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Publications from this research unit

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Hubner, S, Dejager, L, Libert, C, Tuckermann, JP.
The glucocorticoid receptor in inflammatory processes: transrepression is not enough
Biol Chem 396, 1223-1231, 2015. (Epub 2015 Apr 24)

Libert, C.
Cytokine anniversary: TNF trailblazers five centuries apart
Nature 523, 158, 2015. (Epub 2015 Jul 9)

Puimege, L, Van Hauwermeiren, F, Steeland, S, Van Ryckeghem, S, Vandewalle, J, Lodens, S, Dejager, L, Vandevyver, S, Staelens, J, Timmermans, S, Vandenbroucke, RE, Libert, C.
Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1
EMBO Mol Med 7, 1004-1017, 2015. (Epub 2015 May 20)

Singh, P, Dejager, L, Amand, M, Theatre, E, Vandereyken, M, Zurashvili, T, Singh, M, Mack, M, Timmermans, S, Musumeci, L, Dejardin, E, Mustelin, T, Van Ginderachter, JA, Moutschen, M, Oury, C, Libert, C, Rahmouni, S.
DUSP3 Genetic Deletion Confers M2-like Macrophage-Dependent Tolerance to Septic Shock
J Immunol 194, 4951-4962, 2015. (Epub 2015 Apr 15)

Sklyarova, T, van Hengel, J, Van Wonterghem, E, Libert, C, van Roy, F, Vandenbroucke, RE.
Hematopoietic plakophilin-3 regulates acute tissue-specific and systemic inflammation in mice
Eur J Immunol 45, 2898-2910, 2015. (Epub 2015 Jul 14)

Sundahl, N, Bridelance, J, Libert, C, De Bosscher, K, Beck, IM.
Selective glucocorticoid receptor modulation: New directions with non-steroidal scaffolds
Pharmacol Ther 152, 28-41, 2015. (Epub 2015 May 6)

Testa, R, Vanhooren, V, Bonfigli, AR, Boemi, M, Olivieri, F, Ceriello, A, Genovese, S, Spazzafumo, L, Borelli, V, Bacalini, MG, Salvioli, S, Garagnani, P, Dewaele, S, Libert, C, Franceschi, C.
N-glycomic changes in serum proteins in type 2 diabetes mellitus correlate with complications and with metabolic syndrome parameters
PLoS One 10, e0119983, 2015. (Epub 2015 Mar 20)

Timmermans, S, Van Hauwermeiren, F, Puimege, L, Dejager, L, Van Wonterghem, E, Vanhooren, V, Mestdagh, P, Libert, C, Vandenbroucke, RE.
Determining differentially expressed miRNAs and validating miRNA-target relationships using the SPRET/Ei mouse strain
Mamm Genome 26, 94-107, 2015. (Epub 2014 Dec 10)

Vanden Berghe, T, Hulpiau, P, Martens, L, Vandenbroucke, RE, Van Wonterghem, E, Perry, SW, Bruggeman, I, Divert, T, Choi, SM, Vuylsteke, M, Shestopalov, VI, Libert, C, Vandenabeele, P.
Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice
Immunity 43, 200-209, 2015. (Epub 2015 Jul 21)

Vanhooren, V, Santos, AN, Voutetakis, K, Petropoulos, I, Libert, C, Simm, A, Gonos, ES, Friguet, B.
Protein modification and maintenance systems as biomarkers of ageing
Mech Ageing Dev 151, 71-84, 2015. (Epub 2015 Apr 3)

Vettorazzi, S, Bode, C, Dejager, L, Frappart, L, Shelest, E, Klassen, C, Tasdogan, A, Reichardt, HM, Libert, C, Schneider, M, Weih, F, Henriette Uhlenhaut, N, David, JP, Graler, M, Kleiman, A, Tuckermann, JP.
Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1
Nat Commun 6, 7796, 2015. (Epub 2015 Jul 17)

Vilar-Bergua, A, Riba-Llena, I, Vanhooren, V, Dewaele, S, Libert, C, Penalba, A, Montaner, J, Delgado, P.
N-glycome Profile Levels Relate to Silent Brain Infarcts in a Cohort of Hypertensives
J Am Heart Assoc 4, 11, 2015. (Epub 2015 Nov 23)

