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Publications from this research unit
This page shows only publications with IRC as the affiliation of at least one author.
Publications by IRC members mentioning other affiliations are not in our database. Sorry.
See "Extra muros" papers of the units.
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de Haan, W, Dheedene, W, Apelt, K, Decombas-Deschamps, S, Vinckier, S, Verhulst, S, Conidi, A, Deffieux, T, Staring, MW, Vandervoort, P, Caluwe, E, Lox, M, Mannaerts, I, Takagi, T, Jaekers, J, Berx, G, Haigh, J, Topal, B, Zwijsen, A, et al.. Endothelial Zeb2 preserves the hepatic angioarchitecture and protects against liver fibrosis Cardiovasc Res 118, 1262-1275, 2022. (Epub 2021 Apr 28) 
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Ghazavi, F, Huysentruyt, J, De Coninck, J, Kourula, S, Martens, S, Hassannia, B, Wartewig, T, Divert, T, Roelandt, R, Popper, B, Hiergeist, A, Tougaard, P, Vanden Berghe, T, Joossens, M, Berx, G, Takahashi, N, Wahida, A, Vandenabeele, P. Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state Proc Natl Acad Sci U S A 119, e2024508119, 2022. (Epub 2022 Feb 8)
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Han, Y, Villarreal-Ponce, A, Gutierrez, G, Jr., Nguyen, Q, Sun, P, Wu, T, Sui, B, Berx, G, Brabletz, T, Kessenbrock, K, Zeng, YA, Watanabe, K, Dai, X. Coordinate control of basal epithelial cell fate and stem cell maintenance by core EMT transcription factor Zeb1 Cell Rep 38, 110240, 2022. (Epub 2022 Jan 11)
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Jonckheere, S, Adams, J, De Groote, D, Campbell, K, Berx, G, Goossens, S. Epithelial-Mesenchymal Transition (EMT) as a Therapeutic Target Cells Tissues Organs 211, 157-182, 2022. (Epub 2021 Jan 5)
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Loret, N, Vandamme, N, De Coninck, J, Taminau, J, De Clercq, K, Blancke, G, Jonckheere, S, Goossens, S, Lemeire, K, De Prijck, S, Verstaen, K, Seurinck, R, Van Dorpe, J, Weyers, S, Denys, H, Van de Vijver, K, Lambrecht, BN, Tummers, P, Saeys, Y, et al.. Distinct transcriptional programs in ascitic and solid cancer cells induce different responses to chemotherapy in high-grade serous ovarian cancer Mol Cancer Res 20, 1532-1547, 2022. (Epub 2022 Jun 24)
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Martens, S, Takahashi, N, Blancke, G, Vandamme, N, Verschuere, H, Divert, T, Vuylsteke, M, Berx, G, Vandenabeele, P. MLKL deficiency in Braf(V600E)Pten(-/-) melanoma model results in a modest delay of nevi development and reduced lymph node dissemination in male mice Cell Death Dis 13, 347, 2022. (Epub 2022 Apr 14)
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Pieters, T, Almeida, A, T'Sas, S, Lemeire, K, Hochepied, T, Berx, G, Kentsis, A, Goossens, S, Van Vlierberghe, P. Myb drives B-cell neoplasms and myeloid malignancies in vivo Blood Adv 6, 2987-2991, 2022. (Epub 2022 Jan 12)
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Haerinck, J, Berx, G. Partial EMT takes the lead in cancer metastasis Dev Cell 56, 3174-3176, 2021. (Epub 2021 Dec 6)
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Lasierra Losada, M, Pauler, M, Vandamme, N, Goossens, S, Berx, G, Leppkes, M, Schuhwerk, H, Brabletz, S, Brabletz, T, Stemmler, MP. Pancreas morphogenesis and homeostasis depends on tightly regulated Zeb1 levels in epithelial cells Cell Death Discov 7, 138, 2021. (Epub 2021 Jun 11)
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Picard, M, Yonekura, S, Slowicka, K, Petta, I, Rauber, C, Routy, B, Richard, C, Iebba, V, Tidjani Alou, M, Becharef, S, Ly, P, Pizzato, E, Lehmann, CHK, Amon, L, Klein, C, Opolon, P, Gomperts Boneca, I, Scoazec, JY, Hollebecque, A, et al.. Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients Cell Death Differ 28, 1532-1547, 2021. (Epub 2020 Dec 1)
