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Publications from this research unit

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Duprez, L, Takahashi, N, Van Hauwermeiren, F, Vandendriessche, B, Goossens, V, Vanden Berghe, T, Declercq, W, Libert, C, Cauwels, A, Vandenabeele, P.
RIP Kinase-dependent necroptosis drives lethal systemic inflammatory response syndrome
Immunity 35, 908-918, 2011. (Epub 2011 Dec 23)

Krysko, DV, Kaczmarek, A, Krysko, O, Heyndrickx, L, Woznicki, J, Bogaert, P, Cauwels, A, Takahashi, N, Magez, S, Bachert, C, Vandenabeele, P.
TLR-2 and TLR-9 are sensors of apoptosis in a mouse model of doxorubicin-induced acute inflammation
Cell Death Differ 18, 1316-1325, 2011. (Epub 2011 Feb 11)

Minamishima, S, Kida, K, Tokuda, K, Wang, H, Sips, PY, Kosug, iS, Mandeville, JB, Buys, ES, Brouckaert, P, Liu, PK, Liu, CH, Bloch, KD, Ichinose, F.
Inhaled Nitric Oxide improves outcomes after successful cardiopulmonary resuscitation in mice
Circulation 124, 1645-1653, 2011. (Epub 2011 Sep 19)

Nagasaka, Y, Buys, ES, Spagnolli, E, Steinbicker, AU, Hayton, SR, Rauwerdink, KM, Brouckaert, P, Zapol, WM, Bloch, KD.
Soluble guanylate cyclase alpha1 is required for the cardioprotective effects of inhaled nitric oxide
Am J Physiol Heart Circ Physiol 300, H1477-1483, 2011. (Epub 2011 Jan 21)

Sips, PY, Brouckaert, P, Ichinose, F.
The alpha1 isoform of soluble guanylate cyclase regulates cardiac contractility but is not required for ischemic preconditioning
Basic Res Cardiol 106, 635-643, 2011. (Epub 2011 Mar 11)

Steinbicker, AU, Liu, H, Jiramongkolchai, K, Malhotra, R, Choe, EY, Busch, CJ, Graveline, AR, Kao, SM, Nagasaka, Y, Ichinose, F, Buys, ES, Brouckaert, P, Zapol, WM, Bloch, KD.
Nitric oxide regulates pulmonary vascular smooth muscle cell expression of the inducible cAMP early repressor gene
Nitric Oxide 25, 294-302, 2011. (Epub 2011 May 27)

Wang, E, Feng, Y, Zhang, M, Zou, L, Li, Y, Buys, ES, Huang, P, Brouckaert, P, Chao, W.
Toll-like receptor 4 signaling confers cardiac protection against ischemic injury via inducible nitric oxide synthase- and soluble guanylate cyclase-dependent mechanisms
Anesthesiology 114, 603-613, 2011. (Epub ---)

Atochin, DN, Yuzawa, I, Li, Q, Rauwerdink, KM, Malhotra, R, Chang, J, Brouckaert, P, Ayata, C, Moskowitz, MA, Bloch, KD, Huang, PL, Buys, ES.
Soluble Guanylate Cyclase alpha1beta1 limits stroke size and attenuates neurological injury
Stroke 41, 1815-1819, 2010. (Epub 2010 Jul 1)

Cauwels, A, Rogge, E, Janssen, B, Brouckaert, P.
Reactive oxygen species and small conductance calcium-dependent potassium channels are key mediators of inflammation-induced hypotension and shock
J Mol Med 88, 921-930, 2010. (Epub 2010 May 25)

Decaluwe, K, Nimmegeers, S, Thoonen, R, Buys, E, Brouckaert, P, Van de Voorde, J.
In vitro and in vivo studies on the importance of the soluble guanylyl cyclase alpha1 subunit in penile erection
World J Urol 28, 643-650, 2010. (Epub 2010 Jan 23)

Houthuys, E, Movahedi, K, De Baetselier, P, Van Ginderachter, JA, Brouckaert, P.
A method for the isolation and purification of mouse peripheral blood monocytes
J Immunol Methods 359, 1-10, 2010. (Epub 2010 May 7)

