Publications from this research unit

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See "Extra muros" papers of the units.

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Stryjewska, A, Dries, R, Pieters, T, Verstappen, G, Conidi, A, Coddens, K, Francis, A, Umans, L, van, IWF, Berx, G, van Grunsven, LA, Grosveld, F, Goossens, S, Haigh, JJ, Huylebroeck, D.
Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells
Stem Cells 35, 611-625, 2017. (Epub 2016 Oct 14)

Vergauwen, G, Dhondt, B, Van Deun, J, De Smedt, E, Berx, G, Timmerman, E, Gevaert, K, Miinalainen, I, Cocquyt, V, Braems, G, Van den Broecke, R, Denys, H, De Wever, O, Hendrix, A.
Confounding factors of ultrafiltration and protein analysis in extracellular vesicle research
Sci Rep 7, 2704, 2017. (Epub 2017 Jun 2)

Aaes, TL, Kaczmarek, A, Delvaeye, T, De Craene, B, De Koker, S, Heyndrickx, L, Delrue, I, Taminau, J, Wiernicki, B, De Groote, P, Garg, AD, Leybaert, L, Grooten, J, Bertrand, MJ, Agostinis, P, Berx, G, Declercq, W, Vandenabeele, P, Krysko, DV.
Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity
Cell Rep 15, 274-287, 2016. (Epub 2016 Mar 30)

Bouhy, D, Geuens, T, De Winter, V, Almeida-Souza, L, Katona, I, Weis, J, Hochepied, T, Goossens, S, Haigh, J, Janssens, S, Timmerman, V.
Characterization of New Transgenic Mouse Models for Two Charcot-Marie-Tooth-Causing HspB1 Mutations using the Rosa26 Locus
Journal of Neuromuscular Diseases 3, 183-200, 2016. (Epub 2016 May 27)

Bourcy, M, Suarez-Carmona, M, Lambert, J, Francart, ME, Schroeder, H, Delierneux, C, Skrypek, N, Thompson, EW, Jerusalem, G, Berx, G, Thiry, M, Blacher, S, Hollier, BG, Noel, A, Oury, C, Polette, M, Gilles, C.
Tissue factor induced by epithelial-mesenchymal transition triggers a pro-coagulant state that drives metastasis of circulating tumor cells
Cancer Res 76, 4270-4282, 2016. (Epub 2016 May 24)

Goossens, S, Van Vlierberghe, P.
Overcoming Steroid Resistance in T Cell Acute Lymphoblastic Leukemia
PLoS Med 13, e1002208, 2016. (Epub 2016 Dec 20)

Helsmoortel, HH, De Moerloose, B, Pieters, T, Ghazavi, F, Bresolin, S, Cave, H, de Vries, A, de Haas, V, Flotho, C, Labarque, V, Niemeyer, C, De Paepe, P, Van Roy, N, Stary, J, van den Heuvel-Eibrink, MM, Benoit, Y, Schulte, J, Goossens, S, Berx, G, et al., Van Vlierberghe, P, Lammens, T.
LIN28B is over-expressed in specific subtypes of paediatric leukaemia and regulates lncRNA H19
Haematologica 101, E240-E244, 2016. (Epub 2016 Mar 11)

Pieters, T, Goossens, S, Haenebalcke, L, Andries, V, Stryjewska, A, De Rycke, R, Lemeire, K, Hochepied, T, Huylebroeck, D, Berx, G, Stemmler, MP, Wirth, D, Haigh, JJ, van Hengel, J, van Roy, F.
p120 Catenin-Mediated Stabilization of E-Cadherin Is Essential for Primitive Endoderm Specification
PLoS Genet 12, e1006243, 2016. (Epub 2016 Aug 24)

Scott, CL, Soen, B, Martens, L, Skrypek, N, Saelens, W, Taminau, J, Blancke, G, Van Isterdael, G, Huylebroeck, D, Haigh, J, Saeys, Y, Guilliams, M, Lambrecht, BN, Berx, G.
The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2
J Exp Med 213, 897-911, 2016. (Epub 2016 May 16)

Andries, V, Vandepoele, K, Staes, K, Berx, G, Bogaert, P, Van Isterdael, G, Ginneberge, D, Parthoens, E, Vandenbussche, J, Gevaert, K, van Roy, F.
NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest
BMC Cancer 15, 391, 2015. (Epub 2015 May 10)

Ballantyne, LL, Sin, YY, St Amand, T, Si, J, Goossens, S, Haenebalcke, L, Haigh, JJ, Kyriakopoulou, L, Schulze, A, Funk, CD.
Strategies to rescue the consequences of inducible arginase-1 deficiency in mice
PLoS One 10, e0125967, 2015. (Epub 2015 May 4)

