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Publications from this research unit
This page shows only publications with IRC as the affiliation of at least one author.
Publications by IRC members mentioning other affiliations are not in our database. Sorry.
See "Extra muros" papers of the units.
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Prabakaran, T, Bodda, C, Krapp, C, Zhang, BC, Christensen, MH, Sun, C, Reinert, L, Cai, Y, Jensen, SB, Skouboe, MK, Nyengaard, JR, Thompson, CB, Lebbink, RJ, Sen, GC, van Loo, G, Nielsen, R, Komatsu, M, Nejsum, LN, Jakobsen, MR, et al. Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1 EMBO J 37, UNSP e97858, 2018. (Epub 2018 Mar 1) 
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Slowicka, K, van Loo, G. Optineurin Functions for Optimal Immunity Front Immunol 9, 769, 2018. (Epub 2018 Apr 10)
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Van Quickelberghe, E, De Sutter, D, van Loo, G, Eyckerman, S, Gevaert, K. A protein-protein interaction map of the TNF-induced NF-kappaB signal transduction pathway Sci Data 5, 180289, 2018. (Epub 2018 Dec 18)
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Van Quickelberghe, E, Martens, A, Goeminne, LJE, Clement, L, van Loo, G, Gevaert, K. Identification of Immune-Responsive Gene 1 (IRG1) as a Target of A20 J Proteome Res 17, 2182-2191, 2018. (Epub 2018 May 11)
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Voet, S, Mc Guire, C, Hagemeyer, N, Martens, A, Schroeder, A, Wieghofer, P, Daems, C, Staszewski, O, Vande Walle, L, Jordao, MJC, Sze, M, Vikkula, HK, Demeestere, D, Van Imschoot, G, Scott, CL, Hoste, E, Goncalves, A, Guilliams, M, Lippens, S, Libert, C, Vandenbroucke, RE, et al., Lamkanfi, M, Prinz, M, van Loo, G. A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation Nat Commun 9, 2036, 2018. (Epub 2018 May 23)
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Voytyuk, I, Mueller, SA, Herber, J, Snellinx, A, Moechars, D, van Loo, G, Lichtenthaler, SF, De Strooper, B. BACE2 distribution in major brain cell types and identification of novel substrates Life Science Alliance 1, e201800026 , 2018. (Epub 2018 Feb 15)
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Vroman, H, Bergen, IM, van Hulst, JAC, van Nimwegen, M, van Uden, D, Schuijs, MJ, Pillai, SY, van Loo, G, Hammad, H, Lambrecht, BN, Hendriks, RW, Kool, M. TNFAIP3 levels in lung dendritic cells instruct Th2 or Th17 cell differentiation in eosinophilic or neutrophilic asthma J Allergy Clin Immunol 141, 1620-1633, 2018. (Epub 2017 Sep 6)
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Vroman, H, Das, T, Bergen, IM, van Hulst, JAC, Ahmadi, F, van Loo, G, Lubberts, E, Hendriks, RW, Kool, M. House dust mite-driven neutrophilic airway inflammation in mice with TNFAIP3-deficient myeloid cells is IL-17-independent Clin Exp Allergy 48, 1705-1714, 2018. (Epub 2018 Sep 1)
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Catrysse, L, van Loo, G. Inflammation and the Metabolic Syndrome: The Tissue-Specific Functions of NF-kappaB Trends Cell Biol 27, 417-429, 2017. (Epub 2017 Feb 22)
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Deckers, J, Sichien, D, Plantinga, M, Van Moorleghem, J, Vanheerswynghels, M, Hoste, E, Malissen, B, Dombrowicz, D, Guilliams, M, De Bosscher, K, Lambrecht, BN, Hammad, H. Epicutaneous sensitization to house dust mite allergen requires IRF4-dependent dermal dendritic cells J Allergy Clin Immunol 140, 1364-1377, 2017. (Epub 2017 Feb 9)
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De Wilde, K, Martens, A, Lambrecht, S, Jacques, P, Drennan, MB, Debusschere, K, Govindarajan, S, Coudenys, J, Verheugen, E, Windels, F, Catrysse, L, Lories, R, McGonagle, D, Beyaert, R, van Loo, G, Elewaut, D. A20 inhibition of STAT1 expression in myeloid cells: a novel endogenous regulatory mechanism preventing development of enthesitis Ann Rheum Dis 76, 585-592, 2017. (Epub 2016 Aug 22)
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Donati, G, Rognoni, E, Hiratsuka, T, Liakath-Ali, K, Hoste, E, Kar, G, Kayikci, M, Russell, R, Kretzschmar, K, Mulder, KW, Teichmann, SA, Watt, FM. Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties Nat Cell Biol 19, 603-613, 2017. (Epub 2017 May 15)
