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Vandenabeele, P, Guisez, Y, Declercq, W, Bauw, G, Vandekerckhove, J, Fiers, W.
Response of murine cell lines to an IL-1/IL-2-induced factor in a rat/mouse T hybridoma (PC60): Differential induction of cytokines by human IL-1a and IL-1b and partial amino acid sequence of rat GM-CSF
Lymphokine Res 9, 381-389, 1990. (Epub ---)

Vanhaesebroeck, B, Cragoe Jr., EJ, Pouysségur, J, Beyaert, R, Van Roy, F, Fiers, W.
Cytotoxic activity of tumor necrosis factor is inhibited by amiloride derivatives without involvement of the Na+/H+ antiporter
FEBS Lett 261, 319-322, 1990. (Epub ---)

Vanhaesebroeck, B, Timmers, HTM, Pronk, GJ, Van Roy, F, van der Eb, AJ, Fiers, W.
Modulation of cellular susceptibility to the cytotoxic/cytostatic action of tumor necrosis factor by adenovirus E1 gene expression is cell type-dependent
Virology 176, 362-368, 1990. (Epub ---)

van Hinsbergh, VWM, van den Berg, EA, Fiers, W, Dooijewaard, G.
Tumor necrosis factor induces the production of urokinase-type plasminogen activator by human endothelial cells
Blood 75, 1991-1998, 1990. (Epub ---)

Van Roy, F, Liebaut, G, Mareel, M, Fiers, W.
Partial transformation of human tumor cell lines showing defective interaction between unusual p53 gene product and SV40 large-T antigen
Oncogene 5, 207-218, 1990. (Epub ---)

Van Roy, F, Mareel, M, Vleminckx, K, Beyaert, R, Fiers, W, Devleeschouwer, N, Muquardt, C, Legros, N, Bracke, M, Leclercq, G.
Hormone sensitivity in vitro and in vivo of v-ras-transfected MCF-7 cell derivatives
Int J Cancer 46, 522-532, 1990. (Epub ---)

Balkwill, FR, Fiers, W.
Introduction
Cancer Surveys 8, 711-712, 1989. (Epub ---)

Behrens, J, Mareel, MM, van Roy, FM, Birchmeier, W.
Dissecting tumor cell invasion: Epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion
J Cell Biol 108, 2435-2447, 1989. (Epub ---)

Bereta, J, Kurdowska, A, Koj, A, Hirano, T, Kishimoto, T, Content, J, Fiers, W, Van Damme, J, Gauldie, J.
Different preparations of natural and recombinant human interleukin-6 (IFN-beta2, BSF-2) similarly stimulate acute phase protein synthesis and uptake of alpha-aminoisobutyric acid by cultured rat hepatocytes
Int J Biochem 21, 361-366, 1989. (Epub ---)

Beyaert, R, Vanhaesebroeck, B, Suffys, P, Van Roy, F, Fiers, W.
Lithium chloride potentiates tumor necrosis factor-mediated cytotoxicity in vitro and in vivo
Proc Natl Acad Sci USA 86, 9494-9498, 1989. (Epub ---)

Brouckaert, PG, Everaerdt, B, Libert, C, Takahashi, N, Fiers, W.
Species specificity and involvement of other cytokines in endotoxic shock action of recombinant tumour necrosis factor in mice
Agents Actions 26, 196-198, 1989. (Epub ---)

Brouckaert, PG, Libert, C, Everaerdt, B, Takahashi, N, Fiers, W.
A role for interleukin 1 in the in vivo actions of tumor necrosis factor
Lymphokine Res 8, 269-274, 1989. (Epub ---)

Brouckaert, P, Spriggs, DR, Demetri, G, Kufe, DW, Fiers, W.
Circulating interleukin 6 during a continuous infusion of tumor necrosis factor and interferon g
J Exp Med 169, 2257-2262, 1989. (Epub ---)