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Pieters, T, T'Sas, S, Vanhee, S, Almeida, A, Driege, Y, Roels, J, Van Loocke, W, Daneels, W, Baens, M, Marchand, A, Van Trimpont, M, Matthijssens, F, Morscio, J, Lemeire, K, Lintermans, B, Reunes, L, Chaltin, P, Offner, F, Van Dorpe, J, et al.. Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice J Exp Med 218, e20202280, 2021. (Epub 2021 Oct 4)
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Ruh, M, Stemmler, MP, Frisch, I, Fuchs, K, van Roey, R, Kleemann, J, Roas, M, Schuhwerk, H, Eccles, RL, Agaimy, A, Baumhoer, D, Berx, G, Muller, F, Brabletz, T, Brabletz, S. The EMT transcription factor ZEB1 blocks osteoblastic differentiation in bone development and osteosarcoma J Pathol 254, 199-211, 2021. (Epub 2021 Mar 5)
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Sreekumar, R, Al-Saihati, H, Emaduddin, M, Moutasim, K, Mellone, M, Patel, A, Kilic, S, Cetin, M, Erdemir, S, Navio, MS, Lopez, MA, Curtis, N, Yagci, T, Primrose, JN, Price, BD, Berx, G, Thomas, GJ, Tulchinsky, E, Mirnezami, A, et al.. The ZEB2-dependent EMT transcriptional programme drives therapy resistance by activating nucleotide excision repair genes ERCC1 and ERCC4 in colorectal cancer Mol Oncol 15, 2065-2083, 2021. (Epub 2021 May 1)
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Wahida, A, Muller, M, Hiergeist, A, Popper, B, Steiger, K, Branca, C, Tschurtschenthaler, M, Engleitner, T, Donakonda, S, De Coninck, J, Ollinger, R, Pfautsch, MK, Muller, N, Silva, M, Usluer, S, Thiele Orberg, E, Bottcher, JP, Pfarr, N, Anton, M, et al.. XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells Sci Immunol 6, eabf7235, 2021. (Epub 2021 Nov 5)
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Wang, J, Farkas, C, Benyoucef, A, Carmichael, C, Haigh, K, Wong, N, Huylebroeck, D, Stemmler, MP, Brabletz, S, Brabletz, T, Nefzger, CM, Goossens, S, Berx, G, Polo, JM, Haigh, JJ. Interplay between the EMT transcription factors ZEB1 and ZEB2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity PLoS Biol 19, e3001394, 2021. (Epub 2021 Sep 22)
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Aaes, TL, Verschuere, H, Kaczmarek, A, Heyndrickx, L, Wiernicki, B, Delrue, I, De Craene, B, Taminau, J, Delvaeye, T, Bertrand, MJM, Declercq, W, Berx, G, Krysko, DV, Adjemian, S, Vandenabeele, P. Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection J Immunol 204, 775-787, 2020. (Epub 2020 Jan 3)
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Bruneel, K, Verstappe, J, Vandamme, N, Berx, G. Intrinsic Balance between ZEB Family Members Is Important for Melanocyte Homeostasis and Melanoma Progression Cancers (Basel) 12, 2248, 2020. (Epub 2020 Aug 11)
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Carmichael, CL, Wang, J, Nguyen, T, Kolawole, O, Benyoucef, A, De Maziere, C, Milne, A, Samuel, S, Gillinder, KR, Hediyeh-Zadeh, S, Vo, ANQ, Huang, Y, Knezevic, K, McInnes, WRL, Shields, BJ, Mitchell, H, Ritchie, ME, Lammens, T, Lintermans, B, et al.. The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1 Blood 136, 957-973, 2020. (Epub 2020 May 5)
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De Thaye, E, Van de Vijver, K, Van der Meulen, J, Taminau, J, Wagemans, G, Denys, H, Van Dorpe, J, Berx, G, Ceelen, W, Van Bocxlaer, J, De Wever, O. Establishment and characterization of a cell line and patient-derived xenograft (PDX) from peritoneal metastasis of low-grade serous ovarian carcinoma Sci Rep 10, 6688, 2020. (Epub 2020 Apr 21)