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Fischer, JC, Otten, V, Kober, M, Drees, C, Rosenbaum, M, Schmickl, M, Heidegger, S, Beyaert, R, van Loo, G, Li, XC, Peschel, C, Schmidt-Supprian, M, Haas, T, Spoerl, S, Poeck, H. A20 Restrains Thymic Regulatory T Cell Development J Immunol 199, 2356-2365, 2017. (Epub 2017 Aug 25)
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Fischer, JC, Otten, V, Steiger, K, Schmickl, M, Slotta-Huspenina, J, Beyaert, R, van Loo, G, Peschel, C, Poeck, H, Haas, T, Spoerl, S. A20 deletion in T cells modulates acute graft-versus-host disease in mice Eur J Immunol 47, 1982-1988, 2017. (Epub 2017 Aug 22)
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Kaushal, G, Rognoni, E, Lichtenberger, BM, Driskell, RR, Kretzschmar, K, Hoste, E, Watt, FM. Stabilization of beta-Catenin Does Not Increase Dermal Papilla Cell Number in the Hair Follicle Reply J Invest Dermatol 137, 247-248, 2017. (Epub 2017 Jan)
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Lee, JH, Jung, SM, Yang, KM, Bae, E, Ahn, SG, Park, JS, Seo, D, Kim, M, Ha, J, Lee, J, Kim, JH, Kim, JH, Ooshima, A, Park, J, Shin, D, Lee, YS, Lee, S, van Loo, G, Jeong, J, et al.. A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1 Nat Cell Biol 19, 1260-1273, 2017. (Epub 2017 Sep 11)
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Merckx, E, Albertini, G, Paterka, M, Jensen, C, Albrecht, P, Dietrich, M, Van Liefferinge, J, Bentea, E, Verbruggen, L, Demuyser, T, Deneyer, L, Lewerenz, J, van Loo, G, De Keyser, J, Sato, H, Maher, P, Methner, A, Massie, A. Absence of system xc- on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis J Neuroinflammation 14, 9, 2017. (Epub 2017 Jan 13)
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Speeckaert, R, Voet, S, Hoste, E, van Geel, N. S100B is a potential disease activity marker in non-segmental vitiligo J Invest Dermatol 137, 1445-1453, 2017. (Epub 2017 Feb 14)
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Catrysse, L, Farhang Ghahremani, M, Vereecke, L, Youssef, SA, Mc Guire, C, Sze, M, Weber, A, Heikenwalder, M, de Bruin, A, Beyaert, R, van Loo, G. A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death Cell Death Dis 7, e2250, 2016. (Epub 2016 Jun 2)
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Drennan, MB, Govindarajan, S, Verheugen, E, Coquet, JM, Staal, J, McGuire, C, Taghon, T, Leclercq, G, Beyaert, R, van Loo, G, Lambrecht, BN, Elewaut, D. NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20 J Exp Med 213, 1973-1981, 2016. (Epub 2016 Aug 22)
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Fukaya, M, Brorsson, CA, Meyerovich, K, Catrysse, L, Delaroche, D, Vanzela, EC, Ortis, F, Beyaert, R, Nielsen, LB, Andersen, ML, Mortensen, HB, Pociot, F, van Loo, G, St Rling, J, Cardozo, AK. A20 inhibits beta-cell Apoptosis by Multiple Mechanisms and Predicts Residual beta-cell Function in Type 1 Diabetes Mol Endocrinol 30, 48-61, 2016. (Epub 2015 Dec 10)
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Goktuna, SI, Shostak, K, Chau, TL, Heukamp, LC, Hennuy, B, Duong, HQ, Ladang, A, Close, P, Klevernic, I, Olivier, F, Florin, A, Ehx, G, Baron, F, Vandereyken, M, Rahmouni, S, Vereecke, L, Van Loo, G, Buttner, R, Greten, F, et al.. The pro-survival IKK-related kinase IKKepsilon integrates LPS and IL-17A signaling cascades to promote Wnt-dependent tumor development in the intestine Cancer Res 76, 2587-2599, 2016. (Epub 2016 Mar 15)
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Maelfait, J, Roose, K, Vereecke, L, Mc Guire, C, Sze, M, Schuijs, MJ, Willart, M, Itati Ibanez, L, Hammad, H, Lambrecht, BN, Beyaert, R, Saelens, X, van Loo, G. A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection PLoS Pathog 12, e1005410, 2016. (Epub 2016 Jan 27)
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Slowicka, K, Vereecke, L, McGuire, C, Sze, M, Maelfait, J, Kolpe, A, Saelens, X, Beyaert, R, van Loo, G. Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-kappaB signaling Eur J Immunol 46, 971-980, 2016. (Epub 2015 Dec 17)
