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Publications from this research unit

This page shows only publications with IRC as the affiliation of at least one author.
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van Zoest, RA, Underwood, J, De Francesco, D, Sabin, CA, Cole, JH, Wit, FW, Caan, MWA, Kootstra, NA, Fuchs, D, Zetterberg, H, Majoie, C, Portegies, P, Winston, A, Sharp, DJ, Gisslen, M, Reiss, P, Comorbidity in Relation to, AC.
Structural Brain Abnormalities in Successfully Treated HIV Infection: Associations With Disease and Cerebrospinal Fluid Biomarkers
J Infect Dis 217, 69-81, 2018. (Epub 2017 Dec 27)

Voet, S, Mc Guire, C, Hagemeyer, N, Martens, A, Schroeder, A, Wieghofer, P, Daems, C, Staszewski, O, Vande Walle, L, Jordao, MJC, Sze, M, Vikkula, HK, Demeestere, D, Van Imschoot, G, Scott, CL, Hoste, E, Goncalves, A, Guilliams, M, Lippens, S, Libert, C, Vandenbroucke, RE, et al., Lamkanfi, M, Prinz, M, van Loo, G.
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation
Nat Commun 9, 2036, 2018. (Epub 2018 May 23)

Zagato, E, Vermeulen, L, Dewitte, H, Van Imschoot, G, Vandenbroucke, RE, Demeester, J, De Schmedt, SC, Neyts, K, Remaut, K, Braeckmans, K.
Quantifying the average number of nucleic acid therapeutics per nanocarrier by Single Particle Tracking microscopy
Mol Pharm 15, 1142-1149, 2018. (Epub 2018 Feb 12)

Booiman, T, Wit, FW, Maurer, I, De Francesco, D, Sabin, CA, Harskamp, AM, Prins, M, Garagnani, P, Pirazzini, C, Franceschi, C, Fuchs, D, Gisslen, M, Winston, A, Reiss, P, Kootstra, NA, Comorbidity in Relation to, AC.
High Cellular Monocyte Activation in People Living With Human Immunodeficiency Virus on Combination Antiretroviral Therapy and Lifestyle-Matched Controls Is Associated With Greater Inflammation in Cerebrospinal Fluid
Open Forum Infect Dis 4, ofx108, 2017. (Epub 2017 May 25)

Cole, JH, Underwood, J, Caan, MW, De Francesco, D, van Zoest, RA, Leech, R, Wit, FW, Portegies, P, Geurtsen, GJ, Schmand, BA, Schim van der Loeff, MF, Franceschi, C, Sabin, CA, Majoie, CB, Winston, A, Reiss, P, Sharp, DJ, collaboration, C.
Increased brain-predicted aging in treated HIV disease
Neurology 88, 1349-1357, 2017. (Epub 2017 Mar 3)

Dendoncker, K, Libert, C.
Glucocorticoid resistance as a major drive in sepsis pathology
Cytokine Growth Factor Rev 35, 85-96, 2017. (Epub 2017 Apr 23)

Dendoncker, K, Timmermans, S, Van Looveren, K, De Cauwer, L, De Bosscher, K, Libert, C.
The nature of the GRE influences the screening for GR-activity enhancing modulators
PLoS One 12, 7, 2017. (Epub 2017 Jul 7)

Greenwood, J, Hammarlund-Udenaes, M, Jones, HC, Stitt, AW, Vandenbroucke, RE, Romero, IA, Campbell, M, Fricker, G, Brodin, B, Manninga, H, Gaillard, PJ, Schwaninger, M, Webster, C, Wicher, KB, Khrestchatisky, M.
Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017
Fluids Barriers CNS 14, 31, 2017. (Epub 2017 Nov 7)

Holvoet, T, Devriese, S, Castermans, K, Boland, S, Leysen, D, Vandewynckel, YP, Devisscher, L, Van den Bossche, L, Van Welden, S, Dullaers, M, Vandenbroucke, RE, De Rycke, R, Geboes, K, Bourin, A, Defert, O, Hindryckx, P, De Vos, M, Laukens, D.
Treatment of intestinal fibrosis in experimental inflammatory bowel disease by the pleiotropic actions of a local Rho kinase inhibitor
Gastroenterology 153, 1054-1067, 2017. (Epub 2017 Jun 19)

Klassen, C, Karabinskaya, A, Dejager, L, Vettorazzi, S, Van Moorleghem, J, Luhder, F, Meijsing, SH, Tuckermann, JP, Bohnenberger, H, Libert, C, Reichardt, HM.
Airway Epithelial Cells Are Crucial Targets of Glucocorticoids in a Mouse Model of Allergic Asthma
J Immunol 199, 48-61, 2017. (Epub 2017 May 17)