Ni, J, McLoughlin, RM, Brodovitch, A, Moulin, P, Brouckaert, P, Casadei, B, Feron, O, Topley, N, Balligand, J-L, Devuyst, O.
Nitric oxide synthase isoforms play distinct roles during acute peritonitis
Nephrol Dial Transplant 25, 86-96, 2010. (Epub 2009 Aug 25)

Van den Bergh, R, Florence, E, Vlieghe, E, Boonefaes, T, Grooten, J, Houthuys, E, Tran Thi Thanh, H, Gali, Y, De Baetselier, P, Vanham, G, Raes, G.
Transcriptome analysis of monocyte-HIV interactions
Retrovirology 7, 53, 2010. (Epub 2010 Jun 14)

Buys, ES, Cauwels, A, Raher, MJ, Passeri, JJ, Hobai, I, Cawley, SM, Rauwerdink, KM, Thibault, HB, Sips, PY, Thoonen, R, Scherrer-Crosbie, M, Ichinose, F, Brouckaert, P, Bloch, KD.
sGCalpha1beta1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models
Am J Physiol Heart Circ Physiol 297, H654-H663, 2009. (Epub 2009 Jun 5)

Cauwels, A, Buys, ES, Thoonen, R, Geary, L, Delanghe, J, Shiva, S, Brouckaert, P.
Nitrite protects against morbidity and mortality associated with TNF or LPS-induced shock in a soluble guanylate cyclase–dependent manner
J Exp Med 206, 2915-2924, 2009. (Epub 2009 Nov 23)

Dhaese, I, Vanneste, G, Sips, P, Buys, E, Brouckaert, P, Lefebvre, RA.
Small intestinal motility in soluble guanylate cyclase a1 knockout mice
Naunyn S Arch Pharmacol 379, 473-487, 2009. (Epub 2008 Dec 4)

Nishida, T, Yu, JD, Minamishima, S, Sips, P, Searles, RJ, Buys, ES, Janssens, S, Brouckaert, P, Bloch, KD, Ichinose, F.
Impact of nitric oxide synthase 3 and soluble guanylate cyclase on the outcome of cardiac arrest and cardiopulmonary resuscitation in mice
Crit Care Med 37, 256-262, 2009. (Epub 2008 Nov 28)

Vanholder, R, Abou-Deif, O, Argiles, A, Baurmeister, U, Beige, J, Brouckaert, P, Brunet, P, Cohen, G, De Deyn, PP, Drueke, TB, Fliser, D, Glorieux, G, Herget-Rosenthal, S, Horl, WH, Jankowski, J, Jorres, A, Massy, ZA, Mischak, H, Perna, AF, et al..
The role of EUTox in uremic toxin research
Semin Dialysis 22, 323-328, 2009. (Epub ---)

Vermeersch, P, Buys, E, Sips, P, Pokreisz, P, Marsboom, G, Gillijns, H, Pellens, M, Dewerchin, M, Bloch, KD, Brouckaert, P, Janssens, S.
Gender-specific modulation of the response to arterial injury by soluble Guanylate Cyclase alpha1
Open Cardiovasc Med J 3, 98-104, 2009. (Epub 2009 Aug 31)

Bredan, A, Cauwels, A.
Is there NO treatment for severe sepsis?
Libyan J Med 3, 34-38, 2008. (Epub 2007 Oct 18)

Buys, ES, Sips, P, Vermeersch, P, Raher, MJ, Rogge, E, Ichinose, F, Dewerchin, M, Bloch, KD, Janssens, S, Brouckaert, P.
Gender-specific hypertension and responsiveness to nitric oxide in sGC{alpha}1 knockout mice
Cardiovasc Res 79, 179-186, 2008. (Epub 2008 Mar 13)

Cauwels, A, Brouckaert, P.
Critical role for small and large conductance calcium-dependent potassium channels in endotoxemia and TNF toxicity
Shock 29, 577-582, 2008. (Epub 2007 Aug 16)

De Backer, O, Elinck, E, Sips, P, Buys, E, Brouckaert, P, Lefebvre, RA.
Role of the soluble guanylyl cyclase alpha1/alpha2 subunits in the relaxant effect of CO and CORM-2 in murine gastric fundus
Naunyn S Arch Pharmacol 378, 493-502, 2008. (Epub 2008 Jun 19)