De Vlieghere, E, Gremonprez, F, Verset, L, Mariën, L, Jones, CJ, De Craene, B, Berx, G, Descamps, B, Vanhove, C, Remon, J-P, Ceelen, W, Demetter, P, Bracke, M, De Geest, BG, De Wever, O.
Tumor-environment biomimetics delay peritoneal metastasis formation by deceiving and redirecting disseminated cancer cells
Biomaterials 54, 148-157, 2015. (Epub 2015 Mar 4)

Durinck, K, Goossens, S, Peirs, S, Wallaert, A, Van Loocke, W, Matthijssens, F, Pieters, T, Milani, G, Lammens, T, Rondou, P, Van Roy, N, De Moerloose, B, Benoit, Y, Haigh, J, Speleman, F, Poppe, B, Van Vlierberghe, P.
Novel biological insights in T-cell acute lymphoblastic leukemia
Exp Hematol 43, 625-639, 2015. (Epub 2015 Jun 26)

Goossens, S, Radaelli, E, Blanchet, O, Durinck, K, Van der Meulen, J, Peirs, S, Taghon, T, Tremblay, CS, Costa, M, Farhang Ghahremani, M, De Medts, J, Bartunkova, S, Haigh, K, Schwab, C, Farla, N, Pieters, T, Matthijssens, F, Van Roy, N, Best, JA, et al..
ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling
Nat Commun 6, 5794, 2015. (Epub 2015 Jan 7)

Horvay, K, Jarde, T, Casagranda, F, Perreau, VM, Haigh, K, Nefzger, CM, Akhtar, R, Gridley, T, Berx, G, Haigh, JJ, Barker, N, Polo, JM, Hime, GR, Abud, HE.
Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium
EMBO J 34, 1319-1335, 2015. (Epub 2015 Mar 10)

Omilusik, KD, Best, JA, Yu, B, Goossens, S, Weidemann, A, Nguyen, JV, Seuntjens, E, Stryjewska, A, Zweier, C, Roychoudhuri, R, Gattinoni, L, Bird, LM, Higashi, Y, Kondoh, H, Huylebroeck, D, Haigh, J, Goldrath, AW.
Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection
J Exp Med 212, 2027-2039, 2015. (Epub 2015 Oct 26)

Ramboer, E, De Craene, B, De Kock, J, Berx, G, Rogiers, V, Vanhaecke, T, Vinken, M.
Development and chararcterization of a new human hepatic cell line
Excli Journal 14, 875-889, 2015. (Epub 2015 Jul 28)

Van der Meulen, J, Sanghvi, V, Mavrakis, K, Durinck, K, Fang, F, Matthijssens, F, Rondou, P, Rosen, M, Pieters, T, Vandenberghe, P, Delabesse, E, Lammens, T, De Moerloose, B, Menten, B, Van Roy, N, Verhasselt, B, Poppe, B, Benoit, Y, Taghon, T, et al..
The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia
Blood 125, 13-21, 2015. (Epub 2014 Oct 15)

van Helden, MJ, Goossens, S, Daussy, C, Mathieu, AL, Faure, F, Marcais, A, Vandamme, N, Farla, N, Mayol, K, Viel, S, Degouve, S, Debien, E, Seuntjens, E, Conidi, A, Chaix, J, Mangeot, P, de Bernard, S, Buffat, L, Haigh, JJ, et al..
Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection
J Exp Med 212, 2015-2025, 2015. (Epub 2015 Oct 26)

Castiglioni, V, Farhang Ghahremani, M, Goossens, S, De Maglie, M, Ardizzone, M, Haigh, JJ, Radaelli, E.
Immunohistological description of nongestational ovarian choriocarcinoma in two female mice with conditional loss of Trp53 driven by the Tie2 promoter
Vet Pathol 52, 752-756, 2014. (Epub 2014 Sep 24)

De Craene, B, Denecker, G, Vermassen, P, Taminau, J, Mauch, C, Derore, A, Jonkers, J, Fuchs, E, Berx, G.
Epidermal Snail expression drives skin cancer initiation and progression through enhanced cytoprotection, epidermal stem/progenitor cell expansion and enhanced metastatic potential
Cell Death Differ 21, 310-320, 2014. (Epub 2013 Oct 25)

De Groote, P, Tran, HT, Fransen, M, Tanghe, G, Urwyler, C, De Craene, B, Leurs, K, Gilbert, B, Van Imschoot, G, De Rycke, R, Guerin, CJ, Holland, P, Berx, G, Vandenabeele, P, Lippens, S, Vleminckx, K, Declercq, W.
A novel RIPK4-IRF6 connection is required to prevent epithelial fusions characteristic for popliteal pterygium syndromes
Cell Death Differ 22, 1012-1024, 2014. (Epub 2014 Nov 28)