Petta, I, Bougarne, N, Vandewalle, J, Dejager, L, Vandevyver, S, Ballegeer, M, Desmet, S, Thommis, J, De Cauwer, L, Lievens, S, Libert, C, Tavernier, J, De Bosscher, K.
Glucocorticoid Receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor
Sci Rep 7, 8941, 2017. (Epub 2017 Aug 21)

Steeland, S, Van Ryckeghem, S, Van Imschoot, G, De Rycke, R, Toussaint, W, Vanhoutte, L, Vanhove, C, De Vos, F, Vandenbroucke, RE, Libert, C.
TNFR1 inhibition with a Nanobody protects against EAE development in mice
Sci Rep 7, 13646, 2017. (Epub 2017 Oct 20)

Timmermans, S, Van Montagu, M, Libert, C.
Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains
Proc Natl Acad Sci U S A 114, 9158-9163, 2017. (Epub 2017 Aug 7)

Vandereyken, MM, Singh, P, Wathieu, CP, Jacques, S, Zurashvilli, T, Dejager, L, Amand, M, Musumeci, L, Singh, M, Moutschen, MP, Libert, C, Rahmouni, S.
Dual-Specificity Phosphatase 3 Deletion Protects Female, but Not Male, Mice from Endotoxemia-Induced and Polymicrobial-Induced Septic Shock
J Immunol 199, 2515-2527, 2017. (Epub 2017 Aug 28)

Balusu, S, Brkic, M, Libert, C, Vandenbroucke, RE.
The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease: more than just a barrier
Neural Regen Res 11, 534-537, 2016. (Epub 2016 Apr)

Balusu, S, Van Wonterghem, E, De Rycke, R, Raemdonck, K, Stremersch, S, Gevaert, K, Brkic, M, Demeestere, D, Vanhooren, V, Hendrix, A, Libert, C, Vandenbroucke, RE.
Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles
EMBO Mol Med 8, 1162-1183, 2016. (Epub 2016 Oct 4)

Carceller, E, Ballegeer, M, Deckers, J, Riccardi, C, Bruscoli, S, Hochepied, T, Libert, C, Perez, P.
Overexpression of Glucocorticoid-induced Leucine Zipper (GILZ) increases susceptibility to Imiquimod-induced psoriasis and involves cutaneous activation of TGF-beta1
Sci Rep 6, 38825, 2016. (Epub 2016 Dec 9)

De Bock, M, Van Haver, V, Vandenbroucke, RE, Decrock, E, Wang, N, Leybaert, L.
Into rather unexplored terrain-transcellular transport across the blood-brain barrier
Glia 64, 1097-1123, 2016. (Epub 2016 Feb 8)

De Bosscher, K, Beck, IM, Ratman, D, Berghe, WV, Libert, C.
Activation of the Glucocorticoid Receptor in Acute Inflammation: the SEDIGRAM Concept
Trends Pharmacol Sci 37, 4-16, 2016. (Epub 2015 Oct 22)

Demeestere, D, Dejonckheere, E, Steeland, S, Hulpiau, P, Haustraete, J, Devoogdt, N, Wichert, R, Becker-Pauly, C, Van Wonterghem, E, Dewaele, S, Van Imschoot, G, Aerts, J, Arckens, L, Saeys, Y, Libert, C, Vandenbroucke, RE.
Development and validation of a small single domain antibody that effectively inhibits matrix metalloproteinase 8
Mol Ther 24, 890-902, 2016. (Epub 2016 Jan 18)

Drechsler, S, Lynch, MA, Novella, S, Gonzalez-Navarro, H, Hecimovic, S, Barini, E, Tucci, V, Castro, RE, Vandenbroucke, RE, Osuchowski, M, Potter, PK.
With mouse age comes wisdom: a review and suggestions of relevant mouse models for age-related conditions
Mech Ageing Dev 160, 54-68, 2016. (Epub 2016 Jul 20)

Gorlé, N, Van Cauwenberghe, C, Libert, C, Vandenbroucke, RE.
The effect of aging on brain barriers and the consequences for Alzheimer's disease development
Mamm Genome 27, 407-420, 2016. (Epub 2016 May 3)

Grine, L, Libert, C, Vandenbroucke, R.
Comment on "Tumour necrosis factor alpha plays a significant role in the Aldara-induced skin inflammation in mice"
Br J Dermatol 174, 1419-1419, 2016. (Epub 2016 Feb 6)