Dhaese, I, Vanneste, G, Sips, P, Buys, E, Brouckaert, P, Lefebvre, RA.
Involvement of soluble guanylate cyclase alpha1 and alpha2, and SKCa channels in NANC relaxation of mouse distal colon
Eur J Pharmacol 589, 251-259, 2008. (Epub 2008 May 23)

Nimmegeers, S, Sips, P, Buys, E, De Caluwé, K, Brouckaert, P, Van de Voorde, J.
Role of the soluble guanylyl cyclase-alpha-1 subunit in mice corpus cavernosum smooth muscle relaxation
Int J Impot Res 20, 278-284, 2008. (Epub 2007 Dec 6)

Rivas, MA, Carnevale, RP, Proietti, CJ, Rosemblit, C, Beguelin, W, Salatino, M, Charreau, EH, Frahm, I, Sapia, S, Brouckaert, P, Elizalde, PV, Schillaci, R.
TNFalpha acting on TNFR1 promotes breast cancer growth via p42/P44 MAPK, JNK, Akt and NF-kappaB-dependent pathways
Exp Cell Res 314, 509-529, 2008. (Epub 2007 Oct 13)

Takahashi, N, Vanlaere, I, de Rycke, R, Cauwels, A, Joosten, LA, Lubberts, E, van den Berg, WB, Libert, C.
IL-17 produced by Paneth cells drives TNF-induced shock
J Exp Med 205, 1755-1761, 2008. (Epub 2008 Jul 28)

Cauwels, A.
Nitric oxide in shock
Kidney Intl 72, 557-565 , 2007. (Epub 2007 May 30)

Cauwels, A, Brouckaert, P.
Survival of TNF toxicity: dependence on caspases and NO
Arch Biochem Biophys 462, 132-139, 2007. (Epub 2007 Feb 8)

Nimmegeers, S, Sips, P, Buys, E, Brouckaert, P, Van de Voorde, J.
Functional role of the soluble guanylyl cyclase alpha1 subunit in vascular smooth muscle relaxation
Cardiovasc Res 76, 149-159, 2007. (Epub 2007 Jun 12)

Tiels, P, Verdonck, F, Coddens, A, Ameloot, P, Goddeeris, B, Cox, E.
Monoclonal antibodies reveal a weak interaction between the F18 fimbrial adhesin FedF and the major subunit FedA
Vet Microbiol 119, 115-120, 2007. (Epub 2006 Sep 10)

Vanneste, G, Dhaese, I, Sips, P, Buys, E, Brouckaert, P, Lefebvre, RA.
Gastric motility in soluble guanylate cyclase alpha1 knock-out mice
J Physiol 584, 907-920, 2007. (Epub 2007 Aug 23)

Vermeersch, P, Buys, E, Pokreisz, P, Marsboom, G, Ichinose, F, Sips, P, Pellens, M, Gillijns, H, Swinnen, M, Graveline, A, Collen, D, Dewerchin, M, Brouckaert, P, Bloch, KD, Janssens, S.
Soluble guanylate cyclase-alpha1 deficiency selectively inhibits the pulmonary vasodilator response to nitric oxide and increases the pulmonary vascular remodeling response to chronic hypoxia
Circulation 116, 936-943, 2007. (Epub 2007 Aug 6)

Bilej, M, Joskova, R, Van den Bergh, R, Prochazkova, P, Silerova, M, Ameloot, P, De Baetselier, P, Beschin, A.
An invertebrate TNF functional analogue activates macrophages via lectin-saccharide interaction with ion channels
Int Immunol 18, 1663-1670, 2006. (Epub 2006 Oct 11)

Bultinck, J, Brouckaert, P, Cauwels, A.
The in vivo contribution of hematopoietic cells to systemic TNF and IL-6 production during endotoxemia
Cytokine 36, 160-166, 2006. (Epub 2007 Jan 3)