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Slowicka, K, Petta, I, Blancke, G, Hoste, E, Dumas, E, Sze, M, Vikkula, H, Radaelli, E, Haigh, J, Jonckheere, S, Taminau, J, Vandamme, N, Wullaert, A, Tulchinsky, E, Nittner, D, Van Vlierberghe, P, De Hertogh, G, Baldin, P, Etlioglu, E, et al. Berx, G, Vereecke, L, van Loo,G. Zeb2 drives invasive and microbiota-dependent colon carcinoma Nature Cancer 1, 620-634, 2020. (Epub 2020 Jun 15)
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Vandamme, N, Denecker, G, Bruneel, K, Blancke, G, Akay, O, Taminau, J, De Coninck, J, De Smedt, E, Skrypek, N, Van Loocke, W, et al.,Nittner, D, Kohler, C, et al.,Bouchez, L, et al, Andries, V, Rambow, F, Van Vlierberghe, P, Goossens, S, van den Oord, J, Marine, J-C, Berx, G The EMT transcription factor ZEB2 promotes proliferation of primary and metastatic melanoma while suppressing an invasive, mesenchymal-like phenotype Cancer Res 80, 2983-2995, 2020. (Epub 2020 Jun 5)
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Yang, J, Antin, P, Berx, G, Blanpain, C, Brabletz, T, Bronner, M, Campbell, K, Cano, A, Casanova, J, Christofori, G, Dedhar, S, Derynck, R, Ford, HL, Fuxe, J, Garcia de Herreros, A, Goodall, GJ, Hadjantonakis, AK, Huang, RJY, Kalcheim, C, et al.. Guidelines and definitions for research on epithelial-mesenchymal transition Nat Rev Mol Cell Biol 21, 341-352, 2020. (Epub 2020 Apr 16)
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Andries, V, De Keuckelaere, E, Staes, K, Hochepied, T, Taminau, J, Lemeire, K, Birembaut, P, Berx, G, van Roy, F. A new mouse model to study the role of ectopic Nanos3 expression in cancer BMC Cancer 19, 598, 2019. (Epub 2019 Jun 17)
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De Coninck, S, Berx, G, Taghon, T, Van Vlierberghe, P, Goossens, S. ZEB2 in T-cells and T-ALL Adv Biol Regul 74, 100639, 2019. (Epub 2019 Jul 27)
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Doornaert, M, De Maere, E, Colle, J, Declercq, H, Taminau, J, Lemeire, K, Berx, G, Blondeel, P. Xenogen-free isolation and culture of human adipose mesenchymal stem cells Stem Cell Res 40, 101532, 2019. (Epub 2019 Aug 8)
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Doornaert, M, Depypere, B, Creytens, D, Declercq, H, Taminau, J, Lemeire, K, Monstrey, S, Berx, G, Blondeel, P. Human decellularized dermal matrix seeded with adipose-derived stem cells enhances wound healing in a murine model: Experimental study Ann Med Surg (Lond) 46, 4-11, 2019. (Epub 2019 Aug 7)
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Goossens, S, Wang, J, Tremblay, C, De Medts, J, T'Sas, S, Nguyen, T, Saw, J, Haigh, K, Curtis, DJ, Van Vlierberghe, P, Berx, G, Taghon, T, Haigh, JJ. ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms Haematologica 104, 1608-1616, 2019. (Epub 2019 Jan 24)
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Haensel, D, Sun, P, MacLean, AL, Ma, X, Zhou, Y, Stemmler, MP, Brabletz, S, Berx, G, Plikus, MV, Nie, Q, Brabletz, T, Dai, X. An Ovol2-Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation EMBO Rep 20, e46273, 2019. (Epub 2018 Nov 9)
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Jin, Q, Martinez, CA, Arcipowski, KM, Zhu, Y, Gutierrez-Diaz, BT, Wang, KK, Johnson, MR, Volk, A, Wang, F, Wu, J, Grove, C, Wang, H, Sokirniy, I, Thomas, PM, Goo, YA, et al., Vandamme, N, Berx, G, Goossens, S, et al.. USP7 cooperates with NOTCH1 to drive the oncogenic transcriptional program in T cell leukemia Clin Cancer Res 25, 222-239, 2019. (Epub 2018 Sep 17)
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Loret, N, Denys, H, Tummers, P, Berx, G. The Role of Epithelial-to-Mesenchymal Plasticity in Ovarian Cancer Progression and Therapy Resistance Cancers (Basel) 11, , 2019. (Epub 2019 Jun 17)
