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Vanhaesebroeck, B, Mareel, M, Van Roy, F, Grooten, J, Fiers, W.
Expression of the tumor necrosis factor gene in tumor cells correlates with reduced tumorigenicity and reduced invasiveness in vivo
Cancer Res 51, 2229-2238, 1991. (Epub ---)

Vanhaesebroeck, B, Van Bladel, S, Lenaerts, A, Suffys, P, Beyaert, R, Lucas, R, Van Roy, F, Fiers, W.
Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line
Cancer Res 51, 2469-2477, 1991. (Epub ---)

Van Ostade, X, Tavernier, J, Prangé, T, Fiers, W.
Localization of the active site of human tumour necrosis factor (hTNF) by mutational analysis
EMBO J 10, 827-836, 1991. (Epub ---)

Vleminckx, K, Vakaet Jr., L, Mareel, M, Fiers, W, Van Roy, F.
Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role
Cell 66, 107-119, 1991. (Epub ---)

Abramowicz, D, Vandervorst, P, Bruyns, C, Doutrelepont, JM, Vandenabeele, P, Goldman, M.
Persistence of anti-donor allohelper T cells after neonatal induction of allotolerance in mice
Eur J Immunol 20, 1647-1653, 1990. (Epub ---)

Alegre, M, Depierreux, M, Florquin, S, Najdovski, T, Vandenabeele, P, Abramowicz, D, Leo, O, Deschodt-Lanckman, M, Goldman, M.
Acute toxicity of anti-CD3 monoclonal antibody in mice: A model for OKT3 first dose reactions
Transplant Proc 22, 1920-1921, 1990. (Epub ---)

Alegre, M, Vandenabeele, P, Flamand, V, Moser, M, Leo, O, Abramowicz, D, Urbain, J, Fiers, W, Goldman, M.
Hypothermia and hypoglycemia induced by anti-CD3 monoclonal antibody in mice: Role of tumor necrosis factor
Eur J Immunol 20, 707-710, 1990. (Epub ---)

Bereta, J, Szuba, K, Fiers, W, Gauldie, J, Koj, A.
Transforming growth factor-b and epidermal growth factor modulate basal and interleukin-6-induced amino acid uptake and acute phase protein synthesis in cultured rat hepatocytes
FEBS Lett 266, 48-50, 1990. (Epub ---)

Beyaert, R, Suffys, P, Van Roy, F, Fiers, W.
Inhibition by glucocorticoids of tumor necrosis factor-mediated cytotoxicity. Evidence against lipocortin involvement
FEBS Lett 262, 93-96, 1990. (Epub ---)

Carlo-Stella, C, Mangoni, L, Almici, C, Frassoni, F, Fiers, W, Rizzoli, V.
Growth of CD34+ acute myeloblastic leukemia colony-forming cells in response to recombinant hematopoietic growth factors
Leukemia 4, 561-566, 1990. (Epub ---)

Carrez, D, Janssens, W, Degrave, P, van den Hondel, CAMJJ, Kinghorn, JR, Fiers, W, Contreras, R.
Heterologous gene expression by filamentous fungi: Secretion of human interleukin-6 by Aspergillus nidulans
Gene 94, 147-154, 1990. (Epub ---)

Devos, R, Tavernier, J, Plaetinck, G, Van der Heyden, J, Rolink, A, Fiers, W.
Expression of the murine interleukin-5 receptor on Xenopus laevis oocytes
Biochem Biophys Res Commun 172, 570-575, 1990. (Epub ---)

De Wachter, R, Maniloff, J, Fiers, W.
Two-dimensional gel electrophoresis of nucleic acids
In Gel Electrophoresis of Nucleic Acids A Practical Approach. (Rickwood, D, Hames, BD, eds.), 2nd ed., Oxford-New York-Tokyo, IRL Press, pp. 151-200, 1990. (Epub ---)

Fiers, W.
De impact van de 'genetic engineering' in de biomedische sector
Ingenieursblad 59, 33-38, 1990. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Everaerdt, B, Haegeman, G, Libert, C, Suffys, P, Takahashi, N, Tavernier, J, Van Bladel, S, Vanhaesebroeck, B, Van Ostade, X, Van Roy, F.
In vitro and in vivo action of tumor necrosis factor
In Tumor Necrosis Factor: Structure, Mechanism of Action, Role in Disease and Therapy. (Bonavida, B, Granger, G, eds.), Basel, Karger, pp. 77-81, 1990. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Everaerdt, B, Libert, C, Suffys, P, Takahashi, N, Vanhaesebroeck, B, Van Roy, F.
Mechanism of action of tumor necrosis factor and its implications for synergizing and antagonizing drugs
In Endotoxin From Pathophysiology to Therapeutic Approaches. (Baumgartner, J-D, Calandra, T, Carlet, J, eds.), Paris, Médecine-Sciences/Flammarion, pp. 59-68, 1990. (Epub ---)

Goldman, M, Vandenabeele, P, Moulart, J, Amraoui, Z, Abramowicz, D, Nortier, J, Vanherweghem, JL, Fiers, W.
Intraperitoneal secretion of interleukin-6 during continuous ambulatory peritoneal dialysis
Nephron 56, 277-280, 1990. (Epub ---)

