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Publications from this research unit

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Desmyter, L, Verstraelen, J, Dewaele, S, Libert, C, Contreras, R, Chen, C.
Nonclassical export pathway: overexpression of NCE102 reduces protein and DNA damage and prolongs lifespan in an SGS1 deficient Saccharomyces cerevisiae
Biogerontology 8, 527-535, 2007. (Epub 2007 Apr 6)

Kaileh, M, Vanden Berghe, W, Heyerick, A, Horion, J, Piette, J, Libert, C, De Keukeleire, D, Essawi, T, Haegeman, G.
Withaferin A strongly elicits IKKbeta hyperphosphorylation, concomitant with potent inhibition of its kinase activity
J Biol Chem 282, 4253-4264, 2007. (Epub 2006 Dec 6)

Liu, X-E, Desmyter, L, Gao, C-F, Laroy, W, Dewaele, S, Vanhooren, V, Wang, L, Zhuang, H, Callewaert, N, Libert, C, Contreras, R, Chen, C.
N-Glycomic changes in hepatocellular carcinoma patients with liver cirrhosis induced by hepatitis B virus
Hepatology 46, 1426-1435, 2007. (Epub 2007 Aug 7)

Mahieu, T, Libert, C.
Should we inhibit type I IFNs in sepsis?
Infect Immun 75, 22-29, 2007. (Epub 2006 Sep 25)

Tian, L, Stefanidakis, M, Ning, L, Van Lint, P, Nyman-Huttunen, H, Libert, C, Itohara, S, Mishina, M, Rauvala, H, Gahmberg, CG.
Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage
J Cell Biol 178, 687-700, 2007. (Epub 2007 Aug 6)

Vanhooren, V, Desmyter, L, Liu, XE, Cardelli, M, Franceschi, C, Federico, A, Libert, C, Laroy, W, Dewaele, S, Contreras, R, Chen, C.
N-Glycomic Changes in Serum Proteins During Human Aging
Rejuvenation Res 10, 521-531a, 2007. (Epub 2007 Nov 29)

Van Lint, P, Libert, C.
Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation
J Leukocyte Biol 82, 1375-1381, 2007. (Epub 2007 Aug 20)

Van Molle, W, Van Roy, M, Van Bogaert, T, Dejager, L, Van Lint, P, Vanlaere, I, Sekikawa, K, Kollias, G, Libert, C.
Protection of zinc against TNF-induced lethal inflammation depends on HSP70 and allows safe anti-tumor therapy
Cancer Res 67, 7301-7307, 2007. (Epub ---)

Van Roy, M, Van Lint, P, Van Laere, I, Wielockx, B, Wilson, C, Lopez-Otin, C, Shapiro, S, Libert, C.
Involvement of specific matrix metalloproteinases during tumor necrosis factor/IFN{gamma} based cancer therapy in mice
Mol Cancer Ther 6, 2563-2571, 2007. (Epub ---)

Van Roy, M, Wielockx, B, Baker, A, Libert, C.
The use of tissue inhibitors of matrix metalloproteinases to increase the efficacy of a tumor necrosis factor/interferongamma antitumor therapy
Cancer Gene Ther 14, 372-379, 2007. (Epub 2007 Jan 12)

Wielockx, B, Staelens, J, Puimege, L, Vanlaere, I, Van Roy, M, van Lint, P, Van Roy, F, Libert, C.
Description and mapping of the resistance of DBA/2 mice to TNF-induced lethal shock
J Immunol 178, 5069-5075, 2007. (Epub ---)

Mahieu, T, Park, JM, Revets, H, Pasche, B, Lengeling, A, Staelens, S, Wullaert, A, Vanlaere, I, Hochepied, T, Van Roy, F, Karin, M, Libert, C.
The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production
Proc Natl Acad Sci USA 103, 2292-2297, 2006. (Epub 2006 Feb 2)

Van Lint, P, Libert, C.
Matrix metalloproteinase-8: Cleavage can be decisive
Cytokine Growth Factor Rev 17, 217-223, 2006. (Epub 2006 Jul 3)

De Bosscher, K, Vanden Berghe, W, Van Molle, W, Hapgood, J, Libert, C, Louw, A, Staels, B, Haegeman, G.
A fully dissociated compound of plant origin for inflammatory gene repression
Proc Natl Acad Sci USA 102, 15827-15832, 2005. (Epub 2005 Oct 24)

Masson, V, de la Ballina, LR, Munaut, C, Wielockx, B, Jost, M, Maillard, C, Blacher, S, Bajou, K, Itoh, T, Itohara, S, Werb, Z, Libert, C, Foidart, JM, Noel, A.
Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes
FASEB J 19, 234-236, 2005. (Epub 2004 Nov 18)

van de Sand, C, Horstmann, S, Schmidt, A, Sturm, A, Bolte, S, Krueger, A, Lütgehetmann, M, Libert, C.
The liver stage of Plasmodium berghei inhibits host cell apoptosis
Mol Microbiol 58, 731-742, 2005. (Epub 2005 Sep 22)