Grine, L, Steeland, S, Van Ryckeghem, S, Ballegeer, M, Lienenklaus, S, Weiss, S, Sanders, NN, Vandenbroucke, RE, Libert, C.
Topical imiquimod yields systemic effects due to unintended oral uptake
Sci Rep 6, 20134, 2016. (Epub 2016 Jan 28)

Kessler, SM, Laggai, S, Van Wonterghem, E, Gemperlein, K, Muller, R, Haybaeck, J, Vandenbroucke, RE, Ogris, M, Libert, C, Kiemer, AK.
Transient Hepatic Overexpression of Insulin-Like Growth Factor 2 Induces Free Cholesterol and Lipid Droplet Formation
Front Physiol 7, 147, 2016. (Epub 2016 Apr 25)

Koks, S, Dogan, S, Tuna, BG, Gonzalez-Navarro, H, Potter, P, Vandenbroucke, RE.
Mouse models of ageing and their relevance to disease
Mech Ageing Dev 160, 41-53, 2016. (Epub 2016 Oct 4)

Lievens, S, Van der Heyden, J, Masschaele, D, De Ceuninck, L, Petta, I, Gupta, S, De Puysseleir, V, Vauthier, V, Lemmens, I, De Clercq, D, Defever, D, Vanderroost, N, De Smet, AS, Eyckerman, S, Van Calenbergh, S, Martens, L, De Bosscher, K, Libert, C, Hill, D, et al..
Proteome-scale binary interactomics in human cells
Mol Cell Proteomics 15, 3624-3639, 2016. (Epub 2016 Nov 1)

Petta, I, Dejager, L, Ballegeer, M, Lievens, S, Tavernier, J, De Bosscher, K, Libert, C.
The Interactome of the Glucocorticoid Receptor and Its Influence on the Actions of Glucocorticoids in Combatting Inflammatory and Infectious Diseases
Microbiol Mol Biol Rev 80, 495-522, 2016. (Epub 2016 May 11)

Petta, I, Lievens, S, Libert, C, Tavernier, J, De Bosscher, K.
Modulation of protein-protein interactions for the development of novel therapeutics
Mol Ther 24, 707-718, 2016. (Epub 2015 Dec 17)

Ratman, D, Mylka, V, Bougarne, N, Pawlak, M, Caron, S, Hennuyer, N, Paumelle, R, De Cauwer, L, Thommis, J, Rider, MH, Libert, C, Lievens, S, Tavernier, J, Staels, B, De Bosscher, K.
Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARalpha
Nucleic Acids Res 15, 10539-10553, 2016. (Epub 2016 Aug 30)

Robajac, D, Vanhooren, V, Masnikosa, R, Mikovic, Z, Mandic, V, Libert, C, Nedic, O.
Preeclampsia transforms membrane N-glycome in human placenta
Exp Mol Pathol 100, 26-30, 2016. (Epub 2015 Dec 2)

Steeland, S, Timmermans, S, Van Ryckeghem, S, Hulpiau, P, Saeys, Y, Van Montagu, M, Vandenbroucke, RE, Libert, C.
Efficient analysis of mouse genome sequences reveal many nonsense variants
Proc Natl Acad Sci U S A 113, 5670-5675, 2016. (Epub 2016 May 17)

Steeland, S, Vandenbroucke, RE, Libert, C.
Nanobodies as therapeutics: big opportunities for small antibodies
Drug Discov Today 21, 1076-1113, 2016. (Epub 2016 Apr 11)

Storck, SE, Meister, S, Nahrath, J, Meissner, JN, Schubert, N, Di Spiezio, A, Baches, S, Vandenbroucke, RE, Bouter, Y, Prikulis, I, Korth, C, Weggen, S, Heimann, A, Schwaninger, M, Bayer, TA, Pietrzik, CU.
Endothelial LRP1 transports amyloid-beta1-42 across the blood-brain barrier
J Clin Invest 126, 123-136, 2016. (Epub 2015 Nov 30)

Stremersch, S, Vandenbroucke, RE, Van Wonterghem, E, Hendrix, A, De Smedt, SC, Raemdonck, K.
Comparing exosome-like vesicles with liposomes for the functional cellular delivery of small RNAs
J Control Release 232, 51-61, 2016. (Epub 2016 Apr 9)

Van Cauwenberghe, C, Vandendriessche, C, Libert, C, Vandenbroucke, RE.
Caloric restriction: beneficial effects on brain aging and Alzheimer's disease
Mamm Genome 27, 300-319, 2016. (Epub 2016 May 30)

Vandenbroucke, RE.
A Hidden Epithelial Barrier in the Brain with a Central Role in Regulating Brain Homeostasis. Implications for Aging
Ann Am Thorac Soc 13, S407-S410, 2016. (Epub 2016 Dec 13)