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Slowicka, K, Vereecke, L, van Loo, G. Cellular Functions of Optineurin in Health and Disease Trends Immunol 37, 621-633, 2016. (Epub 2016 Jul 29)
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Van Overmeire, E, Stijlemans, B, Heymann, F, Keirsse, J, Morias, Y, Elkrim, Y, Brys, L, Abels, C, Lahmar, Q, Ergen, C, Vereecke, L, Tacke, F, De Baetselier, P, Van Ginderachter, JA, Laoui, D. M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment Cancer Res 76, 35-42, 2016. (Epub 2016 Jan 1)
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Vlantis, K, Polykratis, A, Welz, PS, van Loo, G, Pasparakis, M, Wullaert, A. TLR-independent anti-inflammatory function of intestinal epithelial TRAF6 signalling prevents DSS-induced colitis in mice Gut 65, 935-943, 2016. (Epub 2015 Mar 11)
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Catrysse, L, Fukaya, M, Sze, M, Meyerovich, K, Beyaert, R, Cardozo, AK, van Loo, G. A20 deficiency sensitizes pancreatic beta cells to cytokine-induced apoptosis in vitro but does not influence type 1 diabetes development in vivo Cell Death Dis 6, e1918, 2015. (Epub 2015 Oct 15)
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Coppens, F, Iyyathurai, J, Ruer, S, Fioravanti, A, Taganna, J, Vereecke, L, De Greve, H, Remaut, H. Structural and adhesive properties of the long polar fimbriae protein LpfD from adherent-invasive Escherichia coli Acta Crystallogr D Biol Crystallogr 71, 1615-1626, 2015. (Epub 2015 Jul 28)
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Kumar, M, Sahu, SK, Kumar, R, Subuddhi, A, Maji, RK, Jana, K, Gupta, P, Raffetseder, J, Lerm, M, Ghosh, Z, van Loo, G, Beyaert, R, Gupta, UD, Kundu, M, Basu, J. MicroRNA let-7 Modulates the Immune Response to Mycobacterium tuberculosis Infection via Control of A20, an Inhibitor of the NF-kappaB Pathway Cell Host Microbe 17, 345-356, 2015. (Epub 2015 Feb 11)
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Schuijs, MJ, Willart, MA, Vergote, K, Gras, D, Deswarte, K, Ege, MJ, Branco Madeira, F, Beyaert, R, van Loo, G, Bracher, F, von Mutius, E, Chanez, P, Lambrecht, BN, Hammad, H. Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells Science 349, 1106-1110, 2015. (Epub 2015 Sep 4)
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Tyteca, D, Nishino, T, Debaix, H, Van Der Smissen, P, N'Kuli, F, Hoffmann, D, Cnops, Y, Rabolli, V, van Loo, G, Beyaert, R, Huaux, F, Devuyst, O, Courtoy, PJ. Regulation of macrophage motility by the water channel aquaporin-1: crucial role of m0/m2 phenotype switch PLoS One 10, e0117398, 2015. (Epub 2015 Feb 26)
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Catrysse, L, Vereecke, L, Beyaert, R, van Loo, G. A20 in inflammation and autoimmunity Trends Immunol 35, 22-31, 2014. (Epub 2013 Nov 15)
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Giordano, M, Roncagalli, R, Bourdely, P, Chasson, L, Buferne, M, Yamasaki, S, Beyaert, R, van Loo, G, Auphan-Anezin, N, Schmitt-Verhulst, AM, Verdeil, G. The tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells Proc Natl Acad Sci USA 111, 11115-11120, 2014. (Epub 2014 Jul 14)
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Heger, K, Fierens, K, Vahl, C, Aszodi, A, Peschke, K, Schenten, D, Hammad, H, Beyaert, R, Saur, D, van Loo, G, Roers, A, Lambrecht, BN, Kool, M, Schmidt-Supprian, M. A20-deficient mast cells exacerbate inflammatory responses in vivo PLoS Biol 12, e1001762, 2014. (Epub 2014 Jan 14)
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Mc Guire, C, Elton, L, Wieghofer, P, Staal, J, Voet, S, Demeyer, A, Nagel, D, Krappmann, D, Prinz, M, Beyaert, R, van Loo, G. Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis J Neuroinflamm 11, 124, 2014. (Epub 2014 Jul 21)
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Takahashi, N, Vereecke, L, Bertrand, MJ, Duprez, L, Berger, SB, Divert, T, Goncalves, A, Sze, M, Gilbert, B, Kourula, S, Goossens, V, Lefebvre, S, Gunther, C, Becker, C, Bertin, J, Gough, PJ, Declercq, W, van Loo, G, Vandenabeele, P. RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis Nature 513, 95-99, 2014. (Epub 2014 Sep 4)