Campbell, EI, Unkles, SE, Macro, JA, van den Hondel, C, Contreras, R, Kinghorn, JR.
Improved transformation efficiency of Aspergillus niger using the homologous niaD gene for nitrate reductase
Curr Genet 16, 53-56, 1989. (Epub ---)

Coopman, P, Van Roy, F, Dragonetti, C, Gao, J, Fiers, W, Meneguzzi, G, Mareel, M.
Tumorigenicity, invasiveness and metastatic capability of FR3T3 rat cells before and after transfection with bovine papilloma virus type 1 DNA
Clin Exp Metastas 7, 69-84, 1989. (Epub ---)

de Ruiter-Jacobs, YM, Broekhuijsen, M, Unkles, SE, Campbell, EI, Kinghorn, JR, Contreras, R, Pouwels, PH, van den Hondel, CA.
A gene transfer system based on the homologous pyrG gene and efficient expression of bacterial genes in Aspergillus oryzae
Curr Genet 16, 159-163, 1989. (Epub ---)

Everaerdt, B, Brouckaert, P, Shaw, A, Fiers, W.
Four different interleukin-1 species sensitize to the lethal action of tumour necrosis factor
Biochem Biophys Res Commun 163, 378-385, 1989. (Epub ---)

Fiers, W.
TNF: Mechanism of action in vitro and in vivo
In Influence of Molecular Biology on Drug Discovery. (Udaka, K, Furuichi, Y, Drews, J, eds.), Clinical Pharmacology, Vol. 1, München, W. Zuckschwerdt Verlag, pp. 17-24, 1989. (Epub ---)

Fiers, W, Balkwill, FR.
Future prospects and problems
Cancer Surveys 8, 921-927, 1989. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Everaerdt, B, Grooten, J, Haegeman, G, Libert, C, Suffys, P, Takahashi, N, Tavernier, J, Van Bladel, S, Vanhaesebroeck, B, Van Ostade, X, Van Roy, F.
Tumour necrosis factor and interleukin-6: Structure and mechanism of action of the molecular, cellular and in vivo level
In Vectors as Tools for the Study of Normal and Abnormal Growth and Differentiation. (Lother, H, Dernick, R, Ostertag, W, eds.), NATO ASI Series, Vol. H 34, Berlin, Springer-Verlag, pp. 229-240, 1989. (Epub ---)

Fiers, W, Brouckaert, P, Content, J, Contreras, R, Everaerdt, B, Guisez, Y, Libert, C, Spriggs, D, Takahashi, N, Tison, B, Vandenabeele, P, Van Snick, J.
Interleukin-6: Biological function and regulation of the gene expression in vitro and in vivo
In Advances in Immunopharmacology. (Hadden, JW, Spreafico, F, Yamamura, Y, Austen, KF, Dukor, P, Masek, K, eds.), Vol. 4, Oxford, Pergamon Press, pp. 185-190, 1989. (Epub ---)

Grooten, J, Fiers, W.
Acquisition by the murine host of responsiveness toward various neoplastic cell lines, but not toward self, through adoptive transfer of a helper T-lymphocyte clone with antiself specificity
Cancer Res 49, 3872-3878, 1989. (Epub ---)

Jayaram, B, Devos, R, Guisez, Y, Fiers, W.
Purification of human interleukin-4 produced in Escherichia coli
Gene 79, 345-354, 1989. (Epub ---)

Leemans, R, Remaut, E, Fiers, W.
Correlation between temperature-dependent cytoplasmic solubility and periplasmic export of a heterologous protein in Escherichia coli
Gene 85, 99-108, 1989. (Epub ---)

Malik, STA, Griffin, DB, Fiers, W, Balkwill, FR.
Paradoxical effects of tumour necrosis factor in experimental ovarian cancer
Int J Cancer 44, 918-925, 1989. (Epub ---)

Rampart, M, De Smet, W, Fiers, W, Herman, AG.
Inflammatory properties of recombinant tumor necrosis factor in rabbit skin in vivo
J Exp Med 169, 2227-2232, 1989. (Epub ---)

