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Lapierre, LA, Fiers, W, Pober, JS.
Three distinct classes of regulatory cytokines control endothelial cell MHC antigen expression. Interactions with immune gamma interferon differentiate the effects of tumor necrosis factor and lymphotoxin from those of leukocyte a and fibroblast beta interferons
J Exp Med 167, 794-804, 1988. (Epub ---)

Lewit-Bentley, A, Fourme, R, Kahn, R, Prangé, T, Vachette, P, Tavernier, J, Hauquier, G, Fiers, W.
Structure of tumour necrosis factor by X-ray solution scattering and preliminary studies by single crystal X-ray diffraction
J Mol Biol 199, 389-392, 1988. (Epub ---)

Mareel, M, Coopman, P, Dragonetti, C, Fiers, W, Gao, J, Messiaen, L, Van Roy, F.
Spontaneous and oncogene-mediated acquisition of the invasive phenotype by cells in culture
In Tumor Progression and Metastasis. (Nicolson, GL, Fidler, IJ, eds.), UCLA Symposia on Molecular and Cellular Biology, New Series, Vol. 78, New York, Alan R. Liss, pp. 179-188, 1988. (Epub ---)

Mareel, M, Dragonetti, C, Tavernier, J, Fiers, W.
Tumor-selective cytotoxic effects of murine tumor necrosis factor (TNF) and interferon-gamma (IFN-gamma) in organ culture of B16 melanoma cells and heart tissue
Int J Cancer 42, 470-473, 1988. (Epub ---)

Mareel, MM, Van Roy, FM, Messiaen, L, Van Laerebeke, N, Boghaert, E.
Correlations of malignancy in cultured cells
In New Frontiers in Cytology Modern Aspects of Research and Practice. (Goerttler, K, Feichter, GE, Witte, S, eds.), Berlin-Heidelberg, Springer Verlag, pp. 27-31, 1988. (Epub ---)

Marquet, RL, Eggermont, AMM, de Bruin, RWF, Fiers, W, Jeekel, J.
Combined treatment of colon adenocarcinoma in rats with tumor necrosis factor and the interferon inducer ABPP
J Interferon Res 8, 319-323, 1988. (Epub ---)

Mosselmans, R, Hepburn, A, Dumont, JE, Fiers, W, Galand, P.
Endocytic pathway of recombinant murine tumor necrosis factor in L-929 cells
J Immunol 141, 3096-3100, 1988. (Epub ---)

Proietti, E, Belardelli, F, Carpinelli, G, Di Vito, M, Woodrow, D, Moss, J, Sestili, P, Fiers, W, Gresser, I, Podo, F.
Tumor necrosis factor a induces early morphologic and metabolic alterations in Friend leukemia cell tumors and fibrosarcomas in mice
Int J Cancer 42, 582-591, 1988. (Epub ---)

Reuter, A, Bernier, J, Vrindts-Gevaert, Y, Meuleman-Gathy, R, Malaise, M, Fiers, W, Franchimont, P.
Production of interferon gamma by peripheral blood mononuclear cells from normal subjects and from patients with rheumatoid arthritis
Clin Exp Rheumatol 6, 347-354, 1988. (Epub ---)

Suffys, P, Beyaert, R, Van Roy, F, Fiers, W.
Involvement of a serine protease in tumour-necrosis-factor-mediated cytotoxicity
Eur J Biochem 178, 257-265, 1988. (Epub ---)

Suffys, P, Van Roy, F, Fiers, W.
Tumor necrosis factor and interleukin 1 activate phospholipase in rat chondrocytes
FEBS Lett 232, 24-28, 1988. (Epub ---)

Tovey, MG, Content, J, Gresser, I, Gugenheim, J, Blanchard, B, Guymarho, J, Poupart, P, Gigou, M, Shaw, A, Fiers, W.
Genes for IFN-b-2 (IL-6), tumor necrosis factor, and IL-1 are expressed at high levels in the organs of normal individuals
J Immunol 141, 3106-3110, 1988. (Epub ---)