Denecker, G, Vandamme, N, Akay, Ö, Koludrovic, D, Taminau, J, Lemeire, K, Gheldof, A, De Craene, B, Van Gele, M, Brochez, L, Udupi, G, Rafferty, M, Balint, B, Gallagher, WM, Ghanem, G, Huylebroeck, D, Haigh, JJ, van den Oord, J, Larue, L, Davidson, I, Marine, JC, Berx, G.
Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression
Cell Death Differ 21, 1250-1261, 2014. (Epub 2014 Apr 25)

Farhang Ghahremani, M, Radaelli, E, Haigh, K, Bartunkova, S, Haenebalcke, L, Marine, JC, Goossens, S, Haigh, JJ.
Loss of autocrine endothelial-derived VEGF significantly reduces hemangiosarcoma development in conditional p53-deficient mice
Cell Cycle 13, 1501-1507, 2014. (Epub 2014 Mar 11)

Goossens, S, Van Vlierberghe, P.
Controlling Pre-leukemic Thymocyte Self-Renewal
PLoS Genet 10, e1004881, 2014. (Epub 2014 Dec 18)

Mets, E, Van der Meulen, J, Van Peer, G, Boice, M, Mestdagh, P, Van de Walle, I, Lammens, T, Goossens, S, De Moerloose, B, Benoit, Y, Van Roy, N, Clappier, E, Poppe, B, Vandesompele, J, Wendel, HG, Taghon, T, Rondou, P, Soulier, J, Van Vlierberghe, P, Speleman, F.
MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia
Leukemia 29, 798-806, 2014. (Epub 2014 Sep 18)

Mets, E, Van Peer, G, Van der Meulen, J, Boice, M, Taghon, T, Goossens, S, Mestdagh, P, Benoit, Y, De Moerloose, B, Van Roy, N, Poppe, B, Vandesompele, J, Wendel, HG, Van Vlierberghe, P, Speleman, F, Rondou, P.
MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia
Haematologica 99, 1326-1333, 2014. (Epub 2014 Jun 3)

Peirs, S, Matthijssens, F, Goossens, S, Van de Walle, I, Ruggero, K, de Bock, CE, Degryse, S, Cante-Barrett, K, Briot, D, Clappier, E, Lammens, T, De Moerloose, B, Benoit, Y, Poppe, B, Meijerink, J, Cools, J, Soulier, J, Rabbitts, TH, Taghon, T, Speleman, F, Van Vlierberghe, P.
ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia
Blood 124, 3738-3747, 2014. (Epub 2014 Oct 9)

Quimbaya, M, Raspe, E, Denecker, G, De Craene, B, Roelandt, R, Declercq, W, Sagaert, X, De Veylder, L, Berx, G.
Deregulation of the replisome factor MCMBP prompts oncogenesis in colorectal carcinomas through chromosomal instability
Neoplasia 16, 694-709, 2014. (Epub 2014 Sep)

Ramboer, E, De Craene, B, De Kock, J, Vanhaecke, T, Berx, G, Rogiers, V, Vinken, M.
Strategies for immortalization of primary hepatocytes
J Hepatol 61, 925-943, 2014. (Epub 2014 Jun 6)

Tatari, MN, De Craene, B, Soen, B, Taminau, J, Vermassen, P, Goossens, S, Haigh, K, Cazzola, S, Lambert, J, Huylebroeck, D, Haigh, JJ, Berx, G.
ZEB2-transgene expression in the epidermis compromises the integrity of the epidermal barrier through the repression of different tight junction proteins
Cell Mol Life Sci 71, 3599-3609, 2014. (Epub 2014 Feb 27)

Vandamme, N, Berx, G.
Melanoma cells revive an embryonic transcriptional network to dictate phenotypic heterogeneity
Front Oncol 4, 1-6, 2014. (Epub 2014 Dec 9)

De Craene, B, Berx, G.
Regulatory networks defining EMT during cancer initiation and progression
Nat Rev Cancer 13, 97-110, 2013. (Epub 2013 Jan 24)

Gheldof, A, Berx, G.
Cadherins and epithelial-to-mesenchymal transition
In Progress in molecular biology and translational science: The molecular biology of cadherins. (Van Roy, F, ed.), Burlington, Academic Press , pp. 317-336, 2013. (Epub 2013 Mar)

