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Selected IRC publications

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De Vrieze, J, Louage, B, Deswarte, K, Zhong, Z, De Coen, R, Van Herck, S, Nuhn, L, Frich, CK, Zelikin, A, Lienenklaus, S, Sanders, N, David, S, Lambrecht, B, de Geest, B.
Potent lymphatic translocation and spatial control over innate immune activation by polymer-lipid amphiphile conjugates of small molecule TLR7/8 agonists
Angew Chem Int Ed Engl 58, 15390-15395, 2019. (Epub 2019 Aug 9)

Dimitrakopoulou, D, Tulkens, D, Van Vlierberghe, P, Vleminckx, K.
Xenopus tropicalis: Joining the Armada in the Fight Against Blood Cancer
Frontiers in Physiology 10, 48, 2019. (Epub 2019 Feb 1)

Dondelinger, Y, Delanghe, T, Priem, D, Wynosky-Dolfi, MA, Sorobetea, D, Rojas-Rivera, D, Giansanti, P, Roelandt, R, Gropengiesser, J, Ruckdeschel, K, Savvides, SN, Heck, AJR, Vandenabeele, P, Brodsky, IE, Bertrand, MJM.
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
Nat Commun 10, 1729, 2019. (Epub 2019 Apr 15)

Doornaert, M, De Maere, E, Colle, J, Declercq, H, Taminau, J, Lemeire, K, Berx, G, Blondeel, P.
Xenogen-free isolation and culture of human adipose mesenchymal stem cells
Stem Cell Res 40, 101532, 2019. (Epub 2019 Aug 8)

Doornaert, M, Depypere, B, Creytens, D, Declercq, H, Taminau, J, Lemeire, K, Monstrey, S, Berx, G, Blondeel, P.
Human decellularized dermal matrix seeded with adipose-derived stem cells enhances wound healing in a murine model: Experimental study
Ann Med Surg (Lond) 46, 4-11, 2019. (Epub 2019 Aug 7)

Drutman, SB, Haerynck, F, Zhong, FL, Hum, D, Hernandez, NJ, Belkaya, S, Rapaport, F, de Jong, SJ, Creytens, D, Tavernier, SJ, Bonte, K, De Schepper, S, van der Werff Ten Bosch, J, Lorenzo-Diaz, L, Wullaert, A, Bossuyt, X, Orth, G, Bonagura, VR, Beziat, V, et al..
Homozygous NLRP1 gain-of-function mutation in siblings with a syndromic form of recurrent respiratory papillomatosis
Proc Natl Acad Sci U S A 116, 19055-19063, 2019. (Epub 2019 Sep 4)

Dubois, H, Sorgeloos, F, Sarvestani, ST, Martens, L, Saeys, Y, Mackenzie, JM, Lamkanfi, M, van Loo, G, Goodfellow, I, Wullaert, A.
Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection
PLoS Pathog 15, e1007709, 2019. (Epub 2019 Apr 24)

Dubois, H, van Loo, G, Wullaert, A.
Nucleic Acid Induced Interferon and Inflammasome Responses in Regulating Host Defense to Gastrointestinal Viruses
Int Rev Cell Mol Biol 345, 137-171, 2019. (Epub 2018 Oct 3)

Durham, BH, Lopez Rodrigo, E, Picarsic, J, Abramson, D, Rotemberg, V, De Munck, S, Pannecoucke, E, Lu, SX, Pastore, A, Yoshimi, A, Mandelker, D, Ceyhan-Birsoy, O, Ulaner, GA, Walsh, M, Yabe, M, Petrova-Drus, K, Arcila, ME, Ladanyi, M, Solit, DB, et al..
Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms
Nat Med 25, 1839-1842, 2019. (Epub 2019 Nov 25)

Elvas, F, Vanden Berghe, T, Adriaenssens, Y, Vandenabeele, P, Augustyns, K, Staelens, S, Stroobants, S, Van der Veken, P, Wyffels, L.
Caspase-3 probes for PET imaging of apoptotic tumor response to anticancer therapy
Org Biomol Chem 17, 4801-4824, 2019. (Epub 2019 Apr 29)

Emmaneel, A, Bogaert, DJ, Van Gassen, S, Tavernier, SJ, Dullaers, M, Haerynck, F, Saeys, Y.
A Computational Pipeline for the Diagnosis of CVID Patients
Frontiers in Immunology 10, 2009, 2019. (Epub 2019 Aug 30)

Fioravanti, A, Van Hauwermeiren, F, Van der Verren, SE, Jonckheere, W, Goncalves, A, Pardon, E, Steyaert, J, De Greve, H, Lamkanfi, M, Remaut, H.
Structure of S-layer protein Sap reveals a mechanism for therapeutic intervention in anthrax
Nat Microbiol 4, 1805-1814, 2019. (Epub 2019 Jul 15)