Van Lint, P, Wielockx, B, Puimège, L, Noël, A, López-Otin, C, Libert, C.
Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis
J Immunol 175, 7642-7649, 2005. (Epub ---)

Van Molle, W, Libert, C.
How glucocorticoids control their own strength and the balance between pro- and anti-inflammatory mediators
Eur J Immunol 35, 3396-3399, 2005. (Epub 2005 Dec 6)

Wullaert, A, Wielockx, B, Van Huffel, S, Bogaert, V, De Geest, B, Papeleu, P, Schotte, P, El Bakkouri, K, Heyninck, K, Libert, C, Beyaert, R.
Adenoviral gene transfer of ABIN-1 protects mice from TNF/galactosamine-induced acute liver failure and lethality
Hepatology 42, 381-389, 2005. (Epub ---)

de Vries, B, Walter, S, Wolfs, T, Hochepied, T, Rabina, J, Heeringa, P, Parkkinen, J, Libert, C, Buurman, W.
Exogenous alpha-1-acid glycoprotein protects against renal ischemia-reperfusion injury by inhibition of inflammation and apoptosis.
Transplantation 78, 1116-1124, 2004. (Epub ---)

Hochepied, T, Schoonjans, L, Staelens, J, Kreemers, V, Danloy, S, Puimège, L, Collen, D, Van Roy, F, Libert, C.
Breaking the species barrier: derivation of germline-competent embryonic stem cells from Mus spretus x C57BL/6 hybrids
Stem Cells 22, 441-447, 2004. (Epub ---)

Staelens, J, Puimège, L, Mahieu, T, Pynaert, G, Hochepied, T, Vandenabeele, A, Grooten, J, Kontoyiannis, D, Van Roy, F, Kollias, G, Libert, C.
Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders
Mamm Genome 15, 537-543, 2004. (Epub ---)

Wielockx, B, Libert, C, Wilson, C.
Matrilysin (Matrix Metalloproteinase-7): a new promising drug target in cancer and inflammation?
Cytokine Growth Factor Rev 15, 111-115, 2004. (Epub ---)

Hochepied, T, Berger, FG, Baumann, H, Libert, C.
a1-Acid glycoprotein: An acute phase protein with inflammatory and immunomodulating properties
Cytokine Growth Factor Rev 14, 25-34, 2003. (Epub ---)

Lambert, V, Wielockx, B, Munaut, C, Galopin, C, Jost, M, Itoh, T, Werb, Z, Baker, A, Libert, C, Krell, H-W, Foidart, J-M, Noël, A, Rakic, J-M.
MMP-2 and MMP-9 synergize in promoting choroidal neovascularization
FASEB J 17, 2290-2292, 2003. (Epub ---)

Libert, C.
Inflammation: A nervous connection (News & Views)
Nature 421, 328-329, 2003. (Epub ---)

Libert, C.
The Lancet 362, 1426, 2003. (Epub ---)

Van Molle, W, Libert, C.
Bilirubin release induced by tumor necrosis factor in combination with galactosamine is toxic to mice
Cytokine 23, 94-100, 2003. (Epub ---)

Wielockx, B, Libert, C.
Serine proteases of the fibrinolysis pathway are not involved in lethal hepatitis and fibrinogen breakdown induced by tumour necrosis factor
Cytokine 21, 281-285, 2003. (Epub ---)

Bilsborough, J, Uyttenhove, C, Colau, D, Bousso, P, Libert, C, Weynand, B, Boon, T, Van den Eynde, BJ.
TNF-mediated toxicity after massive induction of specific CD8+ T cells following immunization of mice with a tumor-specific peptide
J Immunol 169, 3053-3060, 2002. (Epub ---)

Hochepied, T, Van Leuven, F, Libert, C.
Mice lacking a2-macroglobulin show an increased host defence against Gram-negative bacterial sepsis, but are more susceptible to endotoxic shock
Eur Cytokine Netw 13, 86-91, 2002. (Epub ---)

Hochepied, T, Wullaert, A, Berger, FG, Baumann, H, Brouckaert, P, Steidler, L, Libert, C.
Overexpression of a1-acid glycoprotein in transgenic mice leads to sensitisation to acute colitis
Gut 51, 398-404, 2002. (Epub ---)

Staelens, J, Wielockx, B, Puimège, L, Van Roy, F, Guénet, J-L, Libert, C.
Hyporesponsiveness of SPRET/Ei mice to lethal shock induced by tumor necrosis factor and implications for a TNF-based antitumor therapy
Proc Natl Acad Sci USA 99, 9340-9345, 2002. (Epub 2002 Jun 27)