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Vande Walle, L, Van Opdenbosch, N, Jacques, P, Fossoul, A, Verheugen, E, Vogel, P, Beyaert, R, Elewaut, D, Kanneganti, TV, van Loo, G, Lamkanfi, M. Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis Nature 512, 69-73, 2014. (Epub 2014 Jun 29)
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Vereecke, L, Vieira-Silva, S, Billiet, T, van Es, JH, Mc Guire, C, Slowicka, K, Sze, M, van den Born, M, De Hertogh, G, Clevers, H, Raes, J, Rutgeerts, P, Vermeire, S, Beyaert, R, van Loo, G. A20 controls intestinal homeostasis through cell-specific activities Nat Comm 5, 5103, 2014. (Epub 2014 Sep 30)
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Verhelst, K, van Loo, G, Beyaert, R. A20: attractive without showing cleavage EMBO Rep 15, 734-735, 2014. (Epub 2014 May 30)
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Zabeau, L, Jensen, CJ, Seeuws, S, Venken, K, Verhee, A, Catteeuw, D, van Loo, G, Chen, H, Walder, K, Hollis, J, Foote, S, Morris, MJ, Van der Heyden, J, Peelman, F, Oldfield, BJ, Rubio, JP, Elewaut, D, Tavernier, J. Leptin’s metabolic and immune functions can be uncoupled at the ligand/receptor interaction level Cell Mol Life Sci 72, 629-644, 2014. (Epub 2014 Aug 7)
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Mc Guire, C, Prinz, M, Beyaert, R, van Loo, G. Nuclear Factor-kB in multiple sclerosis pathology Trends Mol Med 19, 604-613, 2013. (Epub 2023 Sep 2)
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Mc Guire, C, Rahman, M, Schwaninger, M, Beyaert, R, van Loo, G. The ubiquitin editing enzyme A20 (TNFAIP3) is upregulated during permanent middle cerebral artery occlusion but does not influence disease outcome Cell Death Dis 4, e531, 2013. (Epub 2013 Mar 7)
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Mc Guire, C, Wieghofer, P, Elton, L, Muyllaert, D, Prinz, M, Beyaert, R, van Loo, G. Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination J Immunol 190, 2896-2903, 2013. (Epub 2013 Feb 11)
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Chu, Y, Soberon, V, Glockner, L, Beyaert, R, Massoumi, R, van Loo, G, Krappmann, D, Schmidt-Supprian, M. A20 and CYLD do not share significant overlapping functions during B cell development and activation J Immunol 189, 4437-4443, 2012. (Epub 2012 Sep 21)
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Maelfait, J, Roose, K, Bogaert, P, Sze, M, Saelens, X, Pasparakis, M, Carpentier, I, van Loo, G, Beyaert, R. A20 (Tnfaip3) deficiency in myeloid cells protects against Influenza A virus infection PLoS Pathog 8, e1002570, 2012. (Epub 2012 Mar 1)
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Polykratis, A, van Loo, G, Xanthoulea, S, Pasparakis, M. Conditional targeting of TRAF6 reveals opposing functions of TLR signaling in endothelial and myeloid cells in a mouse model of atherosclerosis Circulation 126, 1739-1751 , 2012. (Epub 2012 Aug 30)
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Willenborg, S, Lucas, T, van Loo, G, Knipper, JA, Krieg, T, Haase, I, Brachvogel, B, Hammerschmidt, M, Nagy, A, Ferrara, N, Pasparakis, M, Eming, SA. CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair Blood 120, 613-325, 2012. (Epub 2012 May 10)
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Wolf, MJ, Hoos, A, Bauer, J, Boettcher, S, Knust, M, Weber, A, Simonavicius, N, Schneider, C, Lang, M, Sturzl, M, Croner, RS, Konrad, A, Manz, MG, Moch, H, Aguzzi, A, van Loo, G, Pasparakis, M, Prinz, M, Borsig, L, Heikenwalder, M. Endothelial CCR2 signaling induced by colon carcinoma cells licenses extravasation via the JAK2-Stat5 and p38MAPK pathway Cancer Cell 22, 91-105, 2012. (Epub 2012 Jul 10)
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Bonnet, MC, Preukschat, D, Welz, P-S, van Loo, G, Ermolaeva, MA, Bloch, W, Haase, I, Pasparakis, M. The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation Immunity 35, 572-582, 2011. (Epub 2011 Oct 12)
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