Fraire, JC, Stremersch, S, Bouckaert, D, Monteyne, T, De Beer, T, Wuytens, P, De Rycke, R, Skirtach, AG, Raemdonck, K, De Smedt, S, Braeckmans, K.
Improved Label-Free Identification of Individual Exosome-like Vesicles with Au@Ag Nanoparticles as SERS Substrate
ACS Appl Mater Interfaces 11, 39424-39435, 2019. (Epub 2019 Oct 16)

Fritsch, M, Gunther, SD, Schwarzer, R, Albert, MC, Schorn, F, Werthenbach, JP, Schiffmann, LM, Stair, N, Stocks, H, Seeger, JM, Lamkanfi, M, Kronke, M, Pasparakis, M, Kashkar, H.
Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis
Nature 575, 683-687, 2019. (Epub 2019 Nov 20)

Gil-Cruz, C, Perez-Shibayama, C, De Martin, A, Ronchi, F, van der Borght, K, Niederer, R, Onder, L, Lutge, M, Novkovic, M, Nindl, V, Ramos, G, Arnoldini, M, Slack, EMC, Boivin-Jahns, V, Jahns, R, Wyss, M, Mooser, C, Lambrecht, BN, Maeder, MT, et al..
Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy
Science 366, 881-886, 2019. (Epub 2019 Nov 15)

Gilis, E, Gaublomme, D, Staal, J, Venken, K, Dhaenens, M, Lambrecht, S, Coudenys, J, Decruy, T, Schryvers, N, Driege, Y, Dumas, E, Demeyer, A, De Muynck, A, van Hengel, J, Van Hoorebeke, L, Deforce, D, Beyaert, R, Elewaut, D.
Deletion of Mucosa‐Associated Lymphoid Tissue Lymphoma Translocation Protein 1 in Mouse T Cells Protects Against Development of Autoimmune Arthritis but Leads to Spontaneous Osteoporosis
Arthritis Rheumatol 71, 2005-2015, 2019. (Epub 2019 Jul 1)

Goossens, S, Wang, J, Tremblay, C, De Medts, J, T'Sas, S, Nguyen, T, Saw, J, Haigh, K, Curtis, DJ, Van Vlierberghe, P, Berx, G, Taghon, T, Haigh, JJ.
ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms
Haematologica 104, 1608-1616, 2019. (Epub 2019 Jan 24)

Gorle, N, Vandenbroucke, RE.
Interferons: A molecular switch between damage and repair in ageing and Alzheimer's disease
Mech Ageing Dev 183, 111148, 2019. (Epub 2019 Sep 18)

Gracey, E, Dumas, E, Yerushalmi, M, Qaiyum, Z, Inman, RD, Elewaut, D.
The ties that bind: skin, gut and spondyloarthritis
Curr Opin Rheumatol 31, 62-69, 2019. (Epub 2018 Nov 6)

Guerin, CJ, Kremer, A, Borghgraef, P, Shih, AY, Lippens, S.
Combining serial block face and focused ion beam scanning electron microscopy for 3D studies of rare events
Methods Cell Biol 152, 87-101, 2019. (Epub 2019 May 7)

Guilliams, M, Scott, CL.
Priority lane to cDC1 open for IRF8(+) progenitors
Blood 133, 1795-1797, 2019. (Epub 2019 Apr 25)

Guilliams, M, Tamura, T.
Decrypting DC development
Nat Immunol 20, 1090-1092, 2019. (Epub 2019 Aug 12)

Gul, IS, Hulpiau, P, Sanders, E, van Roy, F, van Hengel, J.
Armc8 is a evolutionarily conserved armadillo protein involved in cell-cell adhesion complexes through multiple molecular interactions
Biosci Rep 39, 8, 2019. (Epub 2018 Nov 27)

Guérin, CJ, Kremer, A, Borghgraef, P, Lippens, S.
Targeted Studies Using Serial Block Face and Focused Ion Beam Scan Electron Microscopy.
J Vis Exp 150, e59480, 2019. (Epub 2019 Aug 10)

Gurumurthy, CB, O'Brien, AR, Quadros, RM, Adams, J, Jr., Alcaide, P, Ayabe, S, Ballard, J, Batra, SK, Beauchamp, MC, Becker, KA, Bernas, G, Brough, D, Carrillo-Salinas, F, Chan, W, Chen, H, Dawson, R, DeMambro, V, D'Hont, J, Dibb, KM, et al..
Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation
Genome Biol 20, 171, 2019. (Epub 2019 Aug 26)

Haase, S, Wilck, N, Kleinewietfeld, M, Muller, DN, Linker, RA.
Sodium chloride triggers Th17 mediated autoimmunity
J Neuroimmunol 329, 9-13, 2019. (Epub 2018 Jun 30)