Vandenabeele, P, Jayaram, B, Devos, R, Shaw, A, Fiers, W.
Interleukin 1a acts as an autocrine growth factor for RPMI 1788, an Epstein-Barr virus-transformed human B cell line
Eur J Immunol 18, 1027-1031, 1988. (Epub ---)

van Hinsbergh, VWM, Kooistra, T, van den Berg, EA, Princen, HMG, Fiers, W, Emeis, JJ.
Tumor necrosis factor increases the production of plasminogen activator inhibitor in human endothelial cells in vitro and in rats in vivo
Blood 72, 1467-1473, 1988. (Epub ---)

Van Ostade, X, Tavernier, J, Fiers, W.
Two conserved tryptophan residues of tumor necrosis factor and lymphotoxin are not involved in the biological activity
FEBS Lett 238, 347-352, 1988. (Epub ---)

Vink, A, Vandenabeele, P, Uyttenhove, C, Cayphas, S, Van Snick, J.
Plasmacytoma growth factor activity of murine granulocyte-macrophage colony-stimulating factor
J Immunol 141, 1996-1999, 1988. (Epub ---)

Balkwill, F, Osborne, R, Burke, F, Naylor, S, Talbot, D, Durbin, H, Tavernier, J, Fiers, W.
Evidence for tumour necrosis factor/cachectin production in cancer
Lancet ii, 1229-1232, 1987. (Epub ---)

Balkwill, FR, Ward, BG, Fiers, W.
Effects of tumour necrosis factor on human tumour xenografts in nude mice
In Tumour Necrosis Factor and Related Cytotoxins. (Bock, G, Marsh, J, eds.), Ciba Foundation Symposium, Vol. 131, Chichester, John Wiley & Sons, pp. 154-169, 1987. (Epub ---)

Balkwill, FR, Ward, BG, Fiers, W, Ramani, P.
Mechanisms of anticancer action of interferons on human tumour xenografts in nude mice
In The Biology of the Interferon System 1986. (Cantell, K, Schellekens, H, eds.), Dordrecht-Boston-Lancaster, Martinus Nijhoff Publishers, pp. 293-300, 1987. (Epub ---)

Balkwill, FR, Ward, BG, Moodie, E, Fiers, W.
Therapeutic potential of tumor necrosis factor-alpha and gamma-interferon in experimental human ovarian cancer
Cancer Res 47, 4755-4758, 1987. (Epub ---)

Bevilacqua, MP, Wheeler, ME, Pober, JS, Fiers, W, Mendrick, DL, Cotran, RS, Gimbrone, MA.
Endothelial-dependent mechanisms of leukocyte adhesion: Regulation by interleukin-1 and tumor necrosis factor
In Leukocyte Emigration and Its Sequelae. (Movat, HZ, ed.), Basel, Karger, pp. 79-93, 1987. (Epub ---)

Dealtry, GB, Naylor, MS, Fiers, W, Balkwill, FR.
DNA fragmentation and cytotoxicity caused by tumor necrosis factor is enhanced by interferon-gamma
Eur J Immunol 17, 689-693, 1987. (Epub ---)

Dealtry, GB, Naylor, MS, Fiers, W, Balkwill, FR.
The effect of recombinant human tumour necrosis factor on growth and macromolecular synthesis of human epithelial cells
Exp Cell Res 170, 428-438, 1987. (Epub ---)

Defilippi, P, Poupart, P, Haegeman, G, Tavernier, J, Fiers, W, Content, J.
Induction of 26 kDa protein mRNA in human cells treated with recombinant human tumour necrosis factor (rTNF-a)
In The Biology of the Interferon System 1986. (Cantell, K, Schellekens, H, eds.), Dordrecht-Boston-Lancaster, Martinus Nijhoff Publishers, pp. 217-222, 1987. (Epub ---)