Grunfeld, C, Adi, S, Soued, M, Moser, A, Fiers, W, Feingold, KR.
Search for mediators of the lipogenic effects of tumor necrosis factor: Potential role for interleukin 6
Cancer Res 50, 4233-4238, 1990. (Epub ---)

Kallinowski, F, Friis, RR, Van Roy, F, Vaupel, P.
Oxygenation of tumors derived from ras transformed cells
Adv Exp Med Biol 277, 907-916, 1990. (Epub ---)

Libert, C, Brouckaert, P, Shaw, A, Fiers, W.
Induction of interleukin 6 by human and murine recombinant interleukin 1 in mice
Eur J Immunol 20, 691-694, 1990. (Epub ---)

Mahadevan, V, Malik, STA, Meager, A, Fiers, W, Lewis, GP, Hart, IR.
Role of tumor necrosis factor in flavone acetic acid-induced tumor vasculature shutdown
Cancer Res 50, 5537-5542, 1990. (Epub ---)

Malik, STA, Griffin, DB, Naylor, MS, Fiers, W, Oliff, A, Balkwill, FR.
The complex effects of recombinant tumour necrosis factor-alpha (rhTNF-alpha) in human ovarian cancer xenograft models
In Cytokines and Lipocortins in Inflammation and Differentiation. New York, Wiley-Liss, pp. 393-403, 1990. (Epub ---)

Mareel, MM, Van Roy, FM, De Baetselier, P.
The invasive phenotypes
Cancer Metast Rev 9, 45-62, 1990. (Epub ---)

Parant, F, Tavernier, J, Fiers, W, Parant, M.
Comparative activity of human and murine tumor necrosis factor in toxicity and anti-infectious assays in mice
Microb Pathogen 8, 143-149, 1990. (Epub ---)

Plaetinck, G, Van der Heyden, J, Tavernier, J, Faché, I, Tuypens, T, Fischkoff, S, Fiers, W, Devos, R.
Characterization of interleukin 5 receptors on eosinophilic sublines from human promyelocytic leukemia (HL-60) cells
J Exp Med 172, 683-691, 1990. (Epub ---)

Tavernier, J, Marmenout, A, Bauden, R, Hauquier, G, Van Ostade, X, Fiers, W.
Analysis of the structure-function relationship of tumour necrosis factor. Human/mouse chimeric TNF proteins: General properties and epitope analysis
J Mol Biol 211, 493-501, 1990. (Epub ---)

Vandenabeele, P, Declercq, W, Libert, C, Fiers, W.
Development of a simple, sensitive and specific bioassay for interleukin-1 based on the proliferation of RPMI 1788 cells. Comparison with other bioassays for IL-1
J Immunol Methods 135, 25-32, 1990. (Epub ---)

Vandenabeele, P, Grooten, J, Fiers, W.
IL-4 acts synergistically on the IL-2 response of an autoreactive T-cell clone; synergism correlates with increased intracellular IL-2, but not with a modified IL-2 receptor expression
Cell Immunol 130, 79-91, 1990. (Epub ---)

Vandenabeele, P, Guisez, Y, Declercq, W, Bauw, G, Vandekerckhove, J, Fiers, W.
Response of murine cell lines to an IL-1/IL-2-induced factor in a rat/mouse T hybridoma (PC60): Differential induction of cytokines by human IL-1a and IL-1b and partial amino acid sequence of rat GM-CSF
Lymphokine Res 9, 381-389, 1990. (Epub ---)

Vanhaesebroeck, B, Cragoe Jr., EJ, Pouysségur, J, Beyaert, R, Van Roy, F, Fiers, W.
Cytotoxic activity of tumor necrosis factor is inhibited by amiloride derivatives without involvement of the Na+/H+ antiporter
FEBS Lett 261, 319-322, 1990. (Epub ---)

Vanhaesebroeck, B, Timmers, HTM, Pronk, GJ, Van Roy, F, van der Eb, AJ, Fiers, W.
Modulation of cellular susceptibility to the cytotoxic/cytostatic action of tumor necrosis factor by adenovirus E1 gene expression is cell type-dependent
Virology 176, 362-368, 1990. (Epub ---)

van Hinsbergh, VWM, van den Berg, EA, Fiers, W, Dooijewaard, G.
Tumor necrosis factor induces the production of urokinase-type plasminogen activator by human endothelial cells
Blood 75, 1991-1998, 1990. (Epub ---)

Van Roy, F, Liebaut, G, Mareel, M, Fiers, W.
Partial transformation of human tumor cell lines showing defective interaction between unusual p53 gene product and SV40 large-T antigen
Oncogene 5, 207-218, 1990. (Epub ---)

Van Roy, F, Mareel, M, Vleminckx, K, Beyaert, R, Fiers, W, Devleeschouwer, N, Muquardt, C, Legros, N, Bracke, M, Leclercq, G.
Hormone sensitivity in vitro and in vivo of v-ras-transfected MCF-7 cell derivatives
Int J Cancer 46, 522-532, 1990. (Epub ---)