Haas, M, Gomez Vazquez, JL, Sun, DI, Tran, HT, Brislinger, M, Tasca, A, Shomroni, O, Vleminckx, K, Walentek, P.
DeltaN-Tp63 Mediates Wnt/beta-Catenin-Induced Inhibition of Differentiation in Basal Stem Cells of Mucociliary Epithelia
Cell Rep 28, 3338-3352, 2019. (Epub 2019 Sep 24)

Haensel, D, Sun, P, MacLean, AL, Ma, X, Zhou, Y, Stemmler, MP, Brabletz, S, Berx, G, Plikus, MV, Nie, Q, Brabletz, T, Dai, X.
An Ovol2-Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation
EMBO Rep 20, e46273, 2019. (Epub 2018 Nov 9)

Hanoteau, A, Newton, JM, Krupar, R, Huang, C, Liu, HC, Gaspero, A, Gartrell, RD, Saenger, YM, Hart, TD, Santegoets, SJ, Laoui, D, Spanos, C, Parikh, F, Jayaraman, P, Zhang, B, Van der Burg, SH, Van Ginderachter, JA, Melief, CJM, Sikora, AG.
Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy
J Immunother Cancer 7, 10, 2019. (Epub 2019 Jan 15)

Haspeslagh, E, Vanheerswynghels, M, Deswarte, K, van Moorleghem, J, Jacquet, A, Lambrecht, BN, Hammad, H.
Prophylactic allergen immunotherapy with Der p 2 prevents murine asthma by regulating lung GM-CSF
J Allergy Clin Immunol 143, 2307-2311.e5, 2019. (Epub 2019 Feb 20)

Hassannia, B, Vandenabeele, P, Vanden Berghe, T.
Targeting Ferroptosis to Iron Out Cancer
Cancer Cell 35, 830-849, 2019. (Epub 2019 May 16)

Holgado, A, Braun, H, Van Nuffel, E, Detry, S, Schuijs, MJ, Deswarte, K, Vergote, K, Haegman, M, Baudelet, G, Haustraete, J, Hammad, H, Lambrecht, BN, Savvides, SN, Afonina, IS, Beyaert, R.
IL-33trap is a novel IL-33 neutralizing biologic that inhibits allergic airway inflammation
J Allergy Clin Immunol 144, 204-215, 2019. (Epub 2019 Mar 12)

Hoste, E, Maueroder, C, van Hove, L, Catrysse, L, Vikkula, HK, Sze, M, Maes, B, Karjosukarso, D, Martens, L, Goncalves, A, Parthoens, E, Roelandt, R, Declercq, W, Fuentes, I, Palisson, F, Gonzalez, S, Salas-Alanis, JC, Boon, L, Huebener, P, et al..
Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils for NET Formation
Cell Rep 29, 2689-2701, 2019. (Epub 2019 Nov 26)

Janela, B, Patel, AA, Lau, MC, Goh, CC, Msallam, R, Kong, WT, Fehlings, M, Hubert, S, Lum, J, Simoni, Y, Malleret, B, Zolezzi, F, Chen, J, Poidinger, M, Satpathy, AT, Briseno, C, et al., Vanhoutte, L, Guilliams, M, et al.
A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFalpha-Mediated Recruitment of Neutrophils
Immunity 50, 1069-1083, 2019. (Epub 2019 Mar 26)

Jans, L, De Kock, I, Herregods, N, Verstraete, KL, Van den Bosch, FE, Carron, P, Oei, EH, Elewaut, D, Jacques, P.
Response to: 'The use of dual-energy CT to detect and depict bone marrow oedema in rheumatoid arthritis: is it ready to substitute MRI?' by Wu et al
Ann Rheum Dis 78, E90-E90, 2019. (Epub 2018 Jul 12)

Janssens, J, Bitra, A, Wang, J, Decruy, T, Venken, K, van der Eycken, J, Elewaut, D, Zajonc, DM, van Calenbergh, S.
4"-O-Alkylated alpha-Galactosylceramide Analogues as iNKT-Cell Antigens: Synthetic, Biological, and Structural Studies
ChemMedChem 14, 147-168, 2019. (Epub 2018 Dec 17)

Jin, Q, Martinez, CA, Arcipowski, KM, Zhu, Y, Gutierrez-Diaz, BT, Wang, KK, Johnson, MR, Volk, A, Wang, F, Wu, J, Grove, C, Wang, H, Sokirniy, I, Thomas, PM, Goo, YA, et al., Vandamme, N, Berx, G, Goossens, S, et al..
USP7 cooperates with NOTCH1 to drive the oncogenic transcriptional program in T cell leukemia
Clin Cancer Res 25, 222-239, 2019. (Epub 2018 Sep 17)