De Bock, M, Vandenbroucke, RE, Decrock, E, Culot, M, Cecchelli, R, Leybaert, L.
A new angle on blood-CNS interfaces: A role for connexins?
FEBS Lett 588, 1259-1270, 2014. (Epub 2014 Mar 12)

De Bosscher, K, Beck, IM, Dejager, L, Bougarne, N, Gaigneaux, A, Chateauvieux, S, Ratman, D, Bracke, M, Tavernier, J, Vanden Berghe, W, Libert, C, Diederich, M, Haegeman, G.
Selective modulation of the glucocorticoid receptor can distinguish between transrepression of NF-kappaB and AP-1
Cell Mol Life Sci 71, 143-163, 2014. (Epub 2013 Jun 20)

Dejager, L, Vandevyver, S, Ballegeer, M, Van Wonterghem, E, An, L-L, Riggs, J, Kolbeck., R, Libert, C.
Pharmacological inhibition of Type I Interferon signaling protects mice against lethal sepsis
J Infect Dis 209, 960-970, 2014. (Epub 2013 Nov 11)

Dejager, L, Vandevyver, S, Petta, I, Libert, C.
Dominance of the strongest: Inflammatory cytokines versus glucocorticoids
Cytokine Growth Factor Rev 25, 21-33, 2014. (Epub 2013 Dec 24)

Desmet, SJ, Dejager, L, Clarisse, D, Thommis, J, Melchers, D, Bastiaensen, N, Ruijtenbeek, R, Beck, IM, Libert, C, Houtman, R, Meijer, OC, De Bosscher, K.
Cofactor profiling of the glucocorticoid receptor from a cellular environment
Methods Mol Biol 1204, 83-94, 2014. (Epub 2014 Aug 7)

De Temmerman, ML, Soenen, SJ, Symens, N, Lucas, B, Vandenbroucke, RE, Libert, C, Demeester, J, De Smedt, SC, Himmelreich, U, Rejman, J.
Magnetic layer-by-layer coated particles for efficient MRI of dendritic cells and mesenchymal stem cells
Nanomedicine (Lond) 9, 1363-1376, 2014. (Epub 2013 Oct 9)

Dewitte, H, Verbeke, R, Breckpot, K, Vandenbroucke, RE, Libert, C, De Smedt, SC, Lentacker, I.
Choose your models wisely: How different murine bone marrow-derived dendritic cell protocols influence the success of nanoparticulate vaccines in vitro
J Control Release 195, 138-146, 2014. (Epub 2014 Jun 21)

Grine, L, Dejager, L, Libert, C, Vandenbroucke, RE.
An inflammatory triangle in psoriasis: TNF, type I IFNs and IL-17
Cytok Growth Factor Rev 26, 25-33, 2014. (Epub 2014 Oct 31)

Laukens, D, Devisscher, L, Van den Bossche, L, Hindryckx, P, Vandenbroucke, RE, Vandewynckel, YP, Cuvelier, C, Brinkman, BM, Libert, C, Vandenabeele, P, De Vos, M.
Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death
Lab Invest 94, 1419-1430, 2014. (Epub 2014 Oct 13)

Libert, C, Dejager, L.
How steroids steer T cells
Cell Rep 7, 938-939, 2014. (Epub 2014 May 22)

Puimege, L, Libert, C, Van Hauwermeiren, F.
Regulation and dysregulation of tumor necrosis factor receptor-1
Cytokine Growth Factor Rev 25, 285-300, 2014. (Epub 2014 Mar 24)

Robajac, D, Masnikosa, R, Vanhooren, V, Libert, C, Mikovic, Z, Nedic, O.
The N-glycan profile of placental membrane glycoproteins alters during gestation and ageing
Mech Ageing Dev 138, 1-9, 2014. (Epub 2014 Feb 10)

Steeland, S, Puimege, L, Vandenbroucke, RE, Van Hauwermeiren, F, Haustraete, J, Devoogdt, N, Hulpiau, P, Leroux-Roels, G, Laukens, D, Meuleman, P, De Vos, M, Libert, C.
Generation and characterization of small single domain antibodies inhibiting human TNF receptor 1
J Biol Chem 290, 4022-4037, 2014. (Epub 2014 Dec 23)