Balkwill, FR, Fiers, W.
Cancer Surveys 8, 711-712, 1989. (Epub ---)

Behrens, J, Mareel, MM, van Roy, FM, Birchmeier, W.
Dissecting tumor cell invasion: Epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion
J Cell Biol 108, 2435-2447, 1989. (Epub ---)

Bereta, J, Kurdowska, A, Koj, A, Hirano, T, Kishimoto, T, Content, J, Fiers, W, Van Damme, J, Gauldie, J.
Different preparations of natural and recombinant human interleukin-6 (IFN-beta2, BSF-2) similarly stimulate acute phase protein synthesis and uptake of alpha-aminoisobutyric acid by cultured rat hepatocytes
Int J Biochem 21, 361-366, 1989. (Epub ---)

Beyaert, R, Vanhaesebroeck, B, Suffys, P, Van Roy, F, Fiers, W.
Lithium chloride potentiates tumor necrosis factor-mediated cytotoxicity in vitro and in vivo
Proc Natl Acad Sci USA 86, 9494-9498, 1989. (Epub ---)

Brouckaert, PG, Everaerdt, B, Libert, C, Takahashi, N, Fiers, W.
Species specificity and involvement of other cytokines in endotoxic shock action of recombinant tumour necrosis factor in mice
Agents Actions 26, 196-198, 1989. (Epub ---)

Brouckaert, PG, Libert, C, Everaerdt, B, Takahashi, N, Fiers, W.
A role for interleukin 1 in the in vivo actions of tumor necrosis factor
Lymphokine Res 8, 269-274, 1989. (Epub ---)

Brouckaert, P, Spriggs, DR, Demetri, G, Kufe, DW, Fiers, W.
Circulating interleukin 6 during a continuous infusion of tumor necrosis factor and interferon g
J Exp Med 169, 2257-2262, 1989. (Epub ---)

Campbell, EI, Unkles, SE, Macro, JA, van den Hondel, C, Contreras, R, Kinghorn, JR.
Improved transformation efficiency of Aspergillus niger using the homologous niaD gene for nitrate reductase
Curr Genet 16, 53-56, 1989. (Epub ---)

Coopman, P, Van Roy, F, Dragonetti, C, Gao, J, Fiers, W, Meneguzzi, G, Mareel, M.
Tumorigenicity, invasiveness and metastatic capability of FR3T3 rat cells before and after transfection with bovine papilloma virus type 1 DNA
Clin Exp Metastas 7, 69-84, 1989. (Epub ---)

de Ruiter-Jacobs, YM, Broekhuijsen, M, Unkles, SE, Campbell, EI, Kinghorn, JR, Contreras, R, Pouwels, PH, van den Hondel, CA.
A gene transfer system based on the homologous pyrG gene and efficient expression of bacterial genes in Aspergillus oryzae
Curr Genet 16, 159-163, 1989. (Epub ---)

Everaerdt, B, Brouckaert, P, Shaw, A, Fiers, W.
Four different interleukin-1 species sensitize to the lethal action of tumour necrosis factor
Biochem Biophys Res Commun 163, 378-385, 1989. (Epub ---)

Fiers, W.
TNF: Mechanism of action in vitro and in vivo
In Influence of Molecular Biology on Drug Discovery. (Udaka, K, Furuichi, Y, Drews, J, eds.), Clinical Pharmacology, Vol. 1, München, W. Zuckschwerdt Verlag, pp. 17-24, 1989. (Epub ---)

Fiers, W, Balkwill, FR.
Future prospects and problems
Cancer Surveys 8, 921-927, 1989. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Everaerdt, B, Grooten, J, Haegeman, G, Libert, C, Suffys, P, Takahashi, N, Tavernier, J, Van Bladel, S, Vanhaesebroeck, B, Van Ostade, X, Van Roy, F.
Tumour necrosis factor and interleukin-6: Structure and mechanism of action of the molecular, cellular and in vivo level
In Vectors as Tools for the Study of Normal and Abnormal Growth and Differentiation. (Lother, H, Dernick, R, Ostertag, W, eds.), NATO ASI Series, Vol. H 34, Berlin, Springer-Verlag, pp. 229-240, 1989. (Epub ---)

Fiers, W, Brouckaert, P, Content, J, Contreras, R, Everaerdt, B, Guisez, Y, Libert, C, Spriggs, D, Takahashi, N, Tison, B, Vandenabeele, P, Van Snick, J.
Interleukin-6: Biological function and regulation of the gene expression in vitro and in vivo
In Advances in Immunopharmacology. (Hadden, JW, Spreafico, F, Yamamura, Y, Austen, KF, Dukor, P, Masek, K, eds.), Vol. 4, Oxford, Pergamon Press, pp. 185-190, 1989. (Epub ---)

Grooten, J, Fiers, W.
Acquisition by the murine host of responsiveness toward various neoplastic cell lines, but not toward self, through adoptive transfer of a helper T-lymphocyte clone with antiself specificity
Cancer Res 49, 3872-3878, 1989. (Epub ---)

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