Kariminejad, A, Szenker-Ravi, E, Lekszas, C, Tajsharghi, H, Moslemi, AR, Naert, T, Tran, HT, Ahangari, F, Rajaei, M, Nasseri, M, Haaf, T, Azad, A, Superti-Furga, A, Maroofian, R, Ghaderi-Sohi, S, Najmabadi, H, Abbaszadegan, MR, Vleminckx, K, Nikuei, P, et al..
Homozygous Null TBX4 Mutations Lead to Posterior Amelia with Pelvic and Pulmonary Hypoplasia
Am J Hum Genet 105, 1294-1301, 2019. (Epub 2019 Nov 21)

Kariuki, CK, Stijlemans, B, Magez, S.
The Trypanosomal Transferrin Receptor of Trypanosoma Brucei-A Review
Trop Med Infect Dis 4, 4, 2019. (Epub 2019 Oct 1)

Kavcic, N, Pegan, K, Vandenabeele, P, Turk, B.
Comparative study of the differential cell death protecting effect of various ROS scavengers
Biol Chem 400, 149-160, 2019. (Epub 2018 Sep 19)

Konieczny, P, Lichawska-Cieslar, A, Kwiecinska, P, Cichy, J, Pietrzycka, R, Szukala, W, Declercq, W, Devos, M, Paziewska, A, Rumienczyk, I, Kulecka, M, Mikula, M, Fu, M, Borowczyk, J, Santamaria-Babi, LF, Jura, J.
Keratinocyte-specific ablation of Mcpip1 impairs skin integrity and promotes local and systemic inflammation
J Mol Med (Berl) 97, 1669-1684, 2019. (Epub 2019 Nov 30)

Kovacs, P, Csonka, T, Kovacs, T, Sari, Z, Ujlaki, G, Sipos, A, Karanyi, Z, Szeocs, D, Hegedus, C, Uray, K, Janko, L, Kiss, M, Kiss, B, Laoui, D, Virag, L, Mehes, G, Bai, P, Miko, E.
Lithocholic Acid, a Metabolite of the Microbiome, Increases Oxidative Stress in Breast Cancer
Cancers (Basel) 11, 9, 2019. (Epub 2019 Aug 27)

Krols, M, Asselbergh, B, De Rycke, R, De Winter, V, Seyer, A, Muller, FJ, Kurth, I, Bultynck, G, Timmerman, V, Janssens, S.
Sensory neuropathy-causing mutations in ATL3 affect ER-mitochondria contact sites and impair axonal mitochondrial distribution
Hum Mol Genet 28, 615–627, 2019. (Epub 2018 Oct 18)

Laloo, F, Herregods, N, Jaremko, JL, Carron, P, Elewaut, D, Van den Bosch, F, Verstraete, K, Jans, L.
MRI of the axial skeleton in spondyloarthritis: the many faces of new bone formation
Insights Imaging 10, 67, 2019. (Epub 2019 Jul 24)

Lambrecht, BN, Hammad, H, Fahy, JV.
The Cytokines of Asthma
Immunity 50, 975-991, 2019. (Epub 2019 Apr 16)

Laoui, D, Van Overmeire, E, Abels, C, Keirsse, J, Van Ginderachter, JA.
Adoptive Transfer of Monocytes Sorted from Bone Marrow
Bio-Protocol 9, , 2019. (Epub 2019 Jan 5)

Lecocq, Q, De Vlaeminck, Y, Hanssens, H, D'Huyvetter, M, Raes, G, Goyvaerts, C, Keyaerts, M, Devoogdt, N, Breckpot, K.
Theranostics in immuno-oncology using nanobody derivatives
Theranostics 9, 7772-7791, 2019. (Epub 2019 Oct 15)

Lecocq, Q, Zeven, K, De Vlaeminck, Y, Martens, S, Massa, S, Goyvaerts, C, Raes, G, Keyaerts, M, Breckpot, K, Devoogdt, N.
Noninvasive Imaging of the Immune Checkpoint LAG-3 Using Nanobodies, from Development to Pre-Clinical Use
Biomolecules 9, , 2019. (Epub 2019 Sep 29)

Lepko, T, Pusch, M, Muller, T, Schulte, D, Ehses, J, Kiebler, M, Hasler, J, Huttner, HB, Vandenbroucke, RE, Vandendriessche, C, Modic, M, Martin-Villalba, A, Zhao, S, E, LL-B, Schneider, A, Fischer, A, Breunig, CT, Stricker, SH, Gotz, M, et al..
Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain
EMBO J , e100481, 2019. (Epub 2019 Jul 15)

Libert, C, Ayala, A, Bauer, M, Cavaillon, JM, Deutschman, C, Frostell, C, Knapp, S, Kozlov, AV, Wang, P, Osuchowski, MF, Remick, DG.
Part II: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS) for Types of Infections and Organ Dysfunction Endpoints
Shock 51, 23-32, 2019. (Epub 2018 Aug 14)

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