Vandenbroucke, RE, Libert, C.
Is there new hope for therapeutic matrix metalloproteinase inhibition?
Nat Rev Drug Discov , 904-927, 2014. (Epub 2014 Nov 7)

Vandenbroucke, RE, Vanlaere, I, Van Hauwermeiren, F, Van Wonterghem, E, Wilson, C, Libert, C.
Pro-inflammatory effects of matrix metalloproteinase 7 in acute inflammation
Mucosal Immunol 7, 579-588, 2014. (Epub 2013 Oct 16)

Vandevyver, S, Dejager, L, Libert, C.
Comprehensive overview of the structure and regulation of the glucocorticoid receptor
Endocr Rev 35, 671-693, 2014. (Epub 2014 Jun 17)

Vandevyver, S, Dejager, L, Vandenbroucke, RE, Libert, C.
An acute phase protein ready to go therapeutic in sepsis
EMBO Mol Med 6, 2-3, 2014. (Epub 2014 Jan 9)

Van Hauwermeiren, F, Vandenbroucke, RE, Grine, L, Lodens, S, Van Wonterghem, E, De Rycke, R, De Geest, N, Hassan, B, Libert, C.
TNFR1-induced lethal inflammation is mediated by goblet and Paneth cell dysfunction
Mucosal Immunol 8, 828-840, 2014. (Epub 2014 Nov 26)

Van Hauwermeiren, F, Vandenbroucke, RE, Grine, L, Puimege, L, Van Wonterghem, E, Zhang, H, Libert, C.
Antisense oligonucleotides against TNFR1 prevent toxicity of TNF/IFNgamma treatment in mouse tumor models
Int J Cancer 135, 742-750, 2014. (Epub 2013 Dec 31)

Dall'olio, F, Vanhooren, V, Chen, CC, Slagboom, PE, Wuhrer, M, Franceschi, C.
N-glycomic biomarkers of biological aging and longevity: A link with inflammaging
Ageing Res Rev 12, 685-698, 2013. (Epub 2012 Feb 14)

Gatti, G, Nunez, NG, Nocera, DA, Dejager, L, Libert, C, Giraudo, C, Maccioni, M.
Direct effect of dsRNA mimetics on cancer cells induces endogenous IFN-beta production capable of improving dendritic cell function
Eur J Immunol 43, 1849-1861, 2013. (Epub 2013 May 2)

Moreno-Villanueva, M, Morath, J, Vanhooren, V, Elbert, T, Kolassa, S, Libert, C, BŸrkle, A, Kolassa, I-T.
N-Glycosylation profiling of plasma provides evidence for accelerated physiological aging in posttraumatic stress disorder
Translational Psychiatry 3, e320, 2013. (Epub 2013 Oct 29)

Pinheiro, I, Dejager, L, Petta, I, Vandevyver, S, Puimege, L, Mahieu, T, Ballegeer, M, Van Hauwermeiren, F, Riccardi, C, Vuylsteke, M, Libert, C.
LPS resistance of SPRET/Ei mice is mediated by Gilz, encoded by the Tsc22d3 gene on the X chromosome
EMBO Mol Med 5, 456-470, 2013. (Epub 2013 Mar 4)

Ratman, D, Vanden Berghe, W, Dejager, L, Libert, C, Tavernier, J, Beck, IM, De Bosscher, K.
How glucocorticoid receptors modulate the activity of other transcription factors: A scope beyond tethering
Mol Cell Endocrinol 380, 41-54, 2013. (Epub 2012 Dec 23)

Schughart, K, Libert, C, Kas, MJ.
Controlling complexity: the clinical relevance of mouse complex genetics
Eur J Hum Genet 21, 1191-1196, 2013. (Epub 2013 May 1)

Vandenbroucke, RE, Dejonckheere, E, Van Hauwermeiren, F, Lodens, S, De Rycke, R, Van Wonterghem, E, Staes, A, Gevaert, K, Lopez-Otin, C, Libert, C.
Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF
EMBO Mol Med 5, 1000-1016, 2013. (Epub 2013 May 30)