Van Hove, I, Lefevere, E, De Groef, L, Sergeys, J, Salinas-Navarro, M, Libert, C, Vandenbroucke, R, Moons, L.
MMP-3 Deficiency Alleviates Endotoxin-Induced Acute Inflammation in the Posterior Eye Segment
Int J Mol Sci 17, E1825, 2016. (Epub 2016 Nov 1)

Xiong, R, Vandenbroucke, RE, Broos, K, Brans, T, Van Wonterghem, E, Libert, C, Demeester, J, De Smedt, SC, Braeckmans, K.
Sizing nanomaterials in bio-fluids by cFRAP enables protein aggregation measurements and diagnosis of bio-barrier permeability
Nat Commun 7, 12982, 2016. (Epub 2016 Sep 22)

Aerts, J, Vandenbroucke, RE, Dera, R, Balusu, S, Van Wonterghem, E, Moons, L, Libert, C, Dehaen, W, Arckens, L.
Synthesis and Validation of a Hydroxypyrone-Based, Potent, and Specific Matrix Metalloproteinase-12 Inhibitor with Anti-Inflammatory Activity In Vitro and In Vivo
Mediators Inflamm 2015, 510679, 2015. (Epub 2015 Aug 13)

Borelli, V, Vanhooren, V, Lonardi, E, Reiding, KR, Capri, M, Libert, C, Garagnani, P, Salvioli, S, Franceschi, C, Wuhrer, M.
Plasma N-Glycome Signature of Down Syndrome
Journal of proteome research 14, 4232-4245, 2015. (Epub 2015 Sep 14)

Brkic, M, Balusu, S, Libert, C, Vandenbroucke, RE.
Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases
Mediators Inflamm 2015, 620581, 2015. (Epub 2015 Oct 11)

Brkic, M, Balusu, S, Van Wonterghem, E, Gorle, N, Benilova, I, Kremer, A, Van Hove, I, Moons, L, De Strooper, B, Kanazir, S, Libert, C, Vandenbroucke, RE.
Amyloid beta Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases
J Neurosci 35, 12766-78, 2015. (Epub 2015 Sep 16)

Burkle, A, Moreno-Villanueva, M, Bernhard, J, Blasco, M, Zondag, G, Hoeijmakers, JH, Toussaint, O, Grubeck-Loebenstein, B, Mocchegiani, E, Collino, S, Gonos, ES, Sikora, E, Gradinaru, D, Dolle, M, Salmon, M, Kristensen, P, Griffiths, HR, Libert, C, Grune, T, et al..
MARK-AGE biomarkers of ageing
Mech Ageing Dev 151, 2-12, 2015. (Epub 2015 Mar 24)

De Groef, L, Salinas-Navarro, M, Van Imschoot, G, Libert, C, Vandenbroucke, RE, Moons, L.
Decreased TNF Levels and Improved Retinal Ganglion Cell Survival in MMP-2 Null Mice Suggest a Role for MMP-2 as TNF Sheddase
Mediators Inflamm 2015, 108617, 2015. (Epub 2015 Sep 15)

Dejager, L, Dendoncker, K, Eggermont, M, Souffriau, J, Van Hauwermeiren, F, Willart, M, Van Wonterghem, E, Naessens, T, Ballegeer, M, Vandevyver, S, Hammad, H, Lambrecht, B, De Bosscher, K, Grooten, J, Libert, C.
Neutralizing TNFalpha restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation
Mucosal Immunol 8, 1212-1225, 2015. (Epub 2015 Mar 11)

Demeestere, D, Libert, C, Vandenbroucke, RE.
Clinical implications of leukocyte infiltration at the choroid plexus in (neuro)inflammatory disorders
Drug Discov Today 20, 928-941, 2015. (Epub 2015 May 13)

Demeestere, D, Libert, C, Vandenbroucke, RE.
Therapeutic implications of the choroid plexus-cerebrospinal fluid interface in neuropsychiatric disorders
Brain Behav Immun 50, 1-13, 2015. (Epub 2015 Jun 23)

Gao, Q, Sun, W, Ballegeer, M, Libert, C, Chen, W.
Predominant contribution of cis-regulatory divergence in the evolution of mouse alternative splicing
Mol Syst Biol 11, 816, 2015. (Epub 2015 Jul 1)

Grine, L, Dejager, L, Libert, C, Vandenbroucke, RE.
Dual Inhibition of TNFR1 and IFNAR1 in Imiquimod-Induced Psoriasiform Skin Inflammation in Mice
J Immunol 194, 5094-5102, 2015. (Epub 2015 Apr 24)

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