Defilippi, P, Poupart, P, Tavernier, J, Fiers, W, Content, J.
Induction and regulation of mRNA encoding 26-kDa protein in human cell lines treated with recombinant human tumor necrosis factor
Proc Natl Acad Sci USA 84, 4557-4561, 1987. (Epub ---)

Devos, R, Cheroutre, H, Plaetinck, G, Fiers, W.
Identification and expression of cDNA plasmids corresponding to human interferon-gamma (IFN-gamma) and interleukin 2 (IL-2)
In Molecular Cloning and Analysis of Lymphokines. (Webb, DR, Goeddel, DV, eds.), Lymphokines, Vol. 13, Orlando, Academic Press, pp. 21-34, 1987. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Everaerdt, B, Haegeman, G, Suffys, P, Tavernier, J, Vandenabeele, P, Vanhaesebroeck, B, Van Ostade, X, Van Roy, F.
Gene cloning and structure-function relationship of cytokines such as TNF and interleukins
Immunol Lett 16, 219-226, 1987. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Everaerdt, B, Suffys, P, Tavernier, J, Vanhaesebroeck, B, Van Roy, F.
Tumor necrosis factor: a potential antitumor agent?
J Interferon Res 7, 627-634, 1987. (Epub ---)

Fiers, W, Brouckaert, P, Devos, R, Fransen, L, Haegeman, G, Leroux-Roels, G, Marmenout, A, Remaut, E, Suffys, P, Tavernier, J, Van der Heyden, J, Van Roy, F.
Molecular and cellular biology of tumor necrosis factor, interferon-gamma, and their synergism
In The Biology of the Interferon System 1986. (Cantell, K, Schellekens, H, eds.), Dordrecht-Boston-Lancaster, Martinus Nijhoff Publishers, pp. 205-216, 1987. (Epub ---)

Fiers, W, Brouckaert, P, Goldberg, A, Kettelhut, I, Suffys, P, Tavernier, J, Vanhaesebroeck, B, Van Roy, F.
Structure-function relationship of tumour necrosis factor and its mechanism of action
In Tumour Necrosis Factor and Related Cytotoxins. (Bock, G, Marsh, J, eds.), Ciba Foundation Symposium, Vol. 131, Chichester, John Wiley & Sons, pp. 109-123, 1987. (Epub ---)

Gao, J, Van Roy, F, Messiaen, L, Cosaert, J, Liebaut, G, Coopman, P, Fiers, W, Mareel, M.
Pathology of tumours produced in syngeneic Fischer rats by fibroblast-like cells before and after transfection with oncogenes
Pathol Res Pract 182, 48-57, 1987. (Epub ---)

Gresser, I, Delers, F, Tran Quangs, N, Marion, S, Engler, R, Maury, C, Soria, C, Soria, J, Fiers, W, Tavernier, J.
Tumor necrosis factor induces acute phase proteins in rats
J Biol Regul Homeost Agents 1, 173-176, 1987. (Epub ---)

Gresser, I, Woodrow, D, Moss, J, Maury, C, Tavernier, J, Fiers, W.
Toxic effects of recombinant tumor necrosis factor in suckling mice. Comparisons with interferon alpha/beta
Am J Pathol 128, 13-18, 1987. (Epub ---)

Grooten, J, Leroux-Roels, G, Fiers, W.
Specific suppression elicited by EL4 lymphoma cells in syngeneic mice. Specificity includes self-antigens on EL4
Eur J Immunol 17, 605-611, 1987. (Epub ---)

Hepburn, A, Boeynaems, JM, Fiers, W, Dumont, JE.
Modulation of tumor necrosis factor-alpha cytotoxicity in L929 cells by bacterial toxins, hydrocortisone and inhibitors of arachidonic acid metabolism
Biochem Biophys Res Commun 149, 815-822, 1987. (Epub ---)

Kettelhut, IC, Fiers, W, Goldberg, AL.
The toxic effects of tumor necrosis factor in vivo and their prevention by cyclooxygenase inhibitors
Proc Natl Acad Sci USA 84, 4273-4277, 1987. (Epub ---)