Koopmansch, B, Berx, G, Foidart, JM, Gilles, C, Winkler, R.
Interplay between KLF4 and ZEB2/SIP1 in the regulation of E-cadherin expression
Biochem Biophys Res Commun 431, 652-657, 2013. (Epub 2013 Jan 29)

van den Berghe, V, Stappers, E, Vandesande, B, Dimidschstein, J, Kroes, R, Francis, A, Conidi, A, Lesage, F, Dries, R, Cazzola, S, Berx, G, Kessaris, N, Vanderhaeghen, P, van IJcken, W, Grosveld, FG, Goossens, S, Haigh, JJ, Fishell, G, Goffinet, A, Aerts, S, Huylebroeck, D, Seuntjens, E.
Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1.
Neuron 77, 70-82, 2013. (Epub 2013 Jan 9)

Gheldof, A, Hulpiau, P, van Roy, F, De Craene, B, Berx, G.
Evolutionary functional analysis and molecular regulation of the ZEB transcription factors
Cell Mol Life Sci 69, 2527-2541, 2012. (Epub 2012 Feb 21)

Quimbaya, M, Vandepoele, K, Raspe, E, Matthijs, M, Dhondt, S, Beemster, GT, Berx, G, De Veylder, L.
Identification of putative cancer genes through data integration and comparative genomics between plants and humans
Cell Mol Life Sci 69, 2041-2055, 2012. (Epub 2012 Jan 5)

Raspe, E, Decraene, C, Berx, G.
Gene expression profiling to dissect the complexity of cancer biology: Pitfalls and promise
Semin Cancer Biol 22, 250-260, 2012. (Epub 2012 Mar 7)

Sleeman, JP, Christofori, G, Fodde, R, Collard, JG, Berx, G, Decraene, C, Ruegg, C.
Concepts of metastasis in flux: The stromal progression model
Semin Cancer Biol 22, 174-186, 2012. (Epub 2012 Feb 21)

Tiwari, N, Gheldof, A, Tatari, M, Christofori, G.
EMT as the ultimate survival mechanism of cancer cells
Semin Cancer Biol 22, 194-207, 2012. (Epub 2012 Mar 8)

Goossens, S, Janzen, V, Bartunkova, S, Yokomizo, T, Drogat, B, Crisan, M, Haigh, K, Seuntjens, E, Umans, L, Riedt, T, Bogaert, P, Haenebalcke, L, Berx, G, Dzierzak, E, Huylebroeck, D, Haigh, JJ.
The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization
Blood 117, 5620-5630, 2011. (Epub 2011 Feb 25)

Bonnet, E, Tatari, M, Joshi, A, Michoel, T, Marchal, K, Berx, G, Van de Peer, Y.
Module network inference from a cancer gene expression data set identifies microRNA regulated modules
PLoS One 5, e10162, 2010. (Epub 2010 Apr 14)

Foubert, E, De Craene, B, Berx, G.
Key signalling nodes in mammary gland development and cancer. The Snail1-Twist1 conspiracy in malignant breast cancer progression
Breast Cancer Res 12, 206, 2010. (Epub 2010 Jun 25)

Herfs, M, Hubert, P, Suarez-Carmona, M, Reschner, A, Saussez, S, Berx, G, Savagner, P, Boniver, J, Delvenne, P.
Regulation of p63 isoforms by Snail and Slug transcription factors in human squamous cell carcinoma
Am J Pathol 176, 1941-1949, 2010. (Epub 2010 Feb 11)

Takahashi, N, Quimbaya, M, Schubert, V, Lammens, T, Vandepoele, K, Schubert, I, Matsui, M, Inze, D, Berx, G, De Veylder, L.
The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair
PLoS Genet 6, e1000817, 2010. (Epub 2010 Jan 15)

Berx, G, Van Roy, F.
Involvement of members of the Cadherin superfamily in cancer
Cold Spring Harbor Perspect Biol 1, a003129, 2009. (Epub 2009 Sep 23)

Marine, JC, Berx, G.
Transforming growth factor-beta and mutant p53 conspire to induce metastasis by antagonizing p63: a (ternary) complex affair
Breast Cancer Res 11, 304, 2009. (Epub ---)

Nyabi, O, Naessens, M, Haigh, K, Gembarska, A, Goossens, S, Maetens, M, De Clercq, S, Drogat, B, Haenebalcke, L, Bartunkova, S, De Vos, I, De Craene, B, Karimi, M, Berx, G, Nagy, A, Hilson, P, Marine, JC, Haigh, JJ.
Efficient mouse transgenesis using Gateway-compatible ROSA26 locus targeting vectors and F1 hybrid ES cells
Nucleic Acids Res 37, e55, 2009. (Epub ---)

Van den Bossche, J, Bogaert, P, van Hengel, J, Guerin, CJ, Berx, G, Movahedi, K, Van den Bergh, R, Pereira-Fernandes, A, Geuns, JM, Pircher, H, Dorny, P, Grooten, J, De Baetselier, P, Van Ginderachter, JA.
Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes
Blood 114, 4664-4674, 2009. (Epub 2009 Sep 2)