Vandevyver, S, Dejager, L, Tuckermann, J, Libert, C.
New insights into the anti-inflammatory mechanisms of glucocorticoids: an emerging role for glucocorticoid-receptor-mediated transactivation
Endocrinology 154, 993-1007, 2013. (Epub 2013 Feb 5)

Van Hauwermeiren, F, Armaka, M, Karagianni, N, Kranidioti, K, Vandenbroucke, RE, Loges, S, Van Roy, M, Staelens, J, Puimege, L, Palagani, A, Vanden Berghe, W, Victoratos, P, Carmeliet, P, Libert, C, Kollias, G.
Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium
J Clin Invest 123, 2590-2603, 2013. (Epub 2013 May 15)

Vanhooren, V, Libert, C.
The mouse as a model organism in aging research: Usefulness, pitfalls and possibilities
Ageing Res Rev 21, 8-21, 2013. (Epub 2012 Apr 17)

Vanhooren, V, Vandenbroucke, RE, Dewaele, S, Van Hamme, E, Haigh, J, Hochepied, T, Libert, C.
Mice overexpressing beta-1,4-galactosyltransferase I are resistant to TNF-induced inflammation and DSS-induced colitis
PLoS One 8, e79883, 2013. (Epub 2013 Dec 5)

Bartling, B, Vanhooren, V, Dewaele, S, Libert, C, Hofmann, HS, Haerting, J, Nuding, S, Silber, RE, Simm, A, Chen, CC.
Altered desialylated plasma N-glycan profile in patients with non-small cell lung carcinoma
Cancer Biomarkers 10, 145-154, 2012. (Epub 2011/2012)

De Temmerman, ML, Rejman, J, Vandenbroucke, RE, De Koker, S, Libert, C, Grooten, J, Demeester, J, Gander, B, De Smedt, SC.
Polyelectrolyte LbL microcapsules versus PLGA microparticles for immunization with a protein antigen
J Control Release 158, 233-239, 2012. (Epub 2011 Oct 29)

De Temmerman, M, Rejman, J, Lucas, B, Vandenbroucke, RE, Libert, C, Demeester, J, De Smedt, SC.
Modulation of dendritic cells by lipid grafted polyelectrolyte microcapsules
Adv Funct Mater 122, 4236-4243, 2012. (Epub 2012 Jun 14)

Kleiman, A, Hubner, S, Rodriguez Parkitna, JM, Neumann, A, Hofer, S, Weigand, MA, Bauer, M, Schmid, W, Schütz, G, Libert, C, Reichardt, HM, Tuckermann, JP.
Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of Interleukin-1 in macrophages
FASEB J 26, 722-729, 2012. (Epub 2011 Oct 31)

Nunez, NG, Andreani, V, Crespo, MI, Nocera, DA, Breser, ML, Moron, G, Dejager, L, Libert, C, Rivero, V, Maccioni, M.
IFN beta produced by TLR4-activated tumor cells is involved in improving the antitumoral immune response
Cancer Res 72, 592-603, 2012. (Epub 2011 Dec 2)

Schughart, K, Libert, C, Kas, MJ.
Strength to strength for mouse models
Nature 492, 41, 2012. (Epub 2012 Dec 6)

Takahashi, N, Duprez, L, Grootjans, S, Cauwels, A, Nerinckx, W, Duhadaway, JB, Goossens, V, Roelandt, R, Van Hauwermeiren, F, Libert, C, Declercq, W, Callewaert, N, Prendergast, GC, Degterev, A, Yuan, J, Vandenabeele, P.
Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models
Cell Death Dis 3, e437, 2012. (Epub 2012 Nov 29)

Vandenbroucke, RE, Dejonckheere, E, Van Lint, P, Demeestere, D, Van Wonterghem, E, Vanlaere, I, Puimege, L, Van Hauwermeiren, F, De Rycke, R, Mc Guire, C, Campestre, C, Lopez-Otin, C, Matthys, P, Leclercq, G, Libert, C.
Matrix Metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases
J Neurosci 32, 9805-9816, 2012. (Epub 2012 Jul 18)

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