Krief, P, Boucheix, C, Billard, C, Mishal, Z, Van Agthoven, A, Fiers, W, Azzarone, B.
Modulation of expression of class II histocompatibility antigens by secretion of a cellular inhibitor in K562 leukemic cells
Eur J Immunol 17, 1021-1025, 1987. (Epub ---)

Kruys, V, Wathelet, M, Poupart, P, Contreras, R, Fiers, W, Content, J, Huez, G.
The 3' untranslated region of the human interferon-beta mRNA has an inhibitory effect on translation
Proc Natl Acad Sci USA 84, 6030-6034, 1987. (Epub ---)

Kurt-Jones, EA, Fiers, W, Pober, JS.
Membrane interleukin 1 induction on human endothelial cells and dermal fibroblasts
J Immunol 139, 2317-2324, 1987. (Epub ---)

Leemans, R, Remaut, E, Fiers, W.
A broad-host range expression vector based on the pL promoter of coliphage lambda: Regulated synthesis of human interleukin 2 in Erwinia and Serratia species
J Bacteriol 169, 1899-1904, 1987. (Epub ---)

Leroux-Roels, G, Grooten, J, Fiers, W.
Alloinduced suppression and cytotoxicity: Two functions of a single cell
Immunol Lett 15, 59-65, 1987. (Epub ---)

Malkovsky, M, Loveland, B, North, M, Asherson, GL, Gao, L, Ward, P, Fiers, W.
Recombinant interleukin-2 directly augments the cytotoxicity of human monocytes
Nature 325, 262-265, 1987. (Epub ---)

Mareel, MM, Van Roy, F, Messiaen, L, Bracke, M, Boghaert, E, Coopman, P.
Investigation of tumour-invasion mechanisms
In Cells, Membranes, and Disease, Including Renal. (Reid, E, Cook, GMW, Luzio, JP, eds.), Methodological Surveys in Biochemistry and Analysis, Vol. 17, New York-London, Plenum Press, pp. 359-370, 1987. (Epub ---)

Mareel, MM, van Roy, FM, Messiaen, LM, Boghaert, ER, Bruyneel, EA.
Qualitative and quantitative analysis of tumor invasion in vivo and in vitro
J Cell Sci Suppl. 8, 141-163, 1987. (Epub ---)

Mareel, M, Van Roy, F, Bruyneel, E, Bolscher, J, Schallier, D, De Mets, M.
Molecular biology of minimal invasion
Rec Res Cancer Res 106, 14-20, 1987. (Epub ---)

Marquet, RL, IJzermans, JNM, de Bruin, RWF, Fiers, W, Jeekel, J.
Anti-tumor activity of recombinant mouse tumor necrosis factor (TNF) on colon cancer in rats is promoted by recombinant rat interferon gamma; toxicity is reduced by indomethacin
Int J Cancer 40, 550-553, 1987. (Epub ---)

Messadi, DV, Pober, JS, Fiers, W, Gimbrone, MA, Murphy, GF.
Induction of an activation antigen on postcapillary venular endothelium in human skin organ culture
J Immunol 139, 1557-1562, 1987. (Epub ---)

Mueller, W, Vandenabeele, P.
A T cell clone which responds to interleukin 2 but not to interleukin 4
Eur J Immunol 17, 579-580, 1987. (Epub ---)

Plaetinck, G, Declercq, W, Tavernier, J, Nabholz, M, Fiers, W.
Recombinant tumor necrosis factor can induce interleukin 2 receptor expression and cytolytic activity in a rat x mouse T cell hybrid
Eur J Immunol 17, 1835-1838, 1987. (Epub ---)

Pober, JS, Lapierre, LA, Stolpen, AH, Brock, TA, Springer, TA, Fiers, W, Bevilacqua, MP, Mendrick, DL, Gimbrone, MA.
Activation of cultured human endothelial cells by recombinant lymphotoxin: Comparison with tumor necrosis factor and interleukin 1 species
J Immunol 138, 3319-3324, 1987. (Epub ---)

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