Rampart, M, Fiers, W, De Smet, W, Herman, AG.
Different pro-inflammatory profiles of interleukin 1 (IL1) and tumor necrosis factor (TNF) in an in vivo model of inflammation
Agents Actions 26, 186-188, 1989. (Epub ---)

Robaye, B, Hepburn, A, Lecocq, R, Fiers, W, Boeynaems, JM, Dumont, JE.
Tumor necrosis factor-alpha induces the phosphorylation of 28kDa stress proteins in endothelial cells: Possible role in protection against cytotoxicity?
Biochem Biophys Res Commun 163, 301-308, 1989. (Epub ---)

Saelens, X, Van Haute, E, Fiers, W.
A simple and sensitive test reaction for cDNA synthesis
Colloquium Boehringer Mannheim 2, 10-11, 1989. (Epub ---)

Suffys, P, Beyaert, R, Van Roy, F, Fiers, W.
TNF in combination with interferon-gamma is cytotoxic to normal, untransformed mouse and rat embryo fibroblast-like cells
Anticancer Res 9, 167-172, 1989. (Epub ---)

Tavernier, J, Devos, R, Van der Heyden, J, Hauquier, G, Bauden, R, Faché, I, Kawashima, E, Vandekerckhove, J, Contreras, R, Fiers, W.
Expression of human and murine interleukin-5 in eukaryotic systems
DNA 8, 491-501, 1989. (Epub ---)

Unkles, SE, Campbell, EI, Carrez, D, Grieve, C, Contreras, R, Fiers, W, van den Hondel, CAMJJ, Kinghorn, JR.
Transformation of Aspergillus niger with the homologous nitrate reductase gene
Gene 78, 157-166, 1989. (Epub ---)

Van de Voorde, A, Feys, V, De Waele, P, Casneuf, P, Fiers, W.
Tailoring of an anti-human placental alkaline phosphatase immunoglobulin using genetic engineering
In Advanced Research on Animal Cell Technology. (Miller, AOA, ed.), Dordrecht, Kluwer Academic Publishers, pp. 233-249, 1989. (Epub ---)

Vanhaesebroeck, B, Grooten, J, Fiers, W.
An ongoing in vivo immune response affects the abundancy and differentiation of lymphokine-activated killer cell precursors, but does not influence their broad spectrum target reactivity
J Immunol 143, 1396-1402, 1989. (Epub ---)

Van Roy, FM, Coopman, P, Suffys, P, Liebaut, G, Vleminckx, K, Gao, J, Dragonetti, CH, Fiers, W, Mareel, MM.
Effect of oncogene transfection or passage in vivo on malignant phenotypes of rat2 cells
Anticancer Res 9, 1553-1564, 1989. (Epub ---)

Van Roy, FM, Mareel, MM.
Oncogenes and tumor progression: State of the art
In Cancer Metastasis Molecular and Cellular Biology, Host Immune Responses and Perspective for Treatment. (Schirrmacher, V, Schwartz-Albiez, R, eds.), Berlin-Heidelberg, Springer Verlag, pp. 27-35, 1989. (Epub ---)

Whitehead, MP, Unkles, SE, Ramsden, M, Campbell, EI, Gurr, SJ, Spence, D, van den Hondel, C, Contreras, R, Kinghorn, JR.
Transformation of a nitrate reductase deficient mutant of Penicillium chrysogenum with the corresponding Aspergillus niger and A. nidulans niaD genes
Mol Gen Genet 216, 408-411, 1989. (Epub ---)

Arenzana-Seisdedos, F, Mogensen, SC, Vuillier, F, Fiers, W, Virelizier, JL.
Autocrine secretion of tumor necrosis factor under the influence of interferon-gamma amplifies HLA-DR gene induction in human monocytes
Proc Natl Acad Sci USA 85, 6087-6091, 1988. (Epub ---)