Bultinck, J, Sips, P, Vakaet, L, Brouckaert, P, Cauwels, A.
Systemic NO production during (septic) shock depends on parenchymal and not on hematopoietic cells: in vivo iNOS expression pattern in (septic) shock
FASEB J 20, 2363-2365, 2006. (Epub 2006 Oct 4)

Cauwels, A, Janssen, B, Buys, E, Sips, P, Brouckaert, P.
Anaphylactic shock depends on PI3K and eNOS-derived NO
J Clin Invest 116, 2244-2251, 2006. (Epub ---)

Heirman, I, Ginneberge, D, Brigelius-Flohé, R, Hendrickx, N, Agostinis, P, Brouckaert, P, Rottiers, P, Grooten, J.
Blocking tumor cell eicosanoid synthesis by GPx4 impedes tumor growth and malignancy
Free Radical Biol Med 40, 285-294, 2006. (Epub ---)

Rahman, MM, Barrett, JW, Brouckaert, P, McFadden, G.
Variation in ligand binding specificities of a novel class of poxvirus-encoded Tumor Necrosis Factor-binding protein
J Biol Chem 281, 22517-22526, 2006. (Epub 2006 Jun 16)

Waelput, W, Brouckaert, P, Broekaert, D, Tavernier, J.
A role for leptin in the systemic inflammatory response syndrome (SIRS) and in immune response, an update
Curr Med Chem 13, 465-475, 2006. (Epub ---)

Cauwels, A, Bultinck, J, Brouckaert, P.
Dual role of endogenous nitric oxide in tumor necrosis factor shock: induced NO tempers oxidative stress
Cell Mol Life Sci 62, 1632-1640, 2005. (Epub 2005 Jun 30)

Ameloot, P, Brouckaert, P.
Production and characterization of receptor-specific TNF muteins
Methods Mol Med 98, 33-46, 2004. (Epub ---)

Brouckaert, P, Takahashi, N, van Tiel, S, Hostens, J, Eggermont, AaLB, Seynhaeve, A, Fiers, W, Timo, L.
Tumour Necrosis Factor-alpha augmented tumour response in B16BL6 melanoma-bearing mice treated with Stealth liposomal doxorubicin (Doxil) correlates with altered Doxil pharmacokinetics
Int J Cancer 109, 442-448, 2004. (Epub ---)

Magez, S, Truyens, C, Merimi, M, Radwanska, M, Stijlemans, B, Brouckaert, P, Brombacher, F, Pays, E, De Baetselier, P.
P75 TNF-receptor shedding occurs as a protective host response during African trypanosomiasis
J Infect Dis 189, 527-539, 2004. (Epub 2004 Jan 23)

Wu, G, Brouckaert, P, Olivecrona, T.
Rapid down-regulation of adipose tissue lipoprotein lipase activity on food deprivation. Evidence that TNF- is involved
Am J Physiol Endocrinol Metab 286, E711–E717, 2004. (Epub 2003 Dec 23)

Cauwels, A, Janssen, B, Waeytens, A, Cuvelier, C, Brouckaert, P.
Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2
Nat Immunol 4, 387-393, 2003. (Epub ---)

Ameloot, P, Fiers, W, Buurman, WA, De Baetselier, P, Brouckaert, P.
Characterization of the interaction between murine tumour necrosis factor and monoclonal antibodies
Cytokine 18, 158-163, 2002. (Epub ---)

Ameloot, P, Takahashi, T, Everaerdt, B, Hostens, J, Eugster, H-P, Fiers, W, Brouckaert, P.
Bioavailability of recombinant tumor necrosis factor determines its lethality in mice
Eur J Immunol 32, 2759-2765, 2002. (Epub ---)

Dick, JMC, Van Molle, W, Brouckaert, P, Lefebvre, RA.
Relaxation by vasoactive intestinal polypeptide in the gastric fundus of nitric oxide synthase-deficient mice
J Physiol 538, 133-143, 2002. (Epub ---)

Hochepied, T, Wullaert, A, Berger, FG, Baumann, H, Brouckaert, P, Steidler, L, Libert, C.
Overexpression of a1-acid glycoprotein in transgenic mice leads to sensitisation to acute colitis
Gut 51, 398-404, 2002. (Epub ---)

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