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Milani, G, Matthijssens, F, Van Loocke, W, Durinck, K, Roels, J, Peirs, S, Thenoz, M, Pieters, T, Reunes, L, Lintermans, B, Vandamme, N, Lammens, T, Van Roy, N, Van Nieuwerburgh, F, Deforce, D, Schwab, C, Raimondi, S, Dalla Pozza, L, Carroll, AJ, 3rd, et al.. Genetic characterization and therapeutic targeting of MYC-rearranged T cell acute lymphoblastic leukaemia Br J Haematol 185, 169-174, 2019. (Epub 2018 Jun 25)
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Pieters, T, T'Sas, S, Demoen, L, Almeida, A, Haenebalcke, L, Matthijssens, F, Lemeire, K, D'Hont, J, Van Rockeghem, F, Hochepied, T, Lintermans, B, Reunes, L, Lammens, T, Berx, G, Haigh, JJ, Goossens, S, Van Vlierberghe, P. Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies Sci Rep 9, 10577, 2019. (Epub 2019 Jul 22)
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Punovuori, K, Migueles, RP, Malaguti, M, Blin, G, Macleod, KG, Carragher, NO, Pieters, T, van Roy, F, Stemmler, MP, Lowell, S. N-cadherin stabilises neural identity by dampening anti-neural signals Development 146, dev183269, 2019. (Epub 2019 Nov 8)
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Vandamme, N, Berx, G. From neural crest cells to melanocytes: cellular plasticity during development and beyond Cell Mol Life Sci 76, 1919-1934, 2019. (Epub 2019 Mar 4)
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Van Hove, H, Martens, L, Scheyltjens, I, De Vlaminck, K, Pombo Antunes, AR, De Prijck, S, Vandamme, N, De Schepper, S, Van Isterdael, G, Scott, CL, Aerts, J, Berx, G, Boeckxstaens, GE, Vandenbroucke, RE, Vereecke, L, Moechars, D, Guilliams, M, Van Ginderachter, JA, Saeys, Y, Movahedi, K. A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment Nat Neurosci 22, 1021–1035, 2019. (Epub 2019 May 6)
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Bouhy, D, Juneja, M, Katona, I, Holmgren, A, Asselbergh, B, De Winter, V, Hochepied, T, Goossens, S, Haigh, JJ, Libert, C, Ceuterick-de Groote, C, Irobi, J, Weis, J, Timmerman, V. A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8 Acta Neuropathol 135, 131-148, 2018. (Epub 2017 Aug 5)
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De Jaeghere, E, De Vlieghere, E, Van Hoorick, J, Van Vlierberghe, S, Wagemans, G, Pieters, L, Melsens, E, Praet, M, Van Dorpe, J, Boone, MN, Ghobeira, R, De Geyter, N, Bracke, M, Vanhove, C, Neyt, S, Berx, G, De Geest, BG, Dubruel, P, Declercq, H, et al.. Heterocellular 3D scaffolds as biomimetic to recapitulate the tumor microenvironment of peritoneal metastases in vitro and in vivo Biomaterials 158, 95-105, 2018. (Epub 2017 Dec 23)
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De Keuckelaere, E, Hulpiau, P, Saeys, Y, Berx, G, van Roy, F. Nanos genes and their role in development and beyond Cell Mol Life Sci 75, 1929-1946, 2018. (Epub 2018 Feb 3)
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El Ashkar, S, Schwaller, J, Pieters, T, Goossens, S, Demeulemeester, J, Christ, F, Van Belle, S, Juge, S, Boeckx, N, Engelman, A, Van Vlierberghe, P, Debyser, Z, De Rijck, J. LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis Blood 131, 95-107, 2018. (Epub 2017 Oct 30)
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Renard, M, Vanhauwaert, S, Vanhomwegen, M, Rihani, A, Vandamme, N, Goossens, S, Berx, G, Van Vlierberghe, P, Haigh, JJ, Decaesteker, B, Van Laere, J, Lambertz, I, Speleman, F, Vandesompele, J, Willaert, A. Expressed repetitive elements are broadly applicable reference targets for normalization of reverse transcription-qPCR data in mice Sci Rep 8, 7642, 2018. (Epub 2018 May 16)