Balkwill, FR, Griffin, DB, Moodie, EM, Thomas, JA, Fiers, W.
Effect of TNF-a on human ovarian cancer xenografts in nude mice
In Tumor Necrosis Factor/Cachectin and Related Cytokines. (Bonavida, B, Gifford, GE, Kirchner, H, Old, LJ, eds.), Basel, Karger, pp. 160-164, 1988. (Epub ---)

Devos, R, Tavernier, J, Fiers, W.
Slippage of DNA polymerase I during synthesis of ds-cDNA
Nucleic Acids Res 16, 1630, 1988. (Epub ---)

De Waele, P, Feys, V, Van de Voorde, A, Molemans, F, Fiers, W.
Expression in non-lymphoid cells of mouse recombinant immunoglobulin directed against the tumour marker human placental alkaline phosphatase
Eur J Biochem 176, 287-295, 1988. (Epub ---)

Feys, V, De Waele, P, Van de Voorde, A, Casneuf, P, Fiers, W.
Expression of functional mouse antibodies directed against the tumour marker human placental alkaline phosphatase in non-lymphoid cells
Int J Cancer 41 (Suppl. 2), 26-27, 1988. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Everaerdt, B, Haegeman, G, Suffys, P, Tavernier, J, Vanhaesebroeck, B, Van Roy, F.
TNF. Its potential as an antitumour agent
In Developments in Biological Standardization. (Gearing, AJH, Hennessen, W, eds.), Vol. 69, Basel, Karger, pp. 143-151, 1988. (Epub ---)

Fiers, W, Leemans, R, Mertens, N, Sablon, E, Stanssens, P, Steidler, L, Van Mechelen, E, Remaut, E.
Engineering maximal expression of heterologous genes in gram-negative bacteria
In Proceedings of the 8th International Biotechnology Symposium, Paris, 1988. (Durand, G, Bobichon, L, Florent, J, eds.), Vol. II, Paris, Société Française de Microbiologie, pp. 680-694, 1988. (Epub ---)

Gresser, I, Belardelli, F, Tavernier, J, Fiers, W, Podo, F, Woodrow, D, Moss, J, Proietti, E.
Similarities and dissimilarities in the effects of tumor necrosis factor and interferon-alpha/beta on transplantable tumors and on suckling mice
In Tumor Necrosis Factor/Cachectin and Related Cytokines. (Bonavida, B, Gifford, GE, Kirchner, H, Old, LJ, eds.), Basel, Karger, pp. 165-170, 1988. (Epub ---)

Havell, EA, Fiers, W, North, RJ.
The antitumor function of tumor necrosis factor (TNF). 1. Therapeutic action of TNF against an established murine sarcoma is indirect, immunologically dependent, and limited by severe toxicity
J Exp Med 167, 1067-1085, 1988. (Epub ---)

Hepburn, A, Demolle, D, Boeynaems, JM, Fiers, W, Dumont, GE.
Rapid phosphorylation of a 27 kDa protein induced by tumor necrosis factor
FEBS Lett 227, 175-178, 1988. (Epub ---)

Huylebroeck, D, Maertens, G, Fiers, W, Stunnenberg, H, Fuller, S, Liljestroem, P, Garoff, H.
Viral delivery systems for heterologous antigens and epitopes
In Technological Advances in Vaccine Development. (Lasky, L, ed.), New York, Alan R. Liss, pp. 279-293, 1988. (Epub ---)

Huylebroeck, D, Maertens, G, Verhoeyen, M, Lopez, C, Raeymakers, A, Min Jou, W, Fiers, W.
High-level transient expression of influenza virus proteins from a series of SV40 late and early replacement vectors
Gene 66, 163-181, 1988. (Epub ---)

Krief, P, Azzarone, B, Boucheix, C, Billard, C, Chang, C, Fiers, W, Carloni, G.
Different levels of interferon-gamma induction of class I and class II major histocompatibility antigens in human hepatoma cell lines
In Viral Hepatitis and Liver Disease. New York, Alan R. Liss, pp. 217-220, 1988. (Epub ---)

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