis factor
J Immunother 14, 16-21, 1993. (Epub ---)

Vandenabeele, P, Abramowicz, D, Berus, D, Van der Heyden, J, Grooten, J, Donckier, V, Hooghe-Peters, EL, Goldman, M, Fiers, W.
Increased IL-6 production and IL-6-mediated Ig secretion in murine host-vs-graft disease
J Immunol 150, 4179-4187, 1993. (Epub ---)

Vanhaesebroeck, B, Reed, JC, De Valck, D, Grooten, J, Miyashita, T, Tanaka, S, Beyaert, R, Van Roy, F, Fiers, W.
Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity
Oncogene 8, 1075-1081, 1993. (Epub ---)

Vanlandschoot, P, Maertens, G, Min Jou, W, Fiers, W.
Recombinant secreted haemagglutinin protects mice against a lethal challenge of influenza virus
Vaccine 11, 1185-1187, 1993. (Epub ---)

Van Ostade, X, Vandenabeele, P, Everaerdt, B, Loetscher, H, Gentz, R, Brockhaus, M, Lesslauer, W, Tavernier, J, Brouckaert, P, Fiers, W.
Human TNF mutants with selective activity on the p55 receptor
Nature 361, 266-269, 1993. (Epub ---)

Yue-xin, L, Roggen, E, Min Jou, W, Fiers, W.
Expression of neuraminidase of influenza virus in insect cells
Chin J Biochem Biophys 25, 237-241, 1993. (Epub ---)

Beyaert, R, Fiers, W.
Potentiation of tumour necrosis factor-mediated activities by lithium salts: A review
Lithium 3, 181-189, 1992. (Epub ---)

Beyaert, R, Schulze-Osthoff, K, Van Roy, F, Fiers, W.
Synergistic induction of interleukin-6 by tumor necrosis factor and lithium chloride in mice: Possible role in the triggering and exacerbation of psoriasis by lithium treatment
Eur J Immunol 22, 2181-2184, 1992. (Epub ---)

Brouckaert, P, Everaerdt, B, Fiers, W.
The glucocorticoid antagonist RU38486 mimics interleukin-1 in its sensitization to the lethal and interleukin-6-inducing properties of tumor necrosis factor
Eur J Immunol 22, 981-986, 1992. (Epub ---)

Brouckaert, PGG, Fiers, W, Lejeune, FJ.
Coley's vaccine and TNF therapy
Nature 358, 630, 1992. (Epub ---)

Brouckaert, P, Libert, C, Everaerdt, B, Fiers, W.
Selective species specificity of tumor necrosis factor for toxicity in the mouse
Lymphokine Cytokine Res 11, 193-196, 1992. (Epub ---)

Demolder, J, Fiers, W, Contreras, R.
Efficient synthesis of secreted murine interleukin-2 by Saccharomyces cerevisiae: Influence of 3'-untranslated regions and codon usage
Gene 111, 207-213, 1992. (Epub ---)

De Sutter, K, Feys, V, Van de Voorde, A, Fiers, W.
Production of functionally active murine and murine::human chimeric F(ab')2 fragments in COS-1 cells
Gene 113, 223-230, 1992. (Epub ---)

De Sutter, K, Remaut, E, Fiers, W.
Disulphide bridge formation in the periplasm of Escherichia coli: beta-lactamase::human IgG3 hinge fusions as a model system
Mol Microbiol 6, 2201-2208, 1992. (Epub ---)

Devos, K, Duerinck, F, Van Audenhove, K, Fiers, W.
Cloning and expression of the canine interferon-gamma gene
J Interferon Res 12, 95-102, 1992. (Epub ---)

Feingold, KR, Doerrler, W, Dinarello, CA, Fiers, W, Grunfeld, C.
Stimulation of lipolysis in cultured fat cells by tumor necrosis factor, interleukin-1, and the interferons is blocked by inhibition of prostaglandin synthesis
Endocrinology 130, 10-16, 1992. (Epub ---)

Fiers, W.
De tumor-necrosefactor
Natuur & Techniek 60, 664-675, 1992. (Epub ---)

Fiers, W.
Precursor structures and structure-function analysis of TNF and lymphotoxin
In Tumor Necrosis Factors Structure, Function, and Mechanism of Action. (Aggarwal, BB, Vilcek, J, eds.), New York-Basel-Hong Kong, Marcel Dekker, pp. 79-92, 1992. (Epub ---)

Fiers, W.
Von der bakteriellen Infektion zur Krebstherapie
Naturwissenschaftliche Rundschau 45, 426-428, 1992. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Decoster, E, De Valck, D, Everaerdt, B, Grooten, J, Lenaerts, A, Libert, C, Schulze-Osthoff, K, Takahashi, N, Tavernier, J, Van Bladel, S, Van Dorpe, C, Vanhaesebroeck, B, Van Ostade, X, Van Roy, F.
Tumor necrosis factor: Mechanism of action at the molecular, cellular and in vivo level
In Tumor Necrosis Factor: Structure-function Relationship and Clinical Application. (Osawa, T, Bonavida, B, eds.), Basel, Karger, pp. 66-73, 1992. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Decoster, E, De Valck, D, Everaerdt, B, Grooten, J, Lenaerts, A, Libert, C, Schulze-Osthoff, K, Takahashi, N, Van Bladel, S, Van Dorpe, C, Vanhaesebroeck, B, Van Ostade, X, Van Roy, F.
Tumor necrosis factor: Mechanism of action and its potential for anticancer therapy
In Molecular Aspects of Chemotherapy. , pp. 119-125, 1992. (Epub ---)

Goldman, GH, Demolder, J, Dewaele, S, Herrera-Estrella, A, Geremia, RA, Van Montagu, M, Contreras, R.
Molecular cloning of the imidazoleglycerolphosphate dehydratase gene of Trichoderma harzianum by genetic complementation in Saccharomyces cerevisiae using a direct expression vector
Mol Gen Genet 234, 481-488, 1992. (Epub ---)

Libert, C, Vink, A, Coulie, P, Brouckaert, P, Everaerdt, B, Van Snick, J, Fiers, W.
Limited involvement of interleukin-6 in the pathogenesis of lethal septic shock as revealed by the effect of monoclonal antibodies against interleukin-6 or its receptor in various murine models
Eur J Immunol 22, 2625-2630, 1992. (Epub ---)

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