Van Molle, W, Wielockx, B, Mahieu, T, Takada, M, Taniguchi, T, Sekikawa, K, Libert, C.
HSP70 protects against TNF-induced lethal inflammatory shock
Immunity 16, 685-695, 2002. (Epub ---)

Dick, JMC, Van Molle, W, Libert, C, Lefebvre, RA.
Antisense knockdown of inducible nitric oxide synthase inhibits the relaxant effect of VIP in isolated smooth muscle cells of the mouse gastric fundus
Br J Pharmacol 134, 425-433, 2001. (Epub ---)

Waelput, W, Broekaert, D, Vandekerckhove, J, Brouckaert, P, Tavernier, J, Libert, C.
A mediator role for metallothionein in tumor necrosis factor-induced lethal shock
J Exp Med 194, 1617-1624, 2001. (Epub ---)

Wielockx, B, Bussolino, F, Shapiro, SD, Libert, C.
Involvement of a serine protease, but not of neutrophil elastase, in tumor necrosis factor-induced lethal hepatitis and induction of platelet-activating factor
J Hepatol 35, 490-497, 2001. (Epub ---)

Wielockx, B, Hochepied, T, Staelens, J, Van Molle, W, Brouckaert, P, Libert, C.
Detection, characterisation and purification of a murine liver factor capable of desensitising towards the lethal activity of tumour necrosis factor
Cytokine 15, 59-65, 2001. (Epub ---)

Wielockx, B, Lannoy, K, Shapiro, SD, Itoh, T, Itohara, S, Vandekerckhove, J, Libert, C.
Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy
Nat Med 7, 1202-1208, 2001. (Epub ---)

Hochepied, T, Ameloot, P, Brouckaert, P, Van Leuven, F, Libert, C.
Differential response of a2-macroglobulin-deficient mice in models of lethal TNF-induced inflammation
Eur Cytokine Netw 11, 597-601, 2000. (Epub ---)

Hochepied, T, Van Molle, W, Berger, FG, Baumann, H, Libert, C.
Involvement of the acute phase protein a1-acid glycoprotein in nonspecific resistance to a lethal Gram-negative infection
J Biol Chem 275, 14903-14909, 2000. (Epub ---)

Van Molle, W, Hochepied, T, Brouckaert, P, Libert, C.
The major acute-phase protein, serum amyloid P component, in mice is not involved in endogenous resistance against tumor necrosis factor alpha-induced lethal hepatitis, shock, and skin necrosis
Infect Immun 68, 5026-5029, 2000. (Epub ---)

Van Molle, W, Vanden Berghe, J, Brouckaert, P, Libert, C.
Tumor necrosis factor-induced lethal hepatitis: Pharmacological intervention with verapamil, tannic acid, picotamide and K76COOH
FEBS Lett 467, 201-205, 2000. (Epub ---)

Libert, C, Wielockx, B, Grijalba, B, Van Molle, W, Kremmer, E, Colten, HR, Fiers, W, Brouckaert, P.
The role of complement activation in tumour necrosis factor-induced lethal hepatitis
Cytokine 11, 617-625, 1999. (Epub ---)

Libert, C, Wielockx, B, Hammond, GL, Brouckaert, P, Fiers, W, Elliott, RW.
Identification of a locus on distal mouse chromosome 12 that controls resistance to tumor necrosis factor-induced lethal shock
Genomics 55, 284-289, 1999. (Epub ---)

Van Molle, W, Brouckaert, P, Libert, C.
Caspase-1 is not involved in experimental hepatitis in mouse
FEBS Lett 445, 115-118, 1999. (Epub ---)

Van Molle, W, Denecker, G, Rodriguez, I, Brouckaert, P, Vandenabeele, P, Libert, C.
Activation of caspases in lethal experimental hepatitis and prevention by acute phase proteins
J Immunol 163, 5235-5241, 1999. (Epub ---)

Libert, C, Hochepied, T, Berger, FG, Baumann, H, Fiers, W, Brouckaert, P.
High-level constitutive expression of a1-acid glycoprotein and lack of protection against tumor necrosis factor-induced lethal shock in transgenic mice
Transgenic Res 7, 429-435, 1998. (Epub ---)

Lattanzio, G, Libert, C, Aquilina, M, Cappelletti, M, Ciliberto, G, Musiani, P, Poli, V.
Defective development of pristane-oil-induced plasmacytomas in interleukin-6-deficient BALB/c mice
Am J Pathol 151, 689-696, 1997. (Epub ---)

Van Molle, W, Libert, C, Fiers, W, Brouckaert, P.
a1-Acid glycoprotein and a1-antitrypsin inhibit TNF-induced but not anti-Fas-induced apoptosis of hepatocytes in mice
J Immunol 159, 3555-3564, 1997. (Epub ---)

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