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Scott, CL, T'Jonck, W, Martens, L, Todorov, H, Sichien, D, Soen, B, Bonnardel, J, De Prijck, S, Vandamme, N, Cannoodt, R, Saelens, W, Vanneste, B, Toussaint, W, De Bleser, P, Takahashi, N, Vandenabeele, P, et al., Lambrecht, BN, De Baetselier, P, Milling, SWF, Van Ginderachter, JA, Malissen, B, Berx, G, Beschin, A, Saeys, Y, Guilliams, M. The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages Immunity 49, 312-325, 2018. (Epub 2018 Jul 31)
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Skrypek, N, Bruneel, K, Vandewalle, C, De Smedt, E, Soen, B, Loret, N, Taminau, J, Goossens, S, Vandamme, N, Berx, G. ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 and DNMTs during epithelial-to-mesenchymal transition Epigenetics Chromatin 11, 70, 2018. (Epub 2018 Nov 16)
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Consortium, E-T, Van Deun, J, Mestdagh, P, Agostinis, P, Akay, O, Anand, S, Anckaert, J, Martinez, ZA, Baetens, T, Beghein, E, Bertier, L, Berx, G, Boere, J, al., E, De Smedt, E, al., E, Soen, B, al., E, Van Vliet, AR, Vandamme, N, et al.. EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research Nat Methods 14, 228-232, 2017. (Epub 2017 Feb 28)
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Devos, M, Gilbert, B, Denecker, G, Leurs, K, Mc Guire, C, Lemeire, K, Hochepied, T, Vuylsteke, M, Lambert, J, Van Den Broecke, C, Libbrecht, L, Haigh, J, Berx, G, Lippens, S, Vandenabeele, P, Declercq, W. Elevated DeltaNp63alpha levels facilitate epidermal and biliary oncogenic transformation J Invest Dermatol 137, 494-505, 2017. (Epub 2016 Oct 7)
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Goossens, S, Peirs, S, Van Loocke, W, Wang, J, Takawy, M, Matthijssens, F, Sonderegger, SE, Haigh, K, Nguyen, T, Vandamme, N, Costa, M, Carmichael, C, Van Nieuwerburgh, F, Deforce, D, Kleifeld, O, Curtis, DJ, Berx, G, Van Vlierberghe, P, Haigh, JJ. Oncogenic ZEB2 activation drives sensitivity towards KDM1A inhibition in T-cell acute lymphoblastic leukemia Blood 129, 981-990, 2017. (Epub 2017 Jan 9)
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Goossens, S, Vandamme, N, Van Vlierberghe, P, Berx, G. EMT transcription factors in cancer development re-evaluated: Beyond EMT and MET Biochim Biophys Acta 1868, 584-591, 2017. (Epub 2017 Jun 29)
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Kohler, C, Nittner, D, Rambow, F, Radaelli, E, Stanchi, F, Vandamme, N, Baggiolini, A, Sommer, L, Berx, G, van den Oord, JJ, Gerhardt, H, Blanpain, C, Marine, JC. Mouse Cutaneous Melanoma Induced by Mutant BRaf Arises from Expansion and Dedifferentiation of Mature Pigmented Melanocytes Cell Stem Cell 21, 679-693, 2017. (Epub 2017 Oct 12)
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Li, J, Riedt, T, Goossens, S, Carrillo Garcia, C, Szczepanski, S, Brandes, M, Pieters, T, Dobrosch, L, Gutgemann, I, Farla, N, Radaelli, E, Hulpiau, P, Mallela, N, Frohlich, H, La Starza, R, Matteucci, C, Chen, T, Brossart, P, Mecucci, C, et al.. The EMT transcription factor Zeb2 controls adult murine hematopoietic differentiation by regulating cytokine signaling Blood 129, 460-472, 2017. (Epub 2016 Sep 28)
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Peirs, S, Frismantas, V, Matthijssens, F, Van Loocke, W, Pieters, T, Vandamme, N, Lintermans, B, Dobay, MP, Berx, G, Poppe, B, Goossens, S, Bornhauser, BC, Bourquin, JP, Van Vlierberghe, P. Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia Leukemia 31, 2037-2047, 2017. (Epub 2017 Feb 3 )
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Pieters, T, Haenebalcke, L, Bruneel, K, Vandamme, N, Hochepied, T, van Hengel, J, Wirth, D, Berx, G, Haigh, JJ, van Roy, F, Goossens, S. Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange J Vis Exp , 122, 2017. (Epub 2